Class 536/27.31 - S-Adenosyl-L-methionine, S-Adenosyl-L-homocysteine, salts, or esters thereof

Subclass of Class 536 - Organic compounds -- part of the class 532-570 series
Definition: A compound which is S-Adenosyl-L-methionine, S-Adenosyl-L-homocysteine,
No. of patents: 33
Last issue date: 04/19/2005

Number	Title	Issue Date
6881837	Chemical synthesis of S-adenosyl-L-methionine with enrichment of (S,S)-isomer This invention relates to the production of S-adenosyl-L-methionine by means of a chemical process wherein enrichment of the bioactive (S,S)-isomer is achieved. The process is simple, efficient, economical and reproducible on large scale. ...	04/19/2005
6759395	Soft-gelatin capsule comprising S-adenosylmethionine and a method for producing the same The invention provides a novel soft gelatin capsule comprising a fill material consisting essentially of S-adenosylmethionine (SAMe) salt disposed within an enteric coated soft gelatin film. ...	07/06/2004
6649753	Stable salts of S-adenosyl-L-methionine (SAMe) and the process for their preparation This invention relates to the production of new & stable salts of S-adenosyl-L-methionine SAMe). The source of SAMe used in the salt formation is from chemical process wherein stereoselective methylation of S-adenosyl-L-homocysteine is achieved. The proce...	11/18/2003
6635615	Stable salts of S-adenosyl-l-methionine Stable salts of S-adenosyl-1-methionine with polycations such as chitosan are described. The salts according to the invention are very stable and are valuable for use as active constituents in pharmaceutical compositions....	10/21/2003
6117849	S-(+)-adenosylmethionine and 3'-azido-2', 3'-dideoxy-nucleoside complexes as potent inhibitors of HIV-replication Molecular Complexes, comprising of S-(+)-adenosylmethionine and 3'-azido-2',3'-dideoxy nucleosides are prepared, and shown to have synergistic inhibitory effects on the replication of human-immunodeficiency virus 1 & 2 in vitro and in vivo, particularly o...	09/12/2000
5466678	Co-administration of S-adenosyl-L-methionine to reduce the nephrotoxicity of cisplatin therapy A pharmaceutical composition for use as a nephrotoxicity alleviator for alleviating the nephrotoxicity caused by a drug administered into the living organism, which composition contains S-adenosyl-L-methionine or a salt thereof as an active ingredient is ...	11/14/1995
5455234	Inhibition of hair growth Mammalian hair growth is reduced by applying to the skin an inhibitor of a cysteine synthetic pathway enzyme....	10/03/1995
5416076	S-adenosyl methionine decarboxylase inhibitors The adenosine derivatives represented by the following formula: ##STR1## and the pharmaceutically acceptable salts thereof wherein R is H or C1 -C7 alkyl, Q is the moiety of the formula ##STR2## wherein V is H or --COOH X i...	05/16/1995
5196402	S-adenosyl-methionine in the treatment of pancreatitis and of the immuno rejection in the pancreas transplant Therapeutic composition comprising S-adenosyl-methionine useful in the treatment of pancreatitis and as synergistic agent of cyclosporin in the prevention of the graft rejection in pancreas transplant....	03/23/1993
5128249	Stable sulpho-adenosyl-L-methionine (SAMe) salts, particularly suitable for oral pharmaceutical use This invention relates to new stable sulpho-adenosyl-L-methionine (SAMe) salts and the relative production process. Said salts have the following general formula: SAMe.nR(O)m (SO3 H)p (I) where m can be zero o...	07/07/1992
5114931	Injectable therapeutic compositions containing stable S-adenosyl-L-methionine salts The invention discloses injectable therapeutic compositions containing stable S-adenosyl-L-methionine (SAMe) salts as an active ingredient. Injectable therapeutic compositions which permit large doses of SAMe to be administered by injection, at physiologi...	05/19/1992
5073546	Lipophilic salts of S-adenosyl-L-methionine (SAM) with acylated taurine derivatives Liposoluble salts of S-adenosyl-L-methionine (SAM) with acyl derivatives of taurine having the formula: SAMn [R--CO--NH--(CH2)2 --SO-3 ]n in which R--CO is a member selected from C12 -C	12/17/1991
4990606	Stable sulpho-adenosyl-L-methionine (SAMe) salts, particularly suitable for parenteral use The present invention relates to new stable sulpho-adenosyl-L-methionine (SAMe) salts particularly suitable for parenteral use, their production process, and pharmaceutical compositions containing them as active principles. Said salts correspond to the ge...	02/05/1991
4973678	Salts of 5'-methylthio-5'-deoxyadenosine with long-alkyl chain sulphonic acids New salts of 5'-methylthio-5'-deoxyadenosine (MTA) with long-alkyl chain sulphonic acids, which possess central and peripheral vaso-dilatory, platelet antiaggregation, antiinflammatory, analgesic and antipyretic activity. Said salts are produced by dissol...	11/27/1990
4948783	Anticariogenic or antiperidontitic method An anticariogenic or antiperiodontitic agent containing, as an active component, adenosine or its derivatives having an antibacterial activity against Streptococcus mutans or Bacteroides gingivalis. This anticariogenic or antiperiodontitic agent has stron...	08/14/1990
4794174	5'deoxy-5'-substituted adenosines In accordance with this invention, there are provided 5'-deoxy-5'-substituted adenosines having the formula ##STR1## wherein X is a member selected from the group consisting of NH, NCH3, S, or ##STR2## n is an integer from 2-4; a...	12/27/1988
