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| Number | Title | Issue Date |
| 5696244 | Method for preparing 1-N-ethylsisomicin 1-N-ethylsisomicin represented by the following structural formula I and pharmaceutically acceptable salts thereof are useful antibacterial agents and can be prepared in high yields by a characteristic method comprising the steps of: chelating sisomicin w... | 12/09/1997 |
| 5686588 | Amine acid salt compounds and process for the production thereof A stoichiometric acid moiety transfer reaction for the preparation of an acid salt of an amine compound is disclosed. The acid moiety transfer reaction provides amine acid salts of high purity and having crystalline structure of uniform size and shape.... | 11/11/1997 |
| 5618795 | Dibekacin derivatives and arbekacin derivatives active against resistant bacteria, and the production thereof As new dibekacin derivatives and new arbekacin derivatives are now provided 2"-amino-2"-deoxydibekacin, 2"-amino-5,2"-dideoxydibekacin, 2"-amino-2"-deoxyarbekacin, 2"-amino-5,2"-dideoxyarbekacin, 2"-amino-5,2"-dideoxy-5-epi-fluoroarbekacin and 2"-ami... | 04/08/1997 |
| 4831123 | Process for preparing netilmicin A high yielding process for converting 3,2',6'-tri-N-acetyl sisomicin to netilmicin comprising the step of silylating the starting material at the 5,2' positions, and optionally at the 4' position, converting the 1-amino substituent to a 1-N-imino substit... | 05/16/1989 |
| 4486419 | 5,2',3',4',4",6"-Hexadeoxykanamycin and its 1-N-acylated derivative 5,2',3',4',4",6"-Hexadeoxykanamycin and 1-N-[(S)-4-amino-2-hydroxybutyryl]-5,2',3',4',4",6"-hexadeoxykanamycin are now provided, which are each a new compound useful as antibacterial agent. The hexadeoxykanamycin is semi-synthetically produced from 3... | 12/04/1984 |
| 4438260 | Sisomicin compounds The invention relates to sisomicin derivatives of formula (I) and methods for their preparation. Also included in the invention are compositions containing said sisomicin derivatives and the use of said derivatives and compositions for the treatment of ba... | 03/20/1984 |
| 4404366 | Beta-galactosyl-umbelliferone-labeled hapten conjugates An improved specific binding assay method and reagent for determining a ligand in a liquid medium employing, as an enzyme-cleavable substrate label, a residue having the formula: wherein G is a glycone, D is a dye indicator moiety, and R is a linking grou... | 09/13/1983 |
| 4393051 | 1-N(Aminopolyhydroxyalkyl)aminoglycoside antibiotics and method of use The invention relates to pseudotrisaccharides of Formula (I) as defined above, methods for preparing them, compositions containing them and methods for the use of said compounds and compositions.... | 07/12/1983 |
| 4380625 | Process for the preparation of purified aminoglycoside antibiotics The invention relates to an improved process for the isolation and purification of aminoglycoside antibiotics of Formula (I) as defined herein combining selective lipophilization of the compound of Formula (I) in the crude product obtained by fermentation... | 04/19/1983 |
| 4349667 | Aminoglycoside antibiotic G-367-2 Aminoglycoside antibiotic G-367-2 believed to have the formula ##STR1## is produced by culturing Dactylosporangium thailandense G-367 FERM-P No. 4840 in a nutrient medium and separating the produced antibiotic therefrom. It has strong antibacterial e... | 09/14/1982 |
| 4337335 | Transition metal salt complexes of polyamino organic compounds Described are transition metal salt complexes of available neighboring amino and hydroxyl group pairs in polyamino organic compounds, their preparation, and use as intermediates in the preparation of selectively N-blocked polyamino organic compounds.... | 06/29/1982 |
| 4336369 | Selectively protected 1-N-(ω-aminoalkoxycarbonyl)-sisomicin derivatives The invention relates to selectively protected 1-N-(ω-aminoalkoxycarbonyl)-sisomicin derivatives and methods for their procurement. Said derivatives are useful as intermediates for the procurement of highly active antibacterial agents of low toxicity.... | 06/22/1982 |
| 4335114 | 1-N-Alkylsisomicin derivatives, their production and their medicinal use The invention relates to sisomicin derivatives defined below in Formula (I) and a process for the preparation of said derivatives. Also included in the invention are compositions containing said derivatives and methods for using said derivatives and compo... | 06/15/1982 |
| 4312859 | Sisomicin derivatives, processes for their production and their medicinal use The invention relates to sesomycin derivatives of Formula I, infra as well as processes for preparing said sisomycin derivatives. Also included in the invention are compositions containing said sisomycin derivatives and methods for the use of said compoun... | 01/26/1982 |
