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| Number | Title | Issue Date |
| 8158771 | Host cell protein knock-out cells for production of therapeutic proteins The present invention relates to methods and means for making Vitamin K-dependent protein compositions which are devoid or substantially devoid of protein contaminants. In particular, methods and means useful for the reduction or elimination of protein contaminants ... | 04/17/2012 |
| 8153775 | Kits for detecting rank Isolated receptors, DNAs encoding such receptors, and pharmaceutical compositions made therefrom, are disclosed. The isolated receptors can be used to regulate an immune response. The receptors are also useful in screening for inhibitors thereof. ... | 04/10/2012 |
| 8148512 | Methods for detection and quantification of analytes in complex mixtures The invention provides a diverse population of uniquely labeled probes, containing target specific nucleic acid probes each attached to a unique label bound to a nucleic acid. Also provided is a method of detecting a nucleic acid analyte. The method consists of (a) ... | 04/03/2012 |
| 8129122 | Method of predicting metastasis of oral cavity cancer into cervical lymph node and diagnosis kit to be used in the prediction A method for objectively predicting possibility of metastasis to a cervical lymph node in an early stage for an individual case diagnosed as an oral cavity cancer, and a diagnosis kit to be used in the prediction are provided. The method includes a step of assaying ... | 03/06/2012 |
| 8034917 | Primer-directed chromosome painting An oligonucleotide composition is provided. The subject composition comprises: a mixture of at least 10 of sets of oligonucleotides, wherein each of the sets of oligonucleotides comprises at least 100 different oligonucleotides of the following formula: X1 | 10/11/2011 |
| 8029999 | Complexity management of genomic DNA The presently claimed invention provides for novel methods and kits for analyzing a collection of target sequences in a nucleic acid sample. A sample is amplified under conditions that enrich for a subset of fragments that includes a collection of target sequences. ... | 10/04/2011 |
| 7982026 | FRET probes for fluorescent detection of the ESPS gene The present invention relates to a primer pair for the detection of a specific gene, and more particularly to a probe pair for the detection and analysis of an EPSPS (5-enolpyruvylshikimate-3-phosphate synthase) gene, in which primers complementary to the base seque... | 07/19/2011 |
| 7932375 | Kits for detecting rank nucleic acids Isolated receptors, DNAs encoding such receptors, and pharmaceutical compositions made therefrom, are disclosed. The isolated receptors can be used to regulate an immune response. The receptors are also useful in screening for inhibitors thereof. ... | 04/26/2011 |
| 7906640 | Polynucleotide and protein involved in synaptogenesis, variants thereof, and their therapeutic and diagnostic uses The invention relates to a kit for diagnosing autism linked to a mutation in a protein belonging to the family of human neuroligins. ... | 03/15/2011 |
| 7888496 | Kit for species specific DNA detection The present invention relates to methods and compositions for the identification of species-specific material in pharmaceutical products. In particular, the present invention relates to methods for the identification of species-specific DNA in a population of a diff... | 02/15/2011 |
| 7834169 | P300 histone acetylase inhibitor An inhibitor of histone acetyltransferase p300 was isolated from human cDNA library and identified as a nuclear protein composed of 855 amino acid residues. It binds to the cysteine/histidine-rich region of p300, thereby inhibiting the transcriptional activation by ... | 11/16/2010 |
| 7619079 | Db, the receptor for leptin, nucleic acids encoding the receptor, and uses thereof The present invention relates to identification of a receptor for a satiety factor, which is involved in body weight homeostasis. Mutations in this receptor are associated with obese phenotypes. In particular, the present invention relates to identification and char... | 11/17/2009 |
| 7579453 | Variants of human taste receptor genes Identified herein are different forms of bitter receptor genes that occur in different humans. These alleles are generated by numerous coding single nucleotide polymorphisms (cSNP's) that occur within the members of the T2R gene family. Some SNP's cause amino acid s... | 08/25/2009 |
| 7442543 | Mammalian selenoprotein differentially expressed in tumor cells A 15 kDa selenium-containing protein (“selenoprotein”) is disclosed. The protein is shown to be differentially expressed in cancer cells, such as prostate cancer cells. There is a correlation between the presence of a polymorphism at nucleotide positions 811 and... | 10/28/2008 |
