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...Daniel Webster invented a "bull plow" to pull out tree stumps. It didn't catch on because it was huge and required four oxen to pull it!
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| Number | Title | Issue Date |
| 7396658 | Methods for screening HIF like ouabain-resistant Na—K-ATPase agents The present invention relates to rapid, quantitative, specific, high through-put methods for screening test substances for their ability to inhibit activity of an ouabain-resistant Na+—K+-ATPase involved in a variety of biological processes s... | 07/08/2008 |
| 7319093 | Antidiabetic 2-substituted-5′-O-(1-Boranotriphosphate) adenosine derivatives 2-Substituted-5′-O-(1-boranotriphosphate)adenosine derivatives having at position 2 a radical R1 selected from the group consisting of H; halogen; O-hydrocarbyl; S-hydrocarbyl; NR3R4; and hydrocarbyl optionally substituted by halogen, CN, SCN, NO2, OR3, SR3 or NR3... | 01/15/2008 |
| 7217815 | 2-beta -modified-6-substituted adenosine analogs and their use as antiviral agents Various 2′-beta-methyl-6-substituted adenosine analogs (including 2,6-disubstituted adenosine, 8-aza-6-substituted adenosine, and 2-aza-6-substituted adenosine) are prepared by conventional and combinatorial library approaches. Contemplated compounds are particula... | 05/15/2007 |
| 7090804 | Amplification of nucleic acids with electronic detection The invention relates to compositions and methods useful in the detection of nucleic acids using a variety of amplification techniques, including both signal amplification and target amplification. Detection proceeds through the use of an electron transfer moiety (E... | 08/15/2006 |
| 7022727 | Crystalline drug form The present invention relates to a crystalline form of 6-[(2,2-diphenylethyl)amino]-9-(N-ethyl-β-D-ribofuranosyluronamide)-N-(2-{N′-[1-(2-pyridyl)-4-piperidyl]ureido}ethyl)-9H-purine-2-carboxamide and to a process for the preparation of, compositions containing a... | 04/04/2006 |
| 6956695 | System and method for increasing the contrast of an image produced by an epifluorescence microscope The contrast of an image produced by epifluorescence microscopy may be increased by placing a high-pass dichroic reflecting film behind the sample. The reflecting film reflects the emission light emitted by the fluorescent tags in the sample back through the objecti... | 10/18/2005 |
| 6951932 | Synthesis of 2-aralkoxyadenosines and 2-alkoxyadenosines The invention provides new methods for synthesis of 2-aralkyloxyadenosines and 2-alkoxyadenosines. The invention is particularly useful for synthesis of 2-[2-(4-chlorophenyl)ethoxy]adenosine. Preferred methods of the invention include activating a guanosine compound... | 10/04/2005 |
| 6942771 | Microfluidic systems in the electrochemical detection of target analytes The invention relates generally to methods and apparatus for conducting analyses, particularly microfluidic devices for the detection of target analytes. ... | 09/13/2005 |
| 6875750 | Aziridine compounds and methods of making and using them Aziridine derivatives of formula (I) are disclosed which can be used as cofactor for S-adenosyl-L-methionine-dependent methyltransferases. ... | 04/05/2005 |
| 6852746 | Crystalline drug form The present invention relates to a crystalline form of 6-[(2,2-diphenylethyl)amino]-9-(N-ethyl-β-D-ribofuranosyluronamide)-N-(2-{N′-[1-(2-pyridyl)-4-piperidyl]ureido}ethyl)-9H-purine-2-carboxamide and to a process for the preparation of, compositions containing a... | 02/08/2005 |
| 6846646 | Methods for screening HIF like ouabain-resistant Na+-K+-ATPase agents The present invention relates to rapid, quantitative, specific, high through-put methods for screening test substances for their ability to inhibit activity of an ouabain-resistant Na+-K+-ATPase involved in a variety of biological processes suc... | 01/25/2005 |
| 6831072 | Compositions and methods of synthesis and use of novel nucleic acid structures The present invention is directed to a method to produce 8-amino-2′deoxyadenosine by treating 8-azido-2′deoxyadenosine with an aqueous solution of methylamine or dimethylamine. ... | 12/14/2004 |
| 6759395 | Soft-gelatin capsule comprising S-adenosylmethionine and a method for producing the same The invention provides a novel soft gelatin capsule comprising a fill material consisting essentially of S-adenosylmethionine (SAMe) salt disposed within an enteric coated soft gelatin film. ... | 07/06/2004 |
