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Apparatus for Simulating a High Five
A self-righting hand-arm configuration which is adapted to pivot when struck by a user, thereby simulating a "high five."
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| Number | Title | Issue Date |
| 8148515 | Detection using a dye and a dye modifier The present invention relates to dyes in general. The present invention provides a wide range of dyes and kits containing the same, which are applicable for labeling a variety of biomolecules such as nucleic acids, cells and microorganisms. The present invention als... | 04/03/2012 |
| 8124756 | Method of preparing 5′-amino-linker oligonucleotides derivatives and analogous 5′-labeled-linker oligonucleotides therefrom A method for preparing amino linker oligonucleotides is provided. More specifically, a method of preparing 5′-amino-linker oligonucleotides comprising the steps of: introducing an amino linker having a protecting group into the 5′ terminus of an oligonucleotide;... | 02/28/2012 |
| 7737089 | Photoactivatable two-stage protective groups for the synthesis of biopolymers The present invention relates to a process for synthesizing biopolymers by stepwise assembly from protected synthesis building blocks which carry two-stage protective groups. The two-stage protective groups are activated by a first illumination step and eliminated b... | 06/15/2010 |
| 7541454 | Compounds and methods for fluorescent labeling Compounds useful in the fluorescent labeling of biological materials are provided along with methods for their use and preparation. ... | 06/02/2009 |
| 7432368 | Photolabile protecting groups The present invention relates to novel nucleoside derivatives of general formula (I) wherein R1=H, halogen, NO2, CN, OCH3, an alkyl, alkoxy or alkoxyalkyl residue having 1 to 4 C atoms, pref... | 10/07/2008 |
| 7419833 | Method for nucleic acid sequencing A method for determining the sequence of at least a portion of a single-stranded nucleic acid molecule by base-specifically labeling the exposed bases of the nucleic acid molecule using heavy element-substituted nucleotide bases which form Watson-Crick type base-pai... | 09/02/2008 |
| 7416844 | Composition for nucleic acid sequencing The present invention is directed to a method of sequencing a target nucleic acid molecule having a plurality of bases. In its principle, the temporal order of base additions during the polymerization reaction is measured on a molecule of nucleic acid, i.e. the acti... | 08/26/2008 |
| 7399846 | Libraries of oligomers labeled with different tags A method of making a set of labelled compounds by the use of a preferably particulate support, comprises dividing the support into lots, performing a different chemical reaction on each lot of the support, e.g. to couple a chemical moiety to that lot of the support,... | 07/15/2008 |
| 7385051 | Fluorescent N,N3-etheno-purine (2′-deoxy) riboside derivatives and uses thereof The invention relates to fluorescent N2,N3-etheno-purine (2′-deoxy) riboside derivatives and fluorescent oligonucleotide probes comprising one or more moieties thereof, their preparation and uses thereof for staining DNA/RNA and for detection and quanti... | 06/10/2008 |
| 7368086 | Functionalized fluorescent nanocrystals, and methods for their preparation and use Functionalized fluorescent nanocrystal compositions and methods for making and using these compositions are disclosed. The compositions are fluorescent nanocrystals coated with at least one material. The coating material has chemical compounds or ligands with functi... | 05/06/2008 |
| 7354708 | Invasion assays The present invention relates to means for the detection and characterization of nucleic acid sequences, as well as variations in nucleic acid sequences. The present invention also relates to methods for forming a nucleic acid cleavage structure on a target sequence... | 04/08/2008 |
| 7329493 | One-tube nested PCR for detecting The present invention relates to a kit and method for detecting M. tuberculosis of suspected patient. The present invention also relates to primers and probe used to detect M. tuberculosis by performing one tube nested PCR. ... | 02/12/2008 |
| 7323571 | Heterodimeric dye composition This invention provides for labeling reagents, labeled targets and processes for preparing labeling reagents. The labeling reagents can take the form of cyanine dyes, xanthene dyes, porphyrin dyes, coumarin dyes or composite dyes. These labeling reagents are useful ... | 01/29/2008 |
