"Rail travel at high speeds is not possible because passengers, unable to breathe, would die of asphyxia."
Dionysius Lardner, Professor of Natural Philosophy and Astronomy at University College, London ; 1830
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| Number | Title | Issue Date |
| 8188253 | Penaeidin gene promoters in tiger shrimp and applications thereof The present invention relates to new penaeidin gene promoters found in tiger shrimps and applications thereof. The promoters of the invention are useful for the development of transgenic shrimps and valuable for the shrimp culture industry. ... | 05/29/2012 |
| 8188252 | Rad51 derived cancer cell specific promoters for targeted anti-cancer therapy Provided are compositions and methods for inhibiting growth of cancer cells. The method of the invention relates to delivering to cells an effective amount of a composition that contains a polynucleotide having a Rad51 promoter or a polynucleotide having at least 95... | 05/29/2012 |
| 8173616 | RNA-induced translational silencing and cellular apoptosis The invention is directed to RNA molecules that can be used to inhibit protein synthesis and to induce cells to undergo apoptosis. It also includes pharmaceutical compositions containing the RNAs that can be used in treating or preventing tumors; abnormal dermatolog... | 05/08/2012 |
| 8168607 | Methods of treating eye diseases in diabetic patients The present invention provides novel molecules, compositions, methods and uses for treating microvascular disorders, eye diseases and respiratory conditions based upon inhibition of the RTP801 gene and/or protein. ... | 05/01/2012 |
| 8168602 | Compositions, kits and methods for identification, assessment, prevention and therapy of cancer The invention relates to compositions, kits, and methods for detecting, characterizing, preventing, and treating human cancer. A variety of chromosomal regions (MCRs) and markers corresponding thereto, are provided, wherein alterations in the copy number of one or m... | 05/01/2012 |
| 8163894 | DNA for eukaryotic expression of CymR The invention relates to a new “gene-switch” (cumate-inducible switch) for mammalian cells, having a mammalian promoter which has a TATA element and is linked to the coding sequence of CymR. This switch is as useful in the development of expression systems and c... | 04/24/2012 |
| 8158770 | Content dependent inhibitors of cytidine deaminases and uses thereof This invention relates to cytidine deaminase inhibitors (Cytidine deaminase inhibitors) of cytidine deaminases and uses thereof. ... | 04/17/2012 |
| 8138325 | Promoter variants for expressing genes in a fungal cell The present invention relates to methods for producing a biological substance, comprising: (a) cultivating a fungal host cell in a medium conducive for the production of the biological substance, wherein the fungal host cell comprises a first nucleic acid sequence e... | 03/20/2012 |
| 8133988 | Tissue specific promoters The invention relates to tissue specific promoters which can be used in plants for one or more of the following purposes: a. altering carbohydrate metabolism b. preventing memory substance loss c. expression of an invertase inhibitor d. expression of a fructosyl tra... | 03/13/2012 |
| 8129514 | Nucleotide sequences for regulating gene expression in plant trichomes and constructs and methods utilizing same Provided is a novel plant regulatory sequence active in trichomes which is derived from the TR4 gene of wild tomato (L. hirsutum) and which comprises a nucleic acid at least 80% identical to SEQ ID NO:26. Also provided are nucleic acid constructs and methods ... | 03/06/2012 |
| 8129513 | Plant senescence-inducible promoter This invention provides a plant senescence-inducible promoter and its relevant recombinant plasmid and transgenic plant. ... | 03/06/2012 |
| 8110672 | Promoter engineering and genetic control The present invention relates to expression cassettes libraries of expression vectors comprising the same, wherein each vector comprises at least one gene of interest and a promoter operatively linked thereto wherein each promoter comprises a nucleic acid, whose seq... | 02/07/2012 |
| 8097714 | Actin regulatory elements for use in plants The present invention provides polynucleotide molecules isolated from Oryza sativa and Zea mays and useful for expressing transgenes in plants. The present invention also provides expression constructs containing the polynucleotide molecules useful for... | 01/17/2012 |
| 8093368 | DR5 gene promoter and SIAH-1 gene promoter The inventors discovered for the first time the nucleotide sequence of the human DR5 gene promoter, the nucleotide sequence of the human Siah-1 gene promoter and what appear to be the core promoter regions thereof. The present invention further provides a screening ... | 01/10/2012 |
