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| Number | Title | Issue Date |
| 8114977 | Proteins derived from white spot syndrome virus and uses thereof Embodiments of the present invention generally relate to proteins derived from white spot syndrome virus, nucleic acid sequences encoding them, and their use in the manufacture of a vaccine for prophylaxis and/or treatment of white spot syndrome in crustaceans. ... | 02/14/2012 |
| 8101739 | Recombinant expression vectors comprising a human codon-optimized marburg virus (MARV) angola glycoprotein gene insert and method of immunization employing said vector The invention is related to a nucleic acid molecule comprising a polynucleotide encoding a modified filovirus glycoprotein (GP) having at least one amino acid change located in a relatively conserved region of said GP that decreases in vitro cytotoxicity and retains... | 01/24/2012 |
| 8088910 | Isolated multiple sclerosis (MS)-associated retrovirus (MSRV) nucleic acids corresponding to the gag region An isolated polynucleotide having a nucleotide sequence selected from the group consisting of (a) SEQ ID NO: 21, (b) the full-length sequences encoding a polypeptide having a peptide sequence selected from the group consisting of SEQ ID NOs: 25 and 26, and (c) the f... | 01/03/2012 |
| 8067565 | Dengue serotype 1 attenuated strain The invention relates to live attenuated VDV1 (VERO-Derived Dengue serotype 1 virus) strains which have been derived from the wild-type dengue-1 strain 16007 by passaging on PDK and sanitization on Vero cells and nucleic acids thereof. The invention further relates ... | 11/29/2011 |
| 8067566 | Dengue serotype 2 attenuated strain The invention relates to live attenuated VDV2 (VERO-Derived Vaccine Dengue serotype 2) strains which have been derived from the wild-type dengue-2 strain 16681 by passaging on PDK and Vero cells and nucleic acids thereof. The invention further relates to a vaccine c... | 11/29/2011 |
| 8063195 | Mutations in a toll-like receptor motif in the NS4B of classical swine fever virus strain brescia influences virulence in swine NS4B is one of the non-structural proteins of classical swine fever virus. By using functional genetics, we have discovered, in the predicted amino acid sequence of NS4B of CSFV strain Brescia, a motif that resembles those found in the toll-like receptor (TLR) prote... | 11/22/2011 |
| 8039606 | Seneca Valley virus based compositions and methods for treating disease The present invention relates to a novel RNA picornavirus that is called Seneca Valley virus (“SVV”). The invention provides isolated SVV nucleic acids and proteins encoded by these nucleic acids. Further, the invention provides antibodies that are raised agains... | 10/18/2011 |
| 8022197 | Nucleic acid and gene derived from novel HCV strain and replicon-replicating cell using said gene The present invention relates to a gene derived from a novel fulminant hepatitis C virus strain, an HCV replicon RNA with a high replication efficiency obtained using the gene, and an HCV replicon-replicating cell transfected with the replicon RNA. When the HCV repl... | 09/20/2011 |
| 8017754 | Attenuated virus strains and uses thereof Methods and compositions concerning mutant flaviviruses with reduced virulence. In some embodiments the invention concerns nucleotide sequences that encode mutant flaviviral proteins. Viruses comprising mutant NS1 and NS4B genes display reduced virulence are provide... | 09/13/2011 |
| 7968697 | Hepatitis C virus non-structural NS3/4A fusion gene The creation of mutant hepatitis C virus (HCV) NS3/4A genes encoding proteins with altered protease activity is disclosed. Embodiments include these NS3/4A genes, HCV peptides encoded by these nucleic acids, nucleic acids encoding these HCV peptides, antibodies dire... | 06/28/2011 |
| 7968696 | Viral interleukin-6 The present invention relates to viral interleukin-6 (v-IL-6), which can be obtained by recombinant expression of the DNA of human herpesvirus type 8 (HHV-8), and which may be used in diagnosis and treatment of human diseases such as kaposi sarcoma, Castleman's dise... | 06/28/2011 |
| 7935805 | Polynucleotides encoding antigenic HIV Type C polypeptides, polypeptides and uses thereof The present invention relates to polynucleotides encoding immunogenic HIV type C Pol, Gag- and/or Env-containing polypeptides. Uses of the polynucleotides in applications including DNA immunization, generation of packaging cell lines, and production of Pol, Gag- and... | 05/03/2011 |
| 7910716 | Nucleic acids encoding modified South African HIV-1 subtype C gag proteins Embodiments of the invention provide processes for the selection of HIV-1 subtype (clade) C isolates, selected HIV-1 subtype C isolates, their genes and modifications and derivatives thereof for use in prophylactic and therapeutic vaccines to produce proteins and po... | 03/22/2011 |
