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| Number | Title | Issue Date |
| 7396658 | Methods for screening HIF like ouabain-resistant Na—K-ATPase agents The present invention relates to rapid, quantitative, specific, high through-put methods for screening test substances for their ability to inhibit activity of an ouabain-resistant Na+—K+-ATPase involved in a variety of biological processes s... | 07/08/2008 |
| 7291606 | Compositions and methods for identifying agents which regulate chromosomal stability, gene activation and aging Novel compositions and methods are provided for identifying agents which affect chromosomal stability and aging. ... | 11/06/2007 |
| 7083950 | High affinity fusion proteins and therapeutic and diagnostic methods for use High affinity fusion proteins (“trapbodies”), capable of binding and inhibiting the activity of soluble, interacting proteins (“SIPs”) are described. The trapbodies are multimers, preferably dimers, of SIP-specific fusion polypeptides which comprise SIP bind... | 08/01/2006 |
| 7056894 | Inhibitors of ADP-ribosyl transferases, cyclases, and hydrolases, and uses thereof The present invention provides compounds having the formula: wherein A is chosen from a nitrogen-, oxygen-, or sulfur-linked aryl, alkyl, cyclic, or heterocyclic group; both B and C are hydrogen, or either B or C... | 06/06/2006 |
| 7034011 | Method of stabilizing reduced nicotinamide adenine dinucleotide or reduced nicotinamide adenine dinucleotide phosphate It is an object of the present invention to provide a method of stabilizing reduced nicotinamide adenine dinucleotide or reduced nicotinamide adenine dinucleotide phosphate [hereinafter abbreviated as NAD(P)H] and a preparation containing NAD(P)H stabilized by the m... | 04/25/2006 |
| 7022680 | Inhibitors of ADP-ribosyl transferases, cyclases, and hydrolases The present invention provides compounds having the formula: wherein A is a nitrogen-, oxygen-, or sulfur-linked aryl, alkyl, cyclic, or heterocyclic group, the group being further substituted with an electron contribut... | 04/04/2006 |
| 6846646 | Methods for screening HIF like ouabain-resistant Na+-K+-ATPase agents The present invention relates to rapid, quantitative, specific, high through-put methods for screening test substances for their ability to inhibit activity of an ouabain-resistant Na+-K+-ATPase involved in a variety of biological processes suc... | 01/25/2005 |
| 6713623 | Tetraphosphonate bicyclic trisanhydrides Disclosed are novel bicyclic tris(anhydride)s useful as intermediates in the synthesis of biologically active compounds, and the compounds which may be synthesized from such intermediates. ... | 03/30/2004 |
| 6689760 | Anti-mycobacterial compositions This invention provides compositions of matter, pharmaceutical compounds, methods of synthesizing such compounds and methods for using such compounds to treat animals infected with a pathogenic mycobacterium. The invention specifically provides compositio... | 02/10/2004 |
| 6380380 | Use of nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucliotide phosphate (NADP) analogs to measure enzyme activities metabolites and substrates Kits and methods for measuring enzyme activities and metabolites using NAD analogs and NADP analogs are disclosed. The analogs can be used as replacements for NAD and NADP cofactors in analytical procedures. Preferred aspects of the invention include kits... | 04/30/2002 |
| 6344201 | Methods of identifying bacterial genes that are incompatible with bacterial pathogenicity, and the use of such genes, such as cadA, to reduce pathogenicity in a bacteria or to combat pathogenic bacterial infections "Black holes" in the genomes of bacterial pathogens represent deletions of "anti-virulence" genes, i.e. genes that are detrimental to a pathogenic lifestyle. Identification of the missing genetic loci in the "black hole" identifies genes that are incompat... | 02/05/2002 |
| 6339073 | Uses of nicotinamide adenine dinucleotide and its derivatives for treatment of malignant and infectious diseases This invention provides a method of killing tumor cells or microorganisms which comprises contacting the tumor cells or the microorganisms with an amount of nicotinamide adenine dinucleotide (NAD) or its analogs effective to increase clonogenic toxicity o... | 01/15/2002 |
| 6326490 | Tetraphosphonate bicyclic trisanhydrides Disclosed are novel bicyclic tris(anhydride)s useful as intermediates in the synthesis of biolologically active compounds, and the compounds which may be synthesized from such intermediates.... | 12/04/2001 |
