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Class 536/16.8 - Antibiotics


Subclass of Class 536 - Organic compounds -- part of the class 532-570 series
Definition: Compounds which have the capacity to inhibit the growth
No. of patents: 371
Last issue date: 05/03/2011


1                    
NumberTitleIssue Date
7935799Methods of treating diarrhea caused by small intestinal bacterial overgrowth
Disclosed is a method of diagnosing irritable bowel syndrome, fibromyalgia, chronic fatigue syndrome, depression, attention deficit/hyperactivity disorder, autoimmune diseases, such as multiple sclerosis and systemic lupus erythematosus, or Crohn's disease, which in...
05/03/2011
7605240Methods of treating diarrhea and bloating caused by small intestinal bacterial overgrowth
Disclosed is a method of diagnosing irritable bowel syndrome, fibromyalgia, chronic fatigue syndrome, depression, attention deficit/hyperactivity disorder, autoimmune diseases, such as multiple sclerosis and systemic lupus erythematosus, or Crohn's disease, which in...
10/20/2009
7482439Caprazene as novel compound and derivatives thereof, and caprazol as novel compound and derivatives thereof
Caprazene and caprazol could be synthesized by hydrolysis of a caprazamycin. There could be synthesized a caprazene-1′″-amide derivative of the formula (II) and a caprazene-1′″-ester derivative of the formula (III) ...
01/27/2009
7417129Combinatorial libraries of monosaccharides
A monosaccharide compound of formula I as shown in the specification. Processes for the preparation of the compound of formula I and methods of screening for antibacterial or antibiotic compounds involving the compound of formula I. ...
08/26/2008
7407654Antibiotics GE 81112 factors A,B,B1, pharmaceutically acceptable salts and compositions, and use thereof
The invention relates to an antibiotic substances of microbial origin, arbitrarily denominated antibiotic GE 81112 factor A, factor B1 and factor B, which is produced by fermentation of Streptomyces sp. DSMZ 14386, the pharmaceutically acceptable salts and co...
08/05/2008
7375088Polyene polyketides, processes for their production and their use as a pharmaceutical
This invention relates to a new class of polyene polyketides, their pharmaceutically acceptable salts and derivatives, and to methods for obtaining the compounds. One method of obtaining these compounds is by cultivation of novel strains of Streptomyces aizunensi...
05/20/2008
7371733Anti bacterial compounds
The invention relates to novel paranmycin compounds that have activity against gram positive and gram negative bacteria, preferably bacteria that are resistant to other antibiotics. Paranmycins are of the general formula ...
05/13/2008
7368431Polypeptide, the conjugate thereof with doxorubicine and a pharmaceutical composition based thereon
The inventive polypeptide is embodied in the form of a similar fragment of the epidermal growth factor of aminoacid ranging from 21 to 31 and capable of efficiently binding with the receptor of the epidermal growth factor as a vector for the directed supply of antic...
05/06/2008
7365071Heterocyclic compounds, preparation process and intermediates, and use as medicaments, in particular as β-lactamase inhibitors and antibacterials
The invention relates to novel heterocyclic compounds of general formula (I) and to their salts with a base or an acid: The invention also relates to processes and to intermediates for the preparation of these compounds, and ...
04/29/2008
7358232Method for the antibiotic coating of bodies with interconnecting microcavities as well as coated bodies and their usage
The invention relates to a method for the antibiotic coating of bodies with interconnecting microcavities as well as bodies coated this way and their usage. The invented method is characterized in that in the microcavities of non-metallic bodies an aqueous solution ...
04/15/2008
7331920Glycopeptide antibiotics, combinational libraries of glycopeptide antibiotics and methods of producing same
Methods for preparing a glycopeptide are disclosed. The methods comprise the steps of selecting a protected glycopeptide of the formula A1-A2-A3-A4-A5-A6-A7, wherein the groups A1
02/19/2008
7300921Polyene polyketides and methods of production
Novel polyene polyketides, their pharmaceutically acceptable salts, prodrugs and derivatives have been found to have antibiotic activity. One method for obtaining the compounds is by cultivation of Amycolatopsis orientalis ATCC™ 43491 or a mutant or variant...
