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"I watched his countenance closely, to see if he was not deranged ... and I was assured by other senators after he left the room that they had no confidence in it."
U.S. Senator Smith of Indiana ; After seeing Samuel Morse demonstrate the telegraph.
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| Number | Title | Issue Date |
| 8188255 | Human microRNAs associated with cancer The invention provides new sequences for human microRNAs associated with cancer which may be used as molecular markers for cancer diagnostics or as therapeutic targets or agents. ... | 05/29/2012 |
| 8187809 | Method for judging lymph node metastasis of stomach cancer and kit used therefor The present invention provides a novel marker capable of accurately diagnosing the lymph node metastasis of stomach cancer. An mRNA, or a fragment thereof, coding for at least one protein selected from TFF1, AGR2, PRSS8, MUC1, MUC4 and MUC17 can be useful as a lymph... | 05/29/2012 |
| 8183359 | Kits for amplifying DNA Kits for amplifying DNA which include a priming oligonucleotide that hybridizes to a 3′-end of a DNA target sequence, a displacer oligonucleotide that hybridizes to a target nucleic acid containing the DNA target sequence at a position upstream from the priming ol... | 05/22/2012 |
| 8173795 | Methods and compositions for identifying and characterizing hepatitis C The invention provides novel methods and compositions for amplifying portions of the HCV genome. The nucleic acid sequences set forth as SEQ ID NOS:1-64 derived from HCV cDNA and functional equivalents thereof, kits containing same, and methods employing same, are u... | 05/08/2012 |
| 8148511 | Methods and compositions for the detection and quantification of and The present invention is drawn to methods and compositions for the rapid assessment of fecal indicator bacteria in a sample. Provided herein are novel primer and probe compositions for use in detecting the presence of these organisms in a sample, particularly using ... | 04/03/2012 |
| 8148075 | Methods for producing nucleic acid hybridization probes that amplify hybridization signal by promoting network formation This invention describes methods for the generation of nucleic acid probes that improve the sensitivity of hybridization assays. The sensitivity increase results from structural modifications of nucleic acids that promote network formation during hybridization with ... | 04/03/2012 |
| 8143388 | Method and test kit for quantitative determination of polynucleotides in a mixture The invention relates to a method and test kit for quantitative determination of the amounts or relative proportions of polynucleotides in a mixture. The invention enables assessment of dynamic variations in a mixed population of organisms using affinity aided solut... | 03/27/2012 |
| 8138326 | Method and kit for quantitative and qualitative determination of human papillomavirus The present invention relates to a method and kit for quantitative and qualitative determination of human papillomavirus, HPV, in a sample. More precisely, for quantitative and qualitative determination of oncogenic HPV to predict the risk of HPV infection resulting... | 03/20/2012 |
| 8133989 | Nucleic acid primer/construct compositions This invention provides novel processes for amplifying nucleic acid sequences of interest, including linear and non-linear amplification. In linear amplification, a single initial primer or nucleic acid construct is utilized to carry out the amplification process. I... | 03/13/2012 |
| 8129112 | Polymorphisms in the human CYP2D6 gene promoter region and their use in diagnostic and therapeutic applications Provided are polynucleotides of molecular variant promoters of the CYP2D6 gene which, for example, are associated with abnormal drug response or individual predisposition to several common diseases and disorders caused by drug under- or over-metabolization, and vect... | 03/06/2012 |
| 8129117 | Genetic markers for assessing risk of developing bipolar disorder This document provides methods and materials related to genetic markers of Bipolar Disorder (BD) and Schizophrenia (SZ). For example, methods for using such genetic markers to assess risk of developing BD and/or SZ are provided, as are methods for making a different... | 03/06/2012 |
| 8124343 | IRE-1α substrates IRE-1α substrates useful for identifying agonists and antagonists of IRE-1α RNase activity. ... | 02/28/2012 |