| 7897744 | SARS virus nucleotide and amino acid sequences and uses thereof The invention provides, in part, the genomic sequence of a putative coronavirus, the SARS virus, and provides novel nucleic acid and amino acid sequences that may be used, for example, for the diagnosis, prophylaxis, or therapy of a variety of SARS virus related dis... | 03/01/2011 |
| 7858766 | Subunits of the adenovirus fiber protein and uses thereof as vaccines A nucleic acid sequence encoding a fragment of the adenovirus fiber capsid protein, a DNA construct including a replicable expression vector and at least one heterologous nucleic acid, and recombinant protein including fragment of the adenovirus fiber cpasid protein... | 12/28/2010 |
| 7847085 | Recombinant HIV-1 gp120 immunogen with three different V3 loops from viruses of different clades A novel immunogenic HIV-1 Env, particularly gp120, DNA construct is disclosed in which either the V1/V2 loop and the V4 loop, or all three variable loops, including V3, are replaced with a V3 sequence each of which is from a different viral isolate. Preferably, each... | 12/07/2010 |
| 7842798 | Production of attenuated, human-bovine chimeric respiratory syncytial virus vaccines Chimeric human-bovine respiratory syncytial virus (RSV) are infectious and attenuated in humans and other mammals and useful in vaccine formulations for eliciting an anti-RSV immune response. Also provided are isolated polynucleotide molecules and vectors incorporat... | 11/30/2010 |
| 7803926 | Postweaning multisystemic wasting syndrome and porcine circovirus from pigs The cloning of a novel PCVII viral genome is described as is expression of proteins derived from the PCVII genome. These proteins can be used in vaccine compositions for the prevention and treatment of PCVII infections, as well as in diagnostic methods for determini... | 09/28/2010 |
| 7786288 | Immunizing compositions encoding an epitope obtained from the HIV-1 capsid protein cyclophilin A binding site The present invention relates to an immunogenic composition. More particularly, the present invention is a composition directed to eliciting an immune response to at least one binding site of Cyclophilin A on the HIV capsid protein. (SEQ ID NOS: 2, 4, and 6) The pre... | 08/31/2010 |
| 7786287 | Hepatitis C virus assay systems The present invention features assays employing a beta-lactamase reporter system, an HCV replicon enhanced cell, and/or a chimeric HCV replicon containing a 3′ UTR based on the HCV-1a 3′ UTR. These features can be employed alone or together, and are preferably c... | 08/31/2010 |
| 7777020 | Nucleotide sequences derived from the gene of HIV-1 This invention encompasses an env nucleic acid product produced by a process comprising providing a sample containing HIV-1 nucleic acid and amplifying the nucleic acid using primer pairs. ... | 08/17/2010 |
| 7767800 | Nucleic acids obtained from LAV, a variant African AIDS virus A variant of a LAV virus, designated LAVMAL and capable of causing AIDS. The cDNA and antigens of the LAVMAL virus can be used for the diagnosis of AIDS and pre-AIDS. ... | 08/03/2010 |
| 7759477 | HIV-1, HIV-2, and SIV nucleotide fragments The invention relates to polypeptide fragments of HIV-1, HIV-2, and SIV, antibodies that bind to the polypeptides of the invention, methods of using the antibodies, and kits containing the antibodies. The invention also relates to polynucleotides that encode the pol... | 07/20/2010 |
| 7728121 | Hepatitis-C virus type 4, 5 and 6 The present invention relates to a polynucleic acid composition comprising or consisting of at least one polynucleic acid containing 8 or more contiguous nucleotides corresponding to a nucleotide sequence from the region spanning positions 417 to 957 of the Core/E1 ... | 06/01/2010 |
| 7687615 | PAV regions for encapsidation and E1 transcriptional control The present invention provides porcine adenovirus sequence essential for encapsidation and provides adenovirus vectors comprising such sequences. The present invention provides host cells and composition comprising adenovirus vectors comprising porcine adenovirus se... | 03/30/2010 |
| 7626013 | HIV-1 DNA fragments that hybridize to genomic HIV-1DNA The inventors have isolated cloned cDNA encoding the RNA genome of Human Immunodeficiency Virus type 1 (HIV-1). Various clones are described, which encode different regions of the genome, including those regions encoding viral antigens or proteins. Hybridization res... | 12/01/2009 |
| 7572904 | Nucleic acids encoding respiratory syncytial virus subgroup B strain 9320 The complete polynucleotide sequence of the human respiratory syncytial virus subgroup B strain 9320 genome is provided. Proteins encoded by this polynucleotide sequence are also provided. Isolated or recombinant RSV (e.g., attenuated recombinant RSV), nucleic acids... | 08/11/2009 |
