Did You Know...
...that the Band-Aid Bandage was invented by a Johnson & Johnson employee whose wife had cut herself? Earl Dickson's wife was rather accident prone, so he set out to develop a bandage that she could apply without help. He placed a small piece of gauze in the center of a small piece of surgical tape, and what we know today as the Band Aid bandage was born!
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| Number | Title | Issue Date |
| 8188251 | Transport agents for crossing the blood-brain barrier and into brain cancer cells, and methods of use thereof The present invention discloses methods and materials for delivering a cargo compound into a brain cancer cell and/or across the blood-brain barrier. Delivery of the cargo compound is accomplished by the use of protein transport peptides derived from Neisseria | 05/29/2012 |
| 8188250 | Butanol dehydrogenase enzyme from the bacterium From a bacterial strain isolated from an environmental sample, after enrichment in medium containing 1-butanol as the carbon source, a new enzyme with butanol dehydrogenase activity was identified. The enzyme can convert butyraldehyde to 1-butanol, isobutyraldehyde ... | 05/29/2012 |
| 8143386 | Fusion proteins of antigens and their uses The present invention relates to fusion proteins containing at least two Mycobacterium tuberculosis antigens. In particular, it relates to bi-fusion proteins which contain two individual M. tuberculosis antigens, tri-fusion proteins which contain three... | 03/27/2012 |
| 8143387 | Engineered antibody-stress protein fusions Provided are fusion polypeptides comprising an engineered antibody and a stress protein that bind to antigens with high affinity, are highly immunogenic, exhibit MHC class I priming and are able to be produced in non-mammalian cells, such as E. coli. ... | 03/27/2012 |
| 8138324 | Expression system for proteins The invention provides a novel system for the tunable expression of nucleic acids encoding e.g., polypeptides such as recombinant proteins in prokaryotic systems. The system is based on the ability of T7 lysozyme (T7Lys) to inhibit the activity of T7RNAP. Expression... | 03/20/2012 |
| 8124750 | Recombinant protective protein from The present invention discloses amino acid sequences and nucleic acid sequences relating to a Streptococcus pneumoniae surface associated Pneumo Protective Protein (PPP) having a molecular weight of about 20 kilo Daltons (kDa). The PPP exhibits the ability to... | 02/28/2012 |
| 8114976 | genes and gene products for chemotherapeutic, immunoprophylactic and diagnostic applications Cryptosporidium hominis genes and gene products are provided. The genes and gene products are useful for chemotherapeutic, immunotherapeutic, immunoprophylactic and diagnostic applications. ... | 02/14/2012 |
| 8088909 | Ex vivo animal or challenge model as method to measure protective immunity directed against parasites and vaccines shown to be protective in the method The invention relates to an ex vivo animal or challenge model as a method to identify protective (recombinant) proteins and rapidly measure protective immunity in intestinal segments directed against parasites and vaccines directed against parasitic infections. The ... | 01/03/2012 |
| 8084212 | Assay for nucleic acid Disclosed is a method for determining the presence of Mycobacterium avium complex nucleic acids in a biological sample. In particular, the IS1245 gene of M. avium and the DT1 gene of M. intracellulare are detected, preferably following amplifica... | 12/27/2011 |
| 8080647 | Tetracycline repressor and uses thereof Compositions and methods relating to the use of tetracycline repressor in plants are provided. Compositions include a polynucleotide modified for expression in a plant, wherein the polynucleotide encodes a tetracycline repressor protein, as well as constructs, vecto... | 12/20/2011 |
| 8076469 | TB diagnostic based on antigens from The present invention is based on the identification and characterization of a number of novel M. tuberculosis derived proteins and protein fragments. The invention is directed to the polypeptides and immunologically active fragments thereof, the genes encodi... | 12/13/2011 |
| 8076470 | VMP-like sequences of pathogenic species and strains The present invention relates to DNA sequences encoding Vmp-like polypeptides of pathogenic Borrelia, the use of the DNA sequences in recombinant vectors to express polypeptides, the encoded amino acid sequences, application of the DNA and amino acid sequence... | 12/13/2011 |
| 8071747 | Fusion proteins of mycobacterium tuberculosis The present invention relates to compositions and fusion proteins containing at least two Mycobacterium sp. antigens, and nucleic acids encoding such compositions and fusion proteins. The compositions of the invention increase serological sensitivity of sera ... | 12/06/2011 |
