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| Number | Title | Issue Date |
| 7321828 | System of components for preparing oligonucleotides Interative, preferably computer based iterative processes for generating synthetic compounds with desired physical, chemical and/or bioactive properties, i.e., active compounds, are provided. During iterations of the processes, a target nucleic acid sequence is prov... | 01/22/2008 |
| 7282221 | Antiviral product, use and formulation thereof An antiviral product is comprised of at least three dosages forms, each of which has a different release profile, with the Cmax for the antiviral product being reached in less than about twelve hours. In one embodiment, there is an immediate release dosag... | 10/16/2007 |
| 7205282 | Remedies for hepatitis The object of the present invention is to provide a novel medicinal agent useful in the treatment or the prevention of hepatitis. The present invention is, for example, a therapeutic or preventive agent for hepatitis characterized in that it comprises a compl... | 04/17/2007 |
| 7169916 | Chloral-free DCA in oligonucleotide synthesis A process of manufacturing oligonucleotides includes a 5′-deblocking step in which the 5-blocking group is removed with dichloroacetic acid that is essentially free of chloral. The process is useful for making oligonucleotides that are substantially free of chlora... | 01/30/2007 |
| 7122204 | Antibiotic composition with inhibitor Antibiotic composition having four dosage forms with different release profiles providing for initial release of a beta lactam antibiotic followed by release of a beta-lactamase inhibitor, followed by release of the antibiotic followed by release of the inhibitor. I... | 10/17/2006 |
| 7002006 | Protection of nucleosides A process of manufacturing protected nucleosides comprises reacting a nucleoside with a protecting reagent in the presence of a regioselective activator to produce a regioselectively protected nucleoside. In some embodiments of the inventive method, an optionally su... | 02/21/2006 |
| 6998116 | Apo-2 ligand A novel cytokine, designated Apo-2 ligand, which induces mammalian cell apoptosis is provided. The Apo-2 ligand is believed to be a member of the TNF cytokine family. Compositions including Apo-2 ligand chimeras, nucleic acid encoding Apo-2 ligand, and antibodies to... | 02/14/2006 |
| 6977245 | Oligodeoxynucleotide and its use to induce an immune response D type CpG oligodeoxynucleotides are provided herein that include a sequence represented by the following formula: 5′X1X2X3Pu1 Py2 CpG Pu3 Py4 X4X5X6 | 12/20/2005 |
| 6949521 | Therapeutic azide compounds Pharmaceutical prodrug compositions are provided comprising azide derivatives of drugs which are capable of being converted to the drug in vivo. Azide derivatives of drugs having amine, ketone and hydroxy substituents are converted in vivo to the corresponding drugs... | 09/27/2005 |
| 6906182 | Conjugates of glycosylated/galactosylated peptide, bifunctional linker, and nucleotidic monomers/polymers, and related compositions and method of use A conjugate of formula A-L-P, in which: A represents a glycosylated/galactosylated peptide that binds to a cell-surface receptor, L represents a bifunctional linker, which does not comprise a naturally occurring am... | 06/14/2005 |
| 6812341 | High efficiency mRNA isolation methods and compositions The present invention provides methods and compositions, including kits, for the isolation and purification of mRNA, particularly poly(A) RNA. It concerns the use of isostabilizing salts such as TMAC and TEAC to reduce rRNA carryover during the purification process,... | 11/02/2004 |
| 6743584 | Molecular-biological marker for analytical electron microscopy The invention relates to plasmids derived from pBluescript KS(+), which contains more than 1, preferably 2, 7, 14, 21 and 27, respective SK primer elements, and their use in analytical electron microscopy. ... | 06/01/2004 |
| 6730475 | Methods of diagnosis and treatment of meniere disease The invention features methods of diagnosing and treating Meniere disease. The invention also features kits and probes for diagnosing Meniere disease. ... | 05/04/2004 |
