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Class 536/23.2 - Encodes an enzyme


Subclass of Class 536 - Organic compounds -- part of the class 532-570 series
Definition: Compounds which are DNA fragments which encode specific
No. of patents: 6486
Last issue date: 02/07/2012


1                      
NumberTitleIssue Date
8110670Enhanced production of fatty acid derivatives
Genetically engineered cells and microorganisms are provided that produce products from the fatty acid biosynthetic pathway (fatty acid derivatives), as well as methods of their use. The products are particularly useful as biofuels. ...
02/07/2012
8101738ABFB-2 gene from
The invention relates to the abfB-2 gene of Penicillium funiculosum that codes for a type B α-L-arabinofuranosidase and has a cellulose binding domain. The enzyme α-L-arabinofuranosidase can be incorporated in nutritional additives or in foods for animals f...
01/24/2012
8088906FAD4, FAD5, FAD5-2, and FAD6, novel fatty acid desaturase family members and uses thereof
The invention provides isolated nucleic acid molecules which encode novel fatty acid desaturase family members. The invention also provides recombinant expression vectors containing desaturase nucleic acid molecules, host cells into which the expression vectors have...
01/03/2012
8071741Stable recombinant adenosine deaminase
A mutein recombinant adenosine deaminase having any oxidizable cysteine residue replaced by a non-oxidizable amino acid residue is disclosed. Stabilized recombinant adenosine deaminase, polymer conjugates and methods of treatment using the same are also disclosed.
12/06/2011
8071740Promoters exhibiting endothelial cell specificity and methods of using same for regulation of angiogenesis
Isolated polynucleotide sequences exhibiting endothelial cell specific promoter activity, novel cis regulatory elements and methods of use thereof enabling treatment of diseases characterized by aberrant neovascularization or cell growth are disclosed. ...
12/06/2011
8067561Isolated DNA encoding recombinant glucose isomerase
This invention provides a series of recombinant Thermoanaerobacterium saccharolyticum glucose isomerases with improved catalytic activity and thermostability obtained by using recombinant techniques. These recombinant glucose isomerases comprise amino acid va...
11/29/2011
8058417Biosynthetic pathway and genes required for tropodithietic acid biosynthesis in silicibacter TM1040
Production and use of a sulfur-containing compound, tropodithietic acid (TDA), from the roseobacter Silicibacter sp. TM1040 is described. Specifically, a biosynthetic and regulatory pathway for TDA biosynthesis in roseobacters is described. The TDA pro...
11/15/2011
8034913Recombinantly modified plasmin
Polynucleotides and polypeptides relating to a recombinantly-modified plasmin(ogen) molecule are provided. The plasmin(ogen) molecule has a single kringle domain N-terminal to the activation site present in the native human plasminogen molecule, and exhibits lysine-...
10/11/2011
8034914Nucleic acid constructs, pharmaceutical compositions and methods of using same for treating cancer
A nucleic acid construct that includes (i) a first nucleic acid sequence encoding TNF alpha; (ii) a second nucleic acid sequence encoding a Diphtheria toxin; and (iii) at least one additional nucleic acid sequence of a cancer specific promoter. The TNF alpha and Dip...
10/11/2011
8017750Haemocoagulase
The present invention provides a venene haemocoagulase gene and its expression for the functional protein. The haemocoagulase gene of the present invention has a nucleotide sequence shown by the sequence list SEQ ID NO: 1 or the mutated nucleotide sequence formed by...
09/13/2011
8013137Modified enteropeptidase protein
Disclosed are novel enteropeptidase polypeptides, polynucleotides encoding the polypeptides, nucleotide constructs, vectors, host cells comprising the polynucleotides, and methods for producing the polypeptides and polynucleotides. Such polypeptides are useful as pr...
09/06/2011
8008461Carbonyl reductase, gene therefor and use thereof
The present invention is to provide a process for efficiently producing an optically active alcohol including (R)-3-hydroxy-3-phenylpropanenitrile. One of the features of the present invention is a polypeptide having an activity of asymmetrically reducing 3-oxo-3-ph...
08/30/2011
8003772Chimeric PUFA polyketide synthase systems and uses thereof
Disclosed are chimeric polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) proteins and chimeric PUFA PKS systems, including chimeric PUFA PKS proteins and systems derived from Schizochytrium and Thraustochytrium. Disclosed are nucleic acids an...
