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| Number | Title | Issue Date |
| 7220356 | Method of purifying polypeptides by simulated moving bed chromatography Provided are methods of separating an immunoreactive compound from at least one immaterial component, using a simulated moving bed (“SMB”) system and a SMB apparatus for use in these methods. Also provided are purified immunoreactive compounds prepared using the... | 05/22/2007 |
| 7022835 | Method for binding nucleic acids to a solid phase The invention concerns a method for binding nucleic acids to a solid phase in which a nucleic acid containing solution is contacted with a solid phase which has hydrophobic and hydrophilic groups on its surface or/and which comprises a hydrophilic, water-containing ... | 04/04/2006 |
| 7019128 | Propargylethoxyamino nucleotides Propargylethoxyamino nucleosides are disclosed having the structure wherein R1 and R2 are —H, lower alkyl, or label; B is a 7-deazapurine, purine, or pyrimidine nucleoside base; W1 is ... | 03/28/2006 |
| 6329519 | Intermediates for oligonucleotide synthesis A compound of formula (I) wherein B1 is a radical of a nucleoside base, R1 is hydrogen or a hydroxy-protecting group, R2 is hydrogen, hydroxy or a 2'-nucleoside-modifying atom or group, R3 is an unsubstituted or... | 12/11/2001 |
| 6232465 | Compositions for enzyme catalyzed template-independent creation of phosphodiester bonds using protected nucleotides A method for the stepwise creation of phosphodiester bonds between desired nucleosides resulting in the synthesis of polynucleotides having a predetermined nucleotide sequence by preparing an initiation substrate containing a free and unmodified 3'-hydrox... | 05/15/2001 |
| 6147205 | Photocleavable protecting groups and methods for their use Novel compounds are provided which are useful as linking groups in chemical synthesis, preferably in the solid phase synthesis of oligonucleotides and polypeptides. These compounds are generally photolabile and comprise protecting groups which can be remo... | 11/14/2000 |
| 6111086 | Orthoester protecting groups Novel orthoesters are provided which can be used as a 2'-hydroxyl protecting groups or 2'-modification in the synthesis of polymers containing ribonucleic acid (RNA) nucleotides. The RNA comprising the orthoester can be handled and analyzed while 2'-modif... | 08/29/2000 |
| 5863753 | Chemically reactive unsymmetrical cyanine dyes and their conjugates The invention comprises cyanine dyes, in particular chemically reactive dyes, conjugates of reactive cyanine dyes, the non-covalent complexes of nucleic acids with the dyes and dye-conjugates of the invention, and a method of forming a nucleic acid comple... | 01/26/1999 |
| 5658751 | Substituted unsymmetrical cyanine dyes with selected permeability The invention describes the preparation and use of fluorescent stains for nucleic acids derived from unsymmetrical cyanine dyes comprising a substituted benzazolium ring system linked by a methine bridge to a pyridinium or quinolinium ring system having a... | 08/19/1997 |
| 5656449 | Neutral unsymmetrical cyanine dyes The invention describes the preparation and use of fluorescent stains for nucleic acids derived from neutral unsymmetrical cyanine dyes comprising a substituted benzazolium ring system linked to a methine bridge to a pyridine or quinoline ring system. The... | 08/12/1997 |
| 5623069 | Method for producing 5'-nucleotide A method of producing 5'-nucleotide, which comprises maintaining a nucleoside suspension in an organic solvent at a temperature not lower than about 20° C., and then subjecting the resultant suspension to a phosphorylatipon of the nucleoside(s). Accordin... | 04/22/1997 |
| 5545535 | Fluorescent assay for bacterial gram reaction The invention relates to a method of analyzing a sample thought to contain bacteria using an aqueous solution comprising one or more fluorescent dyes: a fluorescent dye of formula I, a fluorescent dye of formula II, a fluorescent dye of formula III, and a... | 08/13/1996 |
| 5534416 | Fluorescent viability assay using cyclic-substituted unsymmetrical cyanine dyes The invention relates to a method of analyzing the viability of a sample of cells using an aqueous solution comprising two fluorescent dyes. Dye I has the formula: ##STR1## where R2 is C1-6 alkyl; Z- is a biologically... | 07/09/1996 |
| 5436134 | Cyclic-substituted unsymmetrical cyanine dyes The invention describes the preparation and use of fluorescent stains for nucleic acids derived from unsymmetrical cyanine dyes. In particular, the invention describes unsymmetrical cyanine dyes having a saturated or unsaturated cyclic substituent. The dy... | 07/25/1995 |
| 5346999 | Method of nucleic acid extraction An automated apparatus is provided which implements a new method of extracting and purifying nucleic acids from cells without the use of centrifugation. In the method, a lysate is created by treating the cells with proteinase K in the presence of a lysis ... | 09/13/1994 |
| 4961915 | Automatic chemistry machine An automatic chemistry machine particularly suitable for the automatic sequencing of DNA on the microliter scale including a source of reagents, a common means to transfer by contact microliter quantities of reagent, below 5 microliters, and a rotatable r... | 10/09/1990 |
| 4699717 | Chromatographic process for the separation of nucleic acids A process for the chromatographic separation of nucleic acid using a chromatographic carrier material is described in which the surface of the carrier material is specially modified.... | 10/13/1987 |
| 4672110 | Method of deprotecting polynucleotide trimethylethyl phosphotriesters Oligonucleotides protected by trihalomethylethyl phosphotriester groups are deprotected by reaction with tributylphosphine or phosphoramadite. The deprotection step can be carried out with the polynucelotide intermediate attached to a solid support, or in... | 06/09/1987 |
| 4577012 | Method of separation of nucleotides and nucleosides from each other The industrially favored separation of nucleotides and nucleosides from a solution containing both of them can be conducted by contacting said solution, after adjusted to a pH of not higher than 7, with activated carbon to adsorb the nucleosides and nucle... | 03/18/1986 |
| 4430496 | Strong anion exchange composition and methods A strong anion exchange composition useful in monophosphate nucleotide isomer separations is comprised of an inert porous particle having a silyl alkyl ammonium compound fixedly attached by a covalent silicon-oxygen-silicon bond to the surface thereof. A ... | 02/07/1984 |
| 4426517 | Process for de-cyanoethylating blocked nucleotides A ଲ-cyanoethyl blocking group is selectively removed from the phosphate moiety of a nucleotide or polynucleotide by treatment with diethyl amine.... | 01/17/1984 |
| 4419509 | Process for de-cyanoethylating blocked nucleotides A ଲ-cyanoethyl blocking group is selectively removed from the phosphate moiety of a nucleotide or polynucleotide by treatment with a primary amine having from 3 to 5 carbon atoms.... | 12/06/1983 |
| 4310662 | Nucleosidic phosphorylating agent and methods Compounds of the formula ##STR1## where R is a base labile substituted-phenyloxy protecting group, are useful as phosphorylating reagents in the synthesis of oligonucleotides by a phosphotriester method. Such compounds are made by the reaction of ... | 01/12/1982 |
| 4012571 | Enzyme separation A reactive matrix comprises a co-enzyme chemically attached to a water insoluble organic polymeric support material. The reactive matrix may be used in a process for the separation of mixtures containing a plurality of enzymes.... | 03/15/1977 |
