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| Number | Title | Issue Date |
| 7973147 | K04-0144 substance and a process for production thereof A microorganism represented by a strain K04-0144 belonging to Streptomyces sp. having ability to produce K04-0144 substance is cultured in the medium, and the isolated K04-0144A substance, K04-0144B substance and K04-0144C substance therefrom have strong anti... | 07/05/2011 |
| 5079234 | Inhibitors of aminoglycoside nephrotoxicity Certain water-soluble polyanionic organic acid polymers in the weight range of from about 1,000 to 30,000 daltons may be use to inhibit aminoglycoside nephrotoxicity. These polyanionic polymers are homopolymers or copolymers comprised of monomers selected... | 01/07/1992 |
| 4310661 | Antibiotics XK-62-3 and XK-62-4 and process for production thereof New antibacterial compounds, XK-62-3 and XK-62-4, are produced by fermentation of microorganisms belonging to the genus Micromonospora. The compounds are accumulated in the culture liquor and are isolated therefrom.... | 01/12/1982 |
| 4298690 | Antibiotics XK-62-3 and XK-62-4 and process for production thereof New antibacterial compounds, XK-62-3 and XK-62-4, are produced by fermentation of microorganisms belonging to the genus Micromonospora. The compounds are accumulated in the culture liquor and are isolated therefrom.... | 11/03/1981 |
| 4218441 | O-Demethylseldomycin factor 5 A new seldomycin factor 5 derivative is provided, O-demethylseldomycin factor 5. The compound is represented by the formula: ##STR1## The compound is a potent anti-bacterial agent.... | 08/19/1980 |
| 4218562 | Antibiotic derivatives of XK-62-2 Derivatives of the antibiotic XK-62-2 are prepared by chemically modifying the antibiotic XK-62-2. An example of one such derivative is 1-N-[L-(-)--hydroxy-γ-aminobutyryl]XK-62-2.... | 08/19/1980 |
| 4216309 | 1-N-Acyl-aminoglycoside-XK-88-5 A new biologically active substance, 1-HABA-seldomycin-5, is produced by chemically modifying the antibiotic XK-88-5. The composition of matter is useful as an antibacterial agent.... | 08/05/1980 |
| 4214077 | 1-N-Substituted derivatives of seldomycin factor 5 Disclosed are compounds of the formula ##STR1## wherein R is loweralkyl, aminoloweralkyl, hydroxyloweralkyl and aminohydroxyloweralkyl and the pharmaceutically acceptable acid addition salts thereof, all of which are potent antibacterials.... | 07/22/1980 |
| 4195171 | Derivatives of an antibiotic XK-62-2 and process for the production thereof New 3"-N-demethyl- and 3"-N, 6'-N-didemethyl-1--hydroxy-ω-aminoacyl derivatives of the antibiotic XK-62-2, their pharmaceutically-acceptable acid addition salts, and a process for preparing the same are disclosed.... | 03/25/1980 |
| 4189569 | Seldomycin factor 5 derivatives Described are novel derivatives of seldomycin factor 5 (XK-88-5) and particularly 3'-Epi-seldomycin factor 5, which exhibit improved activity against gram-positive and gram-negative bacteria resistant to aminoglycoside antibiotics, and a method of prepari... | 02/19/1980 |
| 4187372 | Seldomycin factor 5 derivative Described are novel derivatives of seldomycin factor 5 (XK-88-5) and particularly 3'-deoxyseldomycin factor 5, which exhibit improved activity against gram-positive and gram-negative bacteria