| 8088911 | Tubulin regulatory elements for use in plants The present invention provides polynucleotide molecules isolated from Zea mays and Oryza sativa and useful for expressing transgenes in plants. The present invention also provides expression constructs containing the polynucleotide molecules useful for... | 01/03/2012 |
| 8071749 | Constitutive expression cassettes for regulation of plant expression The present invention relates to expression cassettes comprising transcription regulating sequences with constitutive expression profiles in plants obtainable from Arabidopsis thaliana genes At5g17920, At3g03780, At2g01100, At2g34770, At5g61560, At4g00830, At... | 12/06/2011 |
| 8067567 | Modified tert promoter with enhanced tumor-specificity and strength and recombinant vector comprising the same The present invention relates to a transcriptional regulatory sequence with enhanced tumor-specificity and strength and a recombinant vector comprising the transcriptional regulatory sequence. More particularly, the present invention relates to a transcriptional reg... | 11/29/2011 |
| 8058420 | Promoters for regulation of gene expression in plant roots The present invention is directed to promoters isolated from maize and functional equivalents thereto. The promoters of the present invention have particular utility in driving root-specific expression of heterologous genes that impart increased agronomic, horticult... | 11/15/2011 |
| 8058419 | Promoters for regulation of gene expression in plant roots The present invention is directed to promoters isolated from maize and functional equivalents thereto. The promoters of the present invention have particular utility in driving root-specific expression of heterologous genes that impart increased agronomic, horticult... | 11/15/2011 |
| 8058422 | Tissue specific promoters The invention relates to tissue specific promoters which can be used in plants for one or more of the following purposes: a. altering carbohydrate metabolism b. preventing memory substance loss c. expression of an invertase inhibitor d. expression of a fructosyl tra... | 11/15/2011 |
| 8058421 | Promoters for regulation of gene expression in plant roots The present invention is directed to promoters isolated from maize and functional equivalents thereto. The promoters of the present invention have particular utility in driving root-specific expression of heterologous genes that impart increased agronomic, horticult... | 11/15/2011 |
| 8049000 | Early endosperm promoter eep2 This invention relates generally to the field of plant molecular biology. More specifically, this invention relates to methods and reagents for the temporally- and/or spatially-regulated expression of genes, particularly in plant seeds and related female reproductiv... | 11/01/2011 |
| 8044192 | Trichoderma promoter A promoter for use in producing proteins in filamentous fungal host cells is provided. In one embodiment, the promoter comprises SEQ ID NO:1, or a variant or a truncated form thereof that has promoter activity in a host cell. Also provided are recombinant nucleic ac... | 10/25/2011 |
| 8044191 | P EF-TU expression units The present invention relates to the use of nucleic acid sequences for regulating the transcription and expression of genes, the novel promoters and expression units themselves, methods for altering or causing the transcription rate and/or expression rate of genes, ... | 10/25/2011 |
| 8034916 | Expression control elements from the family Compositions and methods for regulating expression of nucleotide sequences of interest in a plant are provided. Compositions include novel nucleic acid molecules, and variants and fragments thereof, for expression control elements isolated from the Lemnaceae ... | 10/11/2011 |
| 8034915 | Gene expression construct Provided are novel nucleic acid molecule encoding modified HAP1 DNA-binding domains. Also provided are novel reporter genes based on GFP and extension. The materials provided by the invention may be used in a variety of methods of activating genes having HAP1 upstre... | 10/11/2011 |
| 8030472 | Compositions and methods for the modification of gene expression Novel isolated plant polynucleotide promoter sequences are provided, together with genetic constructs comprising such polynucleotides. Methods for using such constructs in modulating the transcription of DNA sequences of interest are also disclosed, together with tr... | 10/04/2011 |
