Did You Know...
...that while attempting to develop a super strong glue, 3M employee Spencer Silver accidentally developed a glue that was so weak it would barely hold two pieces of paper together? However, his colleague Art Fry needed the glue. Fry sang with his church choir and marked the pages of his hymnal with small scraps of paper that often fell out. He used Silver's glue to hold the papers in place. Today we call this invention Post-it Notes.
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| Number | Title | Issue Date |
| 7439343 | Aminoglycoside-polyamine displacers and methods of use in displacement chromatography Aminoglycoside-polyamines are disclosed along with methods of use thereof in displacement chromatography and as DNA-binding ligands. The aminoglycoside-polyamines are derivatives of carbohydrates, such as sugars, amino sugars, deoxysugars, glycosides, nucleosides an... | 10/21/2008 |
| 7235370 | Site-specific aminoglycoside derivatives for use in immunodiagnostic assays A method of making a derivatized aminoglycoside includes reacting an aminoglycoside with at least 2 equivalents of a divalent metal ion in an aprotic solvent to complex two neighboring amino group and hydroxyl group pairs; reacting the non-complexed amino groups wit... | 06/26/2007 |
| 7169814 | Guanidinium transport reagents and conjugates Transport reagents and conjugates of therapeutic agents linked to transport reagents are described. In particular, the transport reagents have a plurality of guanidinium moieties that are either contiguous or spaced along a backbone, but are sufficiently removed fro... | 01/30/2007 |
| 6833445 | Guanidinylation, guanidinoglycosides, uses, and methods of assaying their activity Provided are reagents and methods useful for the synthesis of guanidinylated compounds. Also provided are methods for assaying molecules, including guanidinylated molecules that modulate viral infection and replication. ... | 12/21/2004 |
| 6642365 | Anti-(retro)viral conjugates of saccharides and acetamidino or guanidino compounds Conjugates of a saccharide and an acetamidino- or guanidino-compound, of the formula: ##STR1## wherein A is CH3 or NH2 ; X is a linear or branched C1 -C8 alkyl chain optionally containing hydroxy, amino and/or o... | 11/04/2003 |
| 6573060 | Methods and compositions for targeting DNA metabolic processes using aminoglycoside derivatives Protein targets for disease intervention through inhibition of nucleic acid metabolism are disclosed. Novel polypeptides for one such target, DNA-dependent ATPase A, and novel polynucleotides encoding DNA-dependent ATPase A are disclosed. Phosphoaminoglyc... | 06/03/2003 |
| 6525182 | Guanidinylation, guanidinoglycosides, uses, and methods of assaying their activity Provided are reagents and methods useful for the synthesis of guanidinylated compounds. Also provided are methods for assaying molecules, including guanidinylated molecules that modulate viral infection and replication.... | 02/25/2003 |
| 5763587 | Process for the synthesis of amikacin In the synthesis of amikacin, having the formula: ##STR1## by acylation of a diprotected derivative of kanamycin A with a reactive derivative of L-(-)-4-amino-2-hydroxybutyric acid, the selection of the reaction solvent and of the pH conditions permi... | 06/09/1998 |
| 5696244 | Method for preparing 1-N-ethylsisomicin 1-N-ethylsisomicin represented by the following structural formula I and pharmaceutically acceptable salts thereof are useful antibacterial agents and can be prepared in high yields by a characteristic method comprising the steps of: chelating sisomicin w... | 12/09/1997 |