| 4297485 | Production of a selectively protected N-acylated derivative of an aminoglycosidic antibiotic Aminoglycosidic antibiotic comprising a 6-0-(3"-aminoglycosyl)-2-deoxystreptamine optionally having a 4-0-(aminogycosyl) group, such as kanamycins, gentamicins, sisomicin, forms reversible complex with zinc cations by association of the zinc cations ... | 10/27/1981 |
| 4294959 | Selectively protected 4,6-di-O-(aminoglycosyl)-1,3-diaminocyclitols and their production The invention relates to selectively protected 4,6-di-O-(aminoglycosyl)-1,3-diamino cyclitols (and methods for their preparation) useful as intermediates for the synthesis of antibiotics, such as those of the sisomycin type.... | 10/13/1981 |
| 4284764 | Process for the preparation of 5-fluoro-5-deoxy and 5-epi-fluoro-5-deoxy-4,6-di-O-(aminoglycosyl)-1,3-diaminocyclitols and novel 5-fluoro-5-deoxy and 5-epi-fluoro-5-deoxy derivatives produced thereby A novel process whereby 4,6-di-O-(aminoglycosyl)-1,3-diaminocyclitols are reacted with a dialkylaminosulfur trifluoride to produce novel 5-fluoro-5-deoxy and 5-epi-fluoro-5-deoxy-4,6-di-O-(aminoglycosyl)-1,3-diaminocyclitol antibacterial agents.... | 08/18/1981 |
| 4282350 | Selective 3"-N-acylation of 1,3"-di-N-unprotected-poly-N-protected-4,6-di-O-(aminoglycosyl)-1,3-diam inocyclitols This invention describes a novel process whereby 1,3"-di-N-unprotected-poly-N-protected-4,6-di-O-(aminoglycosyl)-1,3-diamin ocyclitols are selectively acylated at the 3"-N-position with 1-Z-imidazole, wherein Z is an amino protecting group; to produce nove... | 08/04/1981 |
| 4256876 | Process for precipitating aminoglycosides A highly efficient process for the precipitation of an amorphous (non-crystalline) aminoglycoside antibiotic salt during the purification process. Illustratively, there are disclosed processes for precipitating gentamicin, neomycin, and sisomicin salts.... | 03/17/1981 |
| 4248865 | Novel aminoglycoside derivatives Novel aminoglycoside derivatives and their salts containing 2-deoxystreptamine moiety, of which the 1-amino group is modified with a group represented by the formula: ##STR1## (wherein R is hydrogen or C1 to C6 alkanoyl; and n i... | 02/03/1981 |
| 4243801 | 6"-Amino derivatives of 4-0-aminoglycosyl-6-0-garosaminyl-1,3-diaminocyclitols Novel 6"-amino derivatives of 4-0-aminoglycosyl-6-0-garosaminyl-1,3-diaminocyclitols, useful as antibacterial agents, are described.... | 01/06/1981 |
| 4242331 | Aminoglycosides and method of use Novel aminoglycoside derivatives of desoxystreptamines of the formula ##STR1## wherein R1 and R2 are selected from the group consisting of hydrogen and hydroxyl with at least one of them being hydrogen and their non-toxic, pharm... | 12/30/1980 |
| 4235888 | Pseudotrissaccharides, a process for their production and their use as medicaments Pseudotrisaccharides of the sisomycin type are provided which are effective an antibacterial agents, particularly against gram-negative microorganisms. The invention also includes methods for the manufacture of the pseudotrisaccharides, compositions conta... | 11/25/1980 |
| 4234572 | 1-N-4,6-di-O-(Aminoglycosyl)-1,3-diamino-cyclitol derivatives, processes for their preparation and their use The invention relates to 1-N-4,6-di-O-(aminoglycosyl)-1,3-diamino-cyclitol derivatives useful as antimicrobial agents. Also included in the invention are methods for preparing said derivatives, the provision of pharmaceutical compositions containing said ... | 11/18/1980 |
| 4230847 | Aminoglycoside antibiotic compounds Selective blocking of some amino groups in a polyamino organic compound having at least one pair of available neighboring hydroxyl and amino groups is effected by first preparing in situ transition metal salt complexes of available neighboring amino and h... | 10/28/1980 |
| 4226978 | ଲ-Galactosyl-umbelliferone-labeled aminoglycoside antibiotics and intermediates in their preparation ଲ-Galactosyl-umbelliferone labeled aminoglycoside antibiotics, e.g., gentamicin, useful in homogeneous and heterogeneous specific binding assays for such antibiotics in liquid media such as serum. Also provided are a ଲ-galactosyl-umbelliferone... | 10/07/1980 |
| 4224315 | Pseudotrisaccharides and their medicinal use The invention includes, as novel compounds, aminoglycoside antibiotics of the 4,6-di-O-(aminoglycosyl)-1,3-diaminocyclitols which are 3-N"-substituted. Also included in the invention are compositions containing said novel compounds and methods for the use... | 09/23/1980 |
