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| Number | Title | Issue Date |
| 8101733 | Methods of evaluating mixtures of polysaccharides Methods for analyzing mixtures of polysaccharides, for example heparin or a LMWH, using reduce end labeling are described. In general, the mixture of polysaccharides includes polysaccharides having a desired structural moiety. In some instances, one or more polysacc... | 01/24/2012 |
| 8067555 | Derivatives of partially desulphated glycosaminoglycans as heparanase inhibitors, endowed with antiangiogenic activity and devoid of anticoagulating effect Partially desulphated glycosaminoglycan derivatives are described, particularly heparin, and more particularly a compound of formula (I) where the U, R and R1 groups have the meanings ind... | 11/29/2011 |
| 7838644 | Epimerized derivatives of K5 polysaccharide with a very high degree of sulfation A new method is described for the oversulfation of epiK-N sulfate to obtain an epiK5-amine-O-oversulfate with very high sulfation degree which, by subsequent N-sulfation, provides new epiK5-N,O-oversulfate-derivatives with a sulfation degree of at least 4, basically... | 11/23/2010 |
| 7655769 | Orthogonally protected disaccharide building blocks for synthesis of heparin Orthogonally protected disaccharide building blocks for synthesis of heparin saccharide are disclosed. The disaccharide building block has a formula (I), in which L is a leaving group, P1, P2, P3 and P4 are different, and ... | 02/02/2010 |
| 7605242 | Process for the physical depolymerization of glycosaminoglycanes and products obtained therefrom The invention relates to a process for the depolymerization of glycosaminoglycanes characterized by the use of UVC radiation. The invention also relates to the intermediate depolymerized heparin obtained by the process. The intermediate depolymerized heparin can be ... | 10/20/2009 |
| 7582737 | Orthogonally protected disaccharide building blocks for synthesis of heparin oligosaccharides Orthogonally protected disaccharide building blocks for synthesis of heparin oligosaccharide. The disaccharide building block has a formula (I), in which L is a leaving group, P1, P2, P3 and are different, and of them P1 i... | 09/01/2009 |
| 7541445 | Synthetic heparin pentasaccharides Preparation of synthetic monosaccharides, disaccharides, trisaccharides, tetrasaccharides and pentasaccharides for use in the preparation of synthetic heparinoids. ... | 06/02/2009 |
| 7393938 | Use of lipid conjugates in the treatment of diseases This invention provides compounds represented by the structure of the general formula (A): wherein L is a lipid or a phospholipid, Z is either nothing, ethanolamine, serine, inositol, choline, or glycerol, Y is either nothi... | 07/01/2008 |
| 7332480 | Compositions for the regulation of cytokine activity Substances comprising carboxylated and/or sulfated oligosaccharides in substantially purified form, including compositions containing same and methods of using same, are disclosed for the regulation of cytokine activity in a host. For instance, the secretion of Tumo... | 02/19/2008 |
| 7321034 | Process for the physical depolymerization of glycosaminogylcanes and products obtained thereform The invention relates to a process for the depolymerization of glycosaminoglycanes characterized by the use of electron beam radiation, optionally in the presence of an organic compound selected from the group consisting of ethers, alcohols, aldehydes, amides and fo... | 01/22/2008 |
| 7300457 | Self-supporting metallic implantable grafts, compliant implantable medical devices and methods of making same Implantable medical grafts fabricated of metallic or pseudometallic films of biocompatible materials having a plurality of microperforations passing through the film in a pattern that imparts fabric-like qualities to the graft or permits the geometric deformation of... | 11/27/2007 |
| 7294357 | Plasma coated sutures Suture filaments coated by a plasma polymerization process exhibit a good balance of knot run down and knot security characteristics, superior tissue drag characteristics, and improved fray resistance. ... | 11/13/2007 |
| 7267686 | Implantable prosthetic valve A prosthetic valve for implantation within a fluid conducting lumen within a body includes an elongate generally cylindrical radially collapsible valve body scaffold defining a fluid passageway therethrough for retentive positioning within the lumen. A radially coll... | 09/11/2007 |
| 7259152 | Methods and compositions using sulodexide for the treatment of diabetic nephropathy The present invention provides oral formulations of Sulodexide for the treatment of diabetic nephropathy in patients with both insulin dependent and non-insulin dependent diabetes mellitus. Oral formulations containing doses adapted for administration to obtain a re... | 08/21/2007 |