| 8124751 | Hybridization chain reaction amplification for in situ imaging The present invention relates to the use of fluorescently labeled nucleic acid probes to identify and image analytes in a biological sample. In the preferred embodiments, a probe is provided that comprises a target region able to specifically bind an analyte of inte... | 02/28/2012 |
| 8114979 | Di-alpha amino anthraquinone compositions The invention provides novel anthraquinone compositions that are useful as broad-spectrum quenchers of fluorescence and provides methods for making and using them. The anthraquinone quenchers can be conjugated to a variety of biologically relevant compounds, includi... | 02/14/2012 |
| 8114978 | Methods for genotyping selected polymorphism Methods for genotyping polymorphisms using a locus specific primer that is complementary to a region near a selected polymorphism are described. Methods for synthesizing pools of locus specific primers that incorporate some degenerate positions are also disclosed. A... | 02/14/2012 |
| 8110673 | Aggregation sensor and solutions and kits comprising the same This invention relates to an aggregation sensor useful for the detection and analysis of aggregants in a sample, and methods, articles and compositions relating to such a sensor. The sensor comprises first and second optically active units, where energy may be trans... | 02/07/2012 |
| 8101740 | Positron emission tomography probes for imaging immune activation and selected cancers Compounds for use as PET probes and methods for synthesizing and using these, comprising [18F]D-FAC and other cytosine and adenosine analogs. ... | 01/24/2012 |
| 8097412 | DNA-based test for detection of annual and intermediate ryegrass We have developed a novel TaqMan quantitative PCR (Q-PCR) based DNA test for detecting annual and/or intermediate ryegrass types in perennial ryegrass. This DNA test was designed using an insertion/deletion (InDel) site in the LpVRN2_2 gene. The new DNA test is more... | 01/17/2012 |
| 8092996 | Method for detecting cystic fibrosis The present invention relates to methods for amplifying various regions of the cystic fibrosis transmembrane regulator (CFTR) gene. Methods are provided for amplifying one or all 27 exons of the CFTR gene and a portion of the CFTR promoter region in a single tube. T... | 01/10/2012 |
| RE43096 | Tagged extendable primers and extension products This invention provides a duplex comprising an oligonucleotide primer and a template, wherein the primer is coupled chemically to a chromophore or fluorophore so as to allow chain extension by a polymerase. In one embodiment, the primer is extended by a polymerase t... | 01/10/2012 |
| 8088582 | Compositions for the use in identification of fungi The present invention provides compositions, kits and methods for rapid identification and quantification of fungi by molecular mass and base composition analysis. ... | 01/03/2012 |
| 8080373 | Method for the early detection of pancreatic cancer and other gastrointestinal disease conditions A method for the early diagnosis of pancreatic cancer and other gastrointestinal disease compares the gene expression patterns from a patient's peripheral blood monocytes-lymphocyte's gene system with either the similar gene expression patterns of a normal person, o... | 12/20/2011 |
| 8071750 | Determination of hepatitis C virus genotype The present invention provides compositions and methods for the detection and characterization of HCV sequences. More particularly, the present invention provides compositions, methods and kits for using invasive cleavage structure assays (e.g. the INVADER assay) to... | 12/06/2011 |
| 8063196 | Highly orthogonal universal sequences for use in nucleic acid assays The invention provides a set of highly orthogonal six-code universal sequences for use in bDNA singleplex and multiplex nucleic acid hybridization assays. The six-code orthogonal sequences do not cross-hybridize and thus, minimize or eliminate the 3-mer cross-hybrid... | 11/22/2011 |
| 8063197 | Compositions and methods for detection of hepatitis A virus nucleic acid Nucleic acid oligomeric sequences and in vitro nucleic acid amplification and detection methods for detecting the presence of HAV RNA sequences in samples are disclosed. Kits comprising nucleic acid oligomers for amplifying and detecting HAV nucleic acid sequences a... | 11/22/2011 |
| 8048626 | Multiplex Q-PCR arrays This invention provides methods and systems for measuring the concentration of multiple nucleic acid sequences in a sample. The nucleic acid sequences in the sample are simultaneously amplified, for example, using polymerase chain reaction (PCR) in the presence of a... | 11/01/2011 |
