Did You Know...
...that after Parker Brothers executives turned down the game of Monopoly because it had "52 fundamental errors" (including taking too long to play), a copy of the game wound up in the home of the company president who stayed up until 1 a.m. to finish playing it? He was so impressed by the game that the next day he wrote to inventor Charles Darrow and offered to buy it!
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| Number | Title | Issue Date |
| 8168776 | Method for making a 21 nucleotide double stranded RNA chemically linked at one end The present invention provides methods and compositions for inhibiting gene expression using double stranded RNA molecules that are between 15 and 21 nucleotides in length and are complementary to a target gene sequence. ... | 05/01/2012 |
| 8168777 | Bisulphite reagent treatment of nucleic acid Methods for treating nucleic acid including: (a) providing an alkali environment to a nucleic acid sample; (b) reacting the nucleic acid sample with a bisulphite reagent and incubating the reaction so as to form a treated nucleic acid sample where methylated nucleot... | 05/01/2012 |
| 8163897 | 5-bromo-2′-deoxy-uridine labeled nucleotide triphosphates and nucleic acid probes and methods of making and using the same 5-bromo-2′-deoxy-uridine (BrdU) labeled nucleotide triphosphates and nucleic acid probes are described herein. The BrdU labeled nucleotide triphosphates include a linker between the nucleotide triphosphate and the BrdU moiety. The linker can be cleavable or non-cl... | 04/24/2012 |
| 8158774 | Method for introducing a nucleic-acid protecting group The present invention relates to a simple, economical method for introducing substituent (I) at the 2′-hydroxyl group of the ribose of a ribonucleic acid derivative whose 3′-hydroxyl group and 5′-hydroxyl group are protected with a silicon protecting group, wh... | 04/17/2012 |
| 8129517 | Labeled solid supports for organic synthesis The disclosed invention pertains to improved oligonucleotide manufacturing methods, including novel support compositions that are optionally labeled, their methods of preparation and use. The compositions and methods are particularly well suited for high throughput ... | 03/06/2012 |
| 8093371 | Method of producing a nucleic acid The present invention provides a method of producing a nucleic acid at high reaction efficiency and high reproducibility with a decreased variation in yield and purity among different reaction lots. A nucleic acid synthesis reaction is carried out on a first solid p... | 01/10/2012 |
| 8071755 | Nucleotide analogs The invention provides for nucleotide analogs and methods of using the same, e.g., for sequencing nucleic acids. ... | 12/06/2011 |
| 8067578 | Substrate preparation process The present invention provides novel processes for the large scale preparation of arrays of polymer sequences wherein each array includes a plurality of different, positionally distinct polymer sequences having known monomer sequences. The methods of the invention c... | 11/29/2011 |
| 8039611 | 2′-hydroxyl group-modified ribonucleoside derivatives Provided is a ribonucleoside derivative represented by General Formula (I): (wherein R1 represents a hydrogen atom or the like, R2 represents a hydrogen atom or the like, R3 represents a met... | 10/18/2011 |
| 8030477 | Methods for the synthesis of arrays of DNA probes The synthesis of arrays of DNA probes sequences, polypeptides, and the like is carried out using a patterning process on an active surface of a substrate. An image is projected onto the active surface of the substrate utilizing reflective projection optics. The proj... | 10/04/2011 |
| 8030478 | Method for nucleic acid replication and novel artificial base pairs The present invention relates to a method for nucleic acid replication and novel artificial base pairs. The method of the present invention for nucleic acid replication is characterized in that a deoxyribonucleoside 5′-triphosphate, in which the hydroxyl gr... | 10/04/2011 |
| 7999098 | Triphosphate oligonucleotide modification reagents and uses thereof Hydrazino, oxyamino and carbonyl-based monomers and methods for incorporation into oligonucleotides during enzymatic synthesis are provided. Modified oligonucleotides are provided that incorporate the monomers provided herein. Immobilized oligonucleotides and oligon... | 08/16/2011 |
