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| Number | Title | Issue Date |
| 7626005 | Inhibitors of aminoglycoside 6′--acetyltransferases, compositions and uses thereof The present invention relates to novel inhibitors of aminoglycoside 6′-N-acetyltransferases, more specifically, AAC(6′)-li and AAC(6′)-ly, as well as compositions and uses thereof. Furthermore, the present invention relates to synthetic methodologies for prepa... | 12/01/2009 |
| 7371733 | Anti bacterial compounds The invention relates to novel paranmycin compounds that have activity against gram positive and gram negative bacteria, preferably bacteria that are resistant to other antibiotics. Paranmycins are of the general formula ... | 05/13/2008 |
| 7244712 | Aminoglycoside antibiotics and methods of using same The present invention relates to aminoglycoside compounds having antibiotic activity. Moreover, the present invention relates to L-aminoglycoside compounds and diastereomers thereof which posses antibiotic activity and are not susceptible to development of resistant... | 07/17/2007 |
| 7220727 | Aminoglycosides as antibiotics The present invention provides aminoglycosides and pharmaceutical compositions that include the aminoglycosides. The aminogylcosides are useful to treat or prevent infectious diseases (e.g., bacterial infections) in a mammal (e.g., human). ... | 05/22/2007 |
| 6967242 | Antimicrobial 2-deoxystreptamine compounds The present invention is directed to analogs of aminoglycoside compounds of the class having a glycosylated 2-deoxystreptamine (2-DOS) ring as well as their preparation and use as prophylactic or therapeutics against microbial infection. Compounds of the invention c... | 11/22/2005 |
| 6759523 | Antimicrobial 2-deoxystreptamine compounds The present invention is directed to analogs of aminoglycoside compounds of the class having a glycosylated 2-deoxystreptamine (2-DOS) ring as well as their preparation and use as prophylactic or therapeutics against microbial infection. Compounds of the invention c... | 07/06/2004 |
| 6642365 | Anti-(retro)viral conjugates of saccharides and acetamidino or guanidino compounds Conjugates of a saccharide and an acetamidino- or guanidino-compound, of the formula: ##STR1## wherein A is CH3 or NH2 ; X is a linear or branched C1 -C8 alkyl chain optionally containing hydroxy, amino and/or o... | 11/04/2003 |
| 6541456 | Antimicrobial 2-deoxystreptamine compounds The present invention is directed to analogs of aminoglycoside compounds of the class having a glycosylated 2-deoxystreptamine (2-DOS) ring as well as their preparation and use as prophylactic or therapeutics against microbial infection. Compounds of the ... | 04/01/2003 |
| 6403777 | Metalloligands for cleaving nucleic acids Transition metal complexes, referred to hereinafter as "metalloligands", that catalyze the degradation of DNA and the cleavage of RNA at select sites are provided. In one embodiment, the metalloligand has the following structure: ##STR1## wherein R1 ... | 06/11/2002 |
| 6120997 | Nucleic acid binders having an hydroxyamine motif The invention relates to the combination of hydroxyamines with nucleic acid binding motifs to generate molecules and libraries of molecules targeting specific nucleic acid sequences. In particular, a series of libraries are constructed which contain hydro... | 09/19/2000 |
| 4937257 | Flavanone derivatives New flavanone derivatives of the formula I ##STR1## wherein Ar1 and Ar2 are each phenyl which is unsubstituted or monosubstituted to trisubstituted by OH, alkyl, alkoxy, acylamino, halogen, COOalkyl and/or NO2 and/or ... | 06/26/1990 |
| 4877775 | Polymeric aminosaccharides as antihypercholesterolemic agents Crosslinked copolymers of monomeric aminosaccharides such as aminoglycosidic antibiotics, e.g. neomycin, or of polymeric aminosaccharides, e.g., chitosan, with dialdehydes are useful antihypercholesterolemic agents due to their ability to bind with bile ... | 10/31/1989 |
| 4774231 | Disaccharides formed by patterns having a glucosamine and uronic acid structure, preparation thereof and biological applications 1,4댝isaccharides of formula: ##STR1## with Z representing a nitrogenous functional group, M hydrogen or a sulphate or acetyl group, R an alkyl radical of 1 to 4 carbon atoms and A functional group such as an acid group, or a derivative.... | 09/27/1988 |