| 8071748 | Thermophilic and thermoacidophilic sugar transporter genes and enzymes from and related organisms, methods Isolated and/or purified polypeptides and nucleic acid sequences encoding polypeptides from Alicyclobacillus acidocaldarius are provided. Further provided are methods for transporting sugars across cell membranes using isolated and/or purified polypeptides an... | 12/06/2011 |
| 8063192 | Microbial reductive dehalogenation of vinyl chloride Compositions and methods are provided that relate to the bioremediation of chlorinated ethenes, particularly the bioremediation of vinyl chloride by Dehalococcoides-like organisms. An isolated strain of bacteria, Dehalococcoides sp. strain VS, that met... | 11/22/2011 |
| 8063193 | Nucleotide and amino acid sequences encoding an exported protein 1 derived from and uses thereof The present invention is directed to novel polynucleotides and polypeptides directed to EXP1 of Plasmodium vivax, and methods of using these polynucleotides and polypeptides in the detection of P. vivax antibodies or anti-P. vivax antibodies in ... | 11/22/2011 |
| 8063194 | Specific arabinose transporter from the yeast , and uses thereof The present invention relates to a polypeptide which has a novel specific arabinose transporter function as well as to nucleic acids coding therefore. The invention further relates to host cells, in particular modified yeast strains which contain the coding nucleic ... | 11/22/2011 |
| 8044189 | protective antigen nucleic acid sequences The invention relates to improved methods of producing and recovering B. anthracis protective antigen (PA), especially modified PA which is protease resistant, and to methods of using of these PAs or nucleic acids encoding these PAs for eliciting an immunogen... | 10/25/2011 |
| 8044188 | Genetically engineered clostridial genes, proteins encoded by the engineered genes, and uses thereof The present invention relates to an isolated Clostridial neurotoxin propeptide having a light chain region, a heavy chain region, where the light and heavy chain regions are linked by a disulfide bond, and an intermediate region connecting the light and heavy chain ... | 10/25/2011 |
| 8039605 | Targeting of long chain triacylglycerol hydrolase gene for tuberculosis treatment Disclosed herein are novel methods for screening for compounds useful in treating or preventing tuberculosis. In exemplary embodiments, screening methods are based on the implementation or manipulation of triacylglycerol hydrolase like polypeptides or polynucleotide... | 10/18/2011 |
| 8039604 | DNA sequence encoding penicillin acylase, novel recombinant recombinant DNA constructs and recombinant microorganisms The invention consists in a nucleotide sequence having the size of (2646) bp, wherein the order of nucleotides is identical to the order of the nucleotide sequence encoding penicillin acylase from Achromobacter sp. CCM 4824 (formerly Comamonas testosteroni... | 10/18/2011 |
| 8030471 | and genes and uses thereof The subject invention relates to nucleic acid sequences and amino acid sequences encoded thereby, derived from the Merozoite Surface Protein (MSP1) gene of the Plasmodium species P. malariae and P. ovale. Such genes and proteins have many benefi... | 10/04/2011 |
| 8026354 | Recombinant merozoite surface proteins 4 and 5 and their use Accordingly, the invention provides constructs in which the nucleic acids encoding Plasmodium falciparum MSP4 and MSP5, and the resulting polypeptides, have been modified. More particularly, this invention provides constructs encoding recombinant MSP4 and MSP... | 09/27/2011 |
| 8017753 | Mycobacterial antigens expressed under low oxygen tension A method is provided for identifying mycobacterial genes that are induced or up-regulated under continuous culture conditions defined by a dissolved oxygen tension of up to 10% air saturation measured at 37° C. when compared with a dissolved oxygen tension of at le... | 09/13/2011 |
| 8008465 | Nucleic acids encoding chimera botulinum toxin type E The present invention relates to a toxin comprising a modified light chain of a botulinum toxin type E, wherein the modified light chain comprises amino acid sequence PFVNKQFN (SEQ ID NO: 120) at the N-terminus, and amino acid sequence xExxxLL (SEQ ID NO: 112) at th... | 08/30/2011 |
| 8003776 | Mycobacterial antigens expressed during latency A method is provided for identifying mycobacterial genes that are induced or up-regulated under culture conditions that are nutrient-starving and which maintain mycobacterial latency, said conditions being obtainable by batch fermentation of a mycobacterium for at l... | 08/23/2011 |
