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| Number | Title | Issue Date |
| 6780429 | Chain-shortened polynucleotide and method for preparation thereof The present invention provides a chain-shortened polynucleotide wherein the proportion of a 2′-5′ phosphodiester bond is up to 3% based on the whole phosphodiester bonds or a salt thereof and a pharmaceutical composition containing the same, and a method for pro... | 08/24/2004 |
| 6777180 | Method for full-length cDNA cloning using degenerate stem-loop annealing primers The present invention provides a method for isolating a double-stranded cDNA having a nucleotide sequence of a complete open reading frame which comprises: (A) admixing (i) an isolated single-stranded cDNA, (ii) a first primer capable of forming a stem-loop structur... | 08/17/2004 |
| 6756496 | Nucleoside hydrogen phosphonodithioate diesters and activated phosphonodithioate analogues Novel hydrogen-phosphonodithioate compositions are provided which are particularly useful for forming internucleotide and internucleoside linkages in oligonucleosides or oligonucleotides. The oligonucleotides and analogs thereof made by using the hydrogen-phosphonod... | 06/29/2004 |
| 6713623 | Tetraphosphonate bicyclic trisanhydrides Disclosed are novel bicyclic tris(anhydride)s useful as intermediates in the synthesis of biologically active compounds, and the compounds which may be synthesized from such intermediates. ... | 03/30/2004 |
| 6555676 | Biologically active phosphotriester-type compounds Compounds of formula RS--P(.dbd.O)(QR)--Nu where: R is a radical --(CH2)n--W--X; X is a radical --C(.dbd.Z)(Y) or --S--U; Z is O or S; W is O or S; Q is O or S; Y and U are an alkyl, aryl or saccharide radical which is optionally substituted wi... | 04/29/2003 |
| 6531589 | Base protecting groups and synthons for oligonucleotide synthesis The invention provides new methods for synthesizing oligonucleotides that allow for deprotection of the oligonucleotides under more mild conditions than existing methods. The invention further provides a nucleoside base protecting group that is stable und... | 03/11/2003 |
| 6506888 | 2'-O-amino-containing nucleoside analogs and polynucleotides Novel nucleoside or nucleotide analogs comprising 2'-O-amino residues, processes for their synthesis and incorporation into polynucleotides.... | 01/14/2003 |
| 6504024 | Propargylethoxyamino nucleotide primer extensions Propargylethoxyamino nucleosides are disclosed having the structure ##STR1## wherein R1 and R2 are --H, lower alkyl, or label; B is a 7-deazapurine, purine, or pyrimidine nucleoside base; W1 is --H or --OH; W2 i... | 01/07/2003 |
| 6475985 | Nucleosides with antiviral and anticancer activity The invention provides nucleosides of formulae (I), (II), (V) and (VII) as described in the specification which possess antiviral and anticancer activity. Treatment of breast cancer is a preferred embodiment.... | 11/05/2002 |
| 6440671 | Use of continuous/contiguous stacking hybridization as a diagnostic tool A method for detecting disease-associated alleles in patient genetic material is provided whereby a first group of oligonucleotide molecules, synthesized to compliment base sequences of the disease associated alleles is immobilized on a predetermined posi... | 08/27/2002 |
| 6403781 | Method of synthesizing phosphorothioate oligonucleotides This invention presents novel methods for synthesizing phosphorothioate oligonucleotides, using support-bound phosphoramidites. Novel intermediates useful in the methods are also provided.... | 06/11/2002 |
| 6329519 | Intermediates for oligonucleotide synthesis A compound of formula (I) wherein B1 is a radical of a nucleoside base, R1 is hydrogen or a hydroxy-protecting group, R2 is hydrogen, hydroxy or a 2'-nucleoside-modifying atom or group, R3 is an unsubstituted or... | 12/11/2001 |
| 6326490 | Tetraphosphonate bicyclic trisanhydrides Disclosed are novel bicyclic tris(anhydride)s useful as intermediates in the synthesis of biolologically active compounds, and the compounds which may be synthesized from such intermediates.... | 12/04/2001 |
| 6232465 | Compositions for enzyme catalyzed template-independent creation of phosphodiester bonds using protected nucleotides A method for the stepwise creation of phosphodiester bonds between desired nucleosides resulting in the synthesis of polynucleotides having a predetermined nucleotide sequence by preparing an initiation substrate containing a free and unmodified 3'-hydrox... | 05/15/2001 |
