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| Number | Title | Issue Date |
| 8188254 | C-class oligonucleotide analogs with enhanced immunostimulatory potency The invention relates to a class of CpG immunostimulatory oligonucleotides containing a CpG immunostimulatory motif and a second motif which is capable of forming secondary structure, including duplex and higher order structures, in vitro and in vivo. The oligonucle... | 05/29/2012 |
| 7745606 | Immunostimulatory sequence oligonucleotides and methods of using the same The invention provides immunomodulatory polynucleotides and methods for immunomodulation of individuals using the immunomodulatory polynucleotides. ... | 06/29/2010 |
| 7645868 | Families of non-cross-hybridizing polynucleotides for use as tags and tag complements, manufacture and use thereof A family of minimally cross-hybridizing nucleotide sequences, methods of use, etc. A specific family of 1168 24mers is described. ... | 01/12/2010 |
| 7419829 | Vector system The present invention provides a vector system comprising a mutated post-transcriptional regulatory element. In particular, the present invention relates to a mutated WPRE sequence that can efficiently express nucleotides of interest in a retroviral vector system. T... | 09/02/2008 |
| 7385051 | Fluorescent N,N3-etheno-purine (2′-deoxy) riboside derivatives and uses thereof The invention relates to fluorescent N2,N3-etheno-purine (2′-deoxy) riboside derivatives and fluorescent oligonucleotide probes comprising one or more moieties thereof, their preparation and uses thereof for staining DNA/RNA and for detection and quanti... | 06/10/2008 |
| 7365179 | Multiplexed analytical platform The invention provides a system and reagents for carrying out multiplexed analytical measurements using the hybridization of oligonucleotide tags to addressable solid phase supports to obtain simultaneous readouts from hundreds to tens of thousands of reactions. In ... | 04/29/2008 |
| 7351550 | Exoenzyme toxin of , and uses thereof A protein toxin named Aeromonas salmonicida exoenzyme T (AcxT), which belongs to the family of ADP-ribosylating toxins, is disclosed as is a Calcium (or other cation concentration) dependent promoter of A. salmonicida. Also disclosed are diagnostic, pr... | 04/01/2008 |
| 7342101 | Compositions and methods comprising a protective antigen of Disclosed are protein and peptide antigen and DNA compositions effective in generating immune responses against the pathogenic fungi Coccidioides spp., the causative agents of coccidioidomycosis and Valley Fever. The invention thus provides protein and peptid... | 03/11/2008 |
| 7323305 | Methods of amplifying and sequencing nucleic acids An apparatus and method for performing rapid DNA sequencing, such as genomic sequencing, is provided herein. The method includes the steps of preparing a sample DNA for genomic sequencing, amplifying the prepared DNA in a representative manner, and performing multip... | 01/29/2008 |
| 7306916 | Methods for detecting chromosome aberrations The present invention relates to methods for detecting a change in chromosomal structure. These methods employ labeled probes that bind nucleic acids. For example, these probes may be comprised of nucleic acids or nucleic acid analogs and a detectable label. ... | 12/11/2007 |
| 7297478 | Creation of variable length and sequence linker regions for dual-domain or multi-domain molecules Disclosed are methods and compositions for creating a DNA, RNA or protein molecule with two or more nucleic acid or polypeptide domains, respectively, joined by a linker region. These methods are used to generate random linker libraries of nucleic acids that encode ... | 11/20/2007 |
| 7276595 | DNA sequence encoding a retinoic acid regulated protein The present invention concerns a novel retinoic acid regulated gene whose expression product displays useful morphogenic/mitogenic properties. The present invention further concerns an isolated nucleic acid of SEQ ID NO:1 encoding a retinoic acid regulated expressio... | 10/02/2007 |
| 7271240 | 125P5C8: a tissue specific protein highly expressed in various cancers A novel gene (designated 125P5C8) and its encoded protein are described. While 125P5C8 exhibits tissue specific expression in normal adult tissue, it is aberrantly expressed multiple cancers including prostate, bladder, kidney and colon cancers. Consequently, 125P5C... | 09/18/2007 |