| 6207649 | Nucleoside analogs and uses in treating disease The invention relates to pharmaceutical compositions of nucleoside dimers containing an L-sugar in at least one of the nucleosides.... | 03/27/2001 |
| 6162615 | Stabilized coenzyme solutions and their use thereof for the determination of dehydrogenases or the substrate thereof in an alkaline medium Stabilized aqueous coenzyme solutions which contain up to ca. 60 mM of a heavy metal salt and optionally a complexing agent in a defined ratio to the heavy metal salt as well as their use for the determination of dehydrogenases in particular lactate dehyd... | 12/19/2000 |
| 6046018 | Highly sensitive method for assaying chiro-inositol and compositions for the assay The present invention relates to an assay method of chiroinositol which comprises reacting a specimen containing chiroinositol with 1) a dehydrogenase, which catalyses at least reversible reaction with a substrate of chiroinositol in the presence of a coenzyme... | 04/04/2000 |
| 6025335 | L-Nucleoside Dimer Compounds and therapeutic uses The invention relates to nucleoside dimers containing an L-sugar in at least one of the nucleosides and their pharmaceutical compositions.... | 02/15/2000 |
| 6020480 | Caged NADP and NAD Provided are caged NADP and NAD compounds. The invention includes two types of caged NAD and NADP (NAD/P) analogs, each type having a different caging group binding at a different site on the molecule: Phosphate-caged DMNPE-NAD/P and nicotinamide-caged CN... | 02/01/2000 |
| 5962442 | Irreversible inhibition of human 5-reductase The invention concerns the treatment of hyderandrogenic conditions in humans by the formation of a novel mechanism-based irreversible inhibitor of human 5-reductase enzymes from 3-oxo-4-azasteroids having a 1,2-double bond and the pyridine-nucleoti... | 10/05/1999 |
| 5888532 | Treatment of alcoholism and related disorders with (nicotinamide-adenine dinucleotide) phosphate derivatives Alcoholic addiction is treated by administering pyridine nucleotide phosphate derivatives having the formula represented by Formula 1: ##STR1## where y can be a second NAD group or an adenosine group and x can be 1, 2, or 3.... | 03/30/1999 |
| 5834227 | Kit for assaying creatine kinase A reagent for assaying creatine kinase, which contains glucokinase or hexokinase, glucose-6-phosphate dehydrogenase, adenosine 5'-diphosphate, creatine phosphate, oxidized nicotinamide adenine dinucleotide phosphate, magnesium salt, and glucose; and which... | 11/10/1998 |
| 5712259 | NADH and NADPH pharmaceuticals for treating chronic fatigue syndrome A method for treating Chronic Fatigue Syndrome or alleviating symptoms thereof wherein the reduced form of nicotinamide adenine dinucleotide (NADH) or the reduced form of nicotinamide adenine dinucleotide phosphate (NADPH) or physiologically compatible sa... | 01/27/1998 |
| 5700786 | Analogues of adenosine 5'diphosphate and pharmaceutical compositions thereof This invention provides a compound having the structure: ##STR1## wherein R1, R2, and R3 are same or different, and are hydrogen, hydroxyl, or fluorine; Z is O, CH2 or CF2 ; R is chlorine, bromin... | 12/23/1997 |
| 5658890 | C-nucleoside isostere of nicotinamide adenine dinucleotide, analogs thereof and use as anti-cancer agent This invention provides a compound having the structure: ##STR1## wherein each R1, R2, R3, and R4 is independently fluorine, OH or H; Z is O, CH2 or CF2 ; each Y is independently OH or... | 08/19/1997 |
| 5656613 | Treatment of hyperandrogenic conditions The invention concerns the treatment of hyperandrogenic conditions in humans by the formation of a novel mechanism-based irreversible inhibitor of human 5-reductase enzymes from 3-oxo-4-azasteroids having a 1,2-double bond and the pyridine-nucleoti... | 08/12/1997 |
| 5608047 | Cyclic ADP-ribose and analogs A non-enzymatic stereoselective cyclization of ଲ-NAD+ to yield cyclic ADP-ribose (cADPR). By heating ଲ-NAD+ in an anhydrous solvent in the presence of a metal halide and a nonnucleophilic base, cADPR was obtained as the... | 03/04/1997 |
| 5569650 | C-nucleoside isosters of analogs thereof and pharmaceutical compositions This invention provides a compound having the structure: ##STR1## wherein R1, R2, and R3 are same or different, and are hydrogen, hydroxyl, or fluorine; Z is O, CH2 or CF2 ; R is chlorine, bromin... | 10/29/1996 |
