Celebrity Inventors
Glam girl Heddy Lamar may have used her good looks to good effect on the silver screen, but she put her smarts to better use as an inventor. During World War II, she co-patented a frequency-switching system for torpedo guidance that was considered years ahead of its time.
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| Number | Title | Issue Date |
| 8110670 | Enhanced production of fatty acid derivatives Genetically engineered cells and microorganisms are provided that produce products from the fatty acid biosynthetic pathway (fatty acid derivatives), as well as methods of their use. The products are particularly useful as biofuels. ... | 02/07/2012 |
| 8101738 | ABFB-2 gene from The invention relates to the abfB-2 gene of Penicillium funiculosum that codes for a type B α-L-arabinofuranosidase and has a cellulose binding domain. The enzyme α-L-arabinofuranosidase can be incorporated in nutritional additives or in foods for animals f... | 01/24/2012 |
| 8088906 | FAD4, FAD5, FAD5-2, and FAD6, novel fatty acid desaturase family members and uses thereof The invention provides isolated nucleic acid molecules which encode novel fatty acid desaturase family members. The invention also provides recombinant expression vectors containing desaturase nucleic acid molecules, host cells into which the expression vectors have... | 01/03/2012 |
| 8071741 | Stable recombinant adenosine deaminase A mutein recombinant adenosine deaminase having any oxidizable cysteine residue replaced by a non-oxidizable amino acid residue is disclosed. Stabilized recombinant adenosine deaminase, polymer conjugates and methods of treatment using the same are also disclosed. | 12/06/2011 |
| 8071740 | Promoters exhibiting endothelial cell specificity and methods of using same for regulation of angiogenesis Isolated polynucleotide sequences exhibiting endothelial cell specific promoter activity, novel cis regulatory elements and methods of use thereof enabling treatment of diseases characterized by aberrant neovascularization or cell growth are disclosed. ... | 12/06/2011 |
| 8067561 | Isolated DNA encoding recombinant glucose isomerase This invention provides a series of recombinant Thermoanaerobacterium saccharolyticum glucose isomerases with improved catalytic activity and thermostability obtained by using recombinant techniques. These recombinant glucose isomerases comprise amino acid va... | 11/29/2011 |
| 8058417 | Biosynthetic pathway and genes required for tropodithietic acid biosynthesis in silicibacter TM1040 Production and use of a sulfur-containing compound, tropodithietic acid (TDA), from the roseobacter Silicibacter sp. TM1040 is described. Specifically, a biosynthetic and regulatory pathway for TDA biosynthesis in roseobacters is described. The TDA pro... | 11/15/2011 |
| 8034913 | Recombinantly modified plasmin Polynucleotides and polypeptides relating to a recombinantly-modified plasmin(ogen) molecule are provided. The plasmin(ogen) molecule has a single kringle domain N-terminal to the activation site present in the native human plasminogen molecule, and exhibits lysine-... | 10/11/2011 |
| 8034914 | Nucleic acid constructs, pharmaceutical compositions and methods of using same for treating cancer A nucleic acid construct that includes (i) a first nucleic acid sequence encoding TNF alpha; (ii) a second nucleic acid sequence encoding a Diphtheria toxin; and (iii) at least one additional nucleic acid sequence of a cancer specific promoter. The TNF alpha and Dip... | 10/11/2011 |
| 8017750 | Haemocoagulase The present invention provides a venene haemocoagulase gene and its expression for the functional protein. The haemocoagulase gene of the present invention has a nucleotide sequence shown by the sequence list SEQ ID NO: 1 or the mutated nucleotide sequence formed by... | 09/13/2011 |
| 8013137 | Modified enteropeptidase protein Disclosed are novel enteropeptidase polypeptides, polynucleotides encoding the polypeptides, nucleotide constructs, vectors, host cells comprising the polynucleotides, and methods for producing the polypeptides and polynucleotides. Such polypeptides are useful as pr... | 09/06/2011 |
| 8008461 | Carbonyl reductase, gene therefor and use thereof The present invention is to provide a process for efficiently producing an optically active alcohol including (R)-3-hydroxy-3-phenylpropanenitrile. One of the features of the present invention is a polypeptide having an activity of asymmetrically reducing 3-oxo-3-ph... | 08/30/2011 |
| 8003772 | Chimeric PUFA polyketide synthase systems and uses thereof Disclosed are chimeric polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) proteins and chimeric PUFA PKS systems, including chimeric PUFA PKS proteins and systems derived from Schizochytrium and Thraustochytrium. Disclosed are nucleic acids an... | 08/23/2011 |
