Did You Know...
...that several people are credited with the invention of the flush toilet? Most people have heard of Thomas Crapper (1837-1910), the sanitary engineer who invented the valve-and-siphon arrangement that made the modern toilet possible. Another claimant to "the throne" was British inventor Alexander Cumming who patented a toilet in 1775. Then there's a nameless Minoan (a native of ancient Crete) who lived 4,000 years ago who supposedly was ahead of his time and created the first flush toilet!
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| Number | Title | Issue Date |
| 7439343 | Aminoglycoside-polyamine displacers and methods of use in displacement chromatography Aminoglycoside-polyamines are disclosed along with methods of use thereof in displacement chromatography and as DNA-binding ligands. The aminoglycoside-polyamines are derivatives of carbohydrates, such as sugars, amino sugars, deoxysugars, glycosides, nucleosides an... | 10/21/2008 |
| 7235370 | Site-specific aminoglycoside derivatives for use in immunodiagnostic assays A method of making a derivatized aminoglycoside includes reacting an aminoglycoside with at least 2 equivalents of a divalent metal ion in an aprotic solvent to complex two neighboring amino group and hydroxyl group pairs; reacting the non-complexed amino groups wit... | 06/26/2007 |
| 7128897 | Aerosolized anti-infectives, anti-inflammatories, and decongestants for the treatment of sinusitis Pharmaceutical compositions are described that contain one agent for treatment of sinusitis and a surfactant. The compositions are prepared to have a surface tension that renders the composition effective for treatment of sinusitis. ... | 10/31/2006 |
| 6858589 | Methods of and compositions for potentiating the action of agents active on cell wall sites of the susceptible bacteria The invention provides a method of potentiating the activity of antibacterial agents that act on bacterial cell walls, comprising the step of administering to a subject an antibacterial agent and an aminoglycoside to attain a peak concentration of at least 4 mg/l of... | 02/22/2005 |
| 6642365 | Anti-(retro)viral conjugates of saccharides and acetamidino or guanidino compounds Conjugates of a saccharide and an acetamidino- or guanidino-compound, of the formula: ##STR1## wherein A is CH3 or NH2 ; X is a linear or branched C1 -C8 alkyl chain optionally containing hydroxy, amino and/or o... | 11/04/2003 |
| 6573060 | Methods and compositions for targeting DNA metabolic processes using aminoglycoside derivatives Protein targets for disease intervention through inhibition of nucleic acid metabolism are disclosed. Novel polypeptides for one such target, DNA-dependent ATPase A, and novel polynucleotides encoding DNA-dependent ATPase A are disclosed. Phosphoaminoglyc... | 06/03/2003 |
| 6475992 | Methods of and compositions for potentiating the action of agents active on cell wall sites of the susceptible bacteria The invention provides a method of potentiating the activity of antibacterial agents that act on bacterial cell walls, comprising the step of administering to a subject an antibacterial agent and an aminoglycoside to attain a peak concentration of at leas... | 11/05/2002 |
| 6403777 | Metalloligands for cleaving nucleic acids Transition metal complexes, referred to hereinafter as "metalloligands", that catalyze the degradation of DNA and the cleavage of RNA at select sites are provided. In one embodiment, the metalloligand has the following structure: ##STR1## wherein R1 ... | 06/11/2002 |
| 5814488 | Semisynthetic 1-N-ethylgentamicin C1a and method for its preparation This invention relates to the fields of microbiology and antibiotics. Particularly, it relates to a new mutant strain, a method of its mutation breeding, to a monocomponent Gentamicin C1a produced by this strain which is used as mother nucleus ... | 09/29/1998 |
| 5696244 | Method for preparing 1-N-ethylsisomicin 1-N-ethylsisomicin represented by the following structural formula I and pharmaceutically acceptable salts thereof are useful antibacterial agents and can be prepared in high yields by a characteristic method comprising the steps of: chelating sisomicin w... | 12/09/1997 |
| 5686588 | Amine acid salt compounds and process for the production thereof A stoichiometric acid moiety transfer reaction for the preparation of an acid salt of an amine compound is disclosed. The acid moiety transfer reaction provides amine acid salts of high purity and having crystalline structure of uniform size and shape.... | 11/11/1997 |