| 7544791 | Attenuated rabies virus with nucleoprotein mutation at the phosphorylation site for vaccination against rabies and gene therapy in the CNS A mutant virus is provided which contains a mutation at a phosphorylation site in one or more of the proteins of the virus, which mutation causes the virus to be attenuated, and therefore, an improved vaccine composition can be produced therewith. The invention also... | 06/09/2009 |
| 7524947 | Recombinant viral-based malaria vaccines The present invention relates to novel vaccines against malaria infections, based on recombinant viral vectors, such as alpha viruses, adenoviruses or vaccinia viruses. The recombinant viral-based vaccines can be used to immunize against different Plasmodium ... | 04/28/2009 |
| 7517976 | Polynucleic acids isolated from a porcine reproductive and respiratory syndrome virus (PRRSV) The present invention provides a purified preparation containing a polynucleic acid encoding at least one polypeptide selected from the group consisting of proteins encoded by one or more open reading frames (ORF's) of an Iowa strain of porcine reproductive and resp... | 04/14/2009 |
| 7479554 | AAV5 nucleic acids The present invention provides an adeno-associated virus 5 (AAV5) virus and vectors and particles derived therefrom. In addition, the present invention provides methods of delivering a nucleic acid to a cell using the AAV5 vectors and particles. ... | 01/20/2009 |
| 7479553 | Nucleic acids encoding mutant disulfide bond-stabilized human immunodeficiency virus type 1 (HIV-1) gp140 envelope glycoproteins This invention provides a DNA which upon transcription produces an RNA encoding a modified HIV-1 gp140 polypeptide, which polypeptide upon cleavage produces a modified gp120 and a modified ectodomain of gp41 which together form a complex exhibiting enhanced binding ... | 01/20/2009 |
| 7473772 | Chimeric GB virus B (GBV-B) The present invention relates generally to the fields of biochemistry, molecular biology, and virology. More particularly, it relates to the identification of GB virus B (GBV-B)/HCV chimeras. The invention involves nucleic acid constructs and compositions encoding G... | 01/06/2009 |
| 7465794 | Polynucleotides encoding recombinant respiratory syncytial viruses expressing immune modulatory molecules Recombinant respiratory syncytial virus (RSV) are provided which express one or more immune modulatory molecules. The recombinant virus is modified by addition or substitution of a polynucleotide sequence encoding the immune modulatory molecule, which is preferably ... | 12/16/2008 |
| 7449566 | Polynucleotide encoding novel HCV non-structural polypeptide Polypeptides comprising a mutant non-structural Hepatitis C virus useful in diagnostic and/or immunogenic compositions are disclosed, in which the mutant is an N-terminal mutation that functionally disrupts the catalytic domain of NS3. Polynucleotides encoding these... | 11/11/2008 |
| 7442525 | Method for expressing HIV polypeptides Polynucleotide sequences are provided for the diagnosis of the presence of retroviral infection in a human host associated with lymphadenopathy syndrome and/or acquired immune deficiency syndrome, for expression of polypeptides and use of the polypeptides to prepare... | 10/28/2008 |
| 7439347 | Hepatitis C virus non-structural NS3/4A fusion gene Disclosed herein is the discovery of a novel hepatitis C virus (HCV) isolated from a human patient. Embodiments of the invention include HCV peptides, nucleic acids encoding said HCV peptides, antibodies directed to said peptides, compositions containing said nuclei... | 10/21/2008 |
| 7439058 | HBV/HCV virus-like particle Chimeric antigens derived from hepatitis B virus (HBV) and hepatitis C virus (HCV) are described which form virus-like particles when co-expressed with an excess of hepatitis B virus surface antigen (HBsAg). The chimeric antigens are fusion proteins containing an im... | 10/21/2008 |
| 7438919 | Cold-adapted equine influenza viruses The present invention provides experimentally-generated cold-adapted equine influenza viruses, and reassortant influenza A viruses comprising at least one genome segment of such an equine influenza virus, wherein the equine influenza virus genome segment confers at ... | 10/21/2008 |
| 7423138 | Compositions and methods for treating papillomavirus-infected cells By virtue of the present invention, there is provided methods and compositions for interfering with the proliferation of cells infected and/or transformed by papillomaviruses. The processes and compositions of this invention may be used to treat any mammal, includin... | 09/09/2008 |