| 7439016 | Detection of nucleic acids by type-specific hybrid capture method Target-specific hybrid capture (TSHC) provides a nucleic acid detection method that is not only rapid and sensitive, but is also highly specific and capable of discriminating highly homologous nucleic acid target sequences. The method produces DNA-RNA hybrids which ... | 10/21/2008 |
| 7439020 | Genomic markers of hepatitis B virus associated with hepatocellular carcinoma The present invention provides methods of predicting a pre-disposition of HBV-infected individuals to develop hepatacellular carcinoma (HCC). ... | 10/21/2008 |
| 7432361 | G protein-coupled receptor, GAVE10 Novel GPCR GAVE10 polypeptides, proteins and nucleic acid molecules are provided. GAVE10, recombinant expression vectors, host cells incorporating GAVE10 expression vectors and non-human transgenic animals into which a GAVE10 gene has been introduced or disrupted ar... | 10/07/2008 |
| 7432056 | Biallelic markers derived from genomic regions carrying genes involved in arachidonic acid metabolism The invention provides polynucleotides including biallelic markers derived from genes involved in arachidonic acid metabolism and from genomic regions flanking those genes. Primers hybridizing to regions flanking these biallelic markers are also provided. This inven... | 10/07/2008 |
| 7432367 | Nucleic acid encoding a retinoblastoma binding protein (RBP-7) and polymorphic markers associated with said nucleic acid The present invention is directed to a polynucleotide comprising open reading frames defining a coding region encoding a retinoblastoma binding protein (RBP-7) as well as regulatory regions located both at the 5′ end and the 3′ end of said coding region. The pre... | 10/07/2008 |
| 7429650 | Methods and compositions in breast cancer diagnosis and therapeutics The present invention is directed to compositions regarding a specific mutation in estrogen receptor alpha and their use as diagnostic markers in breast tissue, such as premalignant lesions, for the development of breast cancer. More specifically, cells of breast ca... | 09/30/2008 |
| 7425414 | Method of prognosis of metastasis by detection of FRA12E fragile site within the SMRT gene/locus at chromosome 12q24 Provided are methods for prognostic prediction of metastasis. The method comprises identifying the presence or absence of a fragile site FRA12E on chromosome 12q24 at the SMRT gene locus. The presence of FRA12E in an individual can be determined in cell samples obta... | 09/16/2008 |
| 7422887 | Phospholipase Aand gene thereof To provide a novel phospholipase A2 (PLA2) associated with psoriasis, a nucleic acid encoding the same, a method for characterizing, identifying or screening an inhibitor for the PLA2 or a medicament; and a novel method for diagnosis... | 09/09/2008 |
| 7422854 | Cholesterol reduction signature The present invention provides methods and compositions for use in rapid test or prediction of the propensity of a test compound to induce cholesterol reduction in a subject. The invention also includes a cholesterol reduction signature as well as the method of deri... | 09/09/2008 |
| 7417138 | PNA chip for determining genotypes of mycobacterial species using plastic substrate coated with epoxy group-containing polymer and method of determining genotypes of mycobacterial species using the PNA chip Provided are a PNA chip for determining the genotypes of mycobacterial species in which probe PNAs having DNA sequences of SEQ ID NOs: 5-28 are immobilized on a plastic substrate coated with an epoxy group-containing polymer, and a method of determining the genotype... | 08/26/2008 |
| 7413708 | Methods and reagents for combined PCR amplification An oligonucleotide probe is disclosed, the probe including an oligonucleotide, a fluorescer molecule attached to a first end of the oligonucleotide and a quencher molecule attached to the opposite end of the oligonucleotide. The probe is rendered impervious to diges... | 08/19/2008 |
| 7410777 | Non-endogenous, constitutively activated human G protein-coupled receptors Disclosed herein are constitutively activated, non-endogenous versions of endogenous human G protein-coupled receptors comprising (a) the following amino acid sequence region (C-terminus to N-terminus orientation) and/or (b) the following nucleic acid sequence regio... | 08/12/2008 |
| 7407756 | Methods for detecting mutations associated with familial dysautonomia This invention relates to methods and compositions useful for detecting mutations which cause Familial Dysautonomia. Familial dysautonomia (FD; Riley-Day syndrome), an Ashkenazi Jewish disorder, is the best known and most frequent of a group of congenital sensory ne... | 08/05/2008 |
