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| Number | Title | Issue Date |
| 7335765 | Nucleoside and oligonucleotide analogues A compound of the formula (1): wherein R1 and R2 are the same or different and represent a hydrogen atom, a hydroxyl protecting group, a phosphate group, or —P(R3)R4, wherein R | 02/26/2008 |
| 7314923 | Nucleoside and oligonucleotide analogues A probe for a gene or a primer for starting amplification comprising an oligonucleotide analogue comprising two or more nucleoside units, wherein at least one of the nucleoside units is a structure of the formula (2): ... | 01/01/2008 |
| 7294621 | Lipid analogs for combating tumors The invention relates to methods of treating viral infections, and in particular hepatitis B virus. The method comprises administering to a subject in need of such treatment an infection-controlling amount of a phospholipid or phospholipid derivative to inhibit the ... | 11/13/2007 |
| 7294619 | Lipid analogs for inhibiting the activity of hepatitis B antigen The invention relates to methods of treating viral infections, and in particular hepatitis B virus. The method comprises administering to a subject in need of such treatment an infection-controlling amount of a phospholipid or phospholipid derivative to inhibit the ... | 11/13/2007 |
| 7294620 | Lipid analogs for inhibiting HIV-1 activity The invention relates to methods of treating viral infections, and in particular hepatitis B virus. The method comprises administering to a subject in need of such treatment an infection-controlling amount of a phospholipid or phospholipid derivative to inhibit the ... | 11/13/2007 |
| 7285658 | Nucleotide mimics and their prodrugs The present invention relates to nucleoside diphosphate mimics and nucleoside triphosphate mimics, which contain diphosphate or triphosphate moiety mimics and optionally sugar-modifications and/or base-modifications. The nucleotide mimics of the present invention, i... | 10/23/2007 |
| 7268119 | Tricyclic nucleosides or nucleotides as therapeutic agents Nucleosides and nucleotides containing a tricyclic base portion thereof are useful for treating infectious diseases and proliferative disorders, such as viral infections or cancer respectively. ... | 09/11/2007 |
| 7115585 | Compositions for treating epithelial and retinal tissue diseases The present invention relates to mononucleoside phosphate compounds that have the benefits of a dinucleotide pharmaceutical. These mononucleoside phosphates can be made from a mononucleotide that has been modified by attaching a degradation resistant substituent on ... | 10/03/2006 |
| 7091334 | Method for large-scale production of di(uridine 5′)-tetraphosphate and salts thereof The present invention provides new methods for the synthesis of the therapeutic dinucleotide, P1,P4-di(uridine 5′)-tetraphosphate, and demonstrates applicability to the production of large quantities. The methods of the present invention subs... | 08/15/2006 |
| 7056894 | Inhibitors of ADP-ribosyl transferases, cyclases, and hydrolases, and uses thereof The present invention provides compounds having the formula: wherein A is chosen from a nitrogen-, oxygen-, or sulfur-linked aryl, alkyl, cyclic, or heterocyclic group; both B and C are hydrogen, or either B or C... | 06/06/2006 |
| 7026469 | Compositions and methods of double-targeting virus infections and cancer cells The invention includes compositions and methods useful for treatment of a virus infection in a mammal by double-targeting the virus (i.e. targeting the virus at more than one stage of the virus life cycle) and thereby inhibiting virus replication. The compositions o... | 04/11/2006 |
| 7022680 | Inhibitors of ADP-ribosyl transferases, cyclases, and hydrolases The present invention provides compounds having the formula: wherein A is a nitrogen-, oxygen-, or sulfur-linked aryl, alkyl, cyclic, or heterocyclic group, the group being further substituted with an electron contribut... | 04/04/2006 |
| 7018985 | Composition and method for inhibiting platelet aggregation The present invention provides novel compounds of dinucleotide polyphosphates and the method of preventing or treating diseases or conditions associated with platelet aggregation. The method comprises administering systemically to a patient a pharmaceutical comprisi... | 03/28/2006 |
