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Felix Hoffmann, a German chemist, was searching for something to relieve his father's arthritis. In doing so, he "rediscovered" acetylsalicylic acid and in 1900, patented a stable process for developing it. Hence, we have aspirin.
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| Number | Title | Issue Date |
| 7777024 | Process for preparing a pentopyranosyl nucleic acid conjugate The invention relates to a process for preparing a conjugate that includes a pentopyranosyl nucleic acid and a biomolecule. The process includes the steps of providing a pentopyranosyl nucleic acid having at least two pentopyranosyl nucleotide subunits that are cova... | 08/17/2010 |
| 7435806 | Nucleic acid binding of multi-zinc finger transcription factors A method of identifying transcription factors comprising providing cells with a nucleic acid sequence at least comprising a sequence CACCT (SEQ ID NO:1) as bait for the screening of a library encoding potential transcription factors and performing a specificity test... | 10/14/2008 |
| 7387894 | Recombinant viral-based malaria vaccines The present invention relates to novel vaccines against malaria infections, based on recombinant viral vectors, such as alpha viruses, adenoviruses or vaccinia viruses. The recombinant viral-based vaccines can be used to immunize against different Plasmodium ... | 06/17/2008 |
| 7354907 | Short immunomodulatory oligonucleotides The invention relates to modulation of the immune system. More particularly, the invention relates to modulating the immune system through the use of oligonucleotide-derived compounds. The invention provides immunostimulatory agents that are less expensive to make t... | 04/08/2008 |
| 7335765 | Nucleoside and oligonucleotide analogues A compound of the formula (1): wherein R1 and R2 are the same or different and represent a hydrogen atom, a hydroxyl protecting group, a phosphate group, or —P(R3)R4, wherein R | 02/26/2008 |
| 7332597 | Primers and probe to identify mycobacterium tuberculosis complex Methods and nucleic acids for rapid, reliable and sensitive detection of Mycobacterium tuberculosis (MTB) complex pathogen in a biological sample. Oligonucleotides are provided which amplify MTB DNA and which are useful in carrying out real time PCR of DNA ob... | 02/19/2008 |
| 7326324 | Purification and use of gellan in electrophoresis gels Gellan can be purified from nucleic acid contamination by combining the contaminated gellan with DNase under conditions that allow the DNase to degrade the nucleic acid contaminant. The purified gellan is useful in gel electrophoresis. A buffer which allows cystamin... | 02/05/2008 |
| 7321828 | System of components for preparing oligonucleotides Interative, preferably computer based iterative processes for generating synthetic compounds with desired physical, chemical and/or bioactive properties, i.e., active compounds, are provided. During iterations of the processes, a target nucleic acid sequence is prov... | 01/22/2008 |
| 7314923 | Nucleoside and oligonucleotide analogues A probe for a gene or a primer for starting amplification comprising an oligonucleotide analogue comprising two or more nucleoside units, wherein at least one of the nucleoside units is a structure of the formula (2): ... | 01/01/2008 |
| 7271156 | Immunostimulatory nucleic acids The invention relates to immunostimulatory nucleic acid compositions and methods of using the compositions. The T-rich nucleic acids contain poly T sequences and/or have greater than 25% T nucleotide residues. The TG nucleic acids have TG dinucleotides. The C-rich n... | 09/18/2007 |
| 7256183 | Method for treating or preventing inflammatory diseases The present invention provides a method of preventing or treating an inflammatory disease, including but not limited to, sinusitis, rhinitis, conjunctivitis, asthma, dermatitis, inflammatory bowel disease, inflammatory collagen vascular diseases, glomerulonephritis,... | 08/14/2007 |
| 7232807 | Compositions and methods for binding agglomeration proteins Amplibody compositions and methods used to interact with agglomeration proteins are disclosed herein. Compositions herein comprise one or more DNA or RNA molecules having affinity for at least one agglomeration protein. The nucleic acid component is a naturally or n... | 06/19/2007 |
| 7223744 | Pharmaceutical formulation comprising dinucleoside polyphosphates and salts thereof The present invention provides a method of treating edematous retinal disorders. The method comprises administration of a pharmaceutical formulation comprising a hydrolysis-resistant P2Y receptor agonist to stimulate the removal of pathological extraneous fluid from... | 05/29/2007 |
