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| Number | Title | Issue Date |
| 7960361 | Nucleic acid cancer immunotherapy A method for stimulating a immune response against IL-13Rα2 in a subject having or at risk for developing a disease having cells expressing IL-13Rα2 includes the steps of formulating the anti-cancer vaccine outside of the subject and administering the vaccine to t... | 06/14/2011 |
| 7868151 | Recombinant human interferon-like proteins This application relates to recombinant human interferon-like proteins. In one embodiment a recombinant protein created by gene shuffling technology is described having enhanced anti-viral and anti-proliferative activities in comparison to naturally occurring human ... | 01/11/2011 |
| 7767799 | Nucleic acid molecules encoding recombinant interferon-α2 (IFNα2) mutants The present invention provides IFNα2 mutants and active fragments, analogs, derivatives, and variants thereof that have improved specific agonist or antagonist activity as compared to wild-type IFNα2. The present invention further provides pharmaceutical compositi... | 08/03/2010 |
| 7419805 | Polynucleotides encoding S99T interferon gamma polypeptide variants and means of expression The present invention relates to novel interferon gamma polypeptide variants having interferon gamma (IFNG) activity, methods for their preparation, pharmaceutical compositions comprising the polypeptide variants and their use in the treatment of diseases, in partic... | 09/02/2008 |
| 7390638 | S99T C-11 Truncated polynucleotides encoding interferon gamma polypeptide variants When interferon gamma (IFNG) is produced in mammalian cell lines a heterogenous population of IFNG polypeptides is obtained due to C-terminal processing of the IFNG polypeptide. Clearly, this constitutes a severe problem in that valuable polypeptide material is lost... | 06/24/2008 |
| 7390637 | Keratinocyte derived interferon The present invention relates to a novel KDI protein which is a member of the interferon family. In particular, isolated nucleic acid molecules are provided encoding a human interferon polypeptide, called “KDI”. KDI polypeptides are also provided as are vectors,... | 06/24/2008 |
| 7388087 | Enhancement of immune response to vaccine by interferon alpha Exogenous cDNA capable of expressing interferon α activity, exogenous interferon α protein, inducers of endogenous interferon α protein activity, inducers of endogenous interferon β protein activity, inducers of endogenous interfereon Γ activity, or inducers of... | 06/17/2008 |
| 7364724 | Recombinant super-compound interferon This invention provides a recombinant super-compound interferon or an equivalent thereof with changed spatial configuration. The super-compound interferon possesses anti-viral or anti-tumor activity and therefore is useful to prevent and treat viral diseases and can... | 04/29/2008 |
| 7355056 | Transfection agents The present invention provides compounds, compositions and methods that enhance the transfer of an agent into a cell. The agents can include polypeptides, polynucleotides such as genes and antisense nucleic acids, and other molecules. In some embodiments, the agents... | 04/08/2008 |
| 7252969 | Interferon-like protein Zcyto21 The present invention relates to polynucleotide and polypeptide molecules for Zcyto21, an interferon-like protein, which is most closely related to interferon-α at the amino acid sequence level. The present invention also includes antibodies to the Zcyto21 polypept... | 08/07/2007 |
| 7253151 | Genes of IL-12P40 subunit mutated for improving the activity of IL-12 and use thereof for DNA vaccine adjuvant The present invention relates to the IL-12p40 subunit mutant gene which can produce IL-12(interleukin 12) of human and mouse origin with high activity, the expression vector including above mutant gene and the use of them to DNA vaccine adjuvant. Particularly, it re... | 08/07/2007 |
| 7214367 | Orally-administered interferon-tau compositions and methods The present invention includes interferon-tau (IFNτ) pharmaceutical compositions useful for oral administration to treat cancers, autoimmune disorders (particularly multiple sclerosis), cell proliferative disorders and viral disease. ... | 05/08/2007 |