| 6610841 | Nucleotide-based prodrugs This invention relates to nucleotide-based prodrugs and their drug-delivery applications. The nucleotide-based prodrugs of the present invention comprise a drug component covalently attached via junctional ester bond(s) to one or more nucleotide component... | 08/26/2003 |
| 6576464 | Methods for providing differentiated stem cells This invention provides a system for producing differentiated cells from a stem cell population for use wherever a relatively homogenous cell population is desirable. The cells contain an effector gene under control of a transcriptional control element (s... | 06/10/2003 |
| 6545138 | Process for producing composite preparation containing nucleic acid A method for producing a composition including a nucleic-acid-containing complex is characterized in that two single strand nucleic acid polymers which can at least partly form double strands are separately mixed, in a single strand form, with a cationic ... | 04/08/2003 |
| 6538129 | Luminescent compounds Luminescent compounds, reactive intermediates used to synthesize luminescent compounds, and methods of synthesizing and using luminescent compounds. These compounds may be based on squaric, croconic, and rhodizonic acid, and their analogs, among others, a... | 03/25/2003 |
| 6518052 | Human homologue of yeast helicase and uses thereof The present invention provides a nucleic acid and amino acid sequence of a human Pif-1 type helicase. The invention also provides methods of screening for compounds that modulate the activity of human Pif-1 type helicase, as well as methods for affecting ... | 02/11/2003 |
| 6458941 | Compounds for the synthesis of nucleotide or oligonucleotide phosphoramidites This invention presents novel methods for recovery of phophoramidites from the waste products of oligonucleotide synthesis. The methods include reacting a tribromophenoxydichlorophosphorane with an H-phosphonate in the presence of an amine.... | 10/01/2002 |
| 6453244 | Detection of polymorphisms by denaturing high-performance liquid chromatography The present invention provides a method for detecting polymorphisms in a nucleic acid by preconditioning a sample of nucleic acids to completely denature the nucleic acids, e.g., via heating and/or chemical treatment, and performing high-performance liqui... | 09/17/2002 |
| 6316608 | Combined polynucleotide sequence as discrete assay endpoints Methods are provide for determining the relative amounts of individual polynucleotides in a complex mixture. The polynucleotides, after fluorescent labeling, are contacted under hybridization conditions with an array having element disposed at discrete lo... | 11/13/2001 |
| 6245513 | Signal amplification method Methods for detecting the presence or absence of an analyte in a sample are disclosed. Kits for performing the analysis methods of the invention are also disclosed.... | 06/12/2001 |
| 6184369 | Anti-viral guanosine-rich oligonucleotides The oligonucleotides have sufficient guanosine to form a guanosine tetrad and can be composed of at least about 40% guanosine nucleotides, the nucleotide sequence containing at least two runs of at least two guanosines. Some of the new oligonucleotides al... | 02/06/2001 |
| 6136953 | Smooth muscle cell LIM protein A substantially pure DNA comprising a sequence encoding a smooth muscle cell LIM (SmLIM) polypeptide, methods of diagnosing vascular injury by detecting a decrease in SmLIM gene expression, and methods of inhibiting vascular smooth muscle cell proliferati... | 10/24/2000 |
| 6130324 | Amphipathic oligonucleotides and polynucleotides having potent antiviral activity The present invention provides novel compositions that show potent antiviral activity against both DNA and RNA viruses. In particular, the present invention provides oligo- and polyribonucleotides with potent antiviral activity against HIV and HCMV. These... | 10/10/2000 |
| 5994124 | Ribozyme-snRNA chimeric molecules having a catalytic activity for nuclear RNAs The invention is drawn to a chimeric ribozyme molecule that comprises a U1 snRNA component and a ribozyme component where the chimeric ribozyme targets an mRNA in the spliceosome in the nuclease of a cell.... | 11/30/1999 |
| 5981185 | Oligonucleotide repeat arrays A solid support based hybridization assay is provided which allows for the systematic and reproducible analysis of repeat and tandem repeat oligonucleotide sequences of DNA and RNA by hybridization to a reverse dot blot array comprising strings of such re... | 11/09/1999 |
