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| Number | Title | Issue Date |
| 7364846 | Gene expression profiling from FFPE samples Methods and compositions relating to the generation and use of gene expression data from tissue samples that have been fixed and embedded are provided. The data can electronically stored and implemented as well as used to augment diagnosis and treatment of diseases.... | 04/29/2008 |
| 7355038 | Phase isolation process for biomacromolecule components The present invention relates to a phase isolation process for biomacromolecule components, after pretreating the substance to be isolated: 1) adding sufficient amount of buffer (one of the compound selected from ammonium sulfate, cesium chloride, sodium sulfate, an... | 04/08/2008 |
| 7345163 | Process for separating and deprotecting oligonucleotides Methods for deprotecting and derivatizing oligonucleotides that are non-covalently bound to a solid support are described. The methods include providing a plurality of oligonucleotides linked to one or more hydrophobic separation functions, wherein the plurality inc... | 03/18/2008 |
| 7320891 | Methods and kits for isolating sperm cells Disclosed are methods for isolating sperm cells from an aqueous sample and kits for isolating sperm cells from an aqueous sample. ... | 01/22/2008 |
| 7247721 | Materials and methods for binding nucleic acids to surfaces Surfaces containing high purity silica (silicon dioxide) exhibit high loading potential for nucleic acids. Formulations containing nucleic acids and materials which mask the electrostatic interactions between the nucleic acids and surfaces are disclosed. By m... | 07/24/2007 |
| 7238530 | Isolation and amplification of nucleic acid materials The invention relates to methods for easily separating single stranded nucleic acid material from double stranded nucleic acid material in a sample containing both. By the right choice of at lease one chaotropic agent, preferably a guanidine salt, at a selected conc... | 07/03/2007 |
| 7235406 | Nucleic acid analysis device The invention is directed to a method and device for simultaneously testing a sample for the presence, absence, and/or amounts of one or more a plurality of selected analytes. The invention includes, in one aspect, a device for detecting or quantitating a plurality ... | 06/26/2007 |
| 7235140 | Method for cleaning tissue processing molds The present invention is directed to a cleaning system and methods for cleaning tissue embedding molds. The cleaning system includes a cleaning vessel that holds a cleaning solution. The tissue processing molds are supported by a basket receptacle which is placed in... | 06/26/2007 |
| 7211443 | Device and method for multiple analyte detection The invention is directed to a method and device for simultaneously testing a sample for the presence, absence, and/or amounts of one or more a plurality of selected analytes. The invention includes, in one aspect, a device for detecting or quantitating a plurality ... | 05/01/2007 |
| 7173124 | Isolation of nucleic acid The present invention provides a method of isolating nucleic acid from a sample, said method comprising contacting said sample with a detergent and a solid support, whereby soluble nucleic acid in said sample is bound to the support, and separating said support with... | 02/06/2007 |
| 7148343 | Compositions and methods for using a solid support to purify RNA Reagents, methods and kits for the purification of RNA from biological materials are provided. ... | 12/12/2006 |
| 7138507 | Method of determining a chemotherapeutic regimen based on glutathione-s transferase pi expression The present invention relates to prognostic methods which are useful in medicine, particularly cancer chemotherapy. The object of the invention to provide a method for assessing GST-pi expression levels in fixed or fixed and paraffin embedded tissues and prognostica... | 11/21/2006 |
| 7132238 | Method of determining a chemotherapeutic regimen based on ERCC1 expression The present invention relates to prognostic methods which are useful in medicine, particularly cancer chemotherapy. The object of the invention to provide a method for assessing ERCC1 expression levels in fixed or fixed and paraffin embedded tissues and determine a ... | 11/07/2006 |
| 7129344 | Nucleic acid isolation A method for isolating plasmids DNA from a DNA containing material which comprises plasmid DNA and genomic DNA, comprising extracting the plasmid DNA into a water-immiscible organic solvent, a chaotrope and water under conditions to denature the genomic DNA and reco... | 10/31/2006 |