11/27/2007
7291410Orientation independent liquid fuel reservoir
A fuel reservoir for a liquid fuel cell particularly useful for portable electronic devices or for a reformer, includes (a) a container defining a volume for holding a liquid fuel; (b) a wicking structure positioned within the volume and into which at least one port...
11/06/2007
7285653Nucleic acids which code for the enzyme activities of the spinosyn biosynthesis
The present invention relates to nucleic acid coding for enzyme activities of spinosyn biosynthesis and to the relevant enzymes per se. Furthermore, the invention relates to methods for preparing spinsoyn derivatives and spinosyn precursors. ...
10/23/2007
7259141Vancomycin analogs and methods thereof
The present invention provides vancomycin analogs and methods related to synthesis of these analogs via chemoenzymatic techniques. In a preferred embodiment, the vancomycin analogs have a structural moiety selected from the group consisting of:
08/21/2007
7244712Aminoglycoside antibiotics and methods of using same
The present invention relates to aminoglycoside compounds having antibiotic activity. Moreover, the present invention relates to L-aminoglycoside compounds and diastereomers thereof which posses antibiotic activity and are not susceptible to development of resistant...
07/17/2007
7241595Glycosyl-etoposide prodrugs, a process for preparation thereof and the use thereof in combination with functionalized tumor-specific enzyme conjugates
The present invention relates to glycosyl-etoposide prodrugs, a process for the preparation thereof and the use thereof in combination with functionalized tumor-specific enzyme conjugates for treating cancers. ...
07/10/2007
7220727Aminoglycosides as antibiotics
The present invention provides aminoglycosides and pharmaceutical compositions that include the aminoglycosides. The aminogylcosides are useful to treat or prevent infectious diseases (e.g., bacterial infections) in a mammal (e.g., human). ...
05/22/2007
7166270Methods of screening compounds useful for prevention of infection or pathogenicity
Screening procedures are disclosed for identifying compounds useful for inhibiting infection or pathogenicity. Methods are also disclosed for identifying pathogenic virulence factors. ...
01/23/2007
7128897Aerosolized anti-infectives, anti-inflammatories, and decongestants for the treatment of sinusitis
Pharmaceutical compositions are described that contain one agent for treatment of sinusitis and a surfactant. The compositions are prepared to have a surface tension that renders the composition effective for treatment of sinusitis. ...
10/31/2006
7034130Method for producing novel spinosyn derivatives
The present invention relates to methods for producing novel spinosyn derivatives which are substituted with a 1-hydroxy-ethyl radical in the C-21 position and to novel spinosyn derivatives of this type per se and to their use for producing novel spinosyns. ...
04/25/2006
7030093Antibiotic coating for porous bodies and method for its production as well as its use
The invention describes an antibiotic coating for porous bodies and its use. Into the porous system of non-metallic porous bodies and of metallic porous bodies, a coating made of at least one antibiotic salt that is hardly soluble in water or in an aqueous environme...
04/18/2006
7001903Synergistic insecticidal mixtures
The invention relates to insecticidal mixtures of spinosyns and agonists or antagonists of nicotinic acetylcholine receptors for protecting plants against attack by pests. ...
02/21/2006
6994932Liquid fuel reservoir for fuel cells
The present invention concerns a fuel reservoir for a liquid fuel cell particularly useful for portable electronic devices in which the fuel reservoir can deliver the liquid fuel regardless of the orientation. The fuel reservoir comprises (a) a container defining a ...
02/07/2006
6967242Antimicrobial 2-deoxystreptamine compounds
The present invention is directed to analogs of aminoglycoside compounds of the class having a glycosylated 2-deoxystreptamine (2-DOS) ring as well as their preparation and use as prophylactic or therapeutics against microbial infection. Compounds of the invention c...
11/22/2005
6927210Ectoparasiticidal aqueous suspension formulations of spinosyns
The invention provides a stable ectoparasiticidal aqueous suspension formulation of a spinosyn, comprising the spinosyn, or a physiologically acceptable derivative or salt thereof, milled to an average particle size of 1 to 15 microns, a surfactant in an amount effe...
