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| Number | Title | Issue Date |
| 8188245 | Enduracidin biosynthetic gene cluster from This disclosure describes the molecular cloning of an enduracidin biosynthetic gene cluster from Streptomyces fungicidicus, and characterization of individual genes in the gene cluster and the proteins encoded thereby. An enduracidin gene cluster is located w... | 05/29/2012 |
| 8188244 | Carcinoembryonic antigen fusions and uses thereof Polynucleotides encoding carcinoembryonic antigen (CEA) fusion proteins are provided, the CEA fusion proteins comprising a CEA protein, or functional variant thereof, fused to a substantial portion of an immunoenhancing element. The polynucleotides of the present in... | 05/29/2012 |
| 8188246 | Nucleic acid and amino acid sequences encoding high-level expressor factor VIII polypeptides and methods of use Methods and compositions are provided that allow for high-level expression of a factor VIII polypeptide. More specifically, methods and compositions are provided comprising nucleic acid and amino acid sequences comprising a modified factor VIII that result in high-l... | 05/29/2012 |
| 8188061 | RNAi modulation of APOB and uses thereof The invention relates to compositions and methods for modulating the expression of apolipoprotein B, and more particularly to the downregulation of apolipoprotein B by chemically modified oligonucleotides. ... | 05/29/2012 |
| 8187811 | Polymorphisms associated with Parkinson's disease The invention provides human polymorphisms that are associated with Parkinson's disease (PD). Also disclosed are compositions and methods for use in diagnostics, prognostics, prevention, treatment and/or study of PD. ... | 05/29/2012 |
| 8183353 | Breast cancer prognostics A method of providing a prognosis of breast cancer is conducted by analyzing the expression of a group of genes. Gene expression profiles in a variety of medium such as microarrays are included as are kits that contain them. ... | 05/22/2012 |
| 8183355 | Method for the synthesis of oligonucleotide derivatives Method for the synthesis of nucleotide derivatives wherein molecules of interest are grafted on the oligonucleotide with the help of a “click chemistry” reaction between an azide function on the molecule of interest and an alkyne function on the oligonucleotide,... | 05/22/2012 |
| 8182990 | Method for diagnosing or predicting susceptibility to optic neuropathy Disclosed is a set of genetic polymorphisms linked to optic neuropathy including glaucoma and Leber's disease. Those polymorphisms are useful for diagnosing and predicting susceptibility to optic neuropathy. ... | 05/22/2012 |
| 8183354 | Virus coat protein/receptor chimeras and methods of use The invention relates to chimeric molecules comprising a virus coat sequence and a receptor sequence that can inter-act with each other to form a complex that is capable of binding a co-receptor. Such chimeric molecules therefore exhibit functional properties charac... | 05/22/2012 |
| 8183223 | Method for detecting carcinoma and agent for suppressing carcinoma The present invention is directed to methods for suppressing the growth of oral squamous-cell carcinoma cells. The methods include introducing at least one gene selected from miR-137 or miR-193a into oral squamous-cell carcinoma cells. ... | 05/22/2012 |
| 8183352 | Attenuated vif DNA immunization cassettes for genetic vaccines The present invention is directed to nucleic acid molecules encoding attenuated, non-functional virion infectivity factor (vif) proteins. The nucleic acid molecules of the invention are inserted into recombinant expression vectors and administered to mammals in orde... | 05/22/2012 |
| 8178659 | Targets for the identification of antibiotics that are not susceptible to antibiotic resistance To identify conserved and variable regions of the 16 S rRNA, an instant evolution experiment was performed on the entire 16 S rRNA. Analysis of these mutants identified regions that are required for function. These conserved sequences may be used as targets for phar... | 05/15/2012 |
| 8178660 | Vaccines and immunotherapeutics using codon optimized IL-15 and methods for using the same Nucleic acid molecules that encode IL-15 or fragments thereof, which express protein at a higher level than nucleic acid molecules with native coding sequences for IL-15 are disclosed. Nucleic acid molecules with additional modifications such as the absence of codin... | 05/15/2012 |