08/23/2011
8003773Polynucleotides encoding MHC class I-restricted hTERT epitopes, analogues thereof or polyepitopes
This invention relates to the field of anticancer therapy, and to the identification of immunogenic peptides derived from the human telomerase reverse transcriptase (hTERT). The present invention relates to polynucleotides encoding hTERT epitopes restricted to MHC c...
08/23/2011
7985849B12 dependent dehydratases with improved reaction kinetics
Sequences of B12-dependent dehydratases with improved reaction kinetics are presented. Use of these B12-dependent dehydratases reduce the rate of the enzyme's suicide inactivation in the presence of glycerol and 1,3-propanediol. The enzymes wer...
07/26/2011
7977469Fad4, fad5, fad5-2, and fad6, novel fatty acid desaturase family members and uses thereof
The invention provides isolated nucleic acid molecules which encode novel fatty acid desaturase family members. The invention also provides recombinant expression vectors containing desaturase nucleic acid molecules, host cells into which the expression vectors have...
07/12/2011
7968692Elongase genes and uses thereof
The subject invention relates to the identification of several genes involved in the elongation of polyunsaturated fatty acids (i.e., “elongases”) and to uses thereof. At least two of these genes are also involved in the elongation of monounsaturated fatty acids...
06/28/2011
7960528Perhydrolase providing improved peracid stability
An acetyl xylan esterase variant having perhydrolytic activity is provided for producing peroxycarboxylic acids from carboxylic acid esters and a source of peroxygen. More specifically, a Thermotoga maritima acetyl xylan esterase gene was modified using error...
06/14/2011
7951927Reconstructed human mariner transposon capable of stable gene transfer into chromosomes in vertebrates
The present invention refers to a gene transfer system for stably introducing nucleic acid(s) into the DNA of a cell by using a member of the human mariner transposases. The invention further refers to this transposase and to transposons used in the inventive gene t...
05/31/2011
7939649Polynucleotide encoding luciferase
Briefly described, embodiments of this disclosure include polynucleotides that encode mutant Cnidarian luciferases that exhibit modulated properties as compared to the corresponding wild-type luciferases, and the modulated properties include at least one of: modulat...
05/10/2011
7935803Polynucleotides encoding proteins for covalent tethering to functional groups and substrates
A mutant hydrolase optionally fused to a protein of interest is provided. The mutant hydrolase is capable of forming a bond with a substrate for the corresponding nonmutant (wild-type) hydrolase which is more stable than the bond formed between the wild-type hydrola...
05/03/2011
7935802Lignan glycosidase and utilization of the same
The present invention provides an enzyme having the lignan glycosidation activity by identifying the enzyme that is involved in the production of lignan glycosides, identifying the amino acid sequence of the enzyme polypeptide and the base sequence for a polynucleot...
05/03/2011
7932370Sequence-determined DNA fragments encoding cyclopropyl isomerase proteins
The present invention provides DNA molecules that constitute fragments of the genome of a plant, and polypeptides encoded thereby. The DNA molecules are useful for specifying a gene product in cells, either as a promoter or as a protein coding sequence or as an UTR ...
04/26/2011
7906637Compositions and methods for inducing or inhibiting activities of selected human cells
Polynucleotides encoding a mutant human carboxylesterase enzyme and polypeptides encoded by the polynucleotides which are capable of metabolizing a prodrug and inactive metabolites thereof to active drug are provided. Compositions and methods for sensitizing cells t...
03/15/2011
7902348Janus family kinases and identification of immune modulators
An isolated polynucleotide encodes JAK-3 protein. JAK-3 protein is a protein tyrosine kinase having a molecular weight of approximately 125 kDa which has tandem non-identical catalytic domains, lacks SH2 or SH3 domains, and is expressed in NK cells and stimulated or...
03/08/2011
7893234EPSP synthase highly tolerant of glyphosate
An isolated polypeptide comprising an amino acid sequence that is at least 62% identical to SEQ ID NO:2. The polypeptide, when present in a cell, increases the cell's ability to tolerate glyphosate. Also disclosed are related nucleic acid, antibody, vector, transgen...