| 6987180 | Uridine analogs and techniques for making and using Uridine analogs and techniques for making and using uridine analogs are disclosed in this invention. These uridine analogs include nucleoside phosphates having a 5-aminouracil group. These nucleotides can be incorporated into a nucleic acid as an unnatural base, as ... | 01/17/2006 |
| 6900308 | α-modified nucleoside triphosphates The present invention is directed to α-modified nucleoside triphosphates and methods for their preparation. The present invention also provides for methods of inhibiting RNA and viral replication in cells, as well as methods for treating viral infections. ... | 05/31/2005 |
| 6812342 | Esters of cyclic ADP ribose derivatives The present invention is directed to the field of organic chemistry in general and specifically to the preparation of hydrophobic derivatives of cyclic ADP ribose. One form of the present invention is the composition of one or more hydrophobic derivatives of cyclic ... | 11/02/2004 |
| 6781001 | Nucleic acids labelled with extended rhodamine dyes Extended rhodamine compounds exhibiting favorable fluorescence characteristics having the structure are disclosed. In addition, novel intermediates for synthesis of these dyes are disclosed, such intermediates having the... | 08/24/2004 |
| 6765090 | Method for large-scale production of di(uridine 5')-tetraphosphate and salts thereof The present invention provides new methods for the synthesis of the therapeutic dinucleotide, P1,P4-di(uridine 5′-tetraphosphate), and demonstrates applicability to the production of large quantities. The methods of the present invention subs... | 07/20/2004 |
| 6713623 | Tetraphosphonate bicyclic trisanhydrides Disclosed are novel bicyclic tris(anhydride)s useful as intermediates in the synthesis of biologically active compounds, and the compounds which may be synthesized from such intermediates. ... | 03/30/2004 |
| 6670341 | Compositions and methods for double-targeting virus infections and targeting cancer cells The invention includes compositions and methods useful for treatment of a virus infection in a mammal by double-targeting the virus (i.e. targeting the virus at more than one stage of the virus life cycle) and thereby inhibiting virus replication. The com... | 12/30/2003 |
| 6635419 | Polynucleotide sequencing method Disclosed is a method for determining a sequence of one or more nucleotides in a target polynucleotide. In the method, a target-specific primer is contacted with a polynucleotide sample under conditions effective for the primer to anneal specifically to a... | 10/21/2003 |
| 6448392 | Lipid derivatives of antiviral nucleosides: liposomal incorporation and method of use Compounds are disclosed for treating AIDS, herpes, and other viral infections by means of lipid derivatives of antiviral agents. The compounds consist of nucleoside analogues having antiviral activity which are linked, commonly through a phosphate group a... | 09/10/2002 |
| 6326490 | Tetraphosphonate bicyclic trisanhydrides Disclosed are novel bicyclic tris(anhydride)s useful as intermediates in the synthesis of biolologically active compounds, and the compounds which may be synthesized from such intermediates.... | 12/04/2001 |
| 6319908 | Method for large-scale production of di(uridine 5'-tetraphosphate) and salts thereof The present invention provides new methods for the synthesis of the therapeutic dinucleotide, P1,P4 -di(uridine 5'-tetraphosphate), and demonstrates applicability to the production of large quantities. The methods of the present inve... | 11/20/2001 |
| 6255475 | Chain terminators, the use thereof for nucleic acid sequencing and synthesis and a method of their preparation The invention relates to compounds of general structure (I) or salts thereof, wherein B is a nucleobase, X and Z independently are oxygen or sulphur, Y is hydrogen or hydroxy, which optionally may be protected, R1 is hydrocarbyl, which optional... | 07/03/2001 |
| 5872243 | Caged nucleotides The present invention describes a family of photolabile caged nucleotides, including cyclic nucleotides. The compounds of the present invention are caged analogs and derivatives of NAD+, NADH, NADP, NADPH, NAADP and cADPR. The photolysis of the... | 02/16/1999 |
