Did You Know...
...When G.G. Hubbard learned of his future son-in-law's invention, he called it "only a toy." His daughter was engaged to a young man named Alexander Graham Bell.
PatentStorm News
Make the Most of Our Site
See this month's Top Inventors and Most Cited Patents.
Stay on top of the latest innovations by subscribing to an RSS feed.
Registered users: Manage your profile.
| Number | Title | Issue Date |
| 8188243 | Methods and compositions for the detection of biological molecules using a two particle complex The invention provides methods of detecting analytes of interest in a sample using electrogenerated chemiluminescence. The invention also provides compositions comprising at least one solid support that entraps or contains an electrogenerated chemiluminescent moiety... | 05/29/2012 |
| 8173785 | Peptide nucleic acid probes for analysis of certain species The present invention relates to peptide nucleic acid (PNA) probes, PNA probe sets and methods for the analysis of certain Staphylococcus species optionally present in a sample. The invention further relates to diagnostic kits comprising such PNA probes or PN... | 05/08/2012 |
| 8129315 | Labelling strategies for the sensitive detection of analytes The present invention relates to methods and reagents for detecting analytes, e.g. nucleic acids. The new methods and reagents allow a simple and sensitive detection even in complex biological samples. ... | 03/06/2012 |
| 8124746 | Methods and kits using extended rhodamine dyes Extended rhodamine compounds exhibiting favorable fluorescence characteristics having the structure are disclosed. In addition, novel intermediates for synthesis of these dyes are disclosed, such intermediates having the st... | 02/28/2012 |
| 8124745 | Polycyclic sugar surrogate-containing oligomeric compounds and compositions for use in gene modulation Compositions comprising first and second oligomers are provided wherein at least a portion of the first oligomer is capable of hybridizing with at least a portion of the second oligomer, at least a portion of the first oligomer is complementary to and capable of hyb... | 02/28/2012 |
| 8119781 | Luminescent metal ion complexes The present invention provides luminescent metal ion complexes for use in a wide range of biological and chemical studies. The luminescent metal ion complexes of the invention comprise a metal ion chelating component covalently bound to a carrier molecule. Also prov... | 02/21/2012 |
| 8101351 | Process for typing of HCV isolates The invention relates to a process for genotyping any HCV isolate present in a biological sample, previously identified as being HCV positive, and for classifying said isolate according to the percentage of homology with other HCV isolates, comprising the steps of: ... | 01/24/2012 |
| 8071735 | Cotton event MON 88913 and compositions and methods for detection thereof The present invention provides a cotton plant event MON 88913 compositions and seed. Also provided are assays for detecting the presence of the cotton plant event MON 88913 based on a DNA sequence and the use of this DNA sequence as a molecular marker in a DNA detec... | 12/06/2011 |
| 8071734 | Nucleic acid-based detection The invention relates to compositions, systems, and methods for simultaneously detecting the presence and quantity of one or more different compounds in a sample using aptamer beacons. Aptamer beacons are oligonucleotides that have a binding region that can bind to ... | 12/06/2011 |
| 8053191 | Iterative nucleic acid assembly using activation of vector-encoded traits Certain aspects of the present invention provide methods for assembling nucleic acid molecules using iterative activation of one or more vector-encoded traits to progressively assemble a longer nucleic acid insert. Aspects of the invention also provide kits, composi... | 11/08/2011 |
| 8022193 | 6-modified bicyclic nucleic acid analogs The present invention provides 6-modified bicyclic nucleoside analogs and oligomeric compounds comprising these nucleoside analogs. In preferred embodiments the nucleoside analogs have either (R) or (S)-chirality at the 6-position. These bicyclicnucleoside analogs a... | 09/20/2011 |
| 8021845 | Probes for detecting obesity gene Primer sets for amplifying target regions containing sites to be detected in the obesity gene (the β2AR gene, the β3AR gene, and the UCP1 gene) by a gene amplification method are provided, wherein the primer sets can amplify the regions specifically. Three pairs o... | 09/20/2011 |
| 8017744 | Purification of a triple helix formation with an immobilized oligonucleotide A method for double-stranded DNA purification, by which a solution containing DNA in a mixture with other components is passed over a support on which is covalently coupled an oligonucleotide capable of hybridizing with a specific sequence present on the DNA to form... | 09/13/2011 |