| 8003775 | Nucleic acid and amino acid sequences relating to for diagnostics and therapeutics The invention provides isolated polypeptide and nucleic acid sequences derived from Streptococcus pneumoniae that are useful in diagnosis and therapy of pathological conditions; antibodies against the polypeptides; and methods for the production of the polype... | 08/23/2011 |
| 7989610 | Protein, a gene encoding therefor and a method of using the same An object of the present invention is to search and identify novel antifungal proteins capable of inhibiting the growth of plant pathogenic microorganisms including Magnaporthe grisea and Rhizoctonia solani causing two major rice diseases at relatively... | 08/02/2011 |
| 7982025 | Fusion proteins of The present invention relates to fusion proteins containing at least two Mycobacterium species antigens. In particular, it relates to nucleic acids encoding fusion proteins that include two or more individual M. tuberculosis antigens, which increase se... | 07/19/2011 |
| 7973153 | Fusion proteins of mycobacterium tuberculosis The present invention relates to compositions and fusion proteins containing at least two Mycobacterium sp. antigens, and nucleic acids encoding such compositions and fusion proteins. The compositions of the invention increase serological sensitivity of sera ... | 07/05/2011 |
| 7968694 | Tuberculosis antigen detection assays and vaccines The present invention relates to isolated Tuberculosis (TB) antigens that are useful in therapeutic and vaccine compositions for stimulating a TB specific immunological response. The identified antigens are also useful in diagnostic assays to determine the presence ... | 06/28/2011 |
| 7968695 | Nucleic acids encoding recombinant 56 and 82 kDa antigens from gametocytes of and their uses The present invention provides the recombinant cloning and sequencing of two of the major Eimeria maxima gametocyte antigens having molecular weights of 56 and 82 kDa and the expression of these recombinant antigens in an E. coli expression system usin... | 06/28/2011 |
| 7960535 | Recombinant lipidated PsaA protein, methods of preparation and use The present invention relates to recombinant lipidated PsaA proteins and recombinant constructs from which such lipidated PsaA proteins may be expressed. The invention relates further to lipidated PsaA proteins in which lipidation is effected by the use of a heterol... | 06/14/2011 |
| 7960534 | Thermophilic and thermoacidophilic sugar transporter genes and enzymes from alicyclobacillus acidocaldarius and related organisms, methods Isolated and/or purified polypeptides and nucleic acid sequences encoding polypeptides from Alicyclobacillus acidocaldarius are provided. Further provided are methods for transporting sugars across cell membranes using isolated and/or purified polypeptides an... | 06/14/2011 |
| 7960533 | Nucleic acids coding for adhesion factor of group B , adhesion factors of group B and further uses thereof The present invention is related to nucleic acids coding for adhesion factors of group B streptococcus, adhesion factors of group B streptococcus and uses thereof. More particularly, the present invention is related to a polypeptide being such adhesion... | 06/14/2011 |
| 7935804 | Engineered and methods of use thereof The invention provides a bacterium containing a polynucleotide comprising a nucleic acid encoding a heterologous antigen, as well as fusion protein partners. Also provided are vectors for mediating site-specific recombination and vectors comprising removable antibio... | 05/03/2011 |
| 7932373 | Proteins expressed by mycobacterium tuberculosis and not by BCG and their use as diagnostic reagents and vaccines The invention provides polypeptides encoded by open reading frames present in the genome of Mycobacterium tuberculosis but absent from the genome of BCG and diagnostic and prophylactic methodologies using these polypeptides. ... | 04/26/2011 |
| 7928215 | Methods of screening for compounds that inhibit the biosynthesis of GPI in malaria parasites The present inventors succeeded in isolating GWT1 (PfGWT1), which is one of the enzymes involved in GPI biosynthesis in the malaria parasite P. falciparum. In addition, the inventors revealed that degenerate mutant DNAs, with a lower AT content than the DNA e... | 04/19/2011 |
| 7919609 | Toxins Novel bacterial insecticidal proteins and equivalents thereof were isolated. These proteins and the DNA sequences encoding them are useful to make insecticidal compositions or transgenic plants to protect plants from damage by insects, particularly coleopteran insec... | 04/05/2011 |
| 7910715 | Alleles of the oxyR gene from coryneform bacteria The invention relates to mutants and alleles of the oxyR gene of coryneform bacteria coding for variants of the OxyR transcription regulator and processes for producing amino acids using bacteria which comprise these alleles. ... | 03/22/2011 |