| 5756480 | Treatment of hyperandrogenic conditions The invention concerns the treatment of hyperandrogenic conditions in humans by the formation of a novel mechanism-based irreversible inhibitor of human 5-reductase enzymes from 3-oxo-4-oxa end 4-thiasteroids having a 1,2-double bond and the pyridi... | 05/26/1998 |
| 5658731 | 2'-O-alkylnucleotides as well as polymers which contain such nucleotides Oligonucleotides having the general formula, ##STR1## in which B denotes an arbitrary nucleobase, A equals 0 or CH2 ; X or Z equals O, S, NH or denotes CH2 whereby X and Z can be the same or different, V and W denote O, S, Se, NH | 08/19/1997 |
| 5656742 | Ring-opened purine compounds for labeling polynucleotides The invention provides methods for attaching detectable labels to the N7 -formyl group, of imidazole ring-opened alkylated purines and purine derivatives, directly, through a linking group, or by subsequent derivatization of a blocking group. T... | 08/12/1997 |
| 5587472 | Coumarin-labeled nucleoside 5'-triphosphates A fluorescent label compound having the formula A--B1 --B2 --B3 --C wherein A represents the residue of a natural or synthetic nucleotide or nucleoside or a derivative thereof; B1 represents a divalent spacer radical or a... | 12/24/1996 |
| 5585481 | Linking reagents for nucleotide probes A versatile reagent with a non-nucleotide monomeric unit having a ligand, and first and second coupling groups which are linked to the non-nucleotide monomeric unit. The ligand can be either a chemical moiety, such as a label or intercalator, or a linking... | 12/17/1996 |
| 5547941 | Cyclic dinucleoside diphosphorothioates, related compounds and pharmaceutical compositions There are provided compounds of formula (I) ##STR1## wherein each group B is, independently, a naturally occurring or modified heterocyclic base linked through a nitrogen or a carbon atom of the ring to the sugar moiety; each group X is a, independen... | 08/20/1996 |
| 5525711 | Pteridine nucleotide analogs as fluorescent DNA probes The invention provides novel pteridine nucleotides which are highly fluorescent under physiological conditions and which may be used in the chemical synthesis of fluorescent oligonucleotidcs. The invention further provides for fluorescent oligonucleotides... | 06/11/1996 |
| 5512671 | Ether lipid-nucleoside covalent conjugates Ether lipid nucleoli covalent conjugates and derivatives thereof are disclosed, along with pharmaceutical compositions containing the same and methods of using the same to combat HIV-1 infections. Illustrative are 3'-Azido-3'-deoxythmidine-5'-monophosphat... | 04/30/1996 |
| 5486604 | Cyclic ADP ribose antagonists Cyclic ADP-ribose (cADPR) analogs block cADPR from releasing Ca+2, and also inhibit cADPR from potentiating Ca+2 release induced by either divalent cations or by caffeine. 8-amino-cADPR and two other 8-substituted analogs were also ... | 01/23/1996 |
| 5466677 | Dinucleoside phosphinates and their pharmaceutical compositions A dinucleotide analogue of formula ##STR1## where B1 and B2 are each independently a monovalent nucleoside base radical; R1 is R1a or Z; R1a, R2, R3 and R | 11/14/1995 |
| 5401725 | Neovascularization inhibition by adenosine-5'-phosphosulfates The present invention provides, as a noval and safe vascularization inhibitor having an excellent effect, a vascularization inhibitor which is characterized by containing, as the effective ingredient, 3-phosphoadenosine 5'-phosphosulfate or adenosine 5'-p... | 03/28/1995 |
| 5049550 | Diadenosine 5', 5'"-p1, p4,-tetraphosphate analogs as antithrombotic agents A component of blood platelets analogues thereof are described. The invention is based on the discovery that this component, a dinucleotide, as well as several of its chemically synthesized analogues, is an effective anti-platelet and antithrombotic agent... | 09/17/1991 |
| 4966965 | Method for preparing all-trans retinoyl CoA The invention relates to a new method for preparing all trans retinoyl CoA.... | 10/30/1990 |
| 4966964 | Inhibitors of angiogenin An inhibitor of angiogenin and method of use of the inhibitor, wherein the inhibitor inhibits the angiogenic activity of angiogenin. The inhibitor is dispensed at a suitable concentration within a physiologically compatable medium, suitable for administra... | 10/30/1990 |
