Class 536/23.4 - Encodes a fusion protein

Subclass of Class 536 - Organic compounds -- part of the class 532-570 series
Definition: Compounds which are DNA fragments which encode specific
No. of patents: 2245
Last issue date: 05/08/2012

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Number	Title	Issue Date
8173792	Method for regulating protein function in cells using synthetic small molecules Methods and compositions for the rapid and reversible destabilizing of specific proteins using cell-permeable, synthetic molecules are described. Stability-affecting proteins, e.g., derived from FKBP and DHFR proteins are fused to a protein of interest and the prese...	05/08/2012
8163893	Pseudotyped retroviral vectors and methods of use thereof The present invention provides nucleic acids encoding recombinant envelope proteins; and packaging cells comprising the nucleic acids, which packaging cells provide for encapsidation of recombinant retroviral vectors. The present invention provides producer cells th...	04/24/2012
8138322	Human T1R2 nucleic acid sequences and polypeptides Binding assays for identifying compounds that modulate human T1R2 polypeptide associated taste are disclosed. These assays detect the specific binding of compounds to a human T1R2 polypeptide or the modulation of the specific binding of a compound that specifically ...	03/20/2012
8114974	Engineered microorganisms with enhanced fermentation activity Provided herein are genetically modified microorganisms that have enhanced fermentation activity, and methods for making and using such microorganisms. ...	02/14/2012
8106176	Matrix metalloproteinase 11 vaccine Compositions comprising matrix metalloproteinase 11 (MMP-11) or stromelysin-3 (ST-3) or the nucleic acid encoding the MMP-11 for use in vaccines for treating tumors and cancers, which overexpress MMP-11, are described. In particular embodiments, the compositions com...	01/31/2012
8084596	Regulated apoptosis We have developed a general procedure for the regulated (inducible) dimerization or oligomerization of intracellular proteins and disclose methods and materials for using that procedure to regulatably initiate cell-specific apoptosis (programmed cell death) in genet...	12/27/2011
8084597	Artificial entropic bristle domain sequences and their use in recombinant protein production Compositions and methods for recombinant protein production and, more particularly, fusion polypeptides, polynucleotides encoding fusion polypeptides, expression vectors, kits, and related methods for recombinant protein production. ...	12/27/2011
8071743	Nucleic acids encoding a G-protein coupled receptor involved in sensory transduction The invention provides isolated nucleic acid and amino acid sequences of sensory cell specific G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of sensory cell s...	12/06/2011
8071744	TRP/HIS exchange and kynurenin induced TRP transport The present invention provides methods for detecting changes in tryptophan concentrations in a cell and methods for identifying agents that modulate cellular tryptophan concentrations. In particular, the present invention provides methods for detecting cellular exch...	12/06/2011
8071742	Method and composition for crystallizing G protein-coupled receptors Certain embodiments provide a method for crystallizing a GPCR. The method may employ a fusion protein comprising: a) a first portion of a G-protein coupled receptor (GPCR), where the first portion comprises the TM1, TM2, TM3, TM4 and TM5 regions of the GPCR; b) a st...	12/06/2011
8063191	Polynucleotides encoding for fusion proteins with natriuresis activity This document provides methods and material related to natriuretic polypeptides. For example, substantially pure polypeptides having a natriuretic peptide activity, nucleic acids encoding polypeptides having a natriuretic peptide activity, host cells containing such...	11/22/2011
7985553	Method for isolating cell type-specific mRNAs The invention provides methods and compositions for isolation and assessment of riboprotein complexes. ...	07/26/2011
7973150	Reducing the immunogenicity of fusion proteins Disclosed are compositions and methods for producing fusion proteins with reduced immunogenicity. Fusion proteins of the invention include a junction region having an amino acid change that reduces the ability of a junctional epitope to bind to MHC Class II, thereby...	07/05/2011
7964712	Chimeric nucleic acids encoding polypeptides comprising TNF alpha, CD70 and FAS ligand domains The present invention is directed to an isolated polynucleotide sequence encoding a chimeric TNFα, comprising a first nucleotide sequence encoding a domain or subdomain of a tumor necrosis factor ligand other than TNFα, wherein the encoded domain or subdomain repl...	06/21/2011
