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| Number | Title | Issue Date |
| 7217815 | 2-beta -modified-6-substituted adenosine analogs and their use as antiviral agents Various 2′-beta-methyl-6-substituted adenosine analogs (including 2,6-disubstituted adenosine, 8-aza-6-substituted adenosine, and 2-aza-6-substituted adenosine) are prepared by conventional and combinatorial library approaches. Contemplated compounds are particula... | 05/15/2007 |
| 6965041 | N-acylphosphoramidites and their use in oligonucleotide synthesis The present invention provides a compound of formula (I), (II), or (III), wherein R1, R2, R2′, R3, and R3′ are the same or different and each is H an alkyl, an alkenyl, an alkynyl, a cycloalkyl, an aryl, or ... | 11/15/2005 |
| 6875859 | Heterocyclic compounds and their use in the detection of nucleic acids The invention concerns compounds of the general formula (I) in which the residues R1 to R7 have the meanings given in the application as well as methods for their preparation. The compounds are in particular suitable as substrates for RNA or DN... | 04/05/2005 |
| 6812342 | Esters of cyclic ADP ribose derivatives The present invention is directed to the field of organic chemistry in general and specifically to the preparation of hydrophobic derivatives of cyclic ADP ribose. One form of the present invention is the composition of one or more hydrophobic derivatives of cyclic ... | 11/02/2004 |
| 6593307 | Cyclic-ADP-ribose analogs The present invention provides a compound of formula I: ##STR1## wherein A, D, R1, and R2 are as defined in the specification; or a salt or a detectably labeled derivative thereof. The invention also provides methods of using the com... | 07/15/2003 |
| 6043223 | Enhanced opening of abnormal brain tissue capillaries Improved compositions and methods for increasing permeability of abnormal brain tissue to pharmaceutical agents. Cyclic GMP specific phosphodiesterase inhibitors are combined with bradykinin or a bradykinin analog to provide enhanced permeability of brain... | 03/28/2000 |
| 5831074 | Eucaryotic NAD cyclases Eucaryotic NAD cyclases able to cause production of cyclic adenosine diphosphate ribose from nicotinamide adenine dinucleotide.... | 11/03/1998 |
| 5780253 | Screening method for detection of herbicides This invention relates to novel screening methods for identifying compounds that specifically inhibit a biosynthetic pathway in plants. Enzymes which are specifically affected by the novel screening method include plant purine biosynthetic pathway enzymes... | 07/14/1998 |
| 5780254 | Method for detection of herbicides This invention relates to novel screening methods for identifying compounds that specifically inhibit a metabolic target site or pathway in plants. Enzymes which are specifically affected by the novel screening method include plant purine biosynthetic pat... | 07/14/1998 |
| 5728705 | Method of inducing vasorelaxation to treat pulmonary hypertension This invention provides a method of selectively decreasing pulmonary vascular resistance in a subject by administering endobronchially a drug chosen from among cAMP analogs, cGMP analogs, phosphodiesterase inhibitors, nitric oxide precursors, nitric oxide... | 03/17/1998 |
| 5547941 | Cyclic dinucleoside diphosphorothioates, related compounds and pharmaceutical compositions There are provided compounds of formula (I) ##STR1## wherein each group B is, independently, a naturally occurring or modified heterocyclic base linked through a nitrogen or a carbon atom of the ring to the sugar moiety; each group X is a, independen... | 08/20/1996 |
| 5041426 | Immune system enhancing 3-ଲ-d-ribofuranosylthiazolo[4,5-d]pyridimine nucleosides and nucleotides Compounds of the structure: ##STR1## wherein R4, R5, R6 and R7 individually are H, OH or C1 -C18 O-acyl and R3 is H, C1 -C18 acyl or ##STR2## or R... | 08/20/1991 |
| 4965350 | Pyridopyrimidine nucleotide compounds Pyridopyrimidine nucleotide derivatives expressed by formula (I), which are fluorescent and capable of forming base pairing with guanine or adenine, and oligo- or polynucleotide which have at least one of these derivatives in their molecules or at their m... | 10/23/1990 |
| 4880784 | Antiviral methods utilizing ribofuranosylthiazolo[4,5-d]pyrimdine derivatives Compounds of the structure: ##STR1## wherein R1 and R2 individually are H or C1 -C18 acyl and R3 is H, C1 -C18 acyl or ##STR2## or R1 is H and together R | 11/14/1989 |
| 4529796 | Method for making chromogenic and/or fluorogenic substrates for use in monitoring catalytic or enzymatic activity A method for preparing a substrate capable of undergoing catalytic-induced hydrolysis of the phosphate ester at the 3' position, to yield a species capable of being monitored spectrophotometrically or fluorometrically, comprises (a) forming a mononucleoti... | 07/16/1985 |
| 4090021 | Process for the production of N6 -substituted adenosine nucleotides and products resulting therefrom N6 -substituted adenosines of the formula ##STR1## wherein R1 and R2 each are a hydrogen atom or an alkyl, aralkyl, aryl or heterocyclic ring, or R1 is a hydrogen atom and R2 is hydroxy, amino, a... | 05/16/1978 |
| 4056674 | Derivatives of 3-deazaguanine Ribofuranosyl derivatives of 3-deazaguanine including the 5'-phosphate, 3',5'-cyclic phosphate and 5'-deoxy, useful as antiviral agents and antibacterial agents, are disclosed.... | 11/01/1977 |
| 3984396 | 1-(ଲ,-D-ribofuranosyl)-1,2,4-triazole acid esters Phosphate and carboxylic acid esters of 1-(ଲ-D-ribofuranosyl)-1,2,4-triazoles are prepared by a variety of methods and their antiviral activity reported.... | 10/05/1976 |