| 7982029 | Synthesis of four color 3′O-allyl, modified photocleavable fluorescent nucleotides and related methods This invention provides a process for making 3′-O-allyl-dGTP-PC-Biodopy-FL-510, 3′-O-allyl-dATP-PC-ROX, 3′-O-allyl-dCTP-PC-Bodipy-650 and 3′-O-allyl-dUTP-PC-R6G, and related methods. ... | 07/19/2011 |
| 7968701 | Nylon polyribonucleosides The present invention provides a polyribonucleoside ladder copolymer molecule of general formula (I) ... | 06/28/2011 |
| 7956011 | Materials and methods for the photodirected synthesis of oligonucleotide arrays Materials and methods for photodirected synthesis of oligonucleotide arrays on a solid substrate by photodirected synthesis are disclosed which employ a film formed from (i) a photoacid generator that on photolysis generates acid that is capable of directly removing... | 06/07/2011 |
| 7923550 | Reagent compounds and methods of making and using the same The present invention describes novel compounds and methods for capping reactive groups on support and during multistep synthesis. These new capping reagents are also useful for high quality synthesis on solid supports and surfaces used as microarrays, biosensors, o... | 04/12/2011 |
| 7897758 | Activators for oligonucleotide and phosphoramidite synthesis The present invention discloses novel methods for the synthesis of oligonucleotides and nucleoside phosphoramidites. The methods are based on employing aryl-substituted 5-phenyl-1H-tetrazoles with perfluoroalkyl groups on the aromatic ring as activators. In one aspe... | 03/01/2011 |
| 7872120 | Methods for synthesizing a collection of partially identical polynucleotides Methods for synthesizing a collection of partially identical polynucleotides are disclosed. ... | 01/18/2011 |
| 7868161 | Photocrosslinking probes and uses of the same A method of detecting a target nucleic acid is disclosed, the method comprising detecting the presence of a fluorescent covalent crosslinked product from non-fluorescent precursors. The fluorescent covalent crosslinked product comprises a novel fluorophore structure... | 01/11/2011 |
| 7855285 | Methods for selective N-9 glycosylation of purines A process for providing regiospecific and highly stereoselective synthesis of 9-β anomeric purine nucleoside analogs is described. The introduction of the sugar moiety on to 6-(azolyl)-substituted purine bases is performed so that highly stereoselective formation o... | 12/21/2010 |
| 7833942 | Methods for simplifying microbial nucleic acids by chemical modification of cytosines A method for simplification of a microbial genome or microbial nucleic acid comprising treating microbial genome or nucleic acid with an agent that modifies cytosine to form derivative microbial nucleic acid and amplifying the derivative microbial nucleic acid to pr... | 11/16/2010 |
| 7820810 | Process for the synthesis of 2′-O-substituted purine nulceosides The present invention provides an improved process for the synthesis of 2′-O-substituted purine nucleosides. The process includes anhydro or thioanhydro ring opening of a selected 8,2′-cyclopurine nucleoside with a weak nucleophile in the presence of a Lewis aci... | 10/26/2010 |
| 7795423 | Polynucleotide labeling reagent The present invention provides a new labeling reagent for preparing modified oligonucleotides and processes for their production wherein these oligonucleotides contain at least once the structure P═N—SO2-benzole-L-M-X, characterized in that L is eithe... | 09/14/2010 |
| 7786293 | Organic compounds The present invention provides a process for the sulfurization of phosphorus-containing compounds. More particularly, the process involves contacting the compound to be sulfurized with a sulfur transfer reagent as defined hereinbefore in a solvent or a mixture of so... | 08/31/2010 |
| 7786294 | Compositions and methods for amplification and cloning of near full-length viral genome samples A method of producing a polydeoxyribonucleotide molecule by reverse transcriptase polymerase chain reaction wherein the polydeoxyribonucleotide molecule has a length of greater than 5,000 base-pairs is disclosed. The method involves combining two reverse transcripta... | 08/31/2010 |
| 7777023 | Method for the chemical synthesis of oligonucleotides The present invention features novel compositions, linkers, derivatized solid supports, and methods for the efficient solid phase synthesis of oligonucleotides, including RNA, DNA, RNA-DNA chimeras, and analogs thereof. ... | 08/17/2010 |
| 7772390 | Lipid mediated nucleic acid synthesis Methods and compositions for synthesizing polymers, such as nucleic acids, are provided. Aspects of the invention include methods in which lipids and monomeric precursors, e.g., mononucleotides, of the desired polymeric products are combined to produce a reaction mi... | 08/10/2010 |
