Did You Know...
...that in the early 1940s GE engineer James Wright was charged with a task of utmost importance to the war effort: develop a cheap substitute for rubber that could be used to produce tires, gas masks and a whole host of military gear. Wright tackled the task diligently -- and wound up inventing Silly Putty.
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| Number | Title | Issue Date |
| 8188260 | Versatile acylation catalytic RNAs and uses thereof An object of the present invention is to provide novel ribozyme systems capable of catalyzing tRNA acetylation using various carboxylic acids as acyl donors and uses thereof. Disclosed is a ribozyme catalyzing tRNA acetylation having a structure consisting of the RN... | 05/29/2012 |
| 8188263 | Modified siRNA molecules and uses thereof The present invention provides chemically modified siRNA molecules and methods of using such siRNA molecules to silence target gene expression. Advantageously, the modified siRNA of the present invention is less immunostimulatory than its corresponding unmodified si... | 05/29/2012 |
| 8188259 | Oligonucleotide-containing pharmacological compositions and their use The present invention relates to methods and compositions containing oligonucleotides suitable for administration to humans and other mammals. ... | 05/29/2012 |
| 8188262 | Short interference ribonucleic acids for treating allergic diseases Provided herein are compounds, methods and compositions for treating allergic diseases. In particular, an isolated double stranded short interfering ribonucleic acid (siRNA) with a ribonucleotide sequence complementary to at least a portion of a target gene RNA such... | 05/29/2012 |
| 8188264 | RNAi mediated knockdown of NuMA for cancer therapy This invention relates to the use of short interfering nucleic acid molecules (siRNA) to inhibit Nuclear Mitotic Apparatus Protein (NuMA) gene expression and their use in treatment of disease, including cancer. ... | 05/29/2012 |
| 8188261 | Stabilized immune modulatory RNA (SIMRA) compounds The invention relates to the therapeutic use of novel stabilized oligoribonucleotides as immune modulatory agents for immune therapy applications. Specifically, the invention provides novel RNA-based oligoribonucleotides with improved nuclease and RNase stability an... | 05/29/2012 |
| 8183361 | Oligonucleotide-containing pharmacological compositions and their use The present invention relates to methods and compositions containing oligonucleotides suitable for administration to humans and other mammals. ... | 05/22/2012 |
| 8183363 | Antisense oligonucleotide modulation of STAT3 expression Compounds, compositions and methods are provided for inhibiting the expression of human STAT3. The compositions comprise antisense oligonucleotides targeted to nucleic acids encoding STAT3. Methods of using these oligonucleotides for inhibition of STAT3 expression a... | 05/22/2012 |
| 8183362 | Method and medicament for inhibiting the expression of a given gene The invention relates to an isolated RNA that mediates RNA interference of an mRNA to which it corresponds and a method of mediating RNA interference of mRNA of a gene in a cell or organism using the isolated RNA. ... | 05/22/2012 |
| 8178662 | Isolated AEBP1 genomic polynucleotide fragments from chromosome 7 and their uses The invention is directed to isolated genomic polynucleotide fragments that encode human SNARE YKT6, human glucokinase, human adipocyte enhancer binding protein (AEBP1) and DNA directed 50 kD regulatory subunit (POLD2), vectors and hosts containing these fragments a... | 05/15/2012 |
| 8173796 | Oligonucleotide compositions and methods for treating disease including inflammatory conditions The invention relates to therapeutic antisense oligonucleotides directed against genes coding for phosphodiesterase (PDEs) and the use of these in combination. These antisense oligonucleotides may be used as analytical tools and/or as therapeutic agents in the treat... | 05/08/2012 |
| 8168775 | Compositions and methods for inhibiting expression of transthyretin The invention relates to a double-stranded ribonucleic acid (dsRNA) targeting a transthyretin (TTR) gene, and methods of using the dsRNA to inhibit expression of TTR. ... | 05/01/2012 |
| 8168609 | RNAi-mediated inhibition of Rho kinase for treatment of ocular disorders RNA interference is provided for inhibition of Rho kinase mRNA expression for treating patients with ocular disorders, particularly for treating intraocular pressure, ocular hypertension and glaucoma. Rho kinase mRNA targets include mRNA for ROCK1 and ROCK2. ... | 05/01/2012 |