| 5656735 | Process for the preparation of amikacin precursors Process for the preparation of a 3,6'-di-N-Acyl-1-[L-(-)-4-Acylamino-2-hydroxybutyryl] kanamycin A, wherein Acyl is a N-protecting acylating group, which comprises reacting kanamycin A with an aluminum salt in an inert organic solvent, treating the alumin... | 08/12/1997 |
| 5621085 | Process for the preparation of amikacin precursors Process for the preparation of a 3,6'-di-N-Acyl-1-[L-(-)-4-Acylamino-2-hydroxybutyryl] kanamycin A, wherein Acyl is a N-protecting acylating group, which comprises reacting kanamycin A with an aluminum salt in an inert organic solvent, treating the alumin... | 04/15/1997 |
| 5618795 | Dibekacin derivatives and arbekacin derivatives active against resistant bacteria, and the production thereof As new dibekacin derivatives and new arbekacin derivatives are now provided 2"-amino-2"-deoxydibekacin, 2"-amino-5,2"-dideoxydibekacin, 2"-amino-2"-deoxyarbekacin, 2"-amino-5,2"-dideoxyarbekacin, 2"-amino-5,2"-dideoxy-5-epi-fluoroarbekacin and 2"-ami... | 04/08/1997 |
| 5595977 | Salts of amino glycosides The present invention relates to novel amino glycoside salts of sucrose-octa-O-sulfonic acid of formula I: ([sucrose-octa-O-sulfonic acid8- ]-[R-(NH3+)x ]y -Mzn+) ... | 01/21/1997 |
| 5527781 | 4-O-(aminoglycosyl)- or 4,6-di-O-(aminoglycosyl)-2,5-dideoxy-5,5-difluorostreptamine derivatives As new compounds are now synthetized 5-deoxy-5,5-difluoro derivatives of aminoglycosidic antibiotics of neamine, kanamycin A-series, kanamycin B-series, gentamicin-series and seldomycin-series. Further, the 1-N-(-hydroxy-ω-aminoalkanoyl) derivativ... | 06/18/1996 |
| 5488038 | Dibekacin derivatives and arbekacin derivatives active against resistant bacteria As new dibekacin derivatives and new arbekacin derivatives are now provided 2"-amino-2"-deoxydibekacin, 2"-amino-5,2"-dideoxydibekacin, 2"-amino-2"-deoxyarbekacin, 2"-amino-5,2"-dideoxyarbekacin, 2"-amino-5,2"-dideoxy-5-epi-fluoroarbekacin and 2"-ami... | 01/30/1996 |
| 5079234 | Inhibitors of aminoglycoside nephrotoxicity Certain water-soluble polyanionic organic acid polymers in the weight range of from about 1,000 to 30,000 daltons may be use to inhibit aminoglycoside nephrotoxicity. These polyanionic polymers are homopolymers or copolymers comprised of monomers selected... | 01/07/1992 |
| 4985549 | Process for preparing amikacin Described is a process for preparing Amikacin wherein 1-N-(L(-)γ-benzyloxycarbonylamino--hyroxybutyryl)-3,6'-di-N-b enzyloxycarbonyl-Kanamycin A suspended in a suitable solvent, is treated with an aqueous solution of formic acid in the presence of ... | 01/15/1991 |
| 4902790 | Novel process for the synthesis of amikacin A novel process for the synthesis of amikacin starting from kanamycin A protected at the positions 3 and 6' is described comprising the reaction of kanamycin A with a salt of a bivalent metal cation selected from zinc, nickel, iron, cobalt, manganese, cop... | 02/20/1990 |
| 4877775 | Polymeric aminosaccharides as antihypercholesterolemic agents Crosslinked copolymers of monomeric aminosaccharides such as aminoglycosidic antibiotics, e.g. neomycin, or of polymeric aminosaccharides, e.g., chitosan, with dialdehydes are useful antihypercholesterolemic agents due to their ability to bind with bile ... | 10/31/1989 |
