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| Number | Title | Issue Date |
| 8188265 | Method for the isolation of mRNA from formalin fixed, paraffin-embedded tissue Formalin fixation causes cross-linkage between nucleic acids and proteins and covalently modifies RNA. As a result, the molecules are rigid and may comprise subsequent RNA extraction. The invention provides a method for recovering RNA from formalin fixed paraffin-em... | 05/29/2012 |
| 8063199 | Method for isolating both free and protein association DNA A method is disclosed for isolating both free and protein-associated DNA from bodily fluids, such as urine, saliva, serum, tears, sweat, cerebral spinal fluid, and plasma. The method comprises as a first step concentrating and isolating both the free DNA and the pro... | 11/22/2011 |
| 8039613 | Methods of purifying a nucleic acid and formulation and kit for use in performing such methods A formulation containing guanidine thiocyanate together with acetamide, one or more acetamide derivatives, or a combination of acetamide and one or more acetamide derivatives is used to purify one or more nucleic acids contained in a medium. In particular, a medium ... | 10/18/2011 |
| 8030479 | Method of separating small RNA molecules using kosmotropic salt Disclosed is a method of separating small RNAs of 200 nucleotides or less from larger RNAs on a solid support, using a kosmotropic salt of different concentrations. ... | 10/04/2011 |
| 7803935 | Nucleic acid adsorption under low-salt conditions Biscationic organic compounds are disclosed which promote adsorption of nucleic acids from an aqueous solution to a solid phase such as silica. Adsorption takes place under low salt conditions. Further disclosed are methods and kits suitable for nucleic acid isolati... | 09/28/2010 |
| 7459548 | Kits and processes for removing contaminants from nucleic acids in environmental and biological samples The invention provides methods for removing a contaminant or inhibitor from a nucleic acid-comprising sample, wherein the contaminant or inhibitor inhibits the amplification or hybridization of the nucleic acid in the sample, or inhibits an enzymatic reaction utiliz... | 12/02/2008 |
| 7435810 | Use of ionic liquids for fabrication of polynucleotide arrays A method of fabricating polynucleotide arrays includes dissolving a nucleotide monomer, oligonucleotide, or polynucleotide in a solvent containing ionic liquid and depositing the resulting solution on an array substrate. The method has particular application to fabr... | 10/14/2008 |
| 7411061 | Method of synthesizing polynucleotides using ionic liquids A method of synthesizing polynucleotides is disclosed. The method involves contacting a first nucleotide with a selected reactive group in the presence of an ionic liquid. The selected reactive group may be on a second nucleotide, a polynucleotide, or on a moiety on... | 08/12/2008 |
| 7355038 | Phase isolation process for biomacromolecule components The present invention relates to a phase isolation process for biomacromolecule components, after pretreating the substance to be isolated: 1) adding sufficient amount of buffer (one of the compound selected from ammonium sulfate, cesium chloride, sodium sulfate, an... | 04/08/2008 |
| 7345163 | Process for separating and deprotecting oligonucleotides Methods for deprotecting and derivatizing oligonucleotides that are non-covalently bound to a solid support are described. The methods include providing a plurality of oligonucleotides linked to one or more hydrophobic separation functions, wherein the plurality inc... | 03/18/2008 |
| 7314746 | Apparatus and method for preparative scale purification of nucleic acids Apparatus and methods are described for pharmaceutical grade manufacture extrachromosomal nucleic acids from cell lysates using flotation to separate and eliminate undesired insoluble cellular debris including chromosomal DNA from the lysates. A gas is introduced to... | 01/01/2008 |
| 7273702 | Apparatus for purifying nucleic acid and method of purifying nucleic acid A nucleic acid refining apparatus, being ease in automation thereof, keeping high in contacting frequency between nucleic acid within a sample and a solid phase during nucleic acid capture processing, thereby proving high capturing rate, comprises: means for separat... | 09/25/2007 |
| 7270983 | Messenger RNA profiling: body fluid identification using multiplex reverse transcription-polymerase chain reaction (RT-PCR) This invention relates to a body fluids identification method and kit. A parallel, multiplex reverse transcription-polymerase chain reaction (RT-PCR) assay for the definitive identification of body fluids commonly encountered in forensic casework analysis, namely bl... | 09/18/2007 |