| 7244242 | Valve treatment catheter and methods The invention provides a catheter for insertion into a biological passage which contains a first flowing fluid, the catheter including a tubular member having a proximal end and a distal end; a fluid delivery lumen contained within the tubular member; an inflatable ... | 07/17/2007 |
| 7223571 | Targeted glycosaminoglycan polymers by polymer grafting and methods of making and using same The present invention relates to methodology for polymer grafting by a polysaccharide synthase and, more particularly, polymer grafting using the hyaluronate or chondroitin or heparin/heparosan synthases from Pasteurella, in order to create a variety of glyco... | 05/29/2007 |
| 7214667 | Drugs against articular failure The object of the present invention is to provide a composition which exerts a higher effect on recovering health from articular disorders than that attained by amino sugars and glycosaminoglycans. The present invention solves the object by providing an agent for tr... | 05/08/2007 |
| 7202230 | Use of hyaluronic acid derivatives in the preparation of biomaterials with a physical haemostatic and plugging activity The present invention describes the use of polysaccharide derivatives for the preparation of biocompatible and biodegradable biomaterials with absorbent properties for body fluids and physical hemostatic activity, to be used in both venous and arterial vascular anas... | 04/10/2007 |
| 7195641 | Valvular prostheses having metal or pseudometallic construction and methods of manufacture This invention relates to improvements in prosthetic cardiac and venous valves and implantable medical devices having moveable septa. The inventive prosthetic cardiac and venous valves have metallic or pseudometallic valves coupled to metallic or pseudometallic sten... | 03/27/2007 |
| 7196180 | Functionalized derivatives of hyaluronic acid, formation of hydrogels in situ using same, and methods for making and using same Methods for chemical modification of hyaluronic acid, formation of amine or aldehyde functionalized hyaluronic acid, and the cross-linking thereof to form hydrogels are provided. Functionalized hyaluronic acid hydrogels of this invention can be polymerized in situ, ... | 03/27/2007 |
| 7156872 | Implantable valve system An implantable valve having a valve element or leaflet and a base that is attachable to a vessel wall using a connector such as a screw, pin or a staple. The valve can be implanted using a catheter to position the valve in a desired location and drive the connector ... | 01/02/2007 |
| 7139666 | Method for identifying or characterizing properties of polymeric units The invention relates to methods of identifying and characterizing properties of polymers to provide information about the polymer such as the charge of the polymer, the number and types or characteristics of units of the polymer and the sequence of the polymers. Th... | 11/21/2006 |
| 7129224 | Hydrophobic multicomponent heparin conjugates, a preparing method and a use thereof The present invention provides hydrophobic heparin conjugates that are soluble in organic solvents but not in water, a method of preparing them, and a method of using them. Particularly, the present invention provides hydrophobic heparin conjugates that are prepared... | 10/31/2006 |
| 7109354 | Thiophene amidines, compositions thereof, and methods of treating complement-mediated diseases and conditions Disclosed is a method for treating the symptoms of an acute or chronic disorder mediated by the classical pathway of the complement cascade, comprising administering to a mammal in need of such treatment a therapeutically effective amount of a compound of Formula I | 09/19/2006 |
| 7101859 | Use of lipid conjugates in the treatment of diseases The invention provides novel methods for treating disease based upon the medicinal use of lipids and phospholipids covalently bound to physiologically acceptable monomers or polymers. Phosphatidylethanolamine moieties conjugated to physiologically acceptable monomer... | 09/05/2006 |
| 7094550 | Method to determine TGF-beta A method for treating or preventing cardiovascular pathologies by administering a compound of the formula (I): wherein Z is C═O or a covalent bond; Y is H or O(C1–C4)alkyl, R1 | 08/22/2006 |
| 7091337 | Process for the physical depolymerization of glycosaminoglycanes and products obtained therefrom The invention relates to a process for the depolymerization of glycosaminoglycanes characterized by the use of high-energy radiation in the presence of an organic compound selected from the group consisting of ethers, alcohols, aldehydes, amides and formic acid. The... | 08/15/2006 |