| 4607025 | Disaccharides having a glucosamine and uronic acid structure, and biological applications thereof 1,4 disaccharides of formula: ##STR1## with Z representing a nitrogenous functional group, M hydrogen or a sulphate or acetyl group, R an alkyl radical of 1 to 4 carbon atoms and A a functional group such as an acid group, or a derivative.... | 08/19/1986 |
| 4515942 | Antibiotics KA-6606 XII, XIII, XV, XVI and XVII A process for producing an antibiotic, which comprises cultivating an antibiotic KA-6606-producing strain of the genus Saccharopolyspora in a nutrient culture medium, isolating an antibiotic KA-6606-containing substance from the culture broth, and separat... | 05/07/1985 |
| 4503046 | 1-Nitro-aminoglycoside derivatives, pharmaceutical compositions containing them and such derivatives for use as pharmaceuticals Hydroxymethylated aminoglycoside derivatives which are useful, in particular as anti-bacterially active antibiotics.... | 03/05/1985 |
| 4468512 | 1-N-Acylated and 1-N-alkylated derivatives of 4-O-substituted-2-deoxystreptamine aminoglycosides Zinc salts are used to effect the regio-selective acylation and alkylation of the 1-amino group of 4-O-substituted-2-deoxystreptamine-containing aminoglycosides. The 1-N-substituted derivatives of apramycin, 3'-hydroxyapramycin, certain or ଲ... | 08/28/1984 |
| 4468386 | 1-Deamino-1-hydroxy-aminoglycoside compounds, antibacterial compositions and method of use Antibiotic Bu-2659 complex, containing components A, B, C, D and E, is produced by cultivation of Streptomyces hygroscopicus Strain No. J296-21, ATCC No. 39150.... | 08/28/1984 |
| 4424345 | 1-N-Acylated and 1-N-alkylated derivatives of 4-O-substituted-2-deoxystreptamine aminoglycosides and process Zinc salts are used to effect the regio-selective acylation and alkylation of the 1-amino group of 4-O-substituted-2-deoxystreptamine-containing aminoglycosides. The 1-N-substituted derivatives of apramycin, 3'-hydroxyapramycin, certain or ଲ... | 01/03/1984 |
| 4424344 | 2-N-Acylated and 2-N-alkylated derivatives of 4-O-substituted-2-deoxystreptamine aminoglycosides and process Nickel salts are used to effect the regio-selective acylation and alkylation of the 2'-amino group of 4-O-substituted-2-deoxystreptamine containing aminoglycosides. The 2'-N-substituted derivatives of apramycin, certain or ଲ-(lower alkyl)apr... | 01/03/1984 |
| 4281107 | Neamine derivatives and process for preparing the same 5,6-Dideoxyneamine, useful as an antimicrobial agent, and a process for preparing 5,6-dideoxyneamine.... | 07/28/1981 |
| 4252970 | 6-Deoxyneamines 6-Deoxyneamine, 6-deoxy-5-epineamine, their 5-0-glycosyl derivatives, 6-deoxy-5-oxoneamine and the derivatives therefrom are useful as antibacterial agents and/or as intermediates in the synthesis of antibacterially active 6-deoxyneamines.... | 02/24/1981 |
| 4232148 | 6-Deoxyneamines 6-Deoxyneamine, 6-deoxy-5-epineamine, their 5-0-glycosyl derivatives, 6-deoxy-5-oxoneamine and the derivatives therefrom are useful as antibacterial agents and/or as intermediates in the synthesis of antibacterially active 6-deoxyneamines.... | 11/04/1980 |
| 4195173 | Process for preparing pseudo-disaccharides The invention provides pseudo-disaccharides (and their salts) and a method for their preparation. The pseudo-disaccharides are useful as intermediates for the preparation of antibiotics and are also useful as antimicrobial agents, particularly against Gra... | 03/25/1980 |
| 4169197 | 6-Deoxyneamines aminoglycoside compounds 6-Deoxyneamine, 6-deoxy-5-epineamine, their 5-O-glycosyl derivatives, 6-deoxy-5-oxoneamine and the derivatives therefrom are useful as antibacterial agents and/or as intermediates in the synthesis of antibacterially active 6-deoxyneamines.... | 09/25/1979 |
| 4129719 | 5,6-Epineamine and process for preparing the same 5,6-Epineamine represented by the formula (I) ##STR1## and a process for preparing 5,6-epineamine of the formula (I) above which comprises hydrolyzing the epoxy group of a compound of the formula (II) ##STR2## wherein R1 represents a ... | 12/12/1978 |
| 4103082 | Aminocyclitol derivatives and process for producing the same Aminocyclitol derivatives, 5-deoxyneamine and 6-deoxyneamine, having antimicrobial activities against various antibiotic-resistant microorganisms, a process for producing 5-deoxyneamine and 6-deoxyneamine and intermediates useful in producing the aminocyc... | 07/25/1978 |