| 7759480 | Chloral-free DCA in oligonucleotide synthesis A process of manufacturing oligonucleotides includes a 5′-deblocking step in which the 5-blocking group is removed with dichloroacetic acid that is essentially free of chloral. The process is useful for making oligonucleotides that are substantially free of chlora... | 07/20/2010 |
| 7750144 | Methods and compositions for enhancing the efficacy and specificity of RNA silencing The present invention provides methods of enhancing the efficacy and specificity of RNA silencing. The invention also provides compositions for mediating RNA silencing. In particular, the invention provides siRNAs, siRNA-like molecules, shRNAs, vectors and transgene... | 07/06/2010 |
| 7741472 | Polynucleotide containing a phosphate mimetic The present invention concerns modified oligonucleotides and processes for their production wherein these oligonucleotides contain at least once the structure P═N-Acc where Acc is an electron acceptor or an electron acceptor substituted with a residue R and R is a... | 06/22/2010 |
| 7741471 | Reagents for the improved synthesis of isoguanosine containing oligonucleotides The present invention provides the combination of the O-2 diphenylcarbamoyl (“DPC”) and N-6 dimethylaminomethylidene (“DMF”) protecting groups for isoguanosine nucleosides that can be utilized in oligonucleotide synthesis. ... | 06/22/2010 |
| 7723511 | Synthesis of sulfurized oligonucleotides Methods for the formation of sulfurized oligonucleotides are provided. The methods allow for the formation of phosphorothioate linkages in the oligonucleotides or derivatives, without the need for complex solvent mixtures and repeated washing or solvent changes. Oli... | 05/25/2010 |
| 7687618 | Method of manufacturing labelled oligonucleotide conjugates The present invention relates to a method for the manufacture of labeled oligonucleotide conjugates comprising the reaction of (a) an oligonucleotide having a labile protecting group bound to a terminal hydroxy group, and (b) a labeling compound, wherein said labile... | 03/30/2010 |
| 7671191 | Methods for preparing 2-alkynyladenosine derivatives Disclosed are methods for preparing 2-alkynyladenosine derivatives of formula A: or a stereoisomer, pharmaceutically acceptable salt, hydrate, solvate, acid salt hydrate or isomorphic crystalline fo... | 03/02/2010 |
| 7667032 | Method of manufacturing a microarray A method of manufacturing a microarray includes providing a substrate having a surface that is immobilized with a functional group protected with an acid-labile protecting group and capable of coupling with an oligomer probe, providing a photoacid generator onto the... | 02/23/2010 |
| 7667031 | Nucleic acid base pair A novel artificial nucleic acid base pair which is obtained by forming a selective base pair by introducing a group having steric hindrance (preferably a group having steric hindrance and static repulsion and a stacking effect) and can be recognized by a polymerase ... | 02/23/2010 |
| 7667033 | Compositions and methods for the use of FMOC derivatives in DNA/RNA synthesis Methods of nucleic acid preparation are described, including preparation of MnRNA, using FMOC derivatives to synthesize oligonucleotides in addition to applying FMOC protocols to various therapeutic and diagnostic methods. In some embodiments a single stranded oligo... | 02/23/2010 |
| 7659391 | Method for the in vitro synthesis of short double stranded RNAs The present invention relates to the field of synthesis of short double-stranded RNAs. An in vitro transcription method using bacteriophage polymerases and target sequence-specific single-stranded DNA oligonucleotides as templates is disclosed. The present invention... | 02/09/2010 |
| 7632940 | Process for the preparation of 4′-azido cytidine derivatives The invention relates to a novel process for the preparation of 4′-azido-cytidine (I) or a pharmaceutically accepted salt thereof. The compound of formula I is useful for treating virus mediated diseases, particularly for... | 12/15/2009 |
| 7629457 | Method for producing cytosine nucleoside compounds The invention provides a method for producing a cytosine nucleoside compound from pentose-1-phosphate and cytosine or a derivative thereof using a nucleoside phosphorylase reactive to cytosine or a bacterium having the enzyme activity. The invention also provides a ... | 12/08/2009 |
