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| Number | Title | Issue Date |
| 7423025 | L-nucleosides as ligands to adenosine receptors Disclosed herein are compounds having Formula I, which are non-natural L-adenosine analogs. Also disclosed are their methods of making. Still further, disclosed are the uses of the disclosed compounds to treat cardiovascular disease, ischemia related injuries; and n... | 09/09/2008 |
| 7381714 | A1 adenosine receptor agonists Disclosed are novel compounds that are partial and full A1 adenosine receptor agonists having the structure of Formula I: which are useful for treating various disease states, in particular tachycardia and atrial... | 06/03/2008 |
| 7358235 | Analogs of nitrobenzylthioinosine Analogs or derivatives of nitrobenzylthioinosine compounds. The use of these new analogs of nitrobenzylthioinosine and methods for the treatment of pain and various other indications using these analogs of nitrobenzylthioinosine as well as pharmaceutical composition... | 04/15/2008 |
| 7199127 | Purine nucleosides Disclosed are purine nucleoside compounds that are selective to A3 adenosine receptors and are useful for the treatment of cancer and inflammatory diseases. The compounds are shown by the following general formula (I), including isomers thereof: | 04/03/2007 |
| 7141553 | A3AR agonists for the treatment of inflammatory arthritis The present invention concerns a method for the treatment of inflammatory arthritis, and in particular rheumatoid arthritis, by administering to the subject specific low dosages of N6-(3-iodobenzyl)-adenosine 5′-N-methyl-uronamide (IB-MECA) and 2-chloro-N6-(3-iodo... | 11/28/2006 |
| 7132409 | Adenosine derivatives and use thereof 2-(6-Cyano-1-hexyn-1-yl)adenosine, 2-(6-cyano-1-hexyn-1-yl)adenosine 5′-monophosphate, or salts thereof; and drugs containing the same as an active ingredient. The compounds have excellent effects of lowering ocular tension, promoting blood flow in retina, and pro... | 11/07/2006 |
| 7078499 | Nucleotide analogues comprising a reporter moiety and a polymerase enzyme blocking moiety Nucleotides comprising a reporter moiety and a polymerase enzyme blocking moiety in which the reporter moiety does not also act as a polymerase enzyme blocking moiety are described. Also described are compounds of Formula (I): wherein W is a phosphate group, B is a ... | 07/18/2006 |
| 7022727 | Crystalline drug form The present invention relates to a crystalline form of 6-[(2,2-diphenylethyl)amino]-9-(N-ethyl-β-D-ribofuranosyluronamide)-N-(2-{N′-[1-(2-pyridyl)-4-piperidyl]ureido}ethyl)-9H-purine-2-carboxamide and to a process for the preparation of, compositions containing a... | 04/04/2006 |
| 7005425 | Method for treating arrhythmias Methods are provided for treating arrhythmia in a manner that minimizes undesirable side effects, comprising administration of a therapeutically effective minimal dose of an A1 adenosine receptor agonist with a therapeutically effective minimal dose of a ... | 02/28/2006 |
| 6936596 | Adenosine derivatives and use thereof 2-(6-Cyano-1-hexyn-1-yl)adenosine, 2-(6-cyano-1-hexyn-1-yl)adenosine 5′-monophosphate, or salts thereof; and drugs containing the same as an active ingredient. The compounds have excellent effects of lowering ocular tension, promoting blood flow in retina, and pro... | 08/30/2005 |
| 6903079 | Nucleoside compounds and compositions thereof The invention provides a novel class of substituted nucleoside derivatives having the formula: A-Z1-L-Z2-G wherein: A and G are connected via Z1 and Z2 respectively, to a linker, L; and A i... | 06/07/2005 |
| 6852746 | Crystalline drug form The present invention relates to a crystalline form of 6-[(2,2-diphenylethyl)amino]-9-(N-ethyl-β-D-ribofuranosyluronamide)-N-(2-{N′-[1-(2-pyridyl)-4-piperidyl]ureido}ethyl)-9H-purine-2-carboxamide and to a process for the preparation of, compositions containing a... | 02/08/2005 |
| 6803457 | Compounds for the treatment of ischemia A3 agonists, methods of using such A3 agonists and pharmaceutical compositions containing such A3 agonists. The A3 agonists are useful for the reduction of tissue damage resulting from tissue ischemia or hypoxia. ... | 10/12/2004 |
