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| Number | Title | Issue Date |
| 7173018 | Phospholipid derivatives of non-steroidal anti-inflammatory drugs Disclosed are compounds having non-steroidal anti-inflammatory drugs (NSAIDS) covalently linked to a phospholipid moiety via a bridging group. Also disclosed are a process for the synthesis of the compounds, pharmaceutical compositions comprising the compounds and t... | 02/06/2007 |
| 6051699 | Process for the synthesis of oligomeric compounds Synthetic processes are provided wherein oligomeric compounds are prepared having phosphodiester, phosphorothioate, and phosphorodithioate covalent linkages. Also provided are synthetic intermediates useful in the processes.... | 04/18/2000 |
| 5859233 | Synthons for synthesis of oligonucleotide N3-P5 phosphoramidates The invention provides a method of synthesizing oligonucleotide N3'.fwdarw.P5' phosphoramidates using an amine-exchange reaction of phosphoramidites in which a -deprotected 3'-amino group of a solid phase supported oligonucleotide chain is exhanged for th... | 01/12/1999 |
| 5859232 | Process for the synthesis of oligomeric phosphite, phosphodiester, phosphorothioate and phosphorodithioate compounds Synthetic processes are provided wherein oligomeric compounds are prepared having phosphodiester, phosphorothioate, and phosphorodithioate covalent linkages. Also provided are synthetic intermediates useful in such processes.... | 01/12/1999 |
| 5756711 | Phospholipid derivatives of nucleosides and their use as anti-viral medicaments Compounds of the formula I ##STR1## in which R1 and R2 represent a possibly substituted C8 -C15 -alkyl chain, n the number 0, 1 or 2 and A the residue of a nucleoside, processes for their preparation, as we... | 05/26/1998 |
| 5705621 | Oligomeric phosphite, phosphodiester, Phosphorothioate and phosphorodithioate compounds and intermediates for preparing same Synthetic processes are provided wherein oligomeric compounds are prepared having phosphodiester, phosphorothioate, and phosphorodithioate covalent linkages. Also provided are synthetic intermediates useful in such processes.... | 01/06/1998 |
| 5629454 | Conformationally locked nucleoside analogues Conformationally locked 4',6'-cyclopropane-fused carbocyclic nucleoside analogues. The compounds are prepared by condensing a cyclopropane-fused carbocyclic allylic alcohol with substituted purine or pyrimidine bases. The condensation products are then mo... | 05/13/1997 |
| 5563257 | Phospholipid derivatives of nucleosides Liponucleotides containing an ether linkage in the 2-position and a thioether, sulfoxide, or sulfone linkage in the 3-position. The nucleoside component of said liponucleotide is AZT or 3'-deoxy-3'-fluorothymidine. These compounds exhibit antiviral activi... | 10/08/1996 |
| 5547941 | Cyclic dinucleoside diphosphorothioates, related compounds and pharmaceutical compositions There are provided compounds of formula (I) ##STR1## wherein each group B is, independently, a naturally occurring or modified heterocyclic base linked through a nitrogen or a carbon atom of the ring to the sugar moiety; each group X is a, independen... | 08/20/1996 |
| 5192749 | 4'-substituted nucleosides Nucleosides compounds of Formula I: ##STR1## wherein B is a purine or a pyrimidine; X and X' are H; Y is H; Y' is OH, F or H; or Y' and X' together makes a bond; Z is ##STR2## where n is zero, one, two or three; or Y' and Z together form a cyclic ... | 03/09/1993 |
| 4851520 | Method of making radioiodinated pyrimidine nucleoside or nucleotide The method of making radioiodinated pyrimidine nucleoside or nucleotide which comprises contacting a water-insoluble halomercuri pyrimidine nucleoside or nucleotide with an aqueous medium containing a dissolved radioactive iodide ion and an oxidizing agen... | 07/25/1989 |
| 4847244 | Treatment of human viral infections Treatments of AIDS or humans carrying or infected with the AIDS virus or having antibodies to the AIDS virus is disclosed using the compound 3'-azido-3'-deoxythymidine or a pharmaceutically acceptable basic salt thereof. Also disclosed is the use of the 5... | 07/11/1989 |
| 4707440 | Nucleic acid hybridization assay and detectable molecules useful in such assay A detectable molecule of the formula where A3 is A2 or a polymer, where A3 has at least one modifiable reactive group selected from the group consisting of amino, hydroxy, cis OH, halides, aryl, imidazoyl, carbonyl, carboxy, th... | 11/17/1987 |
| 4587044 | Linkage of proteins to nucleic acids A nucleic acid-protein conjugate which is specific with respect to a selected living cell is prepared by linking said nucleic acid to a protein specific to said living cell.... | 05/06/1986 |
| 4529796 | Method for making chromogenic and/or fluorogenic substrates for use in monitoring catalytic or enzymatic activity A method for preparing a substrate capable of undergoing catalytic-induced hydrolysis of the phosphate ester at the 3' position, to yield a species capable of being monitored spectrophotometrically or fluorometrically, comprises (a) forming a mononucleoti... | 07/16/1985 |
| 4369181 | Process for treating proliferative skin diseases using certain 6,8-substituted ribofuranosylpurine-3',5'-cyclic phosphates Proliferative skin diseases such as psoriasis are treated by topically administering cAMP analogs of the following formula to the afflicted skin site at a dose that preferentially and significantly activates type II protein kinase: ##STR1## wher... | 01/18/1983 |
| 4266048 | Synthesis of analogs of 3'-phosphoadenosine 5'-phosphosulfate (PAPS) Analogs of 3'-phosphoadenosine 5'-phosphosulfate, also known as PAPS, are useful in establishing sulfate transfer mechanisms in animals and may be produced by a chemical process yielding an analog B of a pure adenosine 2',3'-cyclic phosphate 5'-phosphate,... | 05/05/1981 |
| 4056674 | Derivatives of 3-deazaguanine Ribofuranosyl derivatives of 3-deazaguanine including the 5'-phosphate, 3',5'-cyclic phosphate and 5'-deoxy, useful as antiviral agents and antibacterial agents, are disclosed.... | 11/01/1977 |
