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| Number | Title | Issue Date |
| 8044187 | Human luteinizing hormone superagonists The invention is directed toward a human glycoprotein hormone having at least one, two, three, four, or five basic amino acids in the α-subunit at positions selected from the group consisting of positions 11, 13, 14, 16, 17, and 20. The invention is also directed t... | 10/25/2011 |
| 8022195 | Vectors encoding cell growth and adhesion factors for simultaneous growth and adhesion of cells The present invention relates to endothelial and smooth muscle cells genetically altered to express or over-express one or more cell adhesion factors. The invention further relates to cells genetically altered to express or over-express both cell proliferation growt... | 09/20/2011 |
| 7812146 | Hybrid hepatocyte growth factor gene having high expression efficiency of two heterotypes of hepatocyte growth factor The present invention relates to a hybrid Hepatocyte Growth Factor (HGF) gene which is prepared by inserting an inherent or foreign intron between exons 4 and 5 in HGF cDNA, which has a base sequence of SEQ ID NO: 2. The gene has high expression efficiency and simul... | 10/12/2010 |
| 7473771 | Polypeptide hormone phosphatonin The present invention relates to a novel human protein called phosphatonin, and isolated polynucleotides encoding this protein. Also provided are vectors, host cells, antibodies, and recombinant methods for producing this human protein. The invention further relates... | 01/06/2009 |
| 7423139 | High level expression of recombinant human erythropoietin having a modified 5′-UTR The present invention provides an expression construct capable of producing high levels of erythropoietin in mammalian cells. More particularly, the expression construct includes an erythropoietin coding region fused to a unique 5′-UTR sequence and a truncated 3â€... | 09/09/2008 |
| 7399848 | Polynucleotides encoding growth differentiation factor-8 Disclosed are polynucleotides encoding growth differentiation factor-8 (GDF-8) useful for increasing the muscle mass in chickens. ... | 07/15/2008 |
| 7374912 | Nucleic acids encoding chimeric interleukin-6 soluble receptor/ligand protein, analogs thereof and uses thereof Chimeric proteins constructed from the fusion of the naturally occurring form of the soluble IL-6 receptor and IL-6 which are useful for treatment of cancer and liver disorders, enhancement of bone marrow transplantation, and treatment of other IL-6 related conditio... | 05/20/2008 |
| 7355038 | Phase isolation process for biomacromolecule components The present invention relates to a phase isolation process for biomacromolecule components, after pretreating the substance to be isolated: 1) adding sufficient amount of buffer (one of the compound selected from ammonium sulfate, cesium chloride, sodium sulfate, an... | 04/08/2008 |
| 7354739 | TML polynucleotides The present invention is directed to polynucleotides, peptides, variants, and uses thereof for a novel peptide fragment designated TML peptides. Binding of the peptide fragment has been shown in kidney and small intestine. The present invention further includes agon... | 04/08/2008 |
| 7351815 | Canine pre-proGHRH and mature GHRH genes The present invention relates to a canine pre-proGHRH polypeptide, a canine mature GHRH peptide, an isolated polynucleotide which encodes the canine pre-proGHRH or the canine mature GHRH. The invention also encompasses vectors encoding and expressing the canine pre-... | 04/01/2008 |
| 7338787 | Nucleic acids encoding OBG3 globular head and uses thereof The present invention relates to the field of obesity research. Obesity is a public health problem that is serious and widespread. A compound, globular OBG3, has been identified that reduces weight gain in animals. This compound should be effective for reducing body... | 03/04/2008 |
| 7317095 | Mutant glycoproteins The inventors have designed novel FSH mutants with increased glycosylation and longer half-lives for use in inducing folliculogenesis in human patients. The use of a FSH mutant preparation of the invention permits the use of lower cumulative doses of FSH to achieve ... | 01/08/2008 |
| 7304150 | Methods and compositions for the prevention and treatment of anemia Methods for increasing and maintaining hematocrit in a mammal comprising administering a hyperglycosylated analog of erythropoietin are disclosed. An analog may be administered less frequently than an equivalent molar amount of recombinant human erythropoietin to ob... | 12/04/2007 |