| 6172217 | Method of synthesizing phosphorothioate oligonucleotides This invention presents novel methods for synthesizing phosphorothioate oligonucleotides, using support-bound phosphoramiditese. Novel intermediates useful in the methods are also provided.... | 01/09/2001 |
| 6159951 | 2'-O-amino-containing nucleoside analogs and polynucleotides Novel nucleoside or nucleotide analogs comprising 2'-O-amino residues, processes for their synthesis and incorporation into polynucleotides.... | 12/12/2000 |
| 6147205 | Photocleavable protecting groups and methods for their use Novel compounds are provided which are useful as linking groups in chemical synthesis, preferably in the solid phase synthesis of oligonucleotides and polypeptides. These compounds are generally photolabile and comprise protecting groups which can be remo... | 11/14/2000 |
| 6140310 | Phosphorous prodrugs The composition and methods of synthesis of phosphorus prodrugs are described. These methods can be used to convert negatively charged phosphorus bearing drugs into neutrally charged; lipid soluble prodrugs which are able to passively diffuse into cells a... | 10/31/2000 |
| 6124445 | Phosphotriester oligonucleotides, amidities and method of preparation Oligonucleotides having bioreversible phosphate blocking groups can be used as pro drugs for the oligonucleotides. The bio-reversible blocking groups can be removed by intercellular enzymes, particularly carboxyesterases, to provide the unprotected oligon... | 09/26/2000 |
| 6111086 | Orthoester protecting groups Novel orthoesters are provided which can be used as a 2'-hydroxyl protecting groups or 2'-modification in the synthesis of polymers containing ribonucleic acid (RNA) nucleotides. The RNA comprising the orthoester can be handled and analyzed while 2'-modif... | 08/29/2000 |
| 6048975 | Process for the chemical synthesis of oligonucleotides A process for the chemical synthesis of oligonucleotides Use of a dansylethoxycarbonyl group as base-labile 5'-hydroxyl protective group in the chemical synthesis of DNA and RNA and suitable synthetic processes. The ease of detection of the dansyl protective g... | 04/11/2000 |
| 6020482 | Phosphotriester type biologically active compounds Phosphotriester compound of general formula (I); ##STR1## wherein R is a radical --(CH2)n --S--X in which X is a radical (a) or --S--U, Z being O or S, and Y and U denote an alkyl, aryl or osidic radical, optionally substituted ... | 02/01/2000 |
| 5986084 | Ribonucleoside-derivative and method for preparing the same The ribonucleoside-derivatives serve for the synthesis of ribonucleic acids and comprise a triple substituted silyloxymethyl-group as a protection-group on the oxygen atom in 2'-position. The ribonucleoside-derivatives may be suitably protected on the nuc... | 11/16/1999 |
| 5955591 | Phosphotriester oligonucleotides, amidites and method of preparation Oligonucleotides having bioreversible phosphate blocking groups can be used as pro drugs for the oligonucleotides. The bio-reversible blocking groups can be removed by intercellular enzymes, particularly carboxyesterases, to provide the unprotected oligon... | 09/21/1999 |
| 5871947 | Method for the determination of low concentrations of heavy metals The present invention provides a highly effective method for determining very low concentrations of heavy metals such as lead, cadminum, mercury, and copper in body fluids. Ratios of d-5'-N/Pyr-5'-N activities which display greater deviation and stronger ... | 02/16/1999 |
| 5849905 | Biologically active phosphotriester-type nucleosides and methods for preparing same Compounds of formula RS--P(.dbd.O) (QR)--Nu where: R is a radical --(CH2)n-W--X; X is a radical --C(.dbd.Z) (Y) or --S--U; Z is O or S; W is O or S; Q is O or S; Y and U are an alkyl, aryl or saccharide radical which is optionally substituted w... | 12/15/1998 |
| 5840879 | Reagents and solid supports for improved synthesis and labeling of polynucleotides The invention provided methods and compositions for oligonucleotide synthesis and labeling. The subject compounds have either rigid ring or long linear linker structures and provide enhanced coupling efficiencies over prior art labeling reagents because o... | 11/24/1998 |