| 7262027 | Polypeptide and DNA immunization against . infections The present invention provides compositions of novel polypeptides and polynucleotides encoding the polypeptides, which polypeptides are useful for generating an immunological response in an individual and in therapeutic application of Coccidioides spp. infect... | 08/28/2007 |
| 7262024 | antigens The present invention relates to polypeptides of Streptococcus pneumoniae which may be used for prophylaxis, diagnostic and/or therapy purposes. ... | 08/28/2007 |
| 7256282 | Nucleic acids encoding antigen and uses thereof The present invention provides novel isolated nucleic acids encoding antigenic proteins derived from Sarcocystis neurona, or unique fragments thereof. In particular, the invention provides novel isolated nucleic acids encoding membrane-associated polypeptides... | 08/14/2007 |
| 7250403 | Biodegradable immunomodulatory formulations and methods for use thereof The invention provides new compositions and methods for immunomodulation of individuals. Immunomodulation is accomplished by administration of immunomodulatory polynucleotide/microcarrier (IMP/MC) complexes. The IMP/MC complexes may be covalently or non-covalently b... | 07/31/2007 |
| 7244838 | Method for detecting, identifying and counting using gene (rpoD) sequence encoding RNA polymerase σ70 factor To prepare high-performance specific gene-amplification primers for detecting, quantitatively determining or identifying Vibrio parahaeinolyticus having low possibility of mis-identification and practically sufficient amplification efficiency and amplificatio... | 07/17/2007 |
| 7244560 | Methods and compositions for synthesis of nucleic acid molecules using multiple recognition sites The present invention provides compositions and methods for recombinational cloning. The compositions include vectors having multiple recombination sites and/or multiple topoisomerase recognition sites. The methods permit the simultaneous cloning of two or more diff... | 07/17/2007 |
| 7241882 | Polyamide nucleic acid derivatives, and agents, and processes for preparing them The present invention relates to PNA derivatives which carry, at the N terminus of the PNA backbone, a phosphoryl radical. The phosphoryl radical can be, for example, a phosphate radical, or a substituted phosphoryl radical, with substituted phosphoryl derivatives c... | 07/10/2007 |
| 7235716 | Plant centromere compositions The present invention provides for the nucleic acid sequences of plant centromeres. This will permit construction of stably inherited recombinant DNA constructs and minichromosomes which can serve as vectors for the construction of transgenic plant and animal cells.... | 06/26/2007 |
| 7227057 | Plant centromere compositions The present invention provides for the nucleic acid sequences of plant centromeres. This will permit construction of stably inherited recombinant DNA constructs and minichromosomes which can serve as vectors for the construction of transgenic plant and animal cells.... | 06/05/2007 |
| 7226782 | Plant centromere compositions The present invention provides for the nucleic acid sequences of plant centromeres. This will permit construction of stably inherited recombinant DNA constructs and minichromosomes which can serve as vectors for the construction of transgenic plant and animal cells.... | 06/05/2007 |
| 7223544 | Nucleic acid-engineered materials The present invention relates to the design and use of nucleic acid molecules to create novel materials. The present invention further relates to the use of DNA as a bulding block for DNA-materials that are of high yield and purity and that can be incorporated into ... | 05/29/2007 |
| 7220414 | Degradable polyacetal polymers Degradable polyacetal polymers and functionalized degradable polyacetal polymers have properties favorable for use in pharmaceutical and biomedical applications. The degradable polyacetal polymers are relatively stable at physiological pH with favorable biodistribut... | 05/22/2007 |
| 7217522 | Genetic analysis by sequence-specific sorting The invention provides methods for sorting polynucleotides from a population based on predetermined sequence characteristics. In one aspect, the method of the invention is carried out by extending a primer annealed polynucleotides having predetermined sequence chara... | 05/15/2007 |
| 7214490 | Method of target enrichment and amplification The presently claimed invention provides methods and kits for amplifying a target sequence from within a nucleic acid population. The presently claimed invention provides selection probes which are complementary to at least a portion of said target sequence and mech... | 05/08/2007 |