| 7119194 | Nucleic acid-bondable magnetic carrier and method for isolating nucleic acid using the same A nucleic acid-bondable magnetic carrier of the present invention is a magnetic silica particle comprising a superparamagnetic metal oxide, wherein the magnetic silica particle has a specific surface of about 100 to about 800 m2/g. ... | 10/10/2006 |
| 7067325 | Removal of embedding media from biological samples and cell conditioning on automated staining instruments The present invention provides reagents for use in an automated environment for removing or etching embedding media by exposing a biological sample to be stained in histochemical or cytochemical procedures without the dependence on organic solvents. The reagents com... | 06/27/2006 |
| 7049059 | Method of determining a chemotherapeutic regimen based on ERCC1 and TS expression The present invention relates to prognostic methods which are useful in medicine, particularly cancer chemotherapy. The object of the invention to provide a method for assessing TS and/or ERCC1 expression levels in fixed or fixed and paraffin embedded tissues and pr... | 05/23/2006 |
| 7045365 | Supported aldehydic silanes and method of manufacture A method for producing a derivatized aldehydic support matrix material includes activating surface hydroxyl groups on the support matrix material and reacting the activated hydroxyl groups with an aldehydic alkoxy silane. The derivatized aldehydic support matrix mat... | 05/16/2006 |
| 7011943 | Method for detecting a designated genetic sequence in murine genomic DNA The present invention provides a method and apparatus for to conduct transgenic and targeted mutagenesis screening of genomic DNA. This invention also provides a system for screening DNA for a designated genetic sequence. The system includes a computer having a proc... | 03/14/2006 |
| 7005278 | Method of determining dihydropyrimidine dehydrogenase gene expression The present invention relates to prognostic methods which are useful in medicine, particularly cancer chemotherapy. The object of the invention to provide a method for assessing Dihydropyrimidine dehydrogenase (DPD) expression levels in tissues and prognosticate the... | 02/28/2006 |
| 7001724 | Compositions, methods, and kits for isolating nucleic acids using surfactants and proteases The invention provides compositions and methods for releasing and for isolating nucleic acids from biological samples, preferably from whole tissue, using cationic surfactants and proteases. The surfactant-protease combinations, when used with whole tissue, macerate... | 02/21/2006 |
| 6969603 | Method for isolating DNA Method for isolating DNA contained in a biological sample. The method includes combining in a solution a DNA-containing biological sample, a salt, a cationic surfactant, and a DNA-binding carrier, the solution having a salt concentration higher than the DNA precipit... | 11/29/2005 |
| 6958392 | Methods for the isolation of nucleic acids and for quantitative DNA extraction and detection for leukocyte evaluation in blood products A method for isolating nucleic acid which comprises: (a) applying a sample comprising cells containing nucleic acid to a filter, whereby the cells are retained as a retentate and contaminants are removed; (b) lysin... | 10/25/2005 |
| 6956111 | Method of determining dihydropyrimidine dehydrogenase gene expression The present invention relates to prognostic methods which are useful in medicine, particularly cancer chemotherapy. The object of the invention to provide a method for assessing Dihydropyrimidine dehydrogenase (DPD) expression levels in tissues and prognosticate the... | 10/18/2005 |
| 6936414 | Nucleic acid isolation method and kit Provided herein is a method for separating nucleic acid from a test sample comprising the steps of contacting a test sample with a metal oxide support material and a binding buffer to form nucleic acid/metal oxide support material complexes, separating the complexes... | 08/30/2005 |
| 6933379 | Method for linking nucleic acids and/or glycosaminoglycans to polar/hydrophilic materials The invention relates to a method for linking nucleic acid and/or glycosaminoglycan or glycosaminoglycan mimetics to a polar/hydrophilic material, characterized by contacting a nucleic acid and/or glycosaminoglycan and a polar/hydrophilic material with each other in... | 08/23/2005 |
| 6905821 | Method of determining Dihydropyrimidine dehydrogenase gene expression The present invention relates to prognostic methods which are useful in medicine, particularly cancer chemotherapy. The object of the invention to provide a method for assessing Dihydropyrimidine dehydrogenase (DPD) expression levels in tissues and prognosticate the... | 06/14/2005 |