| 7282557 | Nucleic acids encoding a G-protein coupled receptor involved in sensory transduction The invention provides isolated nucleic acid and amino acid sequences of sensory cell specific G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of sensory cell s... | 10/16/2007 |
| 7276481 | Method and composition for treatment of skeletal dysplasias The present invention discloses pharmaceutical compositions for the treatment of skeletal dysplasias, comprising as an active ingredient at least one natriuretic peptide. Unexpectedly, it has been shown that the natriuretic factors may be effective for bone elongati... | 10/02/2007 |
| 7270967 | Nucleic acids encoding a G-protein coupled receptor involved in sensory transduction The invention provides isolated nucleic acid and amino acid sequences of sensory cell specific G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of sensory cell s... | 09/18/2007 |
| 7267963 | Modified plant viruses and methods of use thereof The present invention relates to modulating the nature and/or level of an immune response to a molecule. In particular, the invention relates to effecting an increase in the TH1 immune response to molecules such as, but not limited to, antigens or immunogens. The in... | 09/11/2007 |
| 7259293 | Expression of eukaryotic peptides in plant plastids Constructs and methods are provided for expressing peptides derived from eukaryotic organisms in plant plastids. Constructs have a promoter functional in a plant plastid, a DNA sequence encoding a peptide derived from an eukaryotic organism and a transcription termi... | 08/21/2007 |
| 7259253 | Genes associated with mechanical stress, expression products therefrom, and uses thereof The disclosure relates to human and mechanical stress induced genes, in particular gene 608, and functional equivalents, probes therefor, tests to identify such genes, polypeptide expression products of such genes, antibodies to the polypeptides, uses for such genes... | 08/21/2007 |
| 7253254 | Polypeptide variants with increased heparin-binding capacity The invention pertains to polypeptide variants with increased heparin-binding ability. Increased heparin-binding ability is achieved by addition, insertion, and/or substitution of an amino acid sequence X1X2X3X4X5 | 08/07/2007 |
| 7250406 | Compositions and methods for the acceleration of protein secretion dynamics The present invention provides compositions and methods for modulating the secretion of transcriptionally regulated proteins from recombinant cells. More particularly, the present invention provides compositions and methods for accelerating the secretion dynamics of... | 07/31/2007 |
| 7244591 | Yeast transformant producing recombinant human parathyroid hormone and method for producing the hormone Novel Saccharomyces Cerevisiae mutant strains are provided for producing human parathyroid hormone. The novel strains acre genetically disrupted in at least one of the genes encoding the yapsin family of proteases Yapsin 1, Yapsin 2 and Yapsin 3 and harbor a ... | 07/17/2007 |
| 7244834 | Nucleic acids encoding PTH functional domain conjugate peptides Novel parathyroid hormone (PTH) peptides and analogs thereof of the PTH(1–34) fragment are disclosed that combine the N-terminal signaling domain (residues 1–9) and the C-terminal binding domain (residues 15–31) via a linker. Nucleic acid molecules and peptide... | 07/17/2007 |
| 7241617 | Sendai viral vectors comprising foreign genes inserted between the R1 and R2 Loci Use of a negative-sense RNA virus vector has enabled transfer of nucleic acid into nerve cells. The method of this invention can be used for introducing a gene efficiently into nerve cells including the central nerve tissue in gene therapy, etc. ... | 07/10/2007 |
| 7232667 | Keratinocyte growth factor-2 polynucleotides This invention relates to newly identified polynucleotides, polypeptides encoded by such polynucleotides, the use of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides. More particularly, the polypeptide of the ... | 06/19/2007 |
| 7230157 | Chemical inducible promoter used to obtain transgenic plants with a silent marker and organisms and cells and methods of using same for screening for mutations Disclosed is a chemically inducible promoter for transforming plants or plant cells with genes which are regulatable by adding the plants or cells to a medium containing an inducer or by removing them from such medium. The promoter is inducible by a glucocorticoid, ... | 06/12/2007 |
| 7226758 | Nucleic acids encoding glial cell line-derived neurotrophic factor (GDNF) A novel neurotrophic factor referred to as glial cell line-derived neurotrophic factor (GDNF) has been identified and isolated from serum free growth conditioned medium of B49 glioblastoma cells. Rat and human genes encoding GDNF have been cloned and sequenced. A ge... | 06/05/2007 |