| 6784165 | Treatment of heart rhythm disturbances with N6-substituted-5′-(N-substituted) carboxamidoadenosines The present invention discloses a method for treating heart rhythm disturbances in a mammal in need thereof by the administration of N6-substituted-5′(N-substituted)carboxamidoadenosines. More particularly, the invention is directed to a method for trea... | 08/31/2004 |
| 6541626 | Process for selective N-acylation of purine nucleosides Methods for selectively protecting the exocyclic amino function of a purine nucleoside are provided using activating agents to effect acylation at the exocyclic amino site. Methods are also provided for recycling polymer bound coupling supports from the r... | 04/01/2003 |
| 6232297 | Methods and compositions for treating inflammatory response Compounds and methods are provided to treat inflammatory conditions with certain A2A adenosine receptor antagonists.... | 05/15/2001 |
| 6180615 | Propargyl phenyl ether A2A receptor agonists 2-adenosine propargyl phenyl ether compositions having the following formula: ##STR1## and methods for using the compositions as A2A receptor agonists to stimulate mammalian coronary vasodilatation for therapeutic purposes and for purposes... | 01/30/2001 |
| 6072051 | Nucleoside derivatives and process for preparing the same According to the present invention, provided are novel nucleoside derivatives having antiviral activity, in particular, anti-HBV (anti-Hepatitis-B Virus) activity, represented by general formula (I), wherein R1 represents hydrogen, phosphate, p... | 06/06/2000 |
| 5925624 | 2,6-Di (substitutedamino) purine ribonucleoside analogues and administration to treat respiratory inflammation The present invention relates to 2,6-diaminopurine-ଲ-D-ribofuranuronamide derivatives of the following formula (I). These compounds and their salts and solvates are useful as anti-inflammatory agents, particularly in the treatment of patients with ... | 07/20/1999 |
| 5889178 | 2-6-diaminopurine precursors The present invention relates to compounds of formula (IV): ##STR1## wherein Ra and Rb each represent a hydrogen atom or together form an alkylidene group.... | 03/30/1999 |
| 5773423 | A3 adenosine receptor agonists The present invention provides N6 -benzyladenosine-5'-N-uronamide and related substituted compounds, particularly those containing substituents on the benzyl and/or uronamide groups, and modified xanthine ribosides, as well as pharmaceutical co... | 06/30/1998 |
| 5721356 | Orally active adenosine kinase inhibitors This invention relates to adenosine kinase inhibitors and to nucleoside analogs, specifically to orally active, substituted 5-aryl pyrrolo2,3-d!pyrimidine and 3-aryl pyrazolo3,4-d! pyrimidine nucleoside analogs having activity as adenosine kinase inhi... | 02/24/1998 |
| 5714599 | Process for the preparation of ste specific 1'-spiro-nucleosides The invention relates to a novel process for stereocontrolled preparation of 1',1'-disubstituted and 1'-spiro-nucleosides of the formula I ##STR1## in which the substituents A, R8 and R9 are as defined in claim 1, and to novel i... | 02/03/1998 |
| 5593975 | Adenosine derivatives having A2 agonist activity Adenosine A2 agonists of the formula ##STR1## wherein R is hydrogen, alkyl, cycloalkyl or phenylalkyl; R1 is selected from the group consisting of a) optionally substituted phenyl or naphthyl; b) --(CH2)m --Het where... | 01/14/1997 |
| 5498605 | Sulfo-derivatives of adenosine The adenosine derivatives which contain a sulfohydrocarbon substituent, as depicted in the formula: ##STR1## wherein at least one of R1, R2, R3, R4, R5, and R6 is a sulfohydrocarbon ra... | 03/12/1996 |
| 5480983 | Adenosine derivatives, preparation methods and pharmaceutical compositions containing them The present invention relates to the derivatives of the formula ##STR1## and their addition salts, and to their use in therapeutics, especially as analgesics and as antihypertensives.... | 01/02/1996 |
| 5459132 | N6-[(Imidazo[1,2-a]pyridin-3-yl)ethyl]adenosines, their 5'-uronamide analogues and pharmaceutical compositions The present invention relates to the derivatives of the formula ##STR1## and their addition salts, and to their use in therapeutics as analgesics, as antihypertensives and as drugs with antiproliferative properties.... | 10/17/1995 |
