Did You Know...
...that a workman who left the soap mixing machine on too long was responsible for making Ivory Soap? He was so embarrassed by his mistake that he threw the mess in a stream. Imagine his dismay when the evidence of his error floated to the surface! Result: Ivory soap, the soap that floats.
PatentStorm News
Make the Most of Our Site
See this month's Top Inventors and Most Cited Patents.
Stay on top of the latest innovations by subscribing to an RSS feed.
Registered users: Manage your profile.
| Number | Title | Issue Date |
| 7935814 | Nitroguanosine-3′ 5′-cyclic monophosphate compound and protein kinase G activating agent An object of the present invention is to provide a novel compound that is an agonist of guanosine-3′,5′-cyclic monophosphate and has an effect of activating protein kinase G. The present invention provides 8-guanosine-3′,5′-cyclic monophosphate compound whic... | 05/03/2011 |
| 7319093 | Antidiabetic 2-substituted-5′-O-(1-Boranotriphosphate) adenosine derivatives 2-Substituted-5′-O-(1-boranotriphosphate)adenosine derivatives having at position 2 a radical R1 selected from the group consisting of H; halogen; O-hydrocarbyl; S-hydrocarbyl; NR3R4; and hydrocarbyl optionally substituted by halogen, CN, SCN, NO2, OR3, SR3 or NR3... | 01/15/2008 |
| 7238476 | Methods and compositions for genotyping The invention provides compositions and methods for performing primer extension reactions, including employment of amplification primers having 5′ tags to incorporate into amplicons variant nucleotides of interest from target nucleic acids at known ratios, with or... | 07/03/2007 |
| 7217815 | 2-beta -modified-6-substituted adenosine analogs and their use as antiviral agents Various 2′-beta-methyl-6-substituted adenosine analogs (including 2,6-disubstituted adenosine, 8-aza-6-substituted adenosine, and 2-aza-6-substituted adenosine) are prepared by conventional and combinatorial library approaches. Contemplated compounds are particula... | 05/15/2007 |
| 7192700 | Methods and compositions for conducting primer extension and polymorphism detection reactions The invention comprises compositions and methods for performing primer extension reactions, including employment of amplification primers having 5′ tags to incorporate into amplicons variant nucleotides of interest from target nucleic acids at known ratios, along ... | 03/20/2007 |
| 7105499 | Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase The present invention provides nucleoside derivatives which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are pa... | 09/12/2006 |
| 6537748 | Reagent for nucleic acid typing by primer extension This invention concerns a reagent composition comprising at least two different terminators of a nucleic acid template-dependent, primer extension reaction. This invention also concerns a method for determining the identity of a nucleotide base at a speci... | 03/25/2003 |
| 6538128 | Detritylation solvents for nucleic acid synthesis The invention provides improved processes for oligonucleotide synthesis utilizing arenes as solvents for detritylation of oligonucleotides.... | 03/25/2003 |
| 6222025 | Process for the synthesis of 2'-O-substituted pyrimidines and oligomeric compounds therefrom Oligonucleotide analogs are disclosed having pyrimidine monomeric sub-units therein that are modified at the 2' and 5 positions. Monomeric sub-units having these modifications may be further modified at the 2 position. Improved processes for the synthesis... | 04/24/2001 |
| 5859233 | Synthons for synthesis of oligonucleotide N3-P5 phosphoramidates The invention provides a method of synthesizing oligonucleotide N3'.fwdarw.P5' phosphoramidates using an amine-exchange reaction of phosphoramidites in which a -deprotected 3'-amino group of a solid phase supported oligonucleotide chain is exhanged for th... | 01/12/1999 |
| 5831074 | Eucaryotic NAD cyclases Eucaryotic NAD cyclases able to cause production of cyclic adenosine diphosphate ribose from nicotinamide adenine dinucleotide.... | 11/03/1998 |
| 5780254 | Method for detection of herbicides This invention relates to novel screening methods for identifying compounds that specifically inhibit a metabolic target site or pathway in plants. Enzymes which are specifically affected by the novel screening method include plant purine biosynthetic pat... | 07/14/1998 |