| 7317097 | Mutations in the ferroportin 1 gene associated with hereditary haemochromatosis The present invention relates to mutations in the gene coding for ferroportin 1 associated with hereditary haemochromatosis and methods for the diagnosis of hereditary haemochromatosis based on the identification of such mutations. ... | 01/08/2008 |
| 7314928 | Process for manufacturing morpholino-nucleotides, and use thereof for the analysis of and labelling of nucleic acid sequences The invention relates to the use of morpholino-nucleosides of formula: in which R1 represents a nucleic base and R2 represents a group corresponding to one of the following formulae: | 01/01/2008 |
| 7294709 | Detection of Oligonucleotide molecules for the detection of Giardia lamblia (G. lamblia which molecules hybridise under medium to high stringency conditions to unique 18S rDNA/rRNA sequences of G. lamblia, and methods for the detection of the presence of via... | 11/13/2007 |
| 7282581 | Oligonucleotide labeling reactants based on acyclonucleosides and conjugates derived thereof The invention relates to a labeling reactant of formula (I) useful for labeling an oligonucleotide wherein: R is a temporary protecting group. A is either a phosphorylating moiety or a solid support tethered to Z... | 10/16/2007 |
| 7279311 | Use of nucleic acids bound to carrier macromolecules A nucleic acid primer is bound to a soluble carrier macromolecule, a multitude of primer molecules thus being carried by each carrier macromolecule, and hybridisation of the primer to a template followed by extension of the primer to replicate the template in comple... | 10/09/2007 |
| 7267945 | Methods of determining the presence of polynucleotides employing amplification The invention provides methods and kits for determining the presence of polynucleotides in samples. According to certain embodiments, the invention provides methods for determining the presence of target polynucleotides by amplifying the target polynucleotides in th... | 09/11/2007 |
| 7255851 | Non-invasive localization of a light-emitting conjugate in a mammal Methods and compositions for detecting and localizing light originating from a mammal are disclosed. Also disclosed are methods for targeting light emission to selected regions, as well as for tracking entities within the mammal. In addition, animal models for disea... | 08/14/2007 |
| 7250252 | Amplification based polymorphism detection An improved method of amplifying nucleic acids comprising the use of four discrete temperature steps in a thermocyclic amplification reaction, as well as, a method of detecting large nucleic acid insertions or deletions such as those that occur from gene duplication... | 07/31/2007 |
| 7247434 | Methods and compositions for determining the sequence of nucleic acid molecules Methods and compounds, including compositions therefrom, are provided for determining the sequence of nucleic acid molecules. The methods permit the determination of multiple nucleic acid sequences simultaneously. The compounds are used as tags to generate tagged nu... | 07/24/2007 |
| 7244568 | Isolation of nucleic acid Provided is a preparative method for isolating RNA comprising an oligo-or polynucleotide from a sample, which method comprises: (a) treating the sample with a reactant capable of covalently modifying the 2′-OH position of the ribose rings of the RNA under conditio... | 07/17/2007 |
| 7238484 | Comparative genomic hybridization Disclosed are new methods comprising the use of in situ hybridization to detect abnormal nucleic acid sequence copy numbers in one or more genomes wherein repetitive sequences that bind to multiple loci in a reference chromosome spread are either substantially remov... | 07/03/2007 |
| 7229798 | Transposon mediated multiplex sequencing The present invention relates to an automated method of transposon-mediated multiplex sequencing of DNA fragments inserted into a vector. It relates more particularity to an increased efficiency in such automated methods, where the increased efficiency is obtained b... | 06/12/2007 |
| 7223568 | Methods for determining nucleotide sequences of single nucleic acid molecules The present invention relates to a method for determining a nucleotide sequence of a nucleic acid by detecting a single dye molecule. ... | 05/29/2007 |
| 7220847 | Detectable labeled nucleoside analogs and methods of use thereof The invention relates to detectable labels useful for detection of nucleotide sequences. Specifically, the invention relates to labeled-imidazole-PEG compounds, such as nucleosides, nucleotides, and nucleic acids incorporating such compounds, and methods utilizing s... | 05/22/2007 |