| 8048630 | Methods and agents for detecting The present disclosure provides methods that permit detection of all known species of Parechovirus, including Human parechovirus and Ljungan virus (LV). In particular examples the method includes amplifying at least a portion of the 5′NTR of parechovirus nucleic a... | 11/01/2011 |
| 8043810 | Analyte detection using autocatalytic chain reactions Compositions and methods for detecting the presence of analytes employing autocatalytic chain reactions (ACR) having super linear kinetics for amplification of signal are disclosed. ... | 10/25/2011 |
| 8026066 | Detection of nucleic acids from multiple types of human papillomaviruses Nucleic acid oligonucleotide sequences are disclosed which include amplification oligomers and probe oligomers which are useful for detecting multiple types of human papillomaviruses (HPV) associated with cervical cancer. Methods for detecting multiple HPV types in ... | 09/27/2011 |
| 8017756 | Elite event A5547-127 and methods and kits for identifying such event in biological samples Tools are provided which allow rapid and unequivocal identification of elite event A5547-127 in biological samples. ... | 09/13/2011 |
| 8017757 | Kits and method for detecting human papilloma virus with oligo nucleotide bead array Provided are determining methods of human papillomavirus (HPV) genotypes with a high sensitivity. The method includes performing two-step PCRs on an HPV L1 gene in a sample to be analyzed as a biotin-labeled, single-stranded L1 gene, performing a hybridization react... | 09/13/2011 |
| 8017331 | IRE-1α substrates IRE-1α substrates useful for identifying agonists and antagonists of IRE-1α RNase activity. ... | 09/13/2011 |
| 8003778 | Detection of red tide organisms by nucleic acid amplification A real-time reverse transcription-PCR, or NABSA, method (and associated primers) targeting the rbcL gene for the detection and quantitation of the Florida red tide organism, Karenia brevis. ... | 08/23/2011 |
| 7999095 | Nucleic acid supported protein complementation The present invention is directed to novel methods for in vitro and in vivo detection of target nucleic acid molecules, including DNA and RNA targets, as well as nucleic acid analogues. The present invention is based on protein complementation, in which two individu... | 08/16/2011 |
| 7994304 | Methods and compositions for sequencing a nucleic acid The invention provides a family of tethered nucleotide analogs useful in sequencing nucleic acids containing a homopolymer region comprising, for example, two or more base repeats, and to sequencing methods using such tethered nucleotide analogs. ... | 08/09/2011 |
| 7964716 | Fluorescent primer system for detection of nucleic acids (Q priming) The present invention is directed to a self-quenching primer comprising; a fluorophore that can be quenched by guanine; an oligonucleotide sequence that forms a hairpin; an oligonucleotide that is a target specific sequence and; use in amplification reactions, parti... | 06/21/2011 |
| 7960537 | Polynucleotides for use as tags and tag complements, manufacture and use thereof A family of minimally cross-hybridizing nucleotide sequences, methods of use, etc. A specific family of 210 24mers is described. ... | 06/14/2011 |
| 7919611 | Nucleotide primer set and nucleotide probe for detecting genotype of N-acetyltransferase-2 (NAT2) There is provided a nucleotide primer set for LAMP amplification, used for detecting genotypes of single-nucleotide polymorphisms G590A, G857A and T341C of a NAT2 gene. There is also provided a nucleotide probe for detection of an amplification product amplified wit... | 04/05/2011 |
| 7910719 | Method of detecting human papilloma virus by using nucleic acid amplification method and nucleic acid chain-immobilized carrier Provided is a nucleic acid primer for LAMP amplification for use in the detection of human papilloma virus and identification of its genotype. The present invention also provides a method of detecting human papilloma virus and identifying its genotype, includes a st... | 03/22/2011 |
| 7906639 | Oligonucleotides having a 2′-O,4′-C-ethylene nucleotide in the third position of the 3′-end The present invention relates to a method for detecting gene polymorphism by PCR, using, as a primer, an oligonucleotide, wherein the third nucleotide from the 3′-end thereof is a 2′-O,4′-C-ethylene nucleotide (ENA) unit, the other oligonucleotides are natural... | 03/15/2011 |