| 6635615 | Stable salts of S-adenosyl-l-methionine Stable salts of S-adenosyl-1-methionine with polycations such as chitosan are described. The salts according to the invention are very stable and are valuable for use as active constituents in pharmaceutical compositions.... | 10/21/2003 |
| 6555545 | Adenosine A2A receptor antagonists for treating and preventing hepatic fibrosis, cirrhosis and fatty liver Hepatic cirrhosis and fibrosis and fatty liver can be prevented and treated by administering to a subject in need thereof an effective amount of at least one adenosine A2A receptor antagonist or at least one adenosine uptake promotor.... | 04/29/2003 |
| 6420546 | Oligoribonucleotide and ribozyme analogs with terminal 3'--3' and/or 5'--5' linkages The invention relates to oligoribonucleotide analogs with terminal 3'--3' and/or 5'--5' internucleotide linkages. This modification stabilizes the molecules altered in this way, including ribozymes, without adversely altering their properties, including, ... | 07/16/2002 |
| 6372724 | Modulation of human mast cell activation Human mast cell activation is modulated by ATP binding to P2-purinoceptors on the mast cell surface. ATP binding to the purinoceptors provides a target for therapeutic intervention for the treatment of disorders characterized by undesirable mast cell medi... | 04/16/2002 |
| 6225450 | DNA sequencing by mass spectrometry The invention describes a new method to sequence DNA. The improvements over the existing DNA sequencing technologies are high speed, high throughput, no electrophoresis and gel reading artifacts due to the complete absence of an electrophoretic step, and ... | 05/01/2001 |
| 6066722 | Inhibitors of nucleoside metabolism The present invention provides compounds having the formula: ##STR1## wherein A is CH or N; B is chosen from OH, NH2, NHR, H or halogen; D is chosen from OH, NH2, NHR, H, halogen or SCH3 ; R is an optionally substitut... | 05/23/2000 |
| 5968912 | Methods for immunosuppressing Methods for inducing immunosuppression in animals which need immunosuppressive treatment involving administration to animals of a therapeutically effective amount of the cyclic AMP agent HE-33 or its nucleoside.... | 10/19/1999 |
| 5902794 | 8-CI cAMP as anti-cancer drug Site 1- and site 2-selective derivatives of cAMP have been found to inhibit the of a variety of cancer and leukemic cells. The compounds have been found to have a synergistic effect in cancer and leukemic cell growth inhibition when a site 1-selective com... | 05/11/1999 |
| 5843916 | Cyclic amp analogues, individually and in pairs, to inhibit neoplastic cell growth A method of inhibiting the proliferation of cells, particularly cancerous cells, by contacting the cells with a phosphorothioate derivative of a cAMP modified at either or both the C-6 and C-8 positions of the adenine moiety, and pharmaceutical compositio... | 12/01/1998 |
| 5831074 | Eucaryotic NAD cyclases Eucaryotic NAD cyclases able to cause production of cyclic adenosine diphosphate ribose from nicotinamide adenine dinucleotide.... | 11/03/1998 |
| 5792752 | 8-chloro camp and related camp compounds as antineoplastic agents Site 1- and site 2-selective derivatives of cAMP have been found to inhibit the growth of a variety of cancer and leukemic cells. The compounds have been found to have a synergistic effect in cancer and leukemic cell growth inhibition when a site 1-select... | 08/11/1998 |
| 5780253 | Screening method for detection of herbicides This invention relates to novel screening methods for identifying compounds that specifically inhibit a biosynthetic pathway in plants. Enzymes which are specifically affected by the novel screening method include plant purine biosynthetic pathway enzymes... | 07/14/1998 |
| 5780254 | Method for detection of herbicides This invention relates to novel screening methods for identifying compounds that specifically inhibit a metabolic target site or pathway in plants. Enzymes which are specifically affected by the novel screening method include plant purine biosynthetic pat... | 07/14/1998 |
| 5763167 | Applications of fluorescent N-nucleosides and fluorescent structural analogs of N-nucleosides Structural analogs of the six non-fluorescent N-nucleosides commonly found in RNA and DNA, which are inherently fluorescent under physiological conditions, are identified and methods for their preparation provided. Such analogs may be incorporated into DN... | 06/09/1998 |