| 5780253 | Screening method for detection of herbicides This invention relates to novel screening methods for identifying compounds that specifically inhibit a biosynthetic pathway in plants. Enzymes which are specifically affected by the novel screening method include plant purine biosynthetic pathway enzymes... | 07/14/1998 |
| 5677441 | Nucleosides, nucleotides and oligonucleotides containing enzymatically cleavable protecting groups Process for the production of oligonucleotides of formula II, in which the exocyclic amino groups of the bases adenine, guanine, cytosine, 7-deazaadenine and 7-deazaguanine carry N-phenylacetyl groups, are used for oligonucleotide synthesis, wherein in a ... | 10/14/1997 |
| 5629454 | Conformationally locked nucleoside analogues Conformationally locked 4',6'-cyclopropane-fused carbocyclic nucleoside analogues. The compounds are prepared by condensing a cyclopropane-fused carbocyclic allylic alcohol with substituted purine or pyrimidine bases. The condensation products are then mo... | 05/13/1997 |
| 5625056 | Derivatives of cyclic guanosine-3',5'-monophosphorothioate New derivatives of SP - and RP -configures cyclic guanosine-3',5'-phosphorothioates and their physiologically and pharmaceutically acceptable salts according to the general formula ##STR1## are cell membrane permeable inhibitors... | 04/29/1997 |
| 5599798 | Cyclic AMP derivative-containing ointment An ointment comprising an adenosine 3',5'-cyclic phosphate derivative, a base having water-absorbing and drying properties and, incorporated in the base, is one or more salts each having pH in an aqueous solution of from 3 to 7. The ointment maintains the... | 02/04/1997 |
| 5559102 | Adenosine and guanosine-3'-5'-cyclic methylphosphonate derivatives Cyclic AMP and cyclic GMP derivatives, such as 8-bromoadenosine-3', 5'-cyclic methylphosphonate, are effective in inhibiting phosphodiesterases.... | 09/24/1996 |
| 5449664 | Antiviral agents Nucleoside compounds of the formula ##STR1## wherein: B is a purine or a pyrimidine; X and X' are H, OH or F, provided that at least one is H; Y and Y' are H, OH, OCH3 or F, provided that at least one is H; Y' and Z together form a cyclic phosphate ... | 09/12/1995 |
| 5346999 | Method of nucleic acid extraction An automated apparatus is provided which implements a new method of extracting and purifying nucleic acids from cells without the use of centrifugation. In the method, a lysate is created by treating the cells with proteinase K in the presence of a lysis ... | 09/13/1994 |
| 5248770 | Molecular probes for adenosine receptors This application discloses probes for adenosine receptors which are functionalized congeners of the following compound: ##STR1## wherein R is --CH2 --C(O)--R' or ##STR2## These probes bind to A2 and A3 adenosine ... | 09/28/1993 |
| 5218102 | Nucleic acid probe containing a terminal carbamyl linking non-radioactive labeling and preparating processes The subject of the present invention is a nucleic acid probe containing a nucleic acid sequence, wherein the said sequence is linked at its 5' end, via a divalent bifunctional chemical "arm" L, to a "labeling component" M, M being a synthetic or natural m... | 06/08/1993 |
| 5192749 | 4'-substituted nucleosides Nucleosides compounds of Formula I: ##STR1## wherein B is a purine or a pyrimidine; X and X' are H; Y is H; Y' is OH, F or H; or Y' and X' together makes a bond; Z is ##STR2## where n is zero, one, two or three; or Y' and Z together form a cyclic ... | 03/09/1993 |
| 5039797 | 2'-O-(4-benzoyl)benzoyl nucleoside cyclic monophosphate The invention is a 2'-O-(4-benzoyl)benzoyl nucleoside 3', 5'-cyclic monophosphate of formula (I) ##STR1## wherein R' is guanine or adenine. Also disclosed are topical pharmaceutical compositions and methods of using them for reducing intraocular... | 08/13/1991 |
| 5026836 | 6-sulfenamide, 6-sulfinamide and 6-sulfonamide purines, purine nucleosides, purine nucleotides, pharmaceutical compositions, and processes of making 6-Sulfenamide, 6-sulfinamide and 6-sulfonamide purines, purine nucleosides, purine nucleotides and 3 and 7 deaza and 8 aza derivatives thereof of structure: ##STR1## wherein Z is H or --NH2 ; X is --S--NH2, ##STR2## T ... | 06/25/1991 |
| 4956348 | Stimulation of tear secretion with cyclic nucleotides A method and preparation for the stimulation of tear secretion. The method involves topically applying a phosphodiesterase inhibitor and/or cyclic nucleotide analogue to the ocular surface. Inhibition of phosphodiesterase and cyclic nucleotide analogues i... | 09/11/1990 |