| 5679646 | Solvent for a sparingly soluble gentamicin salt A solvent for the salt of gentamicin with 3-p-methoxybenzylidene-6-hydroxy-4 '-methoxyflavanone-6-phosphate which is a mixture of from 6 to 9.75 parts by volume of tetrahydrofuran and from 4 to 0.25 parts by volume of water. In these solvents the active c... | 10/21/1997 |
| 5604208 | Antibiotic preparation and use of the same in plants An antibiotic formulation comprising gentamicin, and optionally tetracycline or oxytetracycline, for use in plants.... | 02/18/1997 |
| 5595977 | Salts of amino glycosides The present invention relates to novel amino glycoside salts of sucrose-octa-O-sulfonic acid of formula I: ([sucrose-octa-O-sulfonic acid8- ]-[R-(NH3+)x ]y -Mzn+) ... | 01/21/1997 |
| 5539121 | 2-formylmercaptobenzothiazole There is disclosed a novel formylating agent, 2-formylmercaptobenzothiazole.... | 07/23/1996 |
| 5527781 | 4-O-(aminoglycosyl)- or 4,6-di-O-(aminoglycosyl)-2,5-dideoxy-5,5-difluorostreptamine derivatives As new compounds are now synthetized 5-deoxy-5,5-difluoro derivatives of aminoglycosidic antibiotics of neamine, kanamycin A-series, kanamycin B-series, gentamicin-series and seldomycin-series. Further, the 1-N-(-hydroxy-ω-aminoalkanoyl) derivativ... | 06/18/1996 |
| 5523288 | Method of treating gram-negative bacterial infection by administration of bactericidal/permeability-increasing (BPI) protein product and antibiotic The present invention relates to methods and compositions for treating gram-negative bacterial infections, using BPI protein products. Co-treatment, or concurrent administration, of BPI protein product with an antibiotic in treatment of gram-negative bact... | 06/04/1996 |
| 5442047 | Process for preparing isepamicin An improved process for converting gentamicin B to isepamicin comprising forming 3,6'-di-N-formylgentamicin B, acylating the 1-amino group with an N-protected (S)-isoserine compound and removing all the blocking groups under conditions which result in hig... | 08/15/1995 |
| 5079234 | Inhibitors of aminoglycoside nephrotoxicity Certain water-soluble polyanionic organic acid polymers in the weight range of from about 1,000 to 30,000 daltons may be use to inhibit aminoglycoside nephrotoxicity. These polyanionic polymers are homopolymers or copolymers comprised of monomers selected... | 01/07/1992 |
| 4975541 | Aminoglycosides for controlled drug release The invention disclosed provides a method for preparing spherical-like encapsulated aminoglycosides which may be administered orally to a patient, and which retain antibacterial properties without significant degradation stomachically. The present inventi... | 12/04/1990 |
| 4937257 | Flavanone derivatives New flavanone derivatives of the formula I ##STR1## wherein Ar1 and Ar2 are each phenyl which is unsubstituted or monosubstituted to trisubstituted by OH, alkyl, alkoxy, acylamino, halogen, COOalkyl and/or NO2 and/or ... | 06/26/1990 |
| 4877775 | Polymeric aminosaccharides as antihypercholesterolemic agents Crosslinked copolymers of monomeric aminosaccharides such as aminoglycosidic antibiotics, e.g. neomycin, or of polymeric aminosaccharides, e.g., chitosan, with dialdehydes are useful antihypercholesterolemic agents due to their ability to bind with bile ... | 10/31/1989 |
| 4831123 | Process for preparing netilmicin A high yielding process for converting 3,2',6'-tri-N-acetyl sisomicin to netilmicin comprising the step of silylating the starting material at the 5,2' positions, and optionally at the 4' position, converting the 1-amino substituent to a 1-N-imino substit... | 05/16/1989 |
| 4824943 | Inosose derivatives and production thereof The novel inosose derivatives ##STR1## wherein Y1 stands for hydroxyl group and Y2 stands for hydrogen atom, or Y1 and Y2 are joined to form a bond between carbon and carbon atoms, and R1 and is ... | 04/25/1989 |
| 4816391 | Amine stabilized aminoglycoside formulations Novel formulations are provided containing conjugated or unconjugated aminoglycosides, particularly labeled glycosides, a small amount of a polyamine, and additional additives, such as buffer, salt, and inert protein. The level of immunologic activity of ... | 03/28/1989 |
| 4645760 | Activated aminoglycosides and aminoglycoside-aminocyclitols pharmaceutical compositions and method of use Aminoglycosides and aminoglycoside-aminocyclitols which have been oxygen-radical activated show a broad spectrum of antibacterial activity. The activated compounds are able to penetrate the cell membranes of bacteria and show substantially enhanced activi... | 02/24/1987 |