| 8017743 | Method for rapid detection and identification of bioagents Method for detecting and identifying unknown bioagents, including bacteria, viruses and the like, by a combination of nucleic acid amplification and molecular weight determination using primers which hybridize to conserved sequence regions of nucleic acids derived f... | 09/13/2011 |
| 7999087 | 2′-silyl containing thiocarbonate protecting groups for RNA synthesis Nucleoside monomers, nucleic acids, e.g., oligonucleotides and polynucleotides, methods of making each, methods of deprotecting each, and the like are disclosed herein. Aspects of the invention include 2′ silyl containing thiocarbonate protecting groups. Correspon... | 08/16/2011 |
| 7989603 | 2′-arabino-fluorooligonucleotide N3′-P5′ phosphoramidates: their synthesis and use Oligonucleotides with a novel sugar-phosphate backbone containing at least one 2′-arabino-fluoronucleoside and an internucleoside 3′-NH—P(═O)(OR)—O-5′ linkage, where R is a positively charged counter ion or hydrogen, and methods of synthesizing and using... | 08/02/2011 |
| 7947817 | Synthesis and compositions of 2'-terminator nucleotides The invention provides compositions that comprise nucleotides and/or nucleosides having blocking groups at 2′-positions of sugar moieties. Methods of synthesizing these nucleic acids are also provided. ... | 05/24/2011 |
| 7947818 | Heteromolecular metal-humic (chelate) complexes Heteromolecular metal-humic organic complexes of the type: (A)n-(Metal)x-(B)m where A is one or several humic complexes which may be totally or partially sulfonated or may have been treated with an amine in order to protect the carboxylic groups from interacting wit... | 05/24/2011 |
| 7939645 | Reaction buffer composition for nucleic acid replication with packed DNA polymerases The invention relates to compositions, methods, and kits for nucleic acid replication, including polymerase chain reaction (PCR) and mutagenesis reactions. A buffer composition is provided which allows higher concentrations of DNA polymerase to be used, resulting in... | 05/10/2011 |
| 7919600 | Compositions that reversibly gel and de-gel A composition that comprises a first polymer having first functional groups attached as side-chains thereto. The composition further comprises a second polymer having second functional groups attached as side-chains thereto. The first and the second functional group... | 04/05/2011 |
| 7902343 | Detection of microsatellite instability and its use in diagnosis of tumors Methods and kits are disclosed for use in the analysis of microsatellite instability in genomic DNA. Methods and kits are also disclosed which can be used to detect microsatellite instability DNA present in biological materials, such as tumors. The methods and kits ... | 03/08/2011 |
| 7897737 | 3′-OH unblocked, nucleotides and nucleosides, base modified with photocleavable, terminating groups and methods for their use in DNA sequencing Provided are novel nucleotides, nucleoside, and their derivatives described herein, that can be used in DNA sequencing technology and other types of DNA analysis. In one embodiment, the nucleotide or nucleoside with an unprotected 3′-OH group is derivatized at the... | 03/01/2011 |
| 7893227 | 3′-OH unblocked nucleotides and nucleosides base modified with non-cleavable, terminating groups and methods for their use in DNA sequencing Provided are novel nucleotides, nucleoside, and their derivatives described herein, that can be used in DNA sequencing technology and other types of DNA analysis. In one embodiment, the nucleotide or nucleoside with an unprotected 3′-OH group is derivatized at the... | 02/22/2011 |
| 7855281 | Cleavable thiocarbonate linkers for polynucleotide synthesis In various embodiments of the invention, novel compositions having a polynucleotide bound to a substrate via a cleavable linker are provided, and methods of cleaving a polynucleotide from a substrate are provided. ... | 12/21/2010 |
| 7807801 | Oligonucleotide analog and method for treating flavivirus infections A method of inhibiting replication of a flavivirus in animal cells, and an oligonucleotide compound for use in the method are disclosed. The oligonucleotide analog (i) has a nuclease-resistant backbone, (ii) is capable of uptake by the cells, (iii) contains b... | 10/05/2010 |
| 7772383 | Chemical PCR: Compositions for enhancing polynucleotide amplification reactions A composition for performing a polynucleotide amplification reaction at low temperature, including a polynucleotide amplification reaction mixture into which is incorporated a sufficiently high concentration of a low molecular weight compound selected from the group... | 08/10/2010 |