08/09/2005
6906040Method for reducing toxicity of combined chemotherapies
Compositions and methods are provided for use in the treatment of cancer. ...
06/14/2005
6867230Hygromycin A derivatives
This invention relates to compounds of the formula and to pharmaceutically acceptable salts, prodrugs and solvates thereof, wherein R1, R2, R3 and R10
03/15/2005
6858589Methods of and compositions for potentiating the action of agents active on cell wall sites of the susceptible bacteria
The invention provides a method of potentiating the activity of antibacterial agents that act on bacterial cell walls, comprising the step of administering to a subject an antibacterial agent and an aminoglycoside to attain a peak concentration of at least 4 mg/l of...
02/22/2005
6841661Glycopeptide antibacterial compounds, compositions containing same and methods of using same
The present invention relates to vancomycin analogs in which the vancosamine residue is substituted with a lipid-like substituent that includes a first aryl moiety and a second aryl moiety joined together by a flexible linker moiety, that is not a single bond direct...
01/11/2005
6812331Aromatic derivatives substituted by a ribose, their preparation process and their use as medicaments
A subject of the invention is the compounds of formula (I): R1═H, OH, alkyl, alkenyl or alkynyl optionally substituted or alkoxy, R2═H, Hal, ...
11/02/2004
6759523Antimicrobial 2-deoxystreptamine compounds
The present invention is directed to analogs of aminoglycoside compounds of the class having a glycosylated 2-deoxystreptamine (2-DOS) ring as well as their preparation and use as prophylactic or therapeutics against microbial infection. Compounds of the invention c...
07/06/2004
6756489Substituted tetrahydropyrane derivatives, method for producing same, their use as medicine or diagnostic agent, as well as medicine containing same
Substituted tetrahydropyran derivatives, processes for their preparation, their use as a pharmaceutical or diagnostic, and pharmaceutical comprising them. The invention relates to compounds of the formula I in which the ...
06/29/2004
6709679Antineoplastic conjugates of transferin, albumin and polyethylene glycol
Conjugates of transferrin, albumin and polyethylence glycol consisting of native or thiolated transferrin or albumin or of polyethylene glycol (MW between approximately 5,000 and 20,0000) with at least one HS—, HO— or H2N group and cytostatic compound...
03/23/2004
6699836Vancomycin analogs
Compounds that are vancomycin analogs bearing terminal carboxyl group modifications as well as modifications to the vancosamine nitrogen and, optionally, modifications to the C6 position of the glucose residue attached to the amino acid four of the vancom...
03/02/2004
6693085Macrolide compound JK
Compound JK represented by the general formula (1): ##STR1## wherein R is H or --CH3 ; or a pharmaceutically acceptable salt thereof. Compound JK has an excellent antimicrobial activity even against resistant strains including MRSA and is useful as ...
02/17/2004
6683056O-aryl glucoside SGLT2 inhibitors and method
##STR1## wherein when Y is ##STR2## or heteroaryl; A is --O(CH2)m, S, --NH(CH2)m, or (CH2)n where n is 0-3 and m is 0-2; and R1 to R6 are as defined herein...
01/27/2004
6562792Hygromycin derivatives
The present invention relates to compounds of the formula 1 ##STR1## and to pharmaceutically acceptable salts, prodrugs and solvates thereof, wherein X, Y, V, W1, W2, Z1 and Z2 are as defined herein. The inventi...
05/13/2003
6548536Agent for inducing apoptosis
Agents for inducing apoptosis comprising a tetrocarcin derivative represented by the following formula (I) or a salt thereof as an active ingredient (---- represents a single bond or a double bond; j and k represent 0 or 1; R1 to R3,...
04/15/2003
6541456Antimicrobial 2-deoxystreptamine compounds
The present invention is directed to analogs of aminoglycoside compounds of the class having a glycosylated 2-deoxystreptamine (2-DOS) ring as well as their preparation and use as prophylactic or therapeutics against microbial infection. Compounds of the ...
04/01/2003
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