| 7214368 | Therapeutic regimen for treating cancer comprising the administration of adenoviral vectors comprising a TNF-α transgene The invention provides a method for treating a tumor in a human comprising administering to the tumor a dose of a pharmaceutical composition comprising (i) a pharmaceutically acceptable carrier and (ii) an adenoviral vector comprising a nucleic acid sequence encodin... | 05/08/2007 |
| 7173116 | Nucleic acid formulations for gene delivery and methods of use A nucleic acid formulation for use in gene delivery comprising a nucleic acid and an anionic polymer is disclosed. Examples of the anionic polymer includes aniionic amino acid polymer or poly-amino acid (such as poly-L-glutamic acid, poly-D-glutamic acid, poly-L-asp... | 02/06/2007 |
| 7141392 | Latent fusion protein The present invention provides a method for providing latency to a pharmaceutically active agent. The method has application in overcoming the toxic effect of systemic administration of potent biological agents. The method comprises associating a fusion protein comp... | 11/28/2006 |
| 7033749 | Ribonuclease resistant RNA preparation and utilization The present invention relates to nuclease resistant nucleic acids in general and ribonuclease resistant RNAs in particular. Methods of making and using such nucleic acids are disclosed. ... | 04/25/2006 |
| 6972322 | Interferon and albumin fusion protein Biologically active polypeptides comprising a therapeutically active polypeptide fused to human serum albumin or a variant thereof, methods for the preparation thereof, nucleotide sequences encoding such fusion polypeptides, expression cassettes comprising such nucl... | 12/06/2005 |
| 6936440 | Selecting ligand agonists and antagonists We have discovered that growth hormones from ternary complexes with their receptors in which site 1 on the hormone first binds to one molecule of receptor and then hormone site 2 then binds to another molecule of receptor, thereby producing a 1:2 complex. We believe... | 08/30/2005 |
| 6936695 | Manufacture and expression of large structural genes Illustrated is the preparation and expression of manufactured genes capable of directing synthesis of human immune and leukocyte interferons and of other biologically active proteinaceous products, which products differ from naturally-occurring forms in terms of the... | 08/30/2005 |
| 6930167 | DNA encoding bovine immunoglobulin a inducing protein and uses therefor The invention provides an isolated and purified nucleic acid molecule encoding mammalian immunoglobulin A inducing protein (IGIP), and methods of using the IGIP nucleic acid molecule and IGIP. ... | 08/16/2005 |
| 6927040 | Interferon-like protein Zcyto21 The present invention relates to polynucleotide and polypeptide molecules for Zcyto21, an interferon-like protein, which is most closely related to interferon-α at the amino acid sequence level. The present invention also includes antibodies to the Zcyto21 polypept... | 08/09/2005 |
| 6906041 | Treatment of immune diseases The invention concerns the use of a nucleic acid capable of expressing beta-interferon for the preparation of a pharmaceutical composition for the treatment of an immune disease. ... | 06/14/2005 |
| 6875748 | Compositions and methods for in vivo delivery of polynucleotide-based therapeutics The present invention relates to pharmaceutical compositions and methods to improve expression of exogenous polypeptides into vertebrate cells in vivo, utilizing delivery of polynucleotides encoding such polypeptides. More particularly, the present invention provide... | 04/05/2005 |
| 6835557 | DNA sequences, recombinant DNA molecules and processes for producing human interferon-like polypeptides DNA sequences, recombinant DNA molecules and hosts transformed with them which produce polypeptides displaying a biological or immunological activity of human interferon, the genes coding for these polypeptides and methods of making and using these molecules, hosts,... | 12/28/2004 |
| 6808923 | Episomally replicating lentiviral vectors The invention is directed to a lentiviral vector system that can be used for episomal replication of a desired gene. The vector system contains a first vector containing a lentiviral gag gene encoding a lentiviral gag protein, a second vector containing an env gene ... | 10/26/2004 |
| 6747131 | Phosphorylated fusion proteins Modified proteins, modified interferons α's and β's, phosphorylated modified proteins and DNA sequences encoding the above, applications and uses thereof. Modified phosphorylated Hu-IFN-α-like proteins are provided which carry an identifiable label such as a radi... | 06/08/2004 |
