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| Number | Title | Issue Date |
| 7485717 | Synthesis of protected 3′-amino nucleoside monomers Orthogonally protected 3′-amino nucleoside monomers and efficient methods for their synthesis are described. The methods employ selective protection of the 3′-amino group in the presence of the unprotected nucleoside base. ... | 02/03/2009 |
| 7414036 | Compounds useful as Aadenosine receptor agonists Adenosine analogue-type A3 receptor agonists having the formula wherein D is N or CH; E is O; X1 is a group of the formula —CR20R2 1-CYCLE, where | 08/19/2008 |
| 7381714 | A1 adenosine receptor agonists Disclosed are novel compounds that are partial and full A1 adenosine receptor agonists having the structure of Formula I: which are useful for treating various disease states, in particular tachycardia and atrial... | 06/03/2008 |
| 7368438 | Non-nucleotide compositions and method for inhibiting platelet aggregation This invention is directed to a method of preventing or treating diseases or conditions associated with platelet aggregation. The method is also directed to a method of treating thrombosis or related disorders. The method comprises administering to a subject a pharm... | 05/06/2008 |
| 7358235 | Analogs of nitrobenzylthioinosine Analogs or derivatives of nitrobenzylthioinosine compounds. The use of these new analogs of nitrobenzylthioinosine and methods for the treatment of pain and various other indications using these analogs of nitrobenzylthioinosine as well as pharmaceutical composition... | 04/15/2008 |
| 7335648 | Non-nucleotide composition and method for inhibiting platelet aggregation This invention is directed to a method of preventing or treating diseases or conditions associated with platelet aggregation. The method is also directed to a method of treating thrombosis or related disorders. The method comprises administering to a compounds usefu... | 02/26/2008 |
| 7235647 | Intermediate and process for preparing of β- anomer enriched 21-deoxy,21,21-difluoro-D-ribofuranosyl nucleosides The present invention provides a highly stereoselective, simple and economical glycosylation process for preparation of β-anomer enriched 21-deoxy-21,21-D-ribofuranosyl difluoronucleosides of formula (II), and physiologically accept... | 06/26/2007 |
| 7217815 | 2-beta -modified-6-substituted adenosine analogs and their use as antiviral agents Various 2′-beta-methyl-6-substituted adenosine analogs (including 2,6-disubstituted adenosine, 8-aza-6-substituted adenosine, and 2-aza-6-substituted adenosine) are prepared by conventional and combinatorial library approaches. Contemplated compounds are particula... | 05/15/2007 |
| 7189706 | C2,5′-disubstituted and N,C2,5′-trisubstituted adenosine derivatives and pharmaceutical compositions containing them The present invention concerns novel C2,5′-disubstituted and N6,C2,5′-trisubstituted adenosine derivatives and their different uses. These adenosine derivatives were found to be potent adenosine receptor agonists and thus are of a therapeutic value in... | 03/13/2007 |
| 7144871 | Partial and full agonists of A adenosine receptors Disclosed are novel compounds that are partial and full A1 adenosine receptor agonists, useful for treating various disease states, in particular tachycardia and atrial flutter, angina, myocardial infarction and hyperlipidemia. ... | 12/05/2006 |
| 7094769 | 2-aminocarbonyl-9H-purine derivatives The present invention relates to compounds of the formula: and pharmaceutically acceptable salts and solvates thereof, and to processes for the preparation of, intermediates used in the preparation of, compositio... | 08/22/2006 |
| 6914053 | Adenosine A3 receptor agonists Disclosed are novel adenosine A3 receptor agonists of Formula I: wherein: R is hydrogen or lower alkyl; R1 is optionally substituted lowe... | 07/05/2005 |
| 6803457 | Compounds for the treatment of ischemia A3 agonists, methods of using such A3 agonists and pharmaceutical compositions containing such A3 agonists. The A3 agonists are useful for the reduction of tissue damage resulting from tissue ischemia or hypoxia. ... | 10/12/2004 |