| 5486604 | Cyclic ADP ribose antagonists Cyclic ADP-ribose (cADPR) analogs block cADPR from releasing Ca+2, and also inhibit cADPR from potentiating Ca+2 release induced by either divalent cations or by caffeine. 8-amino-cADPR and two other 8-substituted analogs were also ... | 01/23/1996 |
| 5480982 | Crystalline potassium salt of thinonicotinamide adenine dinucleotide phosphate The present invention relates to a novel crystalline thio-NADP potassium salt, which is produced by preparing thionicotinamide adenine dinucleotide phosphate (thio-NADP) into the potassium salt thereof and thereafter crystallizing the salt. Conventionally... | 01/02/1996 |
| 5399681 | Method for preparing N6 -substituted NAD, NADP or FAD The invention relates to a method of preparing N6 -substituted NAD, NADP or FAD by Dimroth rearrangement, wherein the rearrangement is carried out without preceding reduction and subsequent reoxidation.... | 03/21/1995 |
| 5356790 | Highly sensitive assay method for myo-inositol, composition for practicing same, novel myo-inositol dehydrogenase, and process for producing same Myo-inositol in a specimen is assayed by reacting a specimen containing myo-inositol with: a) myo-inositol dehydrogenase using a thio-NADP group or thio-NAD group and an NADP group or NAD group as coenzymes, and which catalyzes a reversible reaction formi... | 10/18/1994 |
| 5019496 | Photopolymerization diagnostic test composition and method for immunoassay and nucleic acid assay A diagnostic test composition for detecting and measuring an analyte possessing biologic activity comprising (a) a photocatalyst system capable of converting a monomer to a polymer upon exposure to light, the monomer capable of undergoing addition polymer... | 05/28/1991 |
| 4950602 | Inhibition of lactate production by pyruvate adducts The present invention relates to inhibitors of lactate dehydrogenase that can cross the blood brain barrier and there is described herein the preparation of several analogues of nicotinamide-adenine-dinucleotide (NAD+) pyruvate adduct, of which... | 08/21/1990 |
| 4515943 | Crystal of beta-nicotinamide-adenine-dinucleotide and process for preparing the same Novel highly pure and stable crystals of ଲ-nicotinamide-adenine-dinucleotide tetrahydrate (NAD) which is triclinic system and has a space group of P1 or P1 and lattice constants: a=8.861 Å, b=11.181 Å, c=8.630 Å, =90.82°, ଲ=103... | 05/07/1985 |
| 4443594 | Process for the production of adenine ring system containing co-enzymes bound to macromolecules A process for the production of adenine ring system containing co-enzymes bound to a macro-molecular carrier comprising the steps of alkylating an adenine ring system containing co-enzyme in the 1 position with an alkylating agent containing a terminal gr... | 04/17/1984 |
| 4411995 | Synthesis of nicotinamide cofactors Nicotinamide cofactors are prepared in a process of reacting ribose -5- phosphate with a basic material selected from the group consisting of ammonia, primary and secondary amines in a polar non-aqueous solvent, reacting the resultant 1-ribosylamine -5- p... | 10/25/1983 |
| 4336188 | Method for the preparation of macromolecularized adenine derivatives A method is disclosed for preparing functionalized adenine derivatives, said method comprising the step of reacting a compound which contains an adenine nucleus which has been halogen substituted in the 8-position, with a compound having the general formu... | 06/22/1982 |
| 4258131 | Method of fractional quantitative determination of isoenzyme of lactic dehydrogenase 1,6-Dihydro nicotinamide adenine dinucleotide inhibits both H-type lactic dehydrogenase and M-type lactic dehydrogenase which are isoenzymes of lactic dehydrogenase, but the degree of inhibition thereof against H-type considerably differs from that agains... | 03/24/1981 |
| 4219645 | Stabilized nicotinamide-adenine dinucleotides and process for their preparation Nicotinamide-adenine dinucleotide or the phosphate thereof, each in the reduced as well as the oxidized forms, are stabilized against activity losses in storage by the addition of hydrolytically decomposed, optionally cross-linked collagen.... | 08/26/1980 |
| 4199498 | Macromolecularized adenine derivatives A method is disclosed for preparing functionalized adenine derivatives, said method comprising the step of reacting a compound which contains an adenine nucleus which has been halogen substituted in the 8-position, with a compound having the general formu... | 04/22/1980 |