| 4212859 | 2'-Hydroxy-2'-desamino-4,6-di-O-(aminoglycosyl)-1,3-diaminocyclitols, methods for their manufacture, method for their use as antibacterial agents, and compositions useful therefor 2'-Hydroxy-2'-desamino-4,6-di-O-(aminoglycosyl)-1,3-diaminocyclitols having a 6'-amino function exhibit antibacterial activity and are prepared by reaction of the corresponding N-protected (except the 2'-amino)-4,6-di-O-(aminoglycosyl)-1,3-diaminocyclitol... | 07/15/1980 |
| 4212860 | 4-O-(2,3,5-Trideoxy-5-amino--D-pentofuranosy l)-6-O-aminoglycosyl-1,3-diaminocyclitois, methods for their preparation, pharmaceutical formulations thereof and their use as antibacterial agents 4-O-(2,3,5-Trideoxy-5-amino--D-pentofuranosyl)-6-O-aminoglycosyl-1,3 -diaminocyclitols and 1-N-substituted derivatives thereof are described together with methods for their preparation and their use as antibacterial agents. Preferred are 1-N-(Ï... | 07/15/1980 |
| 4201774 | Novel aminoglycoside derivatives Novel aminoglycoside derivatives and their salts, of which the 1-amino group is modified with groups represented by the formula: ##STR1## (wherein R is hydrogen, lower alkyl, or aralkyl; and n is an integer of 1 to 3.) effective in treatment and prev... | 05/06/1980 |
| 4200628 | Novel aminoglycoside derivatives Novel aminoglycoside derivatives and their salts containing 2-deoxystreptamine moiety, of which the 1-amino group is acylated by a group represented by the formula: ##STR1## (wherein R is 4 to 6 membered heterocyclic group containing 1 to 2 nitr... | 04/29/1980 |
| 4199572 | N-Substituted amino glycoside compounds, their production, and their use as medicaments The invention relates to new derivatives, substituted on one or more nitrogen atoms, of 4,6-di-(amino-glycosyl)-1,3-diamino-cyclitols, which include the gentamycins, sisomicin, verdamycin, tobramycin, the kanamycins, the antibiotics G-418, 66-40 B, 66-40 ... | 04/22/1980 |
| 4199570 | 1-N-Hetero containing aminoglycoside derivatives Novel aminoglycoside derivatives and their salts containing 2-deoxystreptamine moiety, of which the 1-amino group is acylated by a group represented by the formula: ##STR1## wherein R is hydrogen, lower alkyl, aralkyl, or aralkoxycarbonyl; and n is a... | 04/22/1980 |
| 4190722 | 4,6-Di-O-(aminoglycosyl)-1,3-diaminocyclitols, process for their production and their use The invention includes selectively acylated or sulphenylated 4,6-O-(aminoglycosyl)-1,3-diaminocyclitols (and methods for their preparation). Also included in the invention are 1-N-acylated-derivatives, such as 1-N-formyl-sisomicin, useful because of the a... | 02/26/1980 |
| 4180565 | 1-N-substituted derivatives of 4,6-di-O-(aminoglycosyl)-1,3-diaminocyclitols Novel 1-N-aminoalkyl (oxycarbonyl or carboxamido or thiocarboxamido) derivatives of 4,6-di-O-(aminoglycosyl)-1,3-diaminocyclitols, useful as antibacterial agents, are described.... | 12/25/1979 |
| 4171356 | 2-Unsubstituted derivatives of 4,6-di-o-(aminoglycosyl)-1,3-diaminocyclitois, methods for their use as antibacterial agents and compositions useful therefor The preparation of novel 2'-unsubstituted derivatives of 4,6-di-O-(aminoglycosyl)-1,3-diaminocyclitols, useful as antibacterial agents, is described.... | 10/16/1979 |
| 4169141 | 1-Peptidyl derivatives of di-O-aminoglycosyl-1,3-diaminocyclitol antibacterial agents Disclosed herein are di-O-(aminoglycosyl)-1,3-diaminocyclitol antibacterial agents having on the 1-N-position of the 1,3-diaminocyclitol moiety a dipeptidyl or a tripeptidyl substituent. The compounds are useful antibacterial agents, as are their non-toxi... | 09/25/1979 |
| 4166114 | Aminoglycoside antibiotic derivatives and method of use Novel aminoglycoside antibiotic derivatives and their salts containing a 2-deoxystreptamine moiety of which the 1-amino group is substituted by a group represented by the formula: ##STR1## [wherein R is hydrogen atom, lower alkyl or aralkyl; n is an ... | 08/28/1979 |
| 4136254 | Process of selectively blocking amino functions in aminoglycosides using transition metal salts and intermediates used thereby Selective blocking of some amino groups in a polyamino organic compound having at least one pair of available neighboring hydroxyl and amino groups is effected by first preparing in situ transition metal salt complexes of available neighboring amino and h... | 01/23/1979 |
| 4117221 | Aminoacyl derivatives of aminoglycoside antibiotics Disclosed herein are novel 1-N-X-aminoglycoside anti-bacterial agents produced from antibiotics elaborated by species of the genus Micromonospora wherein X is a member selected from the group consisting of S-3-amino-2-hydroxypropionyl and S-4-amino-2-hydr... | 09/26/1978 |