| 6716607 | Chicken interferon gene and novel recombinant DNA A chicken interferon gene coding for the amino acid sequence of SEQ ID NO:1 is disclosed. There is also disclosed a method of producing chicken interferon recombinantly, a method of isolating other non-mammalian interferon genes, a method of making a transgenic fowl... | 04/06/2004 |
| 6703225 | Interferon- A novel human IFN- subtype and its derivative having an unprecedentedly high specific activity, DNA encoding these proteins, an expression vector having said DNA, a transformant transformed with said expression vector, a method of producing the abo... | 03/09/2004 |
| 6685933 | Interferon hybrids Hybrid human interferon- polypeptides, and the corresponding nucleic acid molecules, are disclosed. Pharmaceutical compositions comprising these peptides, and the use of these polypeptides to treat viral disease and regulate cell growth are also pr... | 02/03/2004 |
| 6664077 | DNA encoding ACPL The invention is directed to purified and isolated novel ACPL polypeptides, the nucleic acids encoding such polypeptides, processes for production of recombinant forms of such polypeptides, antibodies generated against these polypeptides, fragmented pepti... | 12/16/2003 |
| 6610830 | Microbial production of mature human leukocyte interferons Disclosed herein are methods and means of microbially producing, via recombinant DNA technology, mature human leukocyte interferons, useful in the treatment of viral and neoplastic diseases.... | 08/26/2003 |
| 6593124 | Hybrid genes for expression of stimulatory factors in activated T cells Recombinant vectors are provided that render the proliferative response of activated lymphocytes, particularly cytotoxic T lymphocytes, of lessened dependency on T helper cells. The vectors are comprised of a region encoding a stimulatory factor polypepti... | 07/15/2003 |
| 6541610 | Fusion proteins comprising tumor necrosis factor receptor Fusion proteins having a tumor necrosis factor receptor (TNF-R) polypeptide and at least one additional polypeptide covalently fused thereto and selected from an interleukin-1 receptor (IL-1R) and a second TNF-R polypeptide. The receptor polypeptides are ... | 04/01/2003 |
| 6509033 | Immunomodulatory peptides A purified preparation of a peptide consisting essentially of an amino acid sequence identical to that of a segment of a naturally-occurring human protein, said segment being of 10 to 30 residues in length, inclusive, wherein said peptide binds to a human... | 01/21/2003 |
| 6497871 | Recombiniant gamma interferons having enhanced stability and methods therefor The present invention relates to novel, stable recombinant gamma interferons exhibiting in greater or less degree the antiviral and antiproliferative activity in humans and pH 2 labile properties characteristic of native human gamma interferon. The amino ... | 12/24/2002 |
| 6482613 | Microbial production of mature human leukocyte interferons Disclosed herein are methods and means of microbially producing, via recombinant DNA technology, mature human leukocyte interferons, useful in the treatment of viral and neoplastic diseases.... | 11/19/2002 |
| 6451986 | Site specific protein modification Processes for conjugating proteins with polyethylene glycol are disclosed. The disclosed processes provide modified proteins having little or no decrease in their activity and include the steps of deleting at least one amino acid residue on the protein, r... | 09/17/2002 |
| 6432677 | Non-human animal interferons Distinct -, ଲ- and γ-interferon genes from various animal species have been identified, cloned and expressed to produce the corresponding non-human animal interferon proteins. Specifically disclosed are interferons of bovine, porcine, feline... | 08/13/2002 |
| 6433158 | Site specific protein modification Processes for conjugating proteins with polyethylene glycol are disclosed. The disclosed processes provide modified proteins having little or no decrease in their activity and include the steps of deleting at least one amino acid residue on the protein, r... | 08/13/2002 |
| 6428985 | Immunosuppressive structural definition of IL-10 Disclosed is the surprising discovery that a single amino acid provides the demarcation between the immunosuppressive and immunostimulatory properties of the cytokine, IL-10. The present invention thus provides mammalian and human IL-10 genes and polypept... | 08/06/2002 |