| 7179481 | Vaginal health products The invention provides compositions and methods for increasing the secretion of mucus within the reproductive tract of a female mammal. ... | 02/20/2007 |
| 7176296 | Modulation of oligonucleotide CpG-mediated immune stimulation by positional modification of nucleosides The invention provides compounds having increased or reduced immunostimulatory effect, said compounds comprising a CpG dinucleotide and an immunomodulatory moiety wherein the increased or reduced immunomodulatory effect is relative to a similar compound lacking the ... | 02/13/2007 |
| 7173125 | Triphosphate oligonucleotide modification reagents and uses thereof Hydrazino, oxyamino and carbonyl-based monomers and methods for incorporation into oligonucleotides during enzymatic synthesis are provided. Modified oligonucleotides are provided that incorporate the monomers provided herein. Immobilized oligonucleotides and oligon... | 02/06/2007 |
| 7153433 | Use of functionalized porous membranes or matrices for purification of nucleic acids and corresponding methods Application of a functionalized porous membrane to purify nucleic acids, the binding properties of the membrane with respect to nucleic acids being adjustable by controlling the conditions of an ambient medium. The membrane is functionalized by deprotonated groups. | 12/26/2006 |
| 7138517 | Sugar modified oligonucleotides Compositions and methods are provided for the treatment and diagnosis of diseases amenable to modulation of the production of selected proteins. In accordance with preferred embodiments, oligonucleotides and oligonucleotide analogs are provided which are specificall... | 11/21/2006 |
| 7132410 | Di(uridine 5′-)tetraphosphate and salts thereof The present invention are directed to P1, P4-di(uridine 5′-)tetraphosphate, tetra-alkali metal salts such as tetrasodium, tetralithium, tetrapotassium, and mixed tetra-alkali metal cations thereof. The tetra alkali metal salts of P1 | 11/07/2006 |
| 7132266 | Method and kit for analyzing target nucleic acid fragment A method of analyzing a target nucleic acid fragment is provided that is capable of being performed simply and promptly, by anyone, using a compact device without requirement of specific technique or complex operation. The method comprises timely detection of a doub... | 11/07/2006 |
| 7132408 | Composition and method for inhibiting platelet aggregation This invention is directed to a method of preventing or treating diseases or conditions associated with platelet aggregation. The method is also directed to a method of treating thrombosis. The method comprises administering to a subject a pharmaceutical composition... | 11/07/2006 |
| 7132233 | Identification of oligonucleotides for the capture, detection and quantitation of West Nile virus West Nile virus capture oligonucleotides, primers and probes derived from conserved regions of the West Nile virus genome are disclosed. Also disclosed are nucleic acid-based assays using the capture oligonucleotides, primers and probes. ... | 11/07/2006 |
| 7115579 | Modulation of oligonucleotide CpG-mediated immune stimulation by positional modification of nucleosides The invention provides methods for modulating the immune response caused by CpG dinucleotide-containing compounds. The methods according to the invention enables both decreasing the immunostimulatory effect for antisense applications, as well as increasing the immun... | 10/03/2006 |
| 7115585 | Compositions for treating epithelial and retinal tissue diseases The present invention relates to mononucleoside phosphate compounds that have the benefits of a dinucleotide pharmaceutical. These mononucleoside phosphates can be made from a mononucleotide that has been modified by attaching a degradation resistant substituent on ... | 10/03/2006 |
| 7109181 | Joint lubrication with P2Y purinergic receptor agonists The present invention is directed to a method of altering the amount or composition of synovial fluids secreted from joints in a subject in need of such treatment. The method comprises administering to a subject a pharmaceutical composition comprising a P2Y purinerg... | 09/19/2006 |
| 7105495 | Modulation of oligonucleotide CpG-mediated immune stimulation by positional modification of nucleosides The invention provides methods for modulating the immune response caused by CpG dinucleotide-containing compounds. The methods according to the invention enables both decreasing the immunostimulatory effect for antisense applications, as well as increasing the immun... | 09/12/2006 |