| 7220541 | Homogeneous assay of biopolymer binding by means of multiple measurements under varied conditions A method for homogeneously assaying biopolymer bonding includes obtaining signals from a test sample before, during and/or after the application of stimulus to the test sample and correlating the signals. The signals, whose magnitude correlate with binding affinity,... | 05/22/2007 |
| 7217813 | Methods for labeling nucleotides, labeled nucleotides and useful intermediates The present invention provides a labeled nucleoside having formula: where X represents an aliphatic diamine, and the labeling moiety comprises a label and a spacer, where the spacer is coupled at one end to a pla... | 05/15/2007 |
| 7214780 | Probes, compositions and kits for determining the presence of in a test sample The present invention relates to oligonucleotides useful for determining the presence of Mycoplasma pneumoniae and/or Mycoplasma genitalium in a test sample. The oligonucleotides of the present invention may be incorporated into hybridization assay pro... | 05/08/2007 |
| 7211381 | β2 andrenergic polymorphism detection Nucleic acid sequences are provided that are useful as amplification primers and hybridization probes for amplifying and detecting target sequence from the β2 adrenergic receptor gene. The primers and probes can be employed in amplification based methods for detect... | 05/01/2007 |
| 7211654 | Linkers and co-coupling agents for optimization of oligonucleotide synthesis and purification on solid supports A method of modulation of synthesis capacity on and cleavage properties of synthetic oligomers from solid support is described. The method utilizes linker molecules attached to a solid surface and co-coupling agents that have similar reactivities to the coupling com... | 05/01/2007 |
| 7205399 | Methods and reagents for oligonucleotide synthesis The present invention features novel compositions, linkers, derivatized solid supports, and methods for the efficient solid phase synthesis of oligonucleotides, including RNA, DNA, RNA-DNA chimeras, and analogs thereof. ... | 04/17/2007 |
| 7199234 | Regulatory segments of the human gene for telomerase reverse transcriptase The invention provides compositions and methods related to human telomerase reverse transcriptase (hTRT), the catalytic protein subunit of human telomerase. The polynucleotides and polypeptides of the invention are useful for diagnosis, prognosis and treatment of hu... | 04/03/2007 |
| 7198774 | Non-invasive localization of a light-emitting conjugate in a mammal Methods and compositions for detecting and localizing light originating from a mammal are disclosed. Also disclosed are methods for targeting light emission to selected regions, as well as for tracking entities within the mammal. In addition, animal models for disea... | 04/03/2007 |
| 7179905 | Nucleic acid labeling compounds Nucleic acid labeling compounds containing heterocyclic derivatives are disclosed. The heterocyclic derivative containing compounds are synthesized by condensing a heterocyclic derivative with a cyclic group (e.g. a ribofuranose derivative). The labeling compounds a... | 02/20/2007 |
| 7173125 | Triphosphate oligonucleotide modification reagents and uses thereof Hydrazino, oxyamino and carbonyl-based monomers and methods for incorporation into oligonucleotides during enzymatic synthesis are provided. Modified oligonucleotides are provided that incorporate the monomers provided herein. Immobilized oligonucleotides and oligon... | 02/06/2007 |
| 7169922 | Derivatives of 1,2-dihydro-7-hydroxyquinolines containing fused rings The present invention describes novel dyes, including coumarins, rhodamines, and rhodols that incorporate additional fused aromatic rings. The dyes of the invention absorb at a longer wavelength than structurally similar dyes that do not possess the fused aromatic r... | 01/30/2007 |
| 7166478 | Labeling reagents and labeled targets, target labeling processes and other processes for using same in nucleic acid determinations and analyses This invention provides for labeling reagents, labeled targets and processes for preparing labeling reagents. The labeling reagents can take the form of cyanine dyes, xanthene dyes, porphyrin dyes, coumarin dyes or composite dyes. These labeling reagents are useful ... | 01/23/2007 |
| 7157449 | Medicament for the treatment of diseases caused by parasitic protozoa The present invention relates to the use of an inhibitor of CTP synthetase, such as a glutamine analogue, and a substance capable of suppressing toxic effects thereof in vivo, in the manufacture of a medicament for the treatment of a disease caused by a parasitic pr... | 01/02/2007 |