| 8168774 | Control of gene expression The present invention relates generally to a method of modifying gene expression and to synthetic genes for modifying endo gene expression in a cell, tissue or organ of a transgenic organism, in particular a transgenic animal or plant. More particularly, the inventi... | 05/01/2012 |
| 8163896 | Bioinformatically detectable group of novel regulatory genes and uses thereof The present invention relates to a first group of novel genes, here identified as genomic address messenger or GAM genes, and a second group of novel operon-like genes, here identified as genomic record or GR genes. GAM genes selectively inhibit translation of known... | 04/24/2012 |
| 8158773 | RNAi modulation of RSV and therapeutic uses thereof The present invention is based on the in vivo demonstration that RSV can be inhibited through intranasal administration of iRNA agents as well as by parenteral administration of such agents. Further, it is shown that effective viral reduction can be achieved with mo... | 04/17/2012 |
| 8153776 | Methods and compositions for RNA interference The present invention provides methods for attenuating gene expression in a cell, especially in a mammalian cell, using gene-targeted double stranded RNA (dsRNA), such as a hairpin RNA. The dsRNA contains a nucleotide sequence that hybridizes under physiologic condi... | 04/10/2012 |
| 8153777 | Modulation of toll-like receptor 5 expression by antisense oligonucleotides Antisense oligonucleotide compounds, compositions and methods are provided for down regulating the expression of TLR5. The compositions comprise antisense oligonucleotides targeted to nucleic acids encoding TLR5. The compositions may also comprise antisense oligonuc... | 04/10/2012 |
| 8153778 | RNA interference mediated inhibition of vascular cell adhesion molecule (VCAM) gene expression using short interfering nucleic acid (siNA) This invention relates to compounds, compositions, and methods useful for modulating vascular cell adhesion molecule gene expression using short interfering nucleic acid (siNA) molecules. This invention also relates to compounds, compositions, and methods useful for... | 04/10/2012 |
| 8148513 | hTERT gene expression regulatory gene Disclosed is a novel substance capable of regulating the expression of a telomerase reverse transcriptase gene in a cell of a mammal. A gene capable of regulating the expression of hTERT, comprising a nucleotide sequence depicted in SEQ ID No: 1 or 2. The expression... | 04/03/2012 |
| 8148514 | hTERT gene expression regulatory gene Disclosed is a novel substance capable of regulating the expression of a telomerase reverse transcriptase gene in a cell of a mammal. A gene capable of regulating the expression of hTERT, comprising a nucleotide sequence depicted in SEQ ID No: 1 or 2. The expression... | 04/03/2012 |
| 8143389 | Inhibiton of metallo-β-lactamase by double-stranded DNA Compositions and methods for identifying double stranded DNA molecules that bind with high affinity to metallo-β-lactamase. Methods for inhibiting the activities of the metallo-β-lactamase in bacteria by double stranded DNA molecules. ... | 03/27/2012 |
| 8143390 | Compositions and methods for inhibiting expression of anti-apoptotic genes The present invention relates to an isolated double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of bcl-2, where the antisense strand comprises a sequence that comprises a region of complementarity which is substantially complementary to at least ... | 03/27/2012 |
| 8138327 | Inducible systems and methods for controlling siRNA expression An inducible system and methods for controlling expression of siRNA are provided. An inducible system for producing siRNA only in the presence of HIV TAT, and methods for inhibiting HIV-1 gene expression in cells comprising such inducible system also are provided. | 03/20/2012 |
| 8138328 | Modulation of apolipoprotein (A) expression Compounds, compositions and methods are provided for modulating the expression of apolipoprotein(a). The compositions comprise oligonucleotides, targeted to nucleic acid encoding apolipoprotein(a). Methods of using these compounds for modulation of apolipoprotein(a)... | 03/20/2012 |
| 8138329 | siRNA targeting connective tissue growth factor (CTGF) Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, co... | 03/20/2012 |
| 8133875 | Method for inhibiting scavenger receptor-A and increasing immune response to antigens Provided is a method for enhancing an immune response to a desired antigen in an individual. The method is performed by administering to the individual an agent capable of inhibiting class A macrophage scavenger receptor (SR-A) and optionally administering the desir... | 03/13/2012 |