| 7759471 | Monomer compositions for the synthesis of RNA, methods of synthesis, and methods of deprotection Nucleotide monomers, polynucleotides, methods of making each, methods of deprotecting each, and the like are disclosed herein. ... | 07/20/2010 |
| 7750131 | 5′-modified bicyclic nucleic acid analogs The present invention provides 5′-modified bicyclic nucleoside analogs and oligomeric compounds comprising at least one of these nucleoside analogs. In preferred embodiments the nucleoside analogs have either (R) or (S)-chirality at the 5′-carbon. These bicyclic... | 07/06/2010 |
| 7745591 | Phosphinoamidite carboxylates and analogs thereof in the synthesis of oligonucleotides having reduced internucleotide charge Nucleoside phosphinoamidite carboxylates and analogs are provided that have the structure of formula (III) wherein A is hydrogen, hydroxyl, lower alkoxy, lower alkoxy-substituted lower alkoxy, halogen, SH, NH2, a... | 06/29/2010 |
| 7741457 | 6-modified bicyclic nucleic acid analogs The present invention provides 6-modified bicyclic nucleoside analogs and oligomeric compounds comprising these nucleoside analogs. In preferred embodiments the nucleoside analogs have either (R) or (S)-chirality at the 6-position. These bicyclicnucleoside analogs a... | 06/22/2010 |
| 7723495 | Amidite for nucleic acid synthesis and nucleic acid synthesizing method To provide an amidite for nucleic acid synthesis, which enables a protective group therein to be removed under moderate conditions and can be practically used, and a nucleic acid synthesizing method using the amidite for nucleic acid synthesis. Specifically, the pre... | 05/25/2010 |
| 7638612 | Compositions and methods for cDNA synthesis Methods for making cDNA molecules, for amplification of RNA by PCR and for preparation of cDNA libraries are provided. Kits for making cDNA molecules also are provided. Compositions are also provided comprising mixtures of reagents, including reverse transcriptases,... | 12/29/2009 |
| 7635762 | Luminescent metal ion complexes The present invention provides luminescent metal ion complexes for use in a wide range of biological and chemical studies. The luminescent metal ion complexes of the invention comprise a metal ion chelating component covalently bound to a carrier molecule. Also prov... | 12/22/2009 |
| 7615618 | Oligonucleotides comprising a non-phosphate backbone linkage One aspect of the present invention relates to a ribonucleoside substituted with a phosphonamidite group at the 3′-position. In certain embodiments, the phosphonamidite is an alkyl phosphonamidite. Another aspect of the present invention relates to a double-strand... | 11/10/2009 |
| 7601821 | Encoding and decoding reactions for determining target molecules The present invention is directed to methods, reagents, and kits for detecting the presence or absence of (or quantifying) target polynucleotide sequences and proteins in at least one sample using encoding and decoding reactions. When a particular target polynucleot... | 10/13/2009 |
| 7582738 | Diagnostic assay for Wiskott-Aldrich syndrome and genetically related disorders The methods and compositions of the invention find use in the clinical diagnosis of primary immunodeficiencies, particularly Wiskott-Aldrich related syndromes. The compositions of the invention include isolated nucleic acid molecules and oligonucleotide pairs suitab... | 09/01/2009 |
| 7566773 | Photolabile compound and substrate for oligomer probe array with the same Provided is a substrate for an oligomer probe array to which a photolabile material having an acetylene derivative is directly attached or attached via a linker. ... | 07/28/2009 |
| 7521546 | Branched and multi-chain nucleic acid switches for sensing and screening Embodiments of the invention relate to a branched or multichain nucleic acid switch adapted to switch from a first conformation to a second conformation upon ligand binding. The switch includes a probe strand, P, which includes the ligand binding domain; a switching... | 04/21/2009 |
| 7517969 | Process for isolating nucleic acid with chaotrope agents and ammonium compounds A process for isolating nucleic acid from a nucleic acid-containing sample, which comprises: (a) providing a chaotrope; (b) providing a nucleic acid binding solid phase capable of binding nucleic acid in the presence of the chaotrope; (c) providing a source of NH4+ ... | 04/14/2009 |
| 7511125 | Pyrimidine derivatives for labeled binding partners Compounds having structure (1) wherein R1 is —H a protecting group, a linker or a binding partner; and R2 and R34 are as defined in the specification. The invention also provides intermedi... | 03/31/2009 |