| 8003773 | Polynucleotides encoding MHC class I-restricted hTERT epitopes, analogues thereof or polyepitopes This invention relates to the field of anticancer therapy, and to the identification of immunogenic peptides derived from the human telomerase reverse transcriptase (hTERT). The present invention relates to polynucleotides encoding hTERT epitopes restricted to MHC c... | 08/23/2011 |
| 7985849 | B12 dependent dehydratases with improved reaction kinetics Sequences of B12-dependent dehydratases with improved reaction kinetics are presented. Use of these B12-dependent dehydratases reduce the rate of the enzyme's suicide inactivation in the presence of glycerol and 1,3-propanediol. The enzymes wer... | 07/26/2011 |
| 7977469 | Fad4, fad5, fad5-2, and fad6, novel fatty acid desaturase family members and uses thereof The invention provides isolated nucleic acid molecules which encode novel fatty acid desaturase family members. The invention also provides recombinant expression vectors containing desaturase nucleic acid molecules, host cells into which the expression vectors have... | 07/12/2011 |
| 7968692 | Elongase genes and uses thereof The subject invention relates to the identification of several genes involved in the elongation of polyunsaturated fatty acids (i.e., “elongases”) and to uses thereof. At least two of these genes are also involved in the elongation of monounsaturated fatty acids... | 06/28/2011 |
| 7960528 | Perhydrolase providing improved peracid stability An acetyl xylan esterase variant having perhydrolytic activity is provided for producing peroxycarboxylic acids from carboxylic acid esters and a source of peroxygen. More specifically, a Thermotoga maritima acetyl xylan esterase gene was modified using error... | 06/14/2011 |
| 7951927 | Reconstructed human mariner transposon capable of stable gene transfer into chromosomes in vertebrates The present invention refers to a gene transfer system for stably introducing nucleic acid(s) into the DNA of a cell by using a member of the human mariner transposases. The invention further refers to this transposase and to transposons used in the inventive gene t... | 05/31/2011 |
| 7939649 | Polynucleotide encoding luciferase Briefly described, embodiments of this disclosure include polynucleotides that encode mutant Cnidarian luciferases that exhibit modulated properties as compared to the corresponding wild-type luciferases, and the modulated properties include at least one of: modulat... | 05/10/2011 |
| 7935803 | Polynucleotides encoding proteins for covalent tethering to functional groups and substrates A mutant hydrolase optionally fused to a protein of interest is provided. The mutant hydrolase is capable of forming a bond with a substrate for the corresponding nonmutant (wild-type) hydrolase which is more stable than the bond formed between the wild-type hydrola... | 05/03/2011 |
| 7935802 | Lignan glycosidase and utilization of the same The present invention provides an enzyme having the lignan glycosidation activity by identifying the enzyme that is involved in the production of lignan glycosides, identifying the amino acid sequence of the enzyme polypeptide and the base sequence for a polynucleot... | 05/03/2011 |
| 7932370 | Sequence-determined DNA fragments encoding cyclopropyl isomerase proteins The present invention provides DNA molecules that constitute fragments of the genome of a plant, and polypeptides encoded thereby. The DNA molecules are useful for specifying a gene product in cells, either as a promoter or as a protein coding sequence or as an UTR ... | 04/26/2011 |
| 7906637 | Compositions and methods for inducing or inhibiting activities of selected human cells Polynucleotides encoding a mutant human carboxylesterase enzyme and polypeptides encoded by the polynucleotides which are capable of metabolizing a prodrug and inactive metabolites thereof to active drug are provided. Compositions and methods for sensitizing cells t... | 03/15/2011 |
| 7902348 | Janus family kinases and identification of immune modulators An isolated polynucleotide encodes JAK-3 protein. JAK-3 protein is a protein tyrosine kinase having a molecular weight of approximately 125 kDa which has tandem non-identical catalytic domains, lacks SH2 or SH3 domains, and is expressed in NK cells and stimulated or... | 03/08/2011 |
| 7893234 | EPSP synthase highly tolerant of glyphosate An isolated polypeptide comprising an amino acid sequence that is at least 62% identical to SEQ ID NO:2. The polypeptide, when present in a cell, increases the cell's ability to tolerate glyphosate. Also disclosed are related nucleic acid, antibody, vector, transgen... | 02/22/2011 |