4764603	Stable salts of S-adenosyl-L-methionine with polyanions Stable salts of S-adenosyl-L-methionine with water-soluble polyanions, such as polyphosphates, polyvinylsulfonates -sulfates or -phosphates, polyacrylates, polystyrene sulfonates, are described. The salts according to the invention, prepared by precipitation f...	08/16/1988
4621056	Process for producing stable sulpho-adenosyl-L-methionine salts A process is described for the large-scale industrial production of any stable SAMe salt at very high purity and with a yield of about 90% or more. The new process is characterized by the following basic operations: (a) production of yeast containing 12-2...	11/04/1986
4558122	Stable s-adenosylmethionine derivatives, the process for their preparation, and therapeutic compositions which contain them as active principle New S-adenosylmethionine (SAM) salts of formula ##STR1## have been prepared in which R, R1, R2, m, n and A are as defined in the text. The methods of preparing the new products starting from SAM salts are described. The new prod...	12/10/1985
4543408	Stable S-adenosylmethionine salts, the process for their preparation, and therapeutic compositions which contain them as active principle S-adenosylmethionine salts have been prepared which are stable even at elevated temperatures for practically indefinite time periods, and which correspond to the formula ##STR1## in which X is the acid equivalent of a strong mineral acid of pK less t...	09/24/1985
4465672	Stable S-adenosylmethionine salts, the process for their preparation, and therapeutic compositions which contain them as active principle New S-adenosylmethionine salts have been prepared which are stable indefinitely with time, even at elevated temperatures. The new salts correspond to the formula: ##STR1## in which X is the equivalent of an organic sulphonic acid of pK less than 2.5,...	08/14/1984
4454122	Adenosine derivatives of anti-inflammatory and analgesic activity, and therapeutic compositions which contain them as their active principle Therapeutic composition of anti-inflammatory, analgesic and antipyretic activity comprising as its active principle at least one component of general formula: ##STR1## in which: R is a linear or branched alkyl radical of 1-18 C atoms, or phenyla...	06/12/1984
4376116	Polyamine biosynthesis inhibitors A compound having the formula: ##STR1## wherein R is ##STR2## wherein R' is hydrogen or aminopropyl and salts thereof....	03/08/1983
4374128	Substituted deoxyadenosine derivatives Novel compounds of the following general Formula I are useful pharmacological agents: ##STR1## wherein: Ado represents 5'-deoxyadenosin-5'-yl; R1 represents methyl, ethyl or, preferably hydrogen; R2 represents C1 -C8	02/15/1983
4369177	Stable composition of S-adenosyl-L-methionine A stable composition of S-adenosyl-L-methionine is disclosed which includes a salt of S-adenosyl-L-methionine and a pharmaceutically acceptable, water-soluble salt of a bivalent or trivalent metal. The salt of S-adenosyl-L-methionine is, for example, a sa...	01/18/1983
4242505	S-Adenosyl-L-methionine compositions and production thereof S-adenosyl-L-methionine compositions stabilized against decomposition of S-adenosyl-L-methionine comprising S-adenosyl-L-methionine, a sulfuric acid equivalent and a nucleoside sulfate, which are produced from a solution comprising the three essential com...	12/30/1980
4182891	଱-Acetylenic derivatives of ଱-amino acids Novel acetylenic derivatives of ଱-amino acids of the following general structure: ##STR1## wherein Z is ଲ-methylthioethyl, ଲ-benzylthioethyl, S-(5'-desoxyadenosin-5' -yl)-S-methylthioethyl, γ-guanidinopropyl, or RHN(CH2	01/08/1980
4139563	଱-ACETYLENIC DERIVATIVES OF AMINES Novel acetylenic derivatives of amines of the following general structure: ##STR1## WHEREIN Z is ଲ-methylthioethyl, ଲ-benzylthioethyl, S-(5'-desoxyadenosin-5'-yl)-S-methylthioethyl, γ-guanidinopropyl, or ##STR2## WHEREIN N IS 2 OR 3...	02/13/1979
4134918	Alpha-halomethyl derivatives of amines Novel halomethyl derivatives of amines of the following general structure: ##STR1## WHEREIN Y is FCH2 --, F2 CH-- or F3 C--; Z is ଲ-methylthioethyl, ଲ-benzylthioethyl, S-(5'-desoxyadenosin-5'-yl)-S-methylt...	01/16/1979
4109079	Stabilized S-adenosyl-L-methionine preparations A stabilized dry S-adenosyl-L-methionine preparation is obtained by incorporating about 1 - 10 parts by weight of lithium in the form of a salt with 100 parts by weight of S-adenosyl-L-methionine or a low-toxicity salt thereof. According to the invention,...	08/22/1978
4057686	Sulphonic acid salts of S-adenosilmethionine Stable salts of S-adenosil-L-methionine (SAM) with sulphonic acids chosen from the group consisting of methanesulphonic, ethanesulphonic, 1-n-dodecanesulphonic, 1-n-octadecanesulphonic, 2-chloroethanesulphonic, 2-bromoethanesulphonic, 2-hydroxyethanesulph...	11/08/1977
4011221	S-Inosylcysteine and a process for producing the same S-Inosylcysteine, possessing a cell-proliferating activity and useful in the treatment of tissue lesions and ulcers, is produced by reacting a 2', 3'-O-protected-inosine derivative with an alkali metal salt of cysteine to produce S-(2', 3'-O-protected-ino...	03/08/1977
3954726	Double salts of S-adenosil-L-methionine New double salts extremely stable of S-Adenosil-L-methionine with sulphuric acid and p.toluensulphonic acid of the formula SAM+.HSO4 -.H2 SO4.2CH.sub.3 C6 H4 SO3 H and ...	05/04/1976

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Class 536/27.31 - S-Adenosyl-L-methionine, S-Adenosyl-L-homocysteine, salts, or esters thereof