| 7105648 | Oligomers substituted by phosphite acid ester, phosphonic acid or carbaborane functions and the corresponding PNA monomers The invention relates to novel oligomers containing PNA units that are substituted by phosphite ester, phosphonic acid, or carbaborane functions and PNA monomers that are substituted by phosphite ester, phosphonic acid, or carbaborane functions, from which the novel... | 09/12/2006 |
| 7101993 | Oligonucleotides containing 2′-O-modified purines Compounds are provided containing purine nucleotides that bear moieties X at the 2′ position thereof wherein X is R1—(R2)n; R1 is C3-C20 alkyl, C4-C20 alkenyl or C2 | 09/05/2006 |
| 7102024 | Functional biopolymer modification reagents and uses thereof Hydrazino, oxyamino and carbonyl-based reagents and methods for incorporation into oligonucleotides during their solid phase synthesis are provided. Modified oligonucleotides are provided that incorporate the reagents provided here in. Immobilized oligonucleotides a... | 09/05/2006 |
| 7091334 | Method for large-scale production of di(uridine 5′)-tetraphosphate and salts thereof The present invention provides new methods for the synthesis of the therapeutic dinucleotide, P1,P4-di(uridine 5′)-tetraphosphate, and demonstrates applicability to the production of large quantities. The methods of the present invention subs... | 08/15/2006 |
| 7084128 | Method for reducing intraocular pressure The present invention is directed to a method of reducing intraocular pressure. The method comprises administering to a subject a pharmaceutical composition comprising an effective amount of a purinerginic receptor ligand, which is a mononucleoside polyphosphate or ... | 08/01/2006 |
| 7078391 | Method of treating edematous retinal disorders The present invention provides a method of treating edematous retinal disorders. The method comprises administration of a pharmaceutical formulation comprising a hydrolysis-resistant P2Y receptor agonist to stimulate the removal of pathological extraneous fluid from... | 07/18/2006 |
| 7056889 | Compounds that bind P2Yor P2Yreceptors The invention provides peptides and compounds that can bind to P2Y2 receptors that are useful for modulating the secretion of mucus within mucosal surfaces. ... | 06/06/2006 |
| 7049432 | Oligonucleotides having alkylphosphonate linkages and methods for their preparation The present invention provides alkylphosphonate dimers and oligonucleotides prepared therefrom. The invention further provides novel methods for the preparation of these alkylphosphonate dimers. Methods for the preparation of substantially diastereomerically pure al... | 05/23/2006 |
| 7038037 | Method for sequential support-bound synthesis of conjugated oligomeric compounds A sequential support-bound synthesis method is disclosed for preparing a conjugated oligomeric compound, preferably a PNA-peptide conjugate or an oligonucleotide-peptide conjugate, using a bridging molecule having at least two N-protecting amino groups. A conjugated... | 05/02/2006 |
| 7018985 | Composition and method for inhibiting platelet aggregation The present invention provides novel compounds of dinucleotide polyphosphates and the method of preventing or treating diseases or conditions associated with platelet aggregation. The method comprises administering systemically to a patient a pharmaceutical comprisi... | 03/28/2006 |
| 7019127 | Solution phase synthesis of oligonucleotides A process for the synthesis in solution phase of a phosphorothioate triester is provided. The process comprises the solution phase coupling of an H-phosphonate with an alcohol in the presence of a coupling agent to form an H-phosphonate diester. The H-phosphonate di... | 03/28/2006 |
| 7015315 | Gapped oligonucleotides Oligonucleotides and other macromolecules are provided which have increased nuclease resistance, substituent groups for increasing binding affinity to complementary strand, and subsequences of 2′-deoxy-erythro-pentofuranosyl nucleotides that activate RNase H. Such... | 03/21/2006 |
| 6977246 | Certain dinucleotides and their use as modulators of mucociliary clearance and ciliary beat frequency The present invention relates to certain novel dinucleotides and formulations thereof which are highly selective agonists of the P2Y2 and/or P2Y4 purinergic receptor. They are useful in the treatment of chronic obstructive pulmonary diseases su... | 12/20/2005 |
| 6977245 | Oligodeoxynucleotide and its use to induce an immune response D type CpG oligodeoxynucleotides are provided herein that include a sequence represented by the following formula: 5′X1X2X3Pu1 Py2 CpG Pu3 Py4 X4X5X6 | 12/20/2005 |