| 8017591 | Substituted, non-coding nucleic acid molecule for therapeutic and prophylactic stimulation of the immune system in humans and higher animals Short deoxyribonucleic acid molecules that are partially single-stranded, dumbbell shaped, and covalently closed, which contain one or more unmethylated cytosine guanosine motif (CpG motif) and exhibit immunomodifying effects. Such molecules can be used for immunost... | 09/13/2011 |
| 8017755 | RNA-based transcriptional regulators RNA molecules have been shown to play a variety of functional roles in biological processes. RNA sequences can adopt 3-D conformations able to regulate transcription. RNA-based transcriptional regulators when recruited to a DNA template act to promote or suppress th... | 09/13/2011 |
| 8013139 | Promoter for introducing a gene into a lymphocyte or blood cell and application thereof It is intended to provide a promoter for inducing expression selectively and strongly in an immunocompetent cell and/or a blood cell such as a lymphocyte. In the invention, the object was achieved by finding that HHV6 MIE promoter, HHV7 MIE promoter and HHV7 U95 pro... | 09/06/2011 |
| 8013140 | Promoter for introducing a gene into a lymphocyte or blood cell and application thereof It is intended to provide a promoter for inducing expression selectively and strongly in an immunocompetent cell and/or a blood cell such as a lymphocyte. In the invention, the object was achieved by finding that HHV6 MIE promoter, HHV7 MIE promoter and HHV7 U95 pro... | 09/06/2011 |
| 8013141 | Promoter with high expression strength and over-expression in various tissues of plant, as well as application thereof The invention provides a promoter that has high expression strength and can be over-expressed in various tissues of plant, said promoter is a promoter for banana polyubiquitin (polyubiquitin) gene MhUBQ1, and has a sequence as SEQ ID No: 3. The invention provides fu... | 09/06/2011 |
| 8013138 | Chimeric promoters capable of mediating gene expression in plants upon pathogen infection and uses thereof Described are synthetic promoters capable of mediating gene expression in plants upon pathogen infection. Furthermore, recombinant genes and vectors comprising said chimeric promoters as well as host cells transformed with such chimeric promoters, recombinant genes ... | 09/06/2011 |
| 8008467 | Promoter for introducing a gene into a lymphocyte or blood cell and application thereof It is intended to provide a promoter for inducing expression selectively and strongly in an immunocompetent cell and/or a blood cell such as a lymphocyte. In the invention, the object was achieved by finding that HHV6 MIE promoter, HHV7 MIE promoter and HHV7 U95 pro... | 08/30/2011 |
| 8008466 | Use of untranslated region of osmotin gene to enhance transgene expression in plants The present invention provides methods, vectors and gene constructs for enhancing expression of a recombinant nucleic acid sequence in transgenic plants and plant tissues. According to the present invention, nucleic acid sequences are obtained and/or derived from th... | 08/30/2011 |
| 8003777 | Use of untranslated region of osmotin gene to enhance transgene expression in plants The present invention provides methods, vectors and gene constructs for enhancing expression of a recombinant nucleic acid sequence in transgenic plants and plant tissues. According to the present invention, nucleic acid sequences are obtained and/or derived from th... | 08/23/2011 |
| 7999094 | Promoter molecules for use in plants The present invention relates to polynucleotide molecules for regulating gene expression in plants. In particular, the present invention relates to promoters isolated from Brassica napus that are useful for regulating gene expression of heterologous polynucle... | 08/16/2011 |
| 7994303 | Penaeidin gene promoters in tiger shrimp and applications thereof The present invention relates to new penaeidin gene promoters found in tiger shrimps and applications thereof. The promoters of the invention are useful for the development of transgenic shrimps and valuable for the shrimp culture industry. ... | 08/09/2011 |
| 7989611 | Expression control sequence An expression control sequence which controls expression of a target gene linked downstream of the expression control sequence depending on an intracellular concentration of an amino acid, wherein in a bacterial cell which harbors a DNA construct comprising the expr... | 08/02/2011 |
| 7968700 | Expression augmenting DNA fragments, use thereof, and methods for finding thereof The invention provides recombinant DNA molecules comprising novel expression augmenting DNA fragments and an expression cassette, said expression cassette comprising a heterologous promoter linked to a nucleic acid of interest. The invention further provides uses of... | 06/28/2011 |