| 4902677 | Treatment of heart failure of mammals with N6 -substituted cyclic adenosine monophosphates A composition for use in the treatment of heart failure of mammals which comprises, as its active ingredient, an N6 -substututed-adenosine-3',5'-cyclic phosphate represented by the following general formula (I) or a physiologically acceptable s... | 02/20/1990 |
| 4880784 | Antiviral methods utilizing ribofuranosylthiazolo[4,5-d]pyrimdine derivatives Compounds of the structure: ##STR1## wherein R1 and R2 individually are H or C1 -C18 acyl and R3 is H, C1 -C18 acyl or ##STR2## or R1 is H and together R | 11/14/1989 |
| 4873227 | 3',5'-Camp derivatives for treatment of certain types of skin ulcers A novel therapeutic agent for skin ulcers comprising as its active component adenosine-3',5'-cyclic phosphate or a derivative thereof, and a method for the treatment of skin ulcers by using the agent. The therapeutic agent is prepared into various forms such a... | 10/10/1989 |
| 4797480 | New biologically active fluorescent cyclic nucleotides Sybthesis of new biologically active fluorescent cyclic nucleotides of general formula: ##STR1## wherein X=OH and Y=NH2 or X=NH2 and Y=H and L is a fluorescent group of the class of 5 (or 6)-thioacetamido-fluorescein or of 5(or ... | 01/10/1989 |
| 4728730 | Synthesis of nucleoside thiophosphoanhydrides A method for preparing sulfur and/or selenium containing phosphoanhydrides that have at least a triphosphate moiety is disclosed, together with a cyclo-intermediate formed during the reaction. The method includes reacting a first compound having an availa... | 03/01/1988 |
| 4587044 | Linkage of proteins to nucleic acids A nucleic acid-protein conjugate which is specific with respect to a selected living cell is prepared by linking said nucleic acid to a protein specific to said living cell.... | 05/06/1986 |
| 4369181 | Process for treating proliferative skin diseases using certain 6,8-substituted ribofuranosylpurine-3',5'-cyclic phosphates Proliferative skin diseases such as psoriasis are treated by topically administering cAMP analogs of the following formula to the afflicted skin site at a dose that preferentially and significantly activates type II protein kinase: ##STR1## wher... | 01/18/1983 |
| 4208406 | Composition for the treatment and prevention of skin, eye and mucosal inflammation Composition for treatment or prevention of skin, eye or mucosal inflammation in human and animals, especially but not exclusively by external topical application comprising an effective amount of a cyclic nucleotide derivative having the following structu... | 06/17/1980 |
| 4058659 | 6,8-Disubstituted purine derivatives of 9-ଲ-D-ribofuranosyl 3',5'-cyclic phosphate Compounds of formula ##STR1## wherein X is --NR1 R2, --Cl, --Br or SR; Y is --X, --OH or --NH2 ; Z is hydrogen or --NH2 ; and R' is hydrogen or C1 -C18 acyl; R being hydrogen, aryl, ar... | 11/15/1977 |
| 4054735 | Stabilized N2,2-O-dibutyrylguanosine-3,5-cyclic phosphate and salts thereof N2,2'-O-dibutyrylguanosine-3',5'-cyclic phosphate or a salt thereof is stabilized by adjusting the moisture content thereof to 3 percent or less by weight.... | 10/18/1977 |
| 4048307 | Cyclic adenosine monophosphate 8-substituted derivatives Novel cyclic adenosine monophosphate derivatives represented by the following general formula: ##STR1## wherein A stands for --S-- or --NH-- and n is an integer of from 2 to 12, ARE SUPERIOR TO KNOWN CYCLIC ADENOSIENE DERIVATIVES IN BIOLOGICAL AND ... | 09/13/1977 |
| 4038033 | Selenium labelled compounds in the saturation analysis of cyclic nucleotide New selenium-75 labelled derivatives of cyclic nucleotides are described, which are of value in the saturation analysis of cyclic nucleotides, particularly adenosine-3', 5'-cyclic monophosphate (cyclic AMP) in body fluids.... | 07/26/1977 |
| 3988442 | Cyclic nucleotide derivatives for treatment of hypothyroidism A method for stimulating the production of thyroid stimulating hormone (TSH) and enhancing thyroid function in animals comprising administering to an animal having low thyroid function an effective amount of a cyclic nucleotide derivative having the struc... | 10/26/1976 |
| 3968101 | 8-Substituted cyclic nucleotides by free radical alkylation and acylation Novel compounds of the general formula ##SPC1## Wherein X is H or NH2 ; R' is C1 to C8 alkyl, C1 to C8 substituted alkyl, benzyl, C1 to C8 acyl, benzoyl, carbamoyl, are disclosed... | 07/06/1976 |