| 8178507 | Method for the modulation of function of transcription factors There is provided a method of modulating the function of transcription factor by administering an effective amount of an oligonucleotide containing optimal nucleotide binding sites for the transcription factor. A therapeutic agent having an effective amount of an ol... | 05/15/2012 |
| 8178661 | Molecules of the card-related protein family and uses thereof Novel CARD-9, CARD-10, or CARD-11 polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated CARD-9, CARD-10, or CARD-11 proteins, the invention further provides CARD-9, CARD-10, or CARD-11, fusion proteins, antigenic peptides and anti... | 05/15/2012 |
| 8173789 | Peptide having ability to activate cancer-related gene To provide a cancer diagnostic reagent for determining malignancy of a cancer patient or a cancer cell and a tendency of canceration of a healthy subject, the reagent including a peptide having an ability to activate a cancer-related gene and extracted from cell mem... | 05/08/2012 |
| 8173790 | Insect desiccation resistance genes and uses thereof An objective of the present invention is to provide polynucleotides encoding insect desiccation resistance proteins, and uses thereof cDNA libraries were produced from Polypedilum vanderplanki larvae in a desiccated state, a P. vanderplanki EST databas... | 05/08/2012 |
| 8173787 | Plant wall degradative compounds and systems The present invention relates to cell wall degradative systems, in particular to systems containing enzymes that bind to and/or depolymerize cellulose. These systems have a number of applications. ... | 05/08/2012 |
| RE43373 | Corn event DAS-59122-7 and methods for detection thereof The invention provides DNA compositions that relate to transgenic insect resistant maize plants. Also provided are assays for detecting the presence of the maize DAS-59122-7 event based on the DNA sequence of the recombinant construct inserted into the maize genome ... | 05/08/2012 |
| 8173786 | Nucleic acid sequences encoding and compositions comprising IgE signal peptide and/or IL-15 and methods for using the same Fusion proteins and nucleic acid molecules encoding fusion proteins are disclosed. Fusion proteins comprising non-IL-15 signal peptide linked to IL-15 protein sequences and fusion proteins comprising an IgE signal peptide linked to non-IgE protein sequences are disc... | 05/08/2012 |
| 8173788 | Peptide having ability to activate cancer-related gene To provide a cancer diagnostic reagent for determining malignancy of a cancer patient or a cancer cell and a tendency of canceration of a healthy subject, the reagent including a peptide having an ability to activate a cancer-related gene and extracted from cell mem... | 05/08/2012 |
| 8168768 | Methods for monitoring multiple gene expression The present invention relates to methods for monitoring differential expression of a plurality of genes in a first filamentous fungal cell relative to expression of the same genes in one or more second filamentous fungal cells using microarrays containing Trichod... | 05/01/2012 |
| 8168769 | HPV vaccines and methods for using the same Improved anti-HIV immunogens and nucleic acid molecules that encode them are disclosed, Immunogens disclosed include those having consensus sequences for HIV Subtype A Envelope protein, those having consensus sequences for HIV Subtype B Envelope protein, those havin... | 05/01/2012 |
| 8163484 | Light emission modifiers and their uses in nucleic acid detection, amplification and analysis The present invention relates to methods and reagents for modifying the emission of light from labeled nucleic acids for the purpose of real time detection, analysis, and quantitation of nucleic acid sequences, e.g., using singly labeled probes. These methods and re... | 04/24/2012 |
| 8163477 | Nuclease-based method for detecting and quantitating oligonucleotides A method for quantitating an oligonucleotide in a sample of bodily fluid and/or extract is provided. The method provides for the detection and/or localization of oligonucleotides, including administered modified oligonucleotides, for therapeutic and/or pharmacokinet... | 04/24/2012 |
| 8163892 | Oncolytic virus replicating selectively in tumor cells By using a virus having a gene sequence comprising a telomerase promoter and an E1 gene (preferably a sequence comprising E1A gene, IRES sequence and E1B gene) or by using an anticancer agent comprising the virus, the virus replicates in cancer cells to thereby prod... | 04/24/2012 |