| 7264927 | Isolation and purification of nucleic acids A method for the isolation and purification of nucleic acids such as DNA, RNA, and PNA from various sources using cellulose particles or cellulose paper. Adjusting the concentrations of the salt and polyalkylene glycol to the levels that result in binding of nucleic... | 09/04/2007 |
| 7247721 | Materials and methods for binding nucleic acids to surfaces Surfaces containing high purity silica (silicon dioxide) exhibit high loading potential for nucleic acids. Formulations containing nucleic acids and materials which mask the electrostatic interactions between the nucleic acids and surfaces are disclosed. By m... | 07/24/2007 |
| 7238530 | Isolation and amplification of nucleic acid materials The invention relates to methods for easily separating single stranded nucleic acid material from double stranded nucleic acid material in a sample containing both. By the right choice of at lease one chaotropic agent, preferably a guanidine salt, at a selected conc... | 07/03/2007 |
| 7235358 | Methods and compositions for diagnosing and monitoring transplant rejection Methods of diagnosing or monitoring transplant rejection, particularly cardiac transplant rejection, in a patient by detecting the expression level of one or more genes in a patient, are described. Diagnostic oligonucleotides for diagnosing or monitoring transplant ... | 06/26/2007 |
| 7227018 | Nucleic acid purification method and purification apparatus The object of the present invention is to provide a nucleic acid purification method and purification apparatus characterized by high washing efficiency where contamination does not occur and liquid does not remain in the nozzle tip. The present invention pro... | 06/05/2007 |
| 7214508 | Method for coarse purification of cell digests from microorganisms The present invention relates to the coarse clarification of lysed cell material from microorganisms and particularly to a method of obtaining nucleic acids. In certain embodiments, the present invention provides a method of coarsely clarifying cell lysate from micr... | 05/08/2007 |
| 7183407 | Nucleic acid purification method and purification apparatus The object of the present invention is to provide a nucleic acid purification method and purification apparatus characterized by high washing efficiency where contamination does not occur and liquid does not remain in the nozzle tip. The present invention pro... | 02/27/2007 |
| 7173124 | Isolation of nucleic acid The present invention provides a method of isolating nucleic acid from a sample, said method comprising contacting said sample with a detergent and a solid support, whereby soluble nucleic acid in said sample is bound to the support, and separating said support with... | 02/06/2007 |
| 7148343 | Compositions and methods for using a solid support to purify RNA Reagents, methods and kits for the purification of RNA from biological materials are provided. ... | 12/12/2006 |
| 7144713 | Method for precipitating nucleic acid with visible carrier A suitable carrier molecule useful in a nucleic acid precipitation method is modified by coupling a suitable visualizable indicator molecule to the carrier molecule. The conjugated carrier facilitates nucleic acid precipitation because the presence and location of n... | 12/05/2006 |
| 7138507 | Method of determining a chemotherapeutic regimen based on glutathione-s transferase pi expression The present invention relates to prognostic methods which are useful in medicine, particularly cancer chemotherapy. The object of the invention to provide a method for assessing GST-pi expression levels in fixed or fixed and paraffin embedded tissues and prognostica... | 11/21/2006 |
| 7135289 | Methods and compositions for mutation analysis of polynucleotides by liquid chromatography Methods, compositions, and kits for separating heteroduplex and homoduplex DNA molecules in a test mixture by temperature-compression denaturing high performance liquid chromatography (tcDHPLC). The method includes use of nitrogen-containing additives in the mobile ... | 11/14/2006 |
| 7132238 | Method of determining a chemotherapeutic regimen based on ERCC1 expression The present invention relates to prognostic methods which are useful in medicine, particularly cancer chemotherapy. The object of the invention to provide a method for assessing ERCC1 expression levels in fixed or fixed and paraffin embedded tissues and determine a ... | 11/07/2006 |