| 8129515 | Oligomeric compounds and compositions for the use in modulation of microRNAs Compounds, compositions and methods are provided for modulating the levels expression, processing and function of miRNAs. The compositions comprise oligomeric compounds targeted to small non-coding RNAs and miRNAs. The oligomeric compounds possess potent miRNA inhib... | 03/06/2012 |
| 8129516 | RNA complexes featuring paranemic binding, methods of their production and sensors and analytical methods involving same The present invention pertains to the use of paranemic crossover motifs for RNA self-assembly, and the use of those self-assembled complexes to carry out analytical methods, and as a basis for the creation of sensors. The invention includes RNA monomeric units compr... | 03/06/2012 |
| 8124753 | Compositions and methods for inhibiting translation of a Mect1-MAML2 chimeric gene Composition for the inhibition of the translation of a Mect1-MAML2 chimeric gene consisting essentially of: (a) a fragment of the nucleic acid encoding the chimeric gene, and (b) a nucleic acid complementary to the fragment, and a method of inhibiting the translatio... | 02/28/2012 |
| 8124752 | Compositions and methods for inhibiting expression of the MYC gene The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of the MYC gene (MYC gene), comprising an antisense strand having a nucleotide sequence which is less that 30 nucleotides in length, generally 19-25 nucleotides in leng... | 02/28/2012 |
| 8124754 | Double-stranded nucleic acid molecule cancer cell proliferation inhibitor and pharmaceutical agent suitable for prevention or treatment of uterine cancer, breast cancer, and bladder cancer A double-stranded nucleic acid molecule for suppressing the expression of at least one of COX7RP and Efp genes which includes (a) a sense strand which includes a nucleotide sequence corresponding to a target sequence indicated by any one of SEQ ID Nos.: 1 to 38 and ... | 02/28/2012 |
| 8124755 | hTERT gene expression regulatory gene Disclosed is a novel substance capable of regulating the expression of a telomerase reverse transcriptase gene in a cell of a mammal A gene capable of regulating the expression of hTERT, comprising a nucleotide sequence depicted in SEQ ID No: 1 or 2. The expression ... | 02/28/2012 |
| 8119789 | Method for the production of a cell and/or tissue and/or disease phase specific medicament The present invention relates to a method for producing of a cell and/or tissue and/or disease phase specific medicament against against chronic inflammatory diseases. Disease, cell type, tissue and/or stage specific proteins and nucleic acids are identified ... | 02/21/2012 |
| 8119790 | Antisense oligonucleotides for treating allergy and neoplastic cell proliferation Antisense oligonucleotides for treating and/or preventing at least one of asthma, allergy, hypereosinophilia, general inflammation and cancer are provided. The oligonucleotides are directed against nucleic acid sequences coding for a receptor selected from the group... | 02/21/2012 |
| 8119791 | si-RNA-mediated gene silencing technology to inhibit tyrosinase and reduce pigmentation The present invention describes compositions and methods for treating, preventing and improving hyperpigmentation, or other unwanted pigmentation of the skin, or other unwanted skin condition, such as age spots, aged skin, skin discoloration, etc., wherein the compo... | 02/21/2012 |
| 8114983 | Compositions and use of EPAS1 inhibitors The present invention relates to inhibitors of endothelial PAS domain protein 1 (EPAS1), and methods and compositions related to the EPAS1 inhibitors. In certain embodiments, the EPAS1 inhibitors include nucleic acids, such as for example siRNAs. ... | 02/14/2012 |
| 8114985 | Anti-MicroRNA oligonucleotide molecules The invention relates to isolated anti-microRNA molecules. In another embodiment, the invention relates to an isolated microRNA molecule. In yet another embodiment, the invention provides a method for inhibiting microRNP activity in a cell. ... | 02/14/2012 |
| 8114980 | Characterisation of gene function using double stranded RNA inhibition There is provided a method of identifying DNA responsible for conferring a particular phenotype in a cell which method comprises a) constructing a cDNA or genomic library of the DNA of the cell in a suitable vector in an orientation relative to a promoter(s) capable... | 02/14/2012 |
| 8114981 | Method and medicament for inhibiting the expression of a given gene The invention relates to an isolated RNA that mediates RNA interference of an mRNA to which it corresponds and a method of mediating RNA interference of mRNA of a gene in a cell or organism using the isolated RNA. ... | 02/14/2012 |