| 4873225 | 1-n-(4-amino-3-fluoro-2-hydroxybutyryl)-kanamycins As new compound are now provided ten compounds, namely 1-N-{(2R,3R)-4-amino-3-fluoro-2-hydroxybutyryl}kanamycin A; 1-N-{(2R,3R)-4-amino-3-fluoro-2-hydroxybutyryl}-2',3'-dideoxykanamycin A; 1-N-{(2R,3R)-4-amino-3-fluoro-2-hydroxybutyryl}-2',3'-dideoxy-2'-f... | 10/10/1989 |
| 4845082 | 3'4'-dideoxy-3'-fluorokanamycin B and production thereof New compound, 3',4'-dideoxy-3'-fluorokanamycin B is now provided, which is useful as antibacterial agent. 3',4'-Dideoxy-3'-fluorokanamycin B is prepared by a process comprising halogenating an N,O-protected derivative of 3'-deoxy-3'-fluoro-4'-O-sulfonylka... | 07/04/1989 |
| 4831123 | Process for preparing netilmicin A high yielding process for converting 3,2',6'-tri-N-acetyl sisomicin to netilmicin comprising the step of silylating the starting material at the 5,2' positions, and optionally at the 4' position, converting the 1-amino substituent to a 1-N-imino substit... | 05/16/1989 |
| 4816391 | Amine stabilized aminoglycoside formulations Novel formulations are provided containing conjugated or unconjugated aminoglycosides, particularly labeled glycosides, a small amount of a polyamine, and additional additives, such as buffer, salt, and inert protein. The level of immunologic activity of ... | 03/28/1989 |
| 4661474 | 2',3'-dideoxy-2'-fluorokanamycin A and 1-N-(-hydroxy-ω-aminoalkanoyl) derivatives thereof New compounds, 2',3'-dideoxy-2'-fluorokanamycin A and 1-N-(-hydroxy-ω-aminoalkanoyl) derivatives thereof, particularly 1-N-(DL- or L-3-amino-2-hydroxypropionyl)- and 1-N-(L-4-amino-2-hydroxybutyryl)-2',3'-dideoxy-2'-fluorokanamycins A are now... | 04/28/1987 |
| 4656160 | Aminoglycoside derivatives Aminoglycoside derivatives and pharmaceutically acceptable salts thereof which are useful as prophylactic and therapeutic agents for infectious diseases caused by pathogenic microorganisms, and a pharmaceutical composition comprising the same.... | 04/07/1987 |
| 4645760 | Activated aminoglycosides and aminoglycoside-aminocyclitols pharmaceutical compositions and method of use Aminoglycosides and aminoglycoside-aminocyclitols which have been oxygen-radical activated show a broad spectrum of antibacterial activity. The activated compounds are able to penetrate the cell membranes of bacteria and show substantially enhanced activi... | 02/24/1987 |
| 4634688 | 3'-fluoro-3'-deoxykanamycin A A new compound, 3'-fluoro-3'-deoxykanamycin A is now provided, which is active against gram-negative and gram-positive bacteria, including kanamycin-resistant strains of bacteria and is useful as antibacterial agent for therapeutic treatment of bacterial ... | 01/06/1987 |
| 4593089 | Fluorescent polarization immunoassay utilizing substituted triazinylaminofluorescein aminoglycosides This disclosure relates to a method and reagents for determining ligands in biological fluids such as serum, plasma, spinal fluid, amnionic fluid and urine. In particular, this disclosure relates to a fluorescent polarization immunoassay procedure and to ... | 06/03/1986 |
| 4567165 | N-Methanesulfonic acid derivatives of 3-demethoxyistamycin B As new semi-synthetic antibiotic derivatives are provided N-methanesulfonic acid derivatives of 3-demethoxyistamycin B which are less toxic than the parent 3-demethoxyistamycin B but retain usefully high antibacterial activity of the parent antibiotic. Th... | 01/28/1986 |
| 4547492 | 1-N-(ω-Amino--hydroxyalkanoyl-2',3'-dideoxykanamycin A and pharmaceutical composition containing same 1-N-(L-3-amino-2-hydroxypropionyl)-2',-3'-dideoxykanamycin A and 1-N-(L-4-amino-2-hydroxybutyryl)-2',3'-dideoxykanamycin A are now provided which each is a new compound useful as antibacterial agent. The new compounds each is produced by acylating the 1-a... | 10/15/1985 |