| 6891032 | Methods and compositions for stripping nucleic acids The present invention is directed to compositions and methods for removal of nucleic acid probes from sample nucleic acids, particularly when the sample nucleic acids are attached to a solid support. The invention also concerns methods of stripping and reusing nucle... | 05/10/2005 |
| 6875857 | Reagent for the isolation of RNA The present invention provides RNA extraction reagents, methods and kits that are especially useful for extracting RNA. The reagents, methods and kits of the present invention are especially useful for extracting RNA, for example, cytoplasmic RNA, from difficult mat... | 04/05/2005 |
| 6872818 | Ammonium sulfate for neutralization of inhibitory effects The present invention provides RNA purification and/or analysis methods that use ammonium sulfate to mitigate or neutralize inhibitory effects of certain molecules. Exemplary inhibitory molecules that interfere with RNA function or analysis are those that bind to or... | 03/29/2005 |
| 6825340 | Methods and reagents for inactivating ribonucleases The present invention is a general method for inactivating or inhibiting ribonucleases. Ribonucleases are treated with a reducing agent and heat. RNA samples contaminated with ribonuclease may be treated with this method to protect them from degradation. The RNA may... | 11/30/2004 |
| 6686460 | Method and formulation for lyophilizing cultured human cells to preserve RNA and DNA contained in cells for use in molecular biology experiments The present invention relates to methods for lyophilizing eukaryotic cells and isolating intact nucleic acids from such cells, and related kits for using the same.... | 02/03/2004 |
| 6686155 | Method of determining a chemotherapeutic regimen based on glutathione-S-transferase pi expression The present invention relates to prognostic methods which are useful in medicine, particularly cancer chemotherapy. The object of the invention to provide a method for assessing GST-pi expression levels in fixed or fixed and paraffin embedded tissues and ... | 02/03/2004 |
| 6673631 | Simultaneous isolation and quantitation of DNA The present invention provides methods for isolating a defined quantity of DNA target material from other substances in a medium. The method may be carried out using a known quantity of a silica-containing solid support, such as silica magnetic particles,... | 01/06/2004 |
| 6613518 | Quantitative measurement of gene expression based on isolation of RNA from formalin-fixed paraffin-embedded tissue specimens Methods are disclosed for rapid, reliable and simple isolation of RNA from formalin-fixed paraffin-embedded tissue samples. RNA purified in this manner can be used for quantitative measurement gene expression levels. The tissue sample can be a tumor or ot... | 09/02/2003 |
| 6610488 | Isolation of RNA, DNA and proteins from formalin-fixed paraffin-embedded tissue specimens Methods are disclosed for rapid, reliable and simple isolation of RNA, DNA and proteins from formalin-fixed paraffin-embedded tissue samples. RNA purified in this manner can be used to monitor gene expression levels. The tissue sample can be a tumor or ot... | 08/26/2003 |
| 6551777 | Methods for preserving DNA integrity Methods for extracting DNA from a biological sample that result in a higher yield of target DNA than conventional methods. More particularly, methods for extracting DNA include exposing the biological sample to inhibitors of DNA degradation.... | 04/22/2003 |
| 6545144 | Method for isolating nucleic acids from a liquid sample containing nucleic acids A method for the isolation of nucleic acids from a liquid sample, which contains nucleic acids, using a filtering device, which has pores, through which the sample is allowed to flow in the course of the isolation, the nucleic acids, and contained in the ... | 04/08/2003 |
| 6528641 | Methods and reagents for preserving RNA in cell and tissue samples This specification relates to the field of molecular biology and provides novel methods and reagents for preserving and protecting the ribonucleic acid (RNA) content of samples from degradation prior to RNA isolation. This preservation may be accomplished... | 03/04/2003 |
| 6472522 | Purification of oligomers using dual-end selection Oligomers are prepared substantially free of error sequences by sequentially adding monomers to a growing chain bound to a support through a first selectably cleavable linkage, a first capture moiety and a second selectably cleavable linkage. At the compl... | 10/29/2002 |