| 7208278 | Concatameric ligation products: compositions, methods and kits for same The present teachings relate to methods, compositions, and kits for detecting one or more target polynucleotide sequences in a sample, and methods compositions and kits for forming concatameric ligation products. In some embodiments of the present teachings, oligonu... | 04/24/2007 |
| 7202079 | Bovine immunodeficiency virus (BIV) based vectors This invention pertains to BIV constructs encompassing BIV combination vectors, BIV vectors and BIV packaging vectors and particularly the invention pertains to a three vector system comprising: a) a BIV vector construct including a DNA segment from a BIV genome, a ... | 04/10/2007 |
| 7198793 | Bovine immunodeficiency virus (BIV) based vectors This invention pertains to BIV constructs encompassing BIV combination vectors, BIV vectors and BIV packaging vectors and particularly the invention pertains to a three vector system comprising: a) a BIV vector construct including a DNA segment from a BIV genome, a ... | 04/03/2007 |
| 7189519 | Bead-based detection of ligand-GPCR-G protein complexes The present invention provides a general approach for G protein coupled receptors that may be used to define agonists and antagonists, and the specificity of receptor coupling to G protein subunits. Methods of the present invention use small volumes (microliters) an... | 03/13/2007 |
| 7179905 | Nucleic acid labeling compounds Nucleic acid labeling compounds containing heterocyclic derivatives are disclosed. The heterocyclic derivative containing compounds are synthesized by condensing a heterocyclic derivative with a cyclic group (e.g. a ribofuranose derivative). The labeling compounds a... | 02/20/2007 |
| 7160924 | Protein conjugates with a water-soluble biocompatible, biodegradable polymer The present invention broadly relates to the field of protein modification, and, more specifically, to conjugates of proteins or analogs thereof to a water-soluble biocompatible polymer and methods of making and using the same. ... | 01/09/2007 |
| 7153512 | Bovine immunodeficiency virus (BIV) based vectors This invention pertains to BIV constructs encompassing BIV combination vectors, BIV vectors and BIV packaging vectors and particularly the invention pertains to a three vector system comprising: a) a BIV vector construct including a DNA segment from a BIV genome, a ... | 12/26/2006 |
| 7148328 | Compositions and methods for regulating autolytic processes in bacteria A nucleic acid sequence required for regulating the autolytic activity of bacteria is provided. Also provided are polypeptides encoded by the gene or mutant gene as well as vector and host cells for expressing these polypeptides. Methods for identifying and using ag... | 12/12/2006 |
| 7129083 | PiggyBac transformation system The present invention is directed to a transformation systems and vectors for making transgenic organisms that includes a vector containing a modified piggyBac transposon into which is inserted at least one fluorescent protein gene linked to a polyubiquitin promoter... | 10/31/2006 |
| 7129330 | Multivalent antibody constructs The present invention relates to multivalent Fvantibody construct having at least four variable domains which are linked with each over via the peptide linkers 1, 2 and 3. The invention also concerns expression plasmids which code for such an Fv | 10/31/2006 |
| 7125712 | Bovine immunodeficiency virus (BIV) based vectors This invention pertains to BIV constructs encompassing BIV combination vectors, BIV vectors and BIV packaging vectors and particularly the invention pertains to a three vector system comprising: a) a BIV vector construct including a DNA segment from a BIV genome, a ... | 10/24/2006 |
| 7108844 | Use of stabilized oligonucleotides for preparing a medicament with antitumor activity The invention concerns the use of stabilized oligonucleotides comprising at least an octamer motif of the type: 5′-purine-purine-CG-pyrimidine-pyrimidine-X1X2-3′ wherein the pair X1-X2- is AT, AA, CT or TT, for prepari... | 09/19/2006 |
| 7109041 | Display of receptors and analysis of binding interactions and drug libraries A display and method of preparing 7-transmembrane and other receptors for real-time kinetic analysis of binding interactions. The invention includes display on beads and in micelles for multi-well and flow cytometric analysis. The invention is useful for ligand disc... | 09/19/2006 |