| 7129344 | Nucleic acid isolation A method for isolating plasmids DNA from a DNA containing material which comprises plasmid DNA and genomic DNA, comprising extracting the plasmid DNA into a water-immiscible organic solvent, a chaotrope and water under conditions to denature the genomic DNA and reco... | 10/31/2006 |
| 7130108 | Display members A display member for use at a temperature greater than at least about 40° C. The display member includes an arrangement of a plurality of optically anisotropic rotatable elements comprising a purified polymer. The plurality of rotatable elements have a surface in c... | 10/31/2006 |
| 7119194 | Nucleic acid-bondable magnetic carrier and method for isolating nucleic acid using the same A nucleic acid-bondable magnetic carrier of the present invention is a magnetic silica particle comprising a superparamagnetic metal oxide, wherein the magnetic silica particle has a specific surface of about 100 to about 800 m2/g. ... | 10/10/2006 |
| 7109322 | Process for the depletion or removal of endotoxins A process for the depletion or removal of endotoxins from preparations containing active ingredients designated for therapeutical use which are obtained from natural sources by genetic engineering and/or biotechnology by treatment with chromatographic material where... | 09/19/2006 |
| 7081366 | Uniform bead dosing from a stable dispersion A primary antibody bead suspension for an enzyme-linked immunoassay (“ELISA”) procedure is formed of a quantity of primary antibody coated magnetic beads (3) uniformly dispersed and held in suspension (9) by a thixotropic non-Newtonian fluid (1 | 07/25/2006 |
| 7074917 | Method for purifying 5′ -protected 2′ -deoxypurine nucleosides A method for efficiently purifying 5′ protected 2′-deoxypurine nucleosides, efficient production of which has previously been difficult. Impurities can be separated by obtaining the 5′ protected 2′-deoxypurine nucleoside as an inclusion crystal including a s... | 07/11/2006 |
| 7060478 | Process for preparing lysozyme A process for preparing lysozyme is provided which is characterized by mixing the egg white or its diluted solution with diatomaceous earth, kaolin, zeolite, or the mixtures thereof, and followed by eluting the adsorbed lysozyme with a salt solution. The diatomaceou... | 06/13/2006 |
| 7049059 | Method of determining a chemotherapeutic regimen based on ERCC1 and TS expression The present invention relates to prognostic methods which are useful in medicine, particularly cancer chemotherapy. The object of the invention to provide a method for assessing TS and/or ERCC1 expression levels in fixed or fixed and paraffin embedded tissues and pr... | 05/23/2006 |
| 7026121 | Methods and compositions for diagnosing and monitoring transplant rejection Methods of diagnosing or monitoring transplant rejection or cytomegalovirus infection in a patient by detecting the expression level of one or more genes or surrogates derived therefrom in the patient are described. Diagnostic oligonucleotides for diagnosing or moni... | 04/11/2006 |
| 7022835 | Method for binding nucleic acids to a solid phase The invention concerns a method for binding nucleic acids to a solid phase in which a nucleic acid containing solution is contacted with a solid phase which has hydrophobic and hydrophilic groups on its surface or/and which comprises a hydrophilic, water-containing ... | 04/04/2006 |
| 7011943 | Method for detecting a designated genetic sequence in murine genomic DNA The present invention provides a method and apparatus for to conduct transgenic and targeted mutagenesis screening of genomic DNA. This invention also provides a system for screening DNA for a designated genetic sequence. The system includes a computer having a proc... | 03/14/2006 |
| 7005278 | Method of determining dihydropyrimidine dehydrogenase gene expression The present invention relates to prognostic methods which are useful in medicine, particularly cancer chemotherapy. The object of the invention to provide a method for assessing Dihydropyrimidine dehydrogenase (DPD) expression levels in tissues and prognosticate the... | 02/28/2006 |
| 6992182 | Method for isolating DNA from biological materials The invention relates to a method for the stabilization, purification or/and isolation of nucleic acids from biological materials, in particular stool samples which may contain contaminations and interfering substances. Furthermore, a reagent kit suitable for carryi... | 01/31/2006 |
| 6969603 | Method for isolating DNA Method for isolating DNA contained in a biological sample. The method includes combining in a solution a DNA-containing biological sample, a salt, a cationic surfactant, and a DNA-binding carrier, the solution having a salt concentration higher than the DNA precipit... | 11/29/2005 |