| 5821356 | Propargylethoxyamino nucleotides Propargylethoxyamino nucleosides are disclosed having the structure ##STR1## wherein R1 and R2 are --H, lower alkyl, or label; B is a 7-deazapurine, purine, or pyrimidine nucleoside base; W1 is --H or --OH; W2 | 10/13/1998 |
| 5808035 | Protected nucleoside and method for its synthesis The present invention relates to a nucleoside having the formula: ##STR1## where R1 is a hydrogen or a protecting group; R2 is a hydrogen or a coupling group; R3 and R4 are each either a hydrogen or an alkyl group, w... | 09/15/1998 |
| 5808045 | Compositions for enzyme catalyzed template-independent creation of phosphodiester bonds using protected nucleotides A method for the stepwise creation of phosphodiester bonds between desired nucleosides resulting in the synthesis of polynucleotides having a predetermined nucleotide sequence by preparing an initiation substrate containing a free and unmodified 3'-hydrox... | 09/15/1998 |
| 5770725 | Phosphotriester type biologically active compounds Compounds of formula RO--P(.dbd.O)(OR)--Nu where: each R is, independently, --(CH2)n --S--X; X is --C(.dbd.Z) (Y) or --S--U; Z is O or S; Y and U are alkyl, aryl or saccharide groups optionally substituted with OH, SH or NH groups; n... | 06/23/1998 |
| 5763418 | 3'-substituted nucleoside derivatives The invention relates to a 3'-substituted nucleoside derivative represented by the following general formula (1): ##STR1## wherein B means a nucleic acid base which may have a substituent, Z represents a lower alkynyl or lower alkenyl group which may... | 06/09/1998 |
| 5750674 | Methods and compounds for the stereoselective enrichment of oligonucleotide diastereomers and oligonucleotides thereby produced The present invention provides new mononucleotide synthons useful in the synthesis of oligonucleotides having from one to all P-chiral centers that are predominantly and independently in the R or S configuration. The invention also provides methods of syn... | 05/12/1998 |
| 5646269 | Method for oligonucleotide analog synthesis The present invention is directed to improved methods to synthesize oligonucleotide analogs having an acetal linkage, such as a 3',5'-formacetal (3' --O--CH2 --O-- 5'), 3',5'-thioformacetal (3' --S--CH2 --O-- 5') or an analogous 2',5... | 07/08/1997 |
| 5639867 | TTTr as protective group in nucleotide synthesis The invention relates to nucleosides, nucleotides and oligonucleotides carrying in their basic structure a primary hydroxyl group protected by tris-4,4',4"-tert-butylphenylmethyl, to processes for the preparation of said nucleosides and nucleotides, to a ... | 06/17/1997 |
| 5627165 | Phosphorous prodrugs and therapeutic delivery systems using same The composition and methods of synthesis of phosphorus prodrugs are described. These methods can be used to convert negatively charged phosphorous bearing drugs into neutrally charged; lipid soluble prodrugs which are able to passively diffuse into cells ... | 05/06/1997 |
| 5623069 | Method for producing 5'-nucleotide A method of producing 5'-nucleotide, which comprises maintaining a nucleoside suspension in an organic solvent at a temperature not lower than about 20° C., and then subjecting the resultant suspension to a phosphorylatipon of the nucleoside(s). Accordin... | 04/22/1997 |
| 5621086 | Sialic acid derivative and method of manufacturing it The present invention is drawn to methods of manufacturing a sialic acid derivative suitable for industrial production. With a method of the present invention, Tetra-O-acetylsialic acid (4a) and acetylcytidine-5'-O-amidite (5a) are condensed in the presen... | 04/15/1997 |
| 5565555 | Nucleoside hydrogen phosphonodithioate diesters and activated phosphonodithioate analogues Novel hydrogen-phosphonodithioate compositions are provided which are particularly useful for forming internucleotide and internucleoside linkages in oligonucleosides or oligonucleotides, The oligonucleotides and analogs thereof made by using the hydrogen... | 10/15/1996 |
| 5446139 | Purine analog nucleoside and nucleotide compounds The invention concerns nucleoside derivatives of the formula I ##STR1## in which Ba signifies an indolyl (A), benzimidazolyl (B), pyrrolopyridinyl (C), imidazopyridinyl (D), triazolopyrimidinyl (E), imidazotriazinyl (F) or imidazopyrimidinyl (G) grou... | 08/29/1995 |