| 4078138 | 3'-Epi-4'deoxykanamycin B 3',4'--Epoxyneamine and its related aminoglycosidic antibiotic derivatives containing 3',4'--epoxyneamine moiety in the molecule thereof are now provided, which may be in the form of their amino-protected and partially hydroxyl-protected pro... | 03/07/1978 |
| 4078139 | Process for deoxygenating secondary alcohols The process for removing a secondary hydroxyl group from an organic compound having at least one secondary hydroxyl group and having any amino groups protected, comprises the reaction of a reactive ester of said secondary hydroxyl group selected from the ... | 03/07/1978 |
| 4065615 | Deoxyaminoglycoside antibiotic derivatives A new deoxystreptamine-containing aminoglycoside antibiotic derivative in which all the amino groups other than the amino group at the 1-position of the deoxystreptamine moiety are formylated is obtained in a high yield by treating a deoxystreptamine-cont... | 12/27/1977 |
| 4064339 | Antibiotic aminoglycosides, processes of preparation and pharmaceutical compositions There are disclosed pharmaceutically-active aminoglycosides comprising 4-O-(2',6'-diamino 2',6'-didesoxy ,D-glucopyrannosyl) 6-O-(3"-amino 3",4",6"-tridesoxy , D-xylohexopyrannosyl) 2-desoxy streptamine of the formula: ##STR1## and... | 12/20/1977 |
| 4060682 | Process for the synthetic production of 3-deoxy derivative of an aminoglycosidic antibiotic 3'-Deoxy derivatives of neamine, 6'-N-alkylneamine, kanamycin B, 6'-N-alkylkanamycin B, ribostamycin, 6'-N-alkylribostamycin and paromamine may be produced by a new process comprising reducing the 3',4'--anhydro derivative (namely, the 3',4'-epoxid... | 11/29/1977 |
| 4048430 | Mercaptopseudotrisaccharides Novel pseudodisaccharide compounds which are related to neamine are prepared. These compounds have a mercapto group or a derivative thereof at position 3 or 4 of the glucose moiety of neamine. The compounds have antibacterial activity and have utility as ... | 09/13/1977 |
| 4024332 | Aminoglycoside antibiotics and intermediates therefor Certain novel derivatives of naturally-occurring aminoglycoside antibiotics such as neamine, kanamycins A and B, 3',4'-dideoxykanamycin B, 3',4'-dideoxy-4,5-dehydrokanamycin B, tobramycin and the gentamicins C2 and C1a. The novel der... | 05/17/1977 |
| 4020269 | Epiminodeaminodeoxyaminoglycoside antibiotics and intermediates Deoxyaminoglycoside antibiotics are prepared in a high yield from phosphorylated aminoglycosides by reacting a phosphorylated aminoglycoside (a) with a silylating agent, or (b) successively with (i) a silylating or acylating agent and (ii) a halogenating ... | 04/26/1977 |
| 4008218 | 1-N-((S)--substituted-ω-aminoacyl)-neamine or -ribostamycin and the production thereof An 1-N-((S)--substituted-ω-aminoacyl)-neamine or -ribostamycin of the formula: ##STR1## wherein R is a hydrogen atom or ଲ-D-ribofuranosyl group of the formula ##STR2## and R3 is hydroxyl, amino-NH2 or acy... | 02/15/1977 |
| 4008362 | 1-N-((S)--substituted-ω-aminoacyl)-neamine or -ribostamycin and the production thereof An 1-N-((S)--substituted-ω-aminoacyl)-neamine or -ribostamycin of the formula ##STR1## wherein R is a hydrogen atom or ଲ-D-ribofuranosyl group of the formula ##STR2## and R3 is hydroxyl, amino-NH2 or acyl... | 02/15/1977 |
| 4001208 | 1-N-[(S)--hydroxy-ω-aminoacyl] A new and useful 1-N-[(S)--hydroxy-ω-aminoacyl]derivative of an aminoglycosidic antiobiotic, including its deoxy derivative, such as kanamycin B, 3'-deoxyneamine, 3',4'-dideoxyneamine, 3',4'-dideoxyribostamycin or 3', 4'-dideoxykanamycin B is now ... | 01/04/1977 |
| 3996205 | Aminoglycoside antibiotics and intermediates 6-0- AND 3'-0-D-glycosyl analogs of neamine, 6-0- and 3'-0-D-glycosyl ortho esters of neamine, novel aminoglycoside antibiotics, and novel intermediates are prepared by a new chemical process. The compounds have utility as antibacterial agents or as inter... | 12/07/1976 |
| 3981861 | Antibiotic aminoglycosides, processes of preparation and pharmaceutical compositions There are disclosed pharmaceutically-active aminoglycosides comprising 4-0-(2',6'-diamino 2', 3', 4', 6'-tetradesoxy ,D-erythrohexopyrannosyl) 6-0-(3"-methylamino 3", 4", 6"-tridesoxy ,D-xylohexopyrannosyl) 2-desoxystreptamine of the formula... | 09/21/1976 |