| 7405044 | Multiplex PCR for simultaneous quantitation of human nuclear, mitochondrial, and male Y-chromosome DNA A comprehensive set of human specific, target specific, multiplex PCR assays for DNA quantitation is provided. Our duplex qPCR for nDNA/mtDNA had a linear quantitation range of 100 ng to 1 pg, and our triplex qPCR assay for nDNA/mtDNA/male Y DNA had a linear range o... | 07/29/2008 |
| 7405040 | Ligase/polymerase method for detecting cytosine methylation in DNA samples Described is a method for detecting 5-methylcytosine in genomic DNA samples. First, a genomic DNA from a DNA sample is chemically converted with a reagent, 5-methylcytosine and cytosine reacting differently, and the pretreated DNA is subsequently amplified using a p... | 07/29/2008 |
| 7399852 | Kits and reaction mixtures containing modified probe molecules The present invention concerns oligonucleotides containing one or more modified nucleotides which increase the binding affinity of the oligonucleotides to target nucleic acids having a complementary nucleotide base sequence. These modified oligonucleotides hybridize... | 07/15/2008 |
| 7396647 | Site- or sequence-specific process for cleaving analytes and library of analytes This invention provides for compositions for use in real time nucleic acid detection processes. Such real time nucleic acid detection processes are carried out with energy transfer elements attached to nucleic acid primers, nucleotides, nucleic acid probes or nuclei... | 07/08/2008 |
| 7396922 | Regulation of hypoxia-inducible gene expression with antisense Inhibitory PAS domain protein A pharmaceutical composition comprises the sequence of SEQ ID NO:s 3-5 or pharmaceutically equivalent sequences. Methods employing the pharmaceutical compositions include treatments to increase angiogenesis, to stimulate HIF-1α function, to treat hypoxia-related co... | 07/08/2008 |
| 7396645 | Cholestasis signature The present invention provides methods and compositions for use in rapid test or prediction of the propensity of a test compound to induce cholestasis in a subject. The invention also includes a Cholestasis signature database as well as the method of deriving such d... | 07/08/2008 |
| 7393643 | Method of detecting ivermectin sensitivity in a canine subject by identifying a mutation in a MDR1-encoding sequence This invention provides the identification of a truncation polymorphism of the mdr1 gene that is linked to ivermectin sensitivity in subjects, such as collies. Also provided are methods for detecting drug transport sensitivity in a subject, and animal models and in ... | 07/01/2008 |
| 7390894 | Glutathione S-transferase sequence variants Isolated GSTO2 nucleic acid molecules that include a nucleotide sequence variant and nucleotides flanking the sequence variant are described, as well as GSTO2 allozymes. Methods for determining if a subject contains a GSTO2 sequence variant also are described. ... | 06/24/2008 |
| 7388093 | Gene for identifying individuals with familial dysautonomia This invention relates to methods and compositions useful for detecting mutations which cause Familial Dysautonomia. Familial dysautonomia (FD; Riley-Day syndrome), an Ashkenazi Jewish disorder, is the best known and most frequent of a group of congenital sensory ne... | 06/17/2008 |
| 7385045 | Canine B7-1 nucleic acid molecules The present invention relates to B7 proteins; to B7 nucleic acid molecules, including those that encode such B7 proteins; to antibodies raised against such B7 proteins; and to therapeutic compounds that regulate B7 function. The present invention also includes metho... | 06/10/2008 |
| 7384750 | Nucleic acid sequences having characteristics of enhanced expression in human neuroblastoma with favorable prognosis based on comparison between human neuroblastoma with favorable prognosis and human neuroblastoma with unfavorable prognosis There are disclosed a nucleic acid which is derived from the gene expressed in human neuroblastoma, and which comprises any sequence selected from the group consisting of the nucleic acid sequences set forth SEQ ID NO:1 to NO:104 in the Sequence Listing, or its comp... | 06/10/2008 |
| 7381542 | Nucleic acids encoding a biogenic amine receptor The present invention relates to novel mammalian biogenic amine receptor proteins and genes that encode such proteins. The invention is directed toward the isolation and characterization of mammalian trace amine receptor proteins. The invention specifically provides... | 06/03/2008 |
| 7378236 | Method for analyzing gene expression patterns A method and device for detecting or monitoring the treatment status of a selected physiological state or disease condition. The device has a subarray of genes which show a statistically significant change in gene expression level when compared with the control expr... | 05/27/2008 |