| 6762170 | 2-(purin-9-yl)-tetrahydrofuran-3,4-diol derivatives There are provided according to the invention, novel compounds of formula (I) wherein R1, R2 and R3 are as described in the specification, processes for preparing them, formulations containing them and their use in therapy for the tr... | 07/13/2004 |
| 6753322 | 2-aminocarbonyl-9H-purine derivatives The present invention relates to compounds of the formula: and pharmaceutically acceptable salts and solvates thereof, and to processes for the preparation of, intermediates used in the preparation of, compositions conta... | 06/22/2004 |
| 6677316 | Adenosine derivatives and methods of administration A method of treating a patient suffering from or susceptible to ischemic heart disease, peripheral vascular disease or stroke or which subject is suffering pain, a CNS disorder or sleep apnea which comprises administering a therapeutically effective amoun... | 01/13/2004 |
| 6649753 | Stable salts of S-adenosyl-L-methionine (SAMe) and the process for their preparation This invention relates to the production of new & stable salts of S-adenosyl-L-methionine SAMe). The source of SAMe used in the salt formation is from chemical process wherein stereoselective methylation of S-adenosyl-L-homocysteine is achieved. The proce... | 11/18/2003 |
| 6610665 | 2-(purin-9-yl)-tetrahydrofuran-3, 4-diol derivatives There are disclosed according to the invention, compounds of formula (I) wherein R1, R2 and R3 are defined in the specification. Additionally, processes of preparing the compounds of formula (I), formulations containing sa... | 08/26/2003 |
| 6492348 | Adenosine derivatives A compound of formula (I) which is an agonist at the adenosine Al receptor, wherein Y, Z, and W represent heteroatoms, and salts and solvates thereof, in particular, physiologically acceptable solvates and salts thereof for use in therapy. ##STR1##... | 12/10/2002 |
| 6429315 | Process for preparing N6-substituted adenosine derivatives This invention is directed to a process for preparing N6-substituted adenosine derivatives, to intermediates useful therefor and to methods of preparing these intermediates.... | 08/06/2002 |
| 6407076 | Adenosine analogues and related method of treatment A compound of formula (I) wherein R2 represents C1-3 alkyl, halogen or hydrogen; R3 represents a fluorinated straight or branched alkyl group of 1-6 carbon atoms; and salts and solvates thereof, in particular, physiologica... | 06/18/2002 |
| 6294522 | N6 heterocyclic 8-modified adenosine derivatives N6 heterocyclic 8 modified adenosine derivatives that are selective, partial or full adenosine A1 receptor partial or full agonists, and as such, are useful for modifying cardiac activity, modifying adipocyte function, treating centr... | 09/25/2001 |
| 5885972 | L-pyranosyl nucleosides This invention relates to and ଲ-L-pyranosyl nucleosides of Formula (I), wherein the nucleoside substitution on the pyranosyl carbohydrate molecule comprises a substituted or unsubstituted purine (adenine or guanine) or pyrimidine (cytosine, ... | 03/23/1999 |
| 5824657 | Aminoacyl sulfamides for the treatment of hyperproliferative disorders Novel aminoacyl sulfamides are described. These compounds are effective in the treatment of hyperproliferative disorders, specifically psoriasis. Exemplary compounds of this invention are 5'-deoxy-adenosine 5'-N(N-L-phenylalanyl)sulfamide and 5'-deoxy-ade... | 10/20/1998 |
| 5795977 | Water soluble adenosine kinase inhibitors This invention relates to adenosine kinase inhibitors and to nucleoside analogs, specifically to water soluble, aryl substituted 4-amino pyrrolo2,3-d! pyrimidine and pyrazolo3,4-d! pyrimidine nucleoside analogs having activity as adenosine kinase inhi... | 08/18/1998 |
| 5763596 | C-4' modified adenosine kinase inhibitors This invention relates to adenosine kinase inhibitors and to nucleoside analogs, C-4' modified pyrrolo2,3-d!pyrimidine and pyrazolo3,4-d!pyrimidine nucleoside analogs having activity as adenosine kinase inhibitors. The invention relates to nucleoside ... | 06/09/1998 |