| 8158766 | Genes with ES cell-specific expression The present invention relates to a probe for selecting ES cells, which characteristically contains one of DNAs having base sequences depicted in SEQ ID Nos; 1, 2, 3, 4, 5, 6, 7 and 8, or DNAs having base sequences depicted in SEQ ID Nos; 9, 11, 13, 15, 17, 19, 21, 2... | 04/17/2012 |
| 8158767 | Polypeptides and methods for making the same An isolated protein having at least 90% homology with the dimeric protein having the following amino acid sequence with the proviso that at the C-terminal end of the monomeric forms, 2 to 10 amino acid distance from Z2... | 04/17/2012 |
| 8158768 | Immunostimulatory sequence oligonucleotides and methods of using the same The invention provides immunomodulatory polynucleotides and methods for immunomodulation of individuals using the immunomodulatory polynucleotides. ... | 04/17/2012 |
| 8158354 | Methods for rapid purification of nucleic acids for subsequent analysis by mass spectrometry by solution capture The present invention provides a method for rapid solution capture purification of nucleic acids for subsequent analysis by electrospray mass spectrometry which is efficient and cost-effective relative to existing methods. The present invention also provides kits us... | 04/17/2012 |
| 8158598 | Compositions and their uses directed to PTPR alpha Disclosed herein are compounds, compositions and methods for modulating the expression of PTPRα in a cell, tissue or animal. Also provided are methods of target validation. Also provided are uses of disclosed compounds and compositions in the manufacture of a medic... | 04/17/2012 |
| 8153772 | Oligonucleotide probes and primers comprising universal bases for diagnostic purposes Aspects of the invention relate to novel oligonucleotides comprising universal and generic bases for use as primers and probes, as well as, methods of using said oligonucleotides for the diagnosis of disease. ... | 04/10/2012 |
| 8153605 | Modulation of toll-like receptor 3 expression by antisense oligonucleotides Antisense oligonucleotide compounds, compositions and methods are provided for down regulating the expression of TLR3. The compositions comprise antisense oligonucleotides targeted to nucleic acids encoding TLR3. The compositions may also comprise antisense oligonuc... | 04/10/2012 |
| 8153773 | Synthesis and use of anti-reverse phosphorothioate analogs of the messenger RNA cap New RNA cap analogs are disclosed containing one or more phosphorothioates groups. The analogs also contain modifications at the 2′-O position of 7-methylguanosine that prevent them from being incorporated in the reverse orientation during in vitro synthesis of mR... | 04/10/2012 |
| 8153604 | CNS-tumor treatment method and composition A method, aerosol composition, and aerosolizing device for treating a brain tumor in a subject are disclosed. The method includes intranasally administering to the subject, an amount of a telomerase inhibitor, such as an oligonucleotide telomerase inhibitor, effecti... | 04/10/2012 |
| 8148343 | Tumor suppressor factor The present invention relates to a tumor suppressor gene, termed HLS-5 and the amino acid sequence that it encodes. The present invention also relates to the use of HLS-5 in regulating cell growth. ... | 04/03/2012 |
| 8148344 | Compositions and methods for mediating RNAi in vivo This invention relates to new formulated lipid particles (FLiPs) comprising at least one of a single or double stranded oligonucleotide, where the oligonucleotide has been conjugated to a lipophile and at least one of an emulsion or liposome to which the conjugated ... | 04/03/2012 |
| 8148506 | Protein kinase-inducible domains Applicants have used protein design to develop novel functional protein architectures, termed protein kinase-inducible domains, whose structures are dependent on phosphorylation by specific protein kinases or are dependent on dephosphorylation by specific protein ph... | 04/03/2012 |
| 8148340 | Immunomodulatory oligonucleotides Oligonucleotides containing unthylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response in a subject are disclosed. Also disclosed are therapies for treating diseases associated with immune system activation that are... | 04/03/2012 |
| 8143233 | RNA aptamers and methods for identifying the same RNA aptamers and methods for identifying the same are disclosed. The RNA aptamers selectively bind coagulation factors, E2F family members, Ang1 or Ang2, and therapeutic and other uses for the RNA aptamers are also disclosed. ... | 03/27/2012 |