7964710	EML4-ALK fusion gene The present inventors found that a fusion gene present in some cancer patients is an oncogene. The present invention relates to a polypeptide as a novel fusion protein, a polynucleotide encoding the polypeptide, a vector comprising the polynucleotide, a transformed ...	06/21/2011
7964711	Compositions comprising polynucleotides encoding TACI-immunoglobulin fusion proteins and methods for producing the same Molecules that interfere with the binding of a tumor necrosis factor receptor with its ligand, such as a soluble receptor, have proven usefulness in both basic research and as therapeutics. The present invention provides improved soluble transmembrane activator and ...	06/21/2011
7960529	Bone delivery conjugates and method of using same to target proteins to bone A bone delivery conjugate having a structure selected from the group consisting of: A) X-Dn-Y-protein-Z; and B) Z-protein-Y-Dn-X, wherein X is absent or is an amino acid sequence of at least one amino acid; Y is absent or is an amino acid seque...	06/14/2011
7928213	Nucleic acids encoding chimeric CD154 polypeptides The present invention provides for an isolated polynucleotide sequence encoding a chimeric CD154, comprising a first nucleotide sequence encoding an extracellular subdomain of non-human CD154, preferably murine CD154, that replaces a cleavage site of human CD154, an...	04/19/2011
7915395	Expression vectors encoding bispecific fusion proteins and methods of producing biologically active bispecific fusion proteins in a mammalian cell The present invention provides an expression vector encoding monospecific or bispecific fusion protein. In one embodiment the expression vector encodes a monospecific fusion protein, which vector comprises a recombinant monospecific single chain cassette comprising ...	03/29/2011
7906638	Chimeric nucleic acids encoding polypeptides comprising CD70 and Fas ligand domains This invention relates to genes which encode accessory molecule ligands and their use for immunomodulation, vaccination and treatments of various human diseases, including malignancies and autoimmune diseases. This invention also describes the use of accessory molec...	03/15/2011
7897742	Twin-arginine translocation in Described herein are methods to enhance protein secretion in a host cell. In preferred embodiment, the host cell is a gram-positive microorganism such as a Bacillus. In another preferred embodiment, the host cell is a gram-negative microorganism. Preferably t...	03/01/2011
7847080	Chimeric T1R1 taste receptor encoding nucleic acid sequences and vectors Newly identified mammalian taste-cell-specific G protein-coupled receptors, and the genes and cDNA encoding said receptors are described. Specifically, T1R G protein-coupled receptors active in taste signaling, and the genes and cDNA encoding the same, are described...	12/07/2010
7847079	Albumin fusion proteins The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors containing these nucleic acids, host cells transformed with these nucleic ac...	12/07/2010
7847081	Nucleic acids encoding B7-H4, a T cell immunoregulatory molecule The invention provides novel B7-H3 and B7-H4 polypeptides useful for co-stimulating T cells, isolated nucleic acid molecules encoding them, vectors containing the nucleic acid molecules, and cells containing the vectors. Also included are methods of making and using...	12/07/2010
7834165	Nucleic acid sequence and vectors encoding chimeric human T1R3 taste receptor Newly identified mammalian taste-cell-specific G protein-coupled receptors, and the genes and cDNA encoding said receptors are described. Specifically, T1R G protein-coupled receptors active in taste signaling, and the genes and cDNA encoding the same, are described...	11/16/2010
7829687	Artificial disulfide isomerases and uses thereof The present invention provides artificial enzymes comprising, e.g., an N-terminal domain derived from E. coli FkpA that allows for dimerization and provides a substrate binding region, and a C-terminal thioredoxin domain derived from E. coli DsbA. Simi...	11/09/2010
7816506	Methods and constructs for producing transgenic plants and methods of recovering expressed proteins This disclosure relates to a regulatory element useful for genetically engineering sugarcane or other monocots, to the transformation of the monocots with the regulatory element so that they produce a desired product, and to the regeneration of the monocots transfor...	10/19/2010