| 4593089 | Fluorescent polarization immunoassay utilizing substituted triazinylaminofluorescein aminoglycosides This disclosure relates to a method and reagents for determining ligands in biological fluids such as serum, plasma, spinal fluid, amnionic fluid and urine. In particular, this disclosure relates to a fluorescent polarization immunoassay procedure and to ... | 06/03/1986 |
| 4550163 | Ligand analog-irreversible enzyme inhibitor conjugates The present invention encompasses a method for determining ligands in test samples comprising intermixing with the test sample a ligand analog-irreversible enzyme inhibitor conjugate and a binding protein bindable to the ligand and the ligand analog-irrev... | 10/29/1985 |
| 4503046 | 1-Nitro-aminoglycoside derivatives, pharmaceutical compositions containing them and such derivatives for use as pharmaceuticals Hydroxymethylated aminoglycoside derivatives which are useful, in particular as anti-bacterially active antibiotics.... | 03/05/1985 |
| 4486419 | 5,2',3',4',4",6"-Hexadeoxykanamycin and its 1-N-acylated derivative 5,2',3',4',4",6"-Hexadeoxykanamycin and 1-N-[(S)-4-amino-2-hydroxybutyryl]-5,2',3',4',4",6"-hexadeoxykanamycin are now provided, which are each a new compound useful as antibacterial agent. The hexadeoxykanamycin is semi-synthetically produced from 3... | 12/04/1984 |
| 4468512 | 1-N-Acylated and 1-N-alkylated derivatives of 4-O-substituted-2-deoxystreptamine aminoglycosides Zinc salts are used to effect the regio-selective acylation and alkylation of the 1-amino group of 4-O-substituted-2-deoxystreptamine-containing aminoglycosides. The 1-N-substituted derivatives of apramycin, 3'-hydroxyapramycin, certain or ଲ... | 08/28/1984 |
| 4424344 | 2-N-Acylated and 2-N-alkylated derivatives of 4-O-substituted-2-deoxystreptamine aminoglycosides and process Nickel salts are used to effect the regio-selective acylation and alkylation of the 2'-amino group of 4-O-substituted-2-deoxystreptamine containing aminoglycosides. The 2'-N-substituted derivatives of apramycin, certain or ଲ-(lower alkyl)apr... | 01/03/1984 |
| 4424345 | 1-N-Acylated and 1-N-alkylated derivatives of 4-O-substituted-2-deoxystreptamine aminoglycosides and process Zinc salts are used to effect the regio-selective acylation and alkylation of the 1-amino group of 4-O-substituted-2-deoxystreptamine-containing aminoglycosides. The 1-N-substituted derivatives of apramycin, 3'-hydroxyapramycin, certain or ଲ... | 01/03/1984 |
| 4412068 | Novel compounds of the gentamicin class 5-Deoxygentamicin C2b and 6'-N-methyl-2-hydroxy- and 6'-N-methyl-5-deoxygentamicins C2b are prepared, as the major fermentation products, by culturing a nutrient medium containing carbohydrates, a source of assimilable nitrogen, esse... | 10/25/1983 |
| 4404366 | Beta-galactosyl-umbelliferone-labeled hapten conjugates An improved specific binding assay method and reagent for determining a ligand in a liquid medium employing, as an enzyme-cleavable substrate label, a residue having the formula: wherein G is a glycone, D is a dye indicator moiety, and R is a linking grou... | 09/13/1983 |
| 4396609 | Aminocyclitol antibiotics, pharmaceutical compositions and method of using same Aminocyclitol analogs of gentamicin C1, C2 and C1a and the corresponding compounds acylated on the 1-, 3- and 2'-amino groups with an ω-amino--hydroxy-lower-alkanoyl group are prepared by culturing a nutrient mediu... | 08/02/1983 |
| 4393051 | 1-N(Aminopolyhydroxyalkyl)aminoglycoside antibiotics and method of use The invention relates to pseudotrisaccharides of Formula (I) as defined above, methods for preparing them, compositions containing them and methods for the use of said compounds and compositions.... | 07/12/1983 |
| 4387219 | 2-Hydroxy gentamicin compounds 2-Hydroxygentamicins B, B1 and A3 and 2-hydroxy antibiotics JI-20A and JI-20B are prepared as fermentation products by culturing a nutrient medium containing carbohydrates, a source of assimilable nitrogen, essential salts and D-stre... | 06/07/1983 |
| 4380625 | Process for the preparation of purified aminoglycoside antibiotics The invention relates to an improved process for the isolation and purification of aminoglycoside antibiotics of Formula (I) as defined herein combining selective lipophilization of the compound of Formula (I) in the crude product obtained by fermentation... | 04/19/1983 |
| 4347354 | Preparation of 1-N-[ω-amino--hydroxyalkanoyl]aminoglycoside polysilylated antibiotics and products obtained therefrom An improved process for the preparation of 1-N-[ω-amino--hydroxyalkanoyl]aminoglycoside antibiotics comprises acylating a polysilylated aminoglycoside antibiotic in a substantially anhydrous organic solvent with an acylating derivative of an ... | 08/31/1982 |