| 5763597 | Orally active adenosine kinase inhibitors This invention relates to adenosine kinase inhibitors and to nucleoside analogs, specifically to orally active, substituted 5-aryl pyrrolo2,3-d! pyrimidine and 3-aryl pyrazolo3,4-d! pyrimidine nucleoside analogs having activity as adenosine kinase inh... | 06/09/1998 |
| 5674998 | C-4' modified adenosine kinase inhibitors This invention relates to adenosine kinase inhibitors and to nucleoside analogs, C-4' modified pyrrolo2,3-d!pyrimidine and pyrazolo3,4-d!pyrimidine nucleoside analogs having activity as adenosine kinase inhibitors. The invention relates to nucleoside ... | 10/07/1997 |
| 5446139 | Purine analog nucleoside and nucleotide compounds The invention concerns nucleoside derivatives of the formula I ##STR1## in which Ba signifies an indolyl (A), benzimidazolyl (B), pyrrolopyridinyl (C), imidazopyridinyl (D), triazolopyrimidinyl (E), imidazotriazinyl (F) or imidazopyrimidinyl (G) grou... | 08/29/1995 |
| 5149795 | Nikkomycin derivatives The nikkomycin compound possessing antimycotic activity and having the following structure: ##STR1##... | 09/22/1992 |
| 5026835 | Pyrimidine 2'-methylidene nucleoside compounds Pyrimidine 2'-deoxy-2'-methylidene nucleoside compounds: ##STR1## wherein R1 represents amino, hydroxy, silylamino, silyloxy, acylamino or acyloxy; R2 represents hydrogen, halogen, a lower alkyl, a lower alkenyl, a lower alkynyl... | 06/25/1991 |
| 5015733 | Nucleosides possessing blocked aliphatic amino groups The invention consists of compounds and methods for the synthesis of oligonucleotides which contain one or more free aliphatic amino groups attached to the sugar moieties of the nucleoside subunits. The synthetic method is versatile and general, permittin... | 05/14/1991 |
| 4997925 | 5'-deoxy-5',5'-dihalo adenosines and purine analogues This invention relates to certain 5',5'-dihaloaristeromycin/adenosine derivatives which are useful in inhibiting AdoMet-dependent transmethylation and in the treatment of patients afflicted with neoplastic or viral disease states.... | 03/05/1991 |
| 4997924 | 5'-deoxy-4',5'-unsaturated-5'-substituted adenosines This invention relates to certain aristeromycin/adenosine derivatives which are useful in inhibiting AdoMet-dependent transmethylation and in the treatment of patients afflicted with neoplastic or viral disease states.... | 03/05/1991 |
| 4996308 | Derivatives with unsaturated substitutions for the 5'-hydroxymethyl group This invention relates to certain acetylenic, cyano and allenic aristeromycin/adenosine derivatives which are useful in inhibiting AdoMet-dependent transmethylation and in the treatment of patients afflicted with neoplastic or viral disease states.... | 02/26/1991 |
| 4994558 | Immunoglobulin conjugates Immunoglobulin conjugates formed by reacting a difluoronucleoside with an immunoglobulin via an alkane dioic acid linking group.... | 02/19/1991 |
| 4985409 | Adenosine derivatives and pharmaceutical composition thereof The present invention relates to novel adenosine derivatives having the formula (I): ##STR1## wherein R is a lower alkyl group; R' is hydrogen or a lower alkyl group; X is a cycloalkyl group, an alkyl group having at least one hydroxy group, an ... | 01/15/1991 |
| 4973677 | 2',3'-dideoxy-2',3'-didehydro-2'-fluoroarabino-nucleosides There are disclosed novel 2',3'-dideoxy-2'-fluoronucleosides and 2'-3'-dideoxy-2',3'-didehydro-2'-fluoronucleosides and processes for their preparation. The compounds so produced exhibit therapeutically useful antiviral and, more particularly, anti-HIV ef... | 11/27/1990 |
| 4965374 | Process for and intermediates of 2',2'-difluoronucleosides The present invention provides a process for preparing lactone intermediates to 2',2'-difluoronucleosides whereby reversion back to the lactone's open chain precursor is minimized and the desired erythro enantiomer can be selectively isolated from an enan... | 10/23/1990 |
| 4962194 | Method of preparing 51,N6-disubstituted adenosines from inosines A processing for preparing 5'-N,6-disubstituted adenosines from inosines. The adenosines have usefulness as neuroleptics, analgesics, cardiotonics, antihypertensives, antilipolytics, antihyperlipaemics, antiinflammatory agents, antithrombotic or antiembol... | 10/09/1990 |