| 5955597 | Chirally enriched synthetic phosphate oligomers Oligomers having phosphonate internucleosidyl linkages which are enriched for phosphonate linkages of a preselected chirality which hybridize to an RNA target sequence and methods for their preparation are provided.... | 09/21/1999 |
| 5952490 | Oligonucleotides having a conserved G4 core sequence Modified oligonucleotides having a conserved G4 sequence and a sufficient number of flanking nucleotides to significantly inhibit the activity of a virus such as HSV-1 or phospholipase A2 or to modulate the telomere length of a chrom... | 09/14/1999 |
| 5902724 | Signal amplification method Methods for detecting the presence or absence of an analyte in a sample are disclosed. Kits for performing the analysis methods of the invention are also disclosed.... | 05/11/1999 |
| 5856466 | Process for the preparation of 2'-O-alkyl purine phosphoramidites Processes for preparing 2'-O-alkylated guanosine, uridine, cytidine, and 2,6-diaminopurine 3'-O-phosphoramidites include the steps of alkylating nucleoside precursors, adding suitable blocking groups and phosphitylating. For the guanosine 2'-O-alkylated 3... | 01/05/1999 |
| 5792847 | 2' Modified Oligonucleotides Oligomers which have substituents on the 2' position are resistant to oligonucleases and furthermore can be derivatized to deliver reagents or drugs, to carry label, or to provide other properties.... | 08/11/1998 |
| 5753789 | Oligonucleotides containing L-nucleosides Oligonucleotides that include a 2'-fluoro ଲ-L-arabinofuranosyl nucleoside at the 3'-terminus, the 5'-terminus or in the interior of the oligomer. A preferred nucleoside is 2'-fluoro-5-methyl-ଲ-L-arabinofuranosyluridine (also referred to as ... | 05/19/1998 |
| 5703218 | Oligonucleotides containing hydroxyl-protecting groups orthogonally removable by reduction Hydroxyl-protecting groups orthogonally removable by reduction with a liquid reducing agent are disclosed. The novel hydroxyl-protecting groups are particularly useful in the chemical synthesis of linear and branched oligonucleotide structures, as they ar... | 12/30/1997 |
| 5683986 | Elaboration of host defense mediators into biological fluids by systemic dsRNA treatment Parenterally administered systemic dsRNAs release host mediators into various compartmentalized biological fluids to combat various microorganisms, particularly viruses, thereby reducing the infectivity and spread of various organisms including those asso... | 11/04/1997 |
| 5663321 | Oligonucleotide prodrugs containing 5-fluorouracil Homo-oligomeric 5-fluorouridine and 5-fluorodeoxyuridine (FrUn and FdUn, n=oligomer length) are synthesized and used as a polymeric drug delivery system for production of FdUMP, the potent inhibitor of thymidylate synthase (TS) and a... | 09/02/1997 |
| 5659025 | 3'-(2')-amino or thiol-modified, fluorescent dye-coupled oligonucleotides and a process for the preparation and the use thereof The OH group located in the 3' and/or 2' position of a nucleoside, nucleotide or oligonucleotide is derivatized to an amino or thiol group and subsequently a fluorescent dye is coupled thereto. The resulting 3'- and/or 2'-amino- and thiol-modified nucleos... | 08/19/1997 |
| 5652359 | Oligonucleotides containing n-methyl thiolated bases having antiviral activity Oligonucleotides containing 1-N-alkyl-6-thiopurine, 3-N-alkyl-4-thiopyrimidine and 5-N-alkyl-4-thiopyrazolopyrimidine bases and the corresponding 2'-O-alkylated or allylated nucleotides demonstrate potent antiviral activity in several assays, including th... | 07/29/1997 |
| 5614505 | Method of treating cancer with homo-oligonuleotides of 5-FU 5'-monophosphate Homo-oligomeric 5-fluorouridine and 5-fluorodeoxyuridine (FrUn and FdUn, n=oligomer length) are synthesized and used as a polymeric drug delivery system for production of FdUMP, the potent inhibitor of thymidylate synthase (TS) and a... | 03/25/1997 |
| 5602240 | Backbone modified oligonucleotide analogs Oligonucleotide analogs are provided wherein phosphodiester inter-sugar linkages are replaced with four atom linking groups. Such linking groups include NR--C(O)--CH2 --CH2, NR--C(S)--CH2 --CH2, CH2 -... | 02/11/1997 |