| 4493831 | Aminoglycoside derivatives Aminoglycoside derivatives and pharmaceutically acceptable salts thereof which are useful as prophylactic and therapeutic agents for infectious diseases caused by pathogenic microorganisms, processes for the preparation thereof and a pharmaceutical compos... | 01/15/1985 |
| 4486419 | 5,2',3',4',4",6"-Hexadeoxykanamycin and its 1-N-acylated derivative 5,2',3',4',4",6"-Hexadeoxykanamycin and 1-N-[(S)-4-amino-2-hydroxybutyryl]-5,2',3',4',4",6"-hexadeoxykanamycin are now provided, which are each a new compound useful as antibacterial agent. The hexadeoxykanamycin is semi-synthetically produced from 3... | 12/04/1984 |
| 4455419 | 2'-Modified kanamycins and production thereof 2'-Modified kanamycins, including 2'-deoxykanamycin A, 2'-epikanamycin A and 2'-epikanamycin B, as new compounds are produced starting from kanamycin A by consecutive reaction steps. These new compounds are useful as antibacterial agent.... | 06/19/1984 |
| 4424343 | Preparation of 1-N-[ω-amino--hydroxyalkanoyl]kanamycin polysilylates and products An improved process for the preparation of 1-N-[ω-amino--hydroxyalkanoyl]kanamycins comprises acylating a polysilylated kanamycin in a substantially anhydrous organic solvent with an acylating derivative of an ω-amino--hydroxyalkanoic ... | 01/03/1984 |
| 4410516 | 1-N(Hydroxy-ω-aminoalkanoyl) derivatives of 5,3',4'-trideoxy- or 5,3', 4'-trideoxy-6'-N- methyl- or 5, 3', 4',6"-tetradeoxykannamyci B and production thereof New antibacterial compounds are provided, including a 1-N-(-hydroxy-ω-aminoalkanoyl)-5,3',4'-trideoxykanamycin B; a 1-N(-hydroxy-ω-aminoalkanoyl)-5,3',4',641 -tetradeoxykanamycin B; and a 1-N-(-hydroxy-ω-aminoalkanoyl)-5,3',4'... | 10/18/1983 |
| 4404366 | Beta-galactosyl-umbelliferone-labeled hapten conjugates An improved specific binding assay method and reagent for determining a ligand in a liquid medium employing, as an enzyme-cleavable substrate label, a residue having the formula: wherein G is a glycone, D is a dye indicator moiety, and R is a linking grou... | 09/13/1983 |
| 4359572 | Process for the production of 3'-deoxykanamycin A and intermediate product 3'-Deoxykanamycin A useful as an antibacterial agent can be produced by a new process comprising reacting a 2',2"-di-O-acylated-3'-O-sulfonylated-tetra-N-protected derivative of kanamycin A with a base such as alkali metal alcoholate in a lower alkanol ... | 11/16/1982 |
| 4357465 | 3',4'-Diedeoxykanamycin B derivatives New routes are provided for the synthesis of 3',4'-dideoxykanamycin B which is effective in inhibiting kanamycin-resistant organisms from kanamycin B through new intermediate, of which a fundamental process comprises a new reaction of a 3',4'-epoxy deriva... | 11/02/1982 |
| 4357466 | Processes for the production of 3'-deoxykanamycin A and intermediates 3'-Deoxykanamycin A useful as antibacterial agent is produced from a protected kanamycin A derivative either by a process comprising imidazolylthiocarbonylation of the 3'- and 2"-hydroxyl groups of 4",6"-O-cyclohexylidene-4'-0:6'-N-carbonyl-5,2'-O-isoprop... | 11/02/1982 |
| 4349666 | Process for the production of kanomycin B derivatives and products obtained therefrom 3'-Deoxykanamycin B, namely tobramycin is produced in an improved yield with a reduced reaction time under moderate reaction conditions, starting from a penta-N-protected 3'-mono-O-alkyl-, aralkyl- or arylsulfonylated derivative of kanamycin B in which al... | 09/14/1982 |