7807809	Molecular characterization of chromosome translocation t(11;18)(q21;q21) and its correlation to carcinogenesis Methods for determining whether a tissue sample or an analogue and/or derivative thereof comprises a cell with a chromosome (11:18) translocation associated with malignancies such as mucosa-associated lymphoid tissue (MALT) lymphomas. The invention further provides ...	10/05/2010
7803924	HSP60 from arthrobacter The hsp60 gene from a strain of Arthrobacter has been isolated and sequenced. The encoded protein is believed to be highly immunogenic, especially in fish, and also has utility as a non-specific adjuvant, and as an adjuvanting carrier for heterologous antigen...	09/28/2010
7795411	Vectors for expressing in vivo biotinylated recombinant proteins The present invention provides compositions and methods for generating in vivo biotinylated, secreted recombinant polypeptides comprising recombinantly co-expressing in a yeast cell (a) a secreted recombinant polypeptide comprising a biotin accepting site; and (b) a...	09/14/2010
7790870	Membrane-anchored GP41 peptides that inhibit subsequent HIV viral entry The invention relates to the genetically engineered treatment of an HIV infection by the expression of membrane-anchored gp41 peptides. With this treatment vectors are made available for the first time which code for a fusion protein that contains a peptide derived ...	09/07/2010
7786282	Nucleic acid molecules encoding TNF-α ligand polypeptides having a CD154 domain The present invention is directed to an isolated polynucleotide sequence encoding a chimeric TNFα and chimeric TNFα polypeptides. The former have a first nucleotide sequence encoding a domain or subdomain of a tumor necrosis factor ligand other than TNFα, wherein...	08/31/2010
7781574	Chimeric osteogenic factor containing proteins capable of increased nuclear localization and methods of use thereof Compositions comprising osteogenic factors fused with membrane transduction domains of viral proteins are provided. Also provided are methods of expression and use of such compositions. Further, the methods of making such compositions are also provided. The methods ...	08/24/2010
7777016	Neurotransmitter sensors and methods of using the same Neurotransmitter biosensors are disclosed, including YbeJ-based glutamate binding biosensors, comprising a neurotransmitter binding domain conjugated to donor and fluorescent moieties that permit detection and measurement of Fluorescence Resonance Energy Transfer up...	08/17/2010
7772385	Chimeric T1R1 taste receptor encoding nucleic acid sequences and vectors Newly identified mammalian taste-cell-specific G protein-coupled receptors, and the genes and cDNA encoding said receptors are described. Specifically, T1R G protein-coupled receptors active in taste signaling, and the genes and cDNA encoding the same, are described...	08/10/2010
7750136	Modified bouganin proteins, cytotoxins and methods and uses thereof The invention provides modified forms of bouganin protein having biological activity and a reduced propensity to activate human T cells as compared to the non-modified bouganin protein. The invention also provides T-cell epitope peptides of bouganin, and modified T-...	07/06/2010
7732586	Modified bacteriocins and methods for their use Modified forms of naturally occurring bacteriocins, such as the R-type pyocins of Pseudomonas aeruginosa, are disclosed. The bacteriocins are modified at the ends of their tail fibers in a region responsible for binding specificity and affinity to their cogna...	06/08/2010
7728120	EML4-ALK fusion gene The present inventors found that a fusion gene present in some cancer patients is an oncogene. The present invention relates to a polypeptide as a novel fusion protein, a polynucleotide encoding the polypeptide, a vector comprising the polynucleotide, a transformed ...	06/01/2010
7709621	Vectors with modified protease-dependent tropism The present invention provides cell fusogenic vectors having replicative ability, whose protease-dependent tropism has been modified. M gene-deficient viral vectors encoding modified F proteins, in which the cleavage site of the F protein of paramyxovirus is modifie...	05/04/2010
7705139	Zinc finger proteins for DNA binding and gene regulation in plants Disclosed herein are modified plant zinc finger proteins; compositions comprising modified plant zinc finger proteins and methods of making and using modified plant zinc finger proteins. The modified plant zinc finger proteins, in contrast to naturally-occurring pla...	04/27/2010

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Class 536/23.4 - Encodes a fusion protein