| 7223563 | Fibroblast growth factor (FGF23) nucleic acids The invention relates to novel nucleic acids encoding a fibroblast growth factor-23(FGF23) and proteins encoded thereby, mutations in which are associated with autosomal dominant rickets (ADHR). The invention further relates to methods of diagnosing and treating hyp... | 05/29/2007 |
| 7223406 | Methods and compositions for preventing and treating male erectile dysfunction and female sexual arousal disorder The invention provides a method for preventing or treating male erectile dysfunction or female sexual arousal disorder by administering an effective amount of one or more factors from a group of factors including vascular endothelial growth factor, brain-derived neu... | 05/29/2007 |
| 7217689 | Glycosylation analogs of erythropoietin Erythropoietin analogs having at least one additional site for glycosylation, or a rearrangement of at least one site for glycosylation are disclosed. The invention also relates to DNA sequences encoding said erythropoietin analogs, and recombinant plasmids and host... | 05/15/2007 |
| 7186529 | Preparation of erythropoietin by endogenous gene activation The invention relates to human cells which are capable, on the basis of an activation of the endogenous human EPO gene, of producing EPO in a sufficient amount and purity to make possible a cost-effective production of human EPO as a pharmaceutical preparation. The ... | 03/06/2007 |
| 7179621 | Pigment epithelium-derived factor: sequence of the PEDF gene Nucleic acids encoding the neurotrophic protein known as pigment epithelium derived factor (PEDF), a truncated version of PEDF referred to as rPEDF, and equivalent proteins, vectors comprising such nucleic acids, host cells into which such vectors have been introduc... | 02/20/2007 |
| 7176292 | Ghrelin variant protein The present invention concerns a protein produced from an alternative splice form of the human Ghrelin gene, an obesity and/or diabetes related gene. ... | 02/13/2007 |
| 7173116 | Nucleic acid formulations for gene delivery and methods of use A nucleic acid formulation for use in gene delivery comprising a nucleic acid and an anionic polymer is disclosed. Examples of the anionic polymer includes aniionic amino acid polymer or poly-amino acid (such as poly-L-glutamic acid, poly-D-glutamic acid, poly-L-asp... | 02/06/2007 |
| 7166461 | Polynucleotides encoding a super-active porcine growth hormone releasing hormone analog Inadequate growth due to deficiencies in growth hormone (GR), growth hormone releasing hormone (GHRH), or genetic diseases can be ameliorated utilizing recombinant protein therapy with a novel GHRH analog having a sequence (SEQ ID NO:1). Also included is (1) a metho... | 01/23/2007 |
| 7153951 | Bioactive peptides and peptide derivatives of parathyroid hormone (PTH) and parathyroid hormone-related peptide (PTHrP) Novel parathyroid hormone peptide (PTH) and parathyroid hormone related peptide (PTHrP) or derivatives thereof which are biologically active are disclosed, as are pharmaceutical compositions containing such peptides, and synthetic and recombinant methods for produci... | 12/26/2006 |
| 7144997 | Vertebrate embryonic patterning-inducing proteins, compositions and uses related therto It is shown here that hedgehog proteins possess novel activities beyond phenotype specification. Using cultures derived from the embryonic day 14.5 (E14.5) rat ventral mesencephalon, we show that hedgehog is also trophic for dopaminergic neurons. Interestingly, hedg... | 12/05/2006 |
| 7141389 | Chromosome DNA coding for human hepatocyte growth factor A chromosome DNA which codes for human hepatocyte growth factor, a recombinant expression vector capable of expressing the DNA, a transformant transformed with the expression vector and a method of producing recombinant human hepatocyte growth factor. The DNA and po... | 11/28/2006 |
| 7122654 | Vascular endothelial growth factor D (VEGF-D) antibodies and vectors, and methods of use VEGF-D, a new member of the PDGF family of growth factors, which among other things stimulates endothelial cell proliferation and angiogenesis and increases vascular permeability, as well as nucleotide sequences encoding it, methods for producing it, antibodies and ... | 10/17/2006 |
| 7122351 | Dimerized PDGF-D and materials and methods for producing it Proteins consisting of two PDGF-D polypeptide chains, polynucleotides encoding the polypeptides, and materials and methods for making the proteins are disclosed. Each of the polypeptide chains consists of, from amino terminus to carboxyl terminus, the following oper... | 10/17/2006 |