| 5455234 | Inhibition of hair growth Mammalian hair growth is reduced by applying to the skin an inhibitor of a cysteine synthetic pathway enzyme.... | 10/03/1995 |
| 5310731 | N-6 substituted-5'-(N-substitutedcarboxamido)adenosines as cardiac vasodilators and antihypertensive agents Compounds of the formula ##STR1## are disclosed, wherein R1, represents secondary alkyl; aralkyl; cycloalkyl; heteroaryl substituted alkyl; norbornyl; and substituted secondary alkyl, aralkyl, cycloalkyl, heteroaryl substituted alkyl, ... | 05/10/1994 |
| 5283327 | Tri-O-acetyl-2-alkynyladenosines The present invention relates to a novel compound represented by the following formula [I] which is useful as a synthetic intermediate of a 2-alkynyladenosine. The present invention also relates to a process for producing the compound and a process for pr... | 02/01/1994 |
| 5280015 | 2-substituted adenosines and 2-substituted adenosine 5'-carboxamides The present invention is directed to compounds useful as probes for characterizing and studying the adenosine A2 receptor. The present invention is also directed to methods of treating central nervous system disorders and cardiovascular disorde... | 01/18/1994 |
| 5229505 | N6 -[3-(1-substituted)indolylethyl] adenosine 5'-carboxamides and their pharmaceutical compositions The present invention relates to the derivatives of the formula ##STR1## and their addition salts, and to their use in therapeutics, especially in the central nervous system as analgesics, anticonvulsants, antiepileptics, anxiolytics, antidepressants... | 07/20/1993 |
| 5219839 | Adenosine derivatives, their methods of preparation and pharmaceutical compositions in which they are present The present invention relates to the derivatives of the formula ##STR1## and the corresponding enantiomers and diastereoisomers and, if appropriate, their addition salts, and to their use in therapeutics, especially in the central nervous system as a... | 06/15/1993 |
| 5219840 | Antihypertensive 9-(2,N6 -disubstituted adenyl) ribofuranuronic acid derivatives N6, 2-disubstituted or 2-substituted 1'-desoxy-1'-(6-amino-9-purinyl)-ଲ-D-ribofuranuronic acid amides, N-substituted amides, N,N-disubstituted amides, thioamides, N-substituted thioamides and N,N-disubstituted thioamides are effective aga... | 06/15/1993 |
| 5206351 | Process for the preparation of 2-amino (2,3,5-tri-O-benzyl-beta-D-arabinofuranosyl)adenine A process for the preparation of 2-amino-9-(2,3,5-tri-O-benzyl-beta-D-arabinofuranosyl) adenine (V) is described. The process uses a protected 2,6-di(tri-alkylsilylamino)-9-trialkylsilylpurine (II) which is reacted with protected chlorosugar 2,3,5-tr... | 04/27/1993 |
| 5206222 | Methods for the reduction of myocardial reperfusion injury This invention relates to a method to treat a heart attack victim to reduce heart muscle damage. In particular, the invention relates to a met Grant Statement This research was supported in part by the National Institute of Health, Grant R01 HL40892-01.... | 04/27/1993 |
| 5140015 | 2-aralkoxy and 2-alkoxy adenosine derivatives as coronary vasodilators and antihypertensive agents Compounds are disclosed having the formulae: ##STR1## wherein R1 is selected from the group, consisting of radicals represented by the general formulae: ##STR2## wherein Y is selected from the group consisting of lower alkyl, lower ... | 08/18/1992 |
| 4997924 | 5'-deoxy-4',5'-unsaturated-5'-substituted adenosines This invention relates to certain aristeromycin/adenosine derivatives which are useful in inhibiting AdoMet-dependent transmethylation and in the treatment of patients afflicted with neoplastic or viral disease states.... | 03/05/1991 |
| 4977144 | Imidazo[4,5-b]pyridine derivatives as cardiovascular agents Disclosed are the compounds of the formula ##STR1## wherein R represents hydrogen, lower alkyl, aryl or aryl-lower alkyl; R1 represents hydrogen, lower alkyl, C3 -C7 -alkenyl, carbocyclic or heterocyclic aryl, carbocy... | 12/11/1990 |
| 4968697 | 2-substituted adenosine 5'-carboxamides as antihypertensive agents The compounds of the formula I ##STR1## wherein R represents hydrogen or lower alkyl; R1 represents C3 -C6 -cycloalkyl optionally substituted by lower alkyl, C3 -C6 -cycloalkyl-lower alkyl option... | 11/06/1990 |