| 5763419 | Treatment of malignant tumors with 8-chloroadenosine 3',5'-cyclic monophasphate The compound 8-chloroadenosine 3',5'-cyclic phosphate and its pharmaceutically acceptable salts are used to treat malignant tumors in afflicted hosts.... | 06/09/1998 |
| 5747474 | Immunosuppression by administration of N6,N6 -disubstituted cAMP's, analogues thereof, and related nucleosides Methods for inducing immunosuppression in animals which need immunosuppressive treatment involving administration to animals of a therapeutically effective amount of the cyclic AMP agent HE-33 or its nucleoside.... | 05/05/1998 |
| 5712259 | NADH and NADPH pharmaceuticals for treating chronic fatigue syndrome A method for treating Chronic Fatigue Syndrome or alleviating symptoms thereof wherein the reduced form of nicotinamide adenine dinucleotide (NADH) or the reduced form of nicotinamide adenine dinucleotide phosphate (NADPH) or physiologically compatible sa... | 01/27/1998 |
| 5629454 | Conformationally locked nucleoside analogues Conformationally locked 4',6'-cyclopropane-fused carbocyclic nucleoside analogues. The compounds are prepared by condensing a cyclopropane-fused carbocyclic allylic alcohol with substituted purine or pyrimidine bases. The condensation products are then mo... | 05/13/1997 |
| 5629298 | Adenosine as a positive inotrop in the compromised heart Disclosed are methods of increasing the contractile performance of a compromised myocardium in a mammal. The methods include administering a therapeutically affective amount of an adenosine A2 receptor agonist. Also disclosed are methods that i... | 05/13/1997 |
| 5599798 | Cyclic AMP derivative-containing ointment An ointment comprising an adenosine 3',5'-cyclic phosphate derivative, a base having water-absorbing and drying properties and, incorporated in the base, is one or more salts each having pH in an aqueous solution of from 3 to 7. The ointment maintains the... | 02/04/1997 |
| 5559102 | Adenosine and guanosine-3'-5'-cyclic methylphosphonate derivatives Cyclic AMP and cyclic GMP derivatives, such as 8-bromoadenosine-3', 5'-cyclic methylphosphonate, are effective in inhibiting phosphodiesterases.... | 09/24/1996 |
| 5506352 | Process for the synthesis of 9-(ଲ-D-arabinofuranosyl)adenine, 5'-phosphate An improved process for the preparation of 9-(ଲ-D-arabinofuranosyl)adenine, 5'-phosphate, is described where dried 9-(ଲ-D-arabinofuranosyl)adenine is reacted with triethyl phosphate and phosphorous oxychloride in dichloromethane and the reacti... | 04/09/1996 |
| 5486604 | Cyclic ADP ribose antagonists Cyclic ADP-ribose (cADPR) analogs block cADPR from releasing Ca+2, and also inhibit cADPR from potentiating Ca+2 release induced by either divalent cations or by caffeine. 8-amino-cADPR and two other 8-substituted analogs were also ... | 01/23/1996 |
| 5470858 | Derivatives of (hetero)aromatic ethers and thioethers having antihyperlipidemic activity, process for their preparation and pharmaceutical compositions containing them A compound represented by the following formula I: (HET)Ar--X--CH2 --Y--CH2 --O--R (I) wherein: (HET)Ar represents a bicyclic hetero aryl nucleus which is unsubstituted or is substituted; X represents --S--; Y represents --CO-... | 11/28/1995 |
| 5449664 | Antiviral agents Nucleoside compounds of the formula ##STR1## wherein: B is a purine or a pyrimidine; X and X' are H, OH or F, provided that at least one is H; Y and Y' are H, OH, OCH3 or F, provided that at least one is H; Y' and Z together form a cyclic phosphate ... | 09/12/1995 |
| 5434086 | Method of testing potential cystic fibrosis treating compounds using cells in culture Cystic fibrosis (CF), a lethal genetic disease associated with a defect in Cl transport, is caused by mutations in the gene coding for cystic fibrosis transmembrane conductance regulator (CFTR). Surprisingly, not only wild type CFTR, but several naturally... | 07/18/1995 |
| 5424298 | Topical powder compositions containing a cyclic AMP derivative A topical powder composition containing a cyclic AMP derivative and a water-absorptive powdery material. The topical powder composition is useful for wet dermatoses. Release of drug can be controlled.... | 06/13/1995 |