| 7084118 | Combination treatment with t-PA variant and low molecular weight heparin The invention concerns an improved therapeutic regimen for the treatment of thrombolytic disorders, such as acute myocardial infarction (AMI). In particular, the present invention concerns the treatment of thrombolytic disorders, e.g. AMI, with a combination of a ti... | 08/01/2006 |
| 7083777 | Immunomodulating polymers A pharmaceutical composition consisting of identical repeating units, each unit having a charge motif composed of a positively charged free amino moiety and a negatively charged moiety, wherein the positively charged free amino moiety and the negatively charged moie... | 08/01/2006 |
| 7056504 | Rationally designed heparinases derived from heparinase I and II Modified heparinases having altered binding specificity and activity are provided. Isolated nucleic acids encoding the same as well as vectors and host cells are provided. Methods for using the modified heparinases are also provided. ... | 06/06/2006 |
| 7034006 | Use of lipid conjugates in the treatment of disease The invention provides novel methods for treating disease based upon the medicinal use of lipids and phospholipids covalently bound to physiologically acceptable monomers or polymers. Phosphatidylethanolamine moieties conjugated to physiologically acceptable monomer... | 04/25/2006 |
| 7034127 | Hydrophilic biopolymer-drug conjugates, their preparation and use Disclosed are methods of conjugating biologically active substances, particularly, alpha-interferon, with a hyaluronan or a mixture of a hyaluronan with at least one other hydrophilic polymer having a functional group capable of reacting with divinyl sulfone. Also d... | 04/25/2006 |
| 7011953 | Diagnostic assay for type 2 heparin-induced thrombocytopenia Methods for detecting the presence of antibodies to PF4/heparin/TSP-1 complexes in a biological sample and for diagnosing Type 2 heparin-induced thrombocytopenia are described. ... | 03/14/2006 |
| 7008933 | Process for prophylaxis and therapy of thrombotic processes employing heparin having particular average molecular weights A process for prophylaxis and therapy of thrombotic processes includes preparing heparin having an average molecular weight ranging from 10 to 11.5 kd; formulating a pharmaceutical preparation which includes the heparin; and employing the pharmaceutical preparation ... | 03/07/2006 |
| 7005426 | Folic acid-polysaccharide complex, its preparation method and pharmaceutical composition containing the same as active component The present invention relates to folic acid-polysaccharide complexs and method of preparation thereof, more particularly relates to folic acid-Dextran complexs, method of preparation thereof, pharmaceutical compositions having said complex as active component and us... | 02/28/2006 |
| 7005508 | Nitroderivatives of polysaccharides The present invention provides a new class of compounds presenting a high compatibility with tissues and organic fluids. Such new compounds are polysaccharides essentially formed of units of uronic acid and/or hexosamine, containing nitro groups —ONO2 c... | 02/28/2006 |
| 6969705 | Compositions of polysaccharides derived from heparin, their preparation and pharmaceutical compositions containing them Alkali and alkali-earth metal salts of polysaccharides derived from heparin, their method of preparation and the pharmaceutical compositions containing them. ... | 11/29/2005 |
| 6953784 | Cross-linked polysaccharide drug carrier A carrier and a method for preparing it are provided for use in the delivery of therapeutic agents. A polysaccharide is reacted with an oxidizing agent to open sugar rings on the polysaccharide to form aldehyde groups. The aldehyde groups are reacted to form covalen... | 10/11/2005 |
| 6947849 | Method for identifying or characterizing properties of polymeric units The invention relates to methods of identifying and characterizing properties of polymers to provide information about the polymer such as the charge of the polymer, the number and types or characteristics of units of the polymer and the sequence of the polymers. Th... | 09/20/2005 |
| 6943154 | Water insoluble derivatives of polyanionic polysaccharides A water insoluble, biocompatible composition that is formed by a method which combines, in an aqueous mixture, a polyanionic polysaccharide, a nucleophile, and an activating agent, under conditions sufficient to form the composition. Also, a water insoluble, biocomp... | 09/13/2005 |