02/22/2011
7872111Process for producing protein with reduction of acidic sugar chain and glycoprotein produced thereby
A protein participating in the addition of mannose phosphate to a sugar chain of a glycoprotein originating in a yeast belonging to the genus Pichia; a gene coding this protein; a mutant of this gene; a vector carrying the mutant gene; a yeast strain belongin...
01/18/2011
7847077PUFA polyketide synthase systems and uses thereof
The invention generally relates to polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems, to homologues thereof, to isolated nucleic acid molecules and recombinant nucleic acid molecules encoding biologically active domains of such a PUFA PKS system, t...
12/07/2010
7847078PDE11A mutations in adrenal disease
The invention provides previously uncharacterized variants of PDE11A that are correlated with a newly discovered form of Cushing Syndrome that presents at a young age. The invention also provides methods useful to research, screen for, treat, or prevent diagnose the...
12/07/2010
7842796PUFA polyketide synthase systems and uses thereof
The invention generally relates to polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems isolated from or derived from non-bacterial organisms, to homologues thereof, to isolated nucleic acid molecules and recombinant nucleic acid molecules encoding bi...
11/30/2010
7838649PUFA polyketide synthase systems and uses thereof
The invention generally relates to polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems, to homologues thereof, to isolated nucleic acid molecules and recombinant nucleic acid molecules encoding biologically active domains of such a PUFA PKS system, t...
11/23/2010
7829685Regulation of kinase, regulated in COPD kinase (RC kinase)
Reagents which regulate human RC Kinase activity and reagents which bind to human RC Kinase gene products can be used to regulate this protein for therapeutic effects. Such regulation is particularly useful for treating chronic obstructive pulmonary disease, asthma,...
11/09/2010
7829686Nucleic acid encoding a subunit of Na,K-ATPase
A recombinant Na+, K+-ATPase α1-subunit protein resistant to cardiac glycosides, e.g. oubain, is disclosed, as well as methods for its production and use. The resistance to cardiac glycosides are obtained by alterations in the region situated between and including ...
11/09/2010
7816504PUFA polyketide synthase systems and uses thereof
The invention generally relates to polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems isolated from or derived from non-bacterial organisms, to homologues thereof, to isolated nucleic acid molecules and recombinant nucleic acid molecules encoding bi...
10/19/2010
7816505PUFA polyketide synthase systems and uses thereof
The invention generally relates to polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems, to homologues thereof, to isolated nucleic acid molecules and recombinant nucleic acid molecules encoding biologically active domains of such a PUFA PKS system, t...
10/19/2010
7799904Gilvocarcin gene cluster, recombinant production and use thereof
A nucleic acid molecule encoding the gilvocarcin V gene cluster and subunits thereof. Recombinant vectors and host cells comprising a nucleic acid compound encoding the gilvocarcin V gene cluster or subunits thereof. Host cells comprising recombinant vectors encodin...
09/21/2010
7795234Newly identified human small intestine extracellular lactase-phlorizin hydrolase (ecLPH) gene
The invention provides a transgenic animal producing low-lactose milk, which is transformed with a gene encoding an extracellular lactase-hydrolyzing enzyme cloned from a human small intestinal cDNA library. The invention also provides a new extracellular lactase-ph...
09/14/2010
7786280Isolated genomic polynucleotide fragments from chromosome 10q25.3 that encode human soluble aminopeptidase P
The invention is directed to an isolated genomic polynucleotide fragment that encodes human soluble (cytosolic) aminopeptidase P, vectors and hosts containing the fragment and fragments hybridizing to noncoding regions as well as antisense oligonucleotides to these ...
08/31/2010
7786281Protein-deamidating enzyme, microorganism producing the same, gene encoding the same, production process therefor, and use thereof
A method for the production of an enzyme, which comprises culturing in a medium a strain that belongs to a bacterium classified into Cytophagales or Actinomycetes, or a new bacterium Chryseobacterium sp. No. 9670 belonging to the genus Chryse...
08/31/2010
7759476Double-stranded RNAS directed to IKK-2
Compositions and methods are provided for treating NF-κB-related conditions. In particular, the invention provides a stimulus-inducible IKK signalsome, and components and variants thereof. An IKK signalsome or component thereof may be used, for example, to identify...
07/20/2010
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