| 7872111 | Process for producing protein with reduction of acidic sugar chain and glycoprotein produced thereby A protein participating in the addition of mannose phosphate to a sugar chain of a glycoprotein originating in a yeast belonging to the genus Pichia; a gene coding this protein; a mutant of this gene; a vector carrying the mutant gene; a yeast strain belongin... | 01/18/2011 |
| 7847077 | PUFA polyketide synthase systems and uses thereof The invention generally relates to polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems, to homologues thereof, to isolated nucleic acid molecules and recombinant nucleic acid molecules encoding biologically active domains of such a PUFA PKS system, t... | 12/07/2010 |
| 7847078 | PDE11A mutations in adrenal disease The invention provides previously uncharacterized variants of PDE11A that are correlated with a newly discovered form of Cushing Syndrome that presents at a young age. The invention also provides methods useful to research, screen for, treat, or prevent diagnose the... | 12/07/2010 |
| 7842796 | PUFA polyketide synthase systems and uses thereof The invention generally relates to polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems isolated from or derived from non-bacterial organisms, to homologues thereof, to isolated nucleic acid molecules and recombinant nucleic acid molecules encoding bi... | 11/30/2010 |
| 7838649 | PUFA polyketide synthase systems and uses thereof The invention generally relates to polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems, to homologues thereof, to isolated nucleic acid molecules and recombinant nucleic acid molecules encoding biologically active domains of such a PUFA PKS system, t... | 11/23/2010 |
| 7829685 | Regulation of kinase, regulated in COPD kinase (RC kinase) Reagents which regulate human RC Kinase activity and reagents which bind to human RC Kinase gene products can be used to regulate this protein for therapeutic effects. Such regulation is particularly useful for treating chronic obstructive pulmonary disease, asthma,... | 11/09/2010 |
| 7829686 | Nucleic acid encoding a subunit of Na,K-ATPase A recombinant Na+, K+-ATPase α1-subunit protein resistant to cardiac glycosides, e.g. oubain, is disclosed, as well as methods for its production and use. The resistance to cardiac glycosides are obtained by alterations in the region situated between and including ... | 11/09/2010 |
| 7816504 | PUFA polyketide synthase systems and uses thereof The invention generally relates to polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems isolated from or derived from non-bacterial organisms, to homologues thereof, to isolated nucleic acid molecules and recombinant nucleic acid molecules encoding bi... | 10/19/2010 |
| 7816505 | PUFA polyketide synthase systems and uses thereof The invention generally relates to polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems, to homologues thereof, to isolated nucleic acid molecules and recombinant nucleic acid molecules encoding biologically active domains of such a PUFA PKS system, t... | 10/19/2010 |
| 7799904 | Gilvocarcin gene cluster, recombinant production and use thereof A nucleic acid molecule encoding the gilvocarcin V gene cluster and subunits thereof. Recombinant vectors and host cells comprising a nucleic acid compound encoding the gilvocarcin V gene cluster or subunits thereof. Host cells comprising recombinant vectors encodin... | 09/21/2010 |
| 7795234 | Newly identified human small intestine extracellular lactase-phlorizin hydrolase (ecLPH) gene The invention provides a transgenic animal producing low-lactose milk, which is transformed with a gene encoding an extracellular lactase-hydrolyzing enzyme cloned from a human small intestinal cDNA library. The invention also provides a new extracellular lactase-ph... | 09/14/2010 |
| 7786280 | Isolated genomic polynucleotide fragments from chromosome 10q25.3 that encode human soluble aminopeptidase P The invention is directed to an isolated genomic polynucleotide fragment that encodes human soluble (cytosolic) aminopeptidase P, vectors and hosts containing the fragment and fragments hybridizing to noncoding regions as well as antisense oligonucleotides to these ... | 08/31/2010 |
| 7786281 | Protein-deamidating enzyme, microorganism producing the same, gene encoding the same, production process therefor, and use thereof A method for the production of an enzyme, which comprises culturing in a medium a strain that belongs to a bacterium classified into Cytophagales or Actinomycetes, or a new bacterium Chryseobacterium sp. No. 9670 belonging to the genus Chryse... | 08/31/2010 |
| 7759476 | Double-stranded RNAS directed to IKK-2 Compositions and methods are provided for treating NF-κB-related conditions. In particular, the invention provides a stimulus-inducible IKK signalsome, and components and variants thereof. An IKK signalsome or component thereof may be used, for example, to identify... | 07/20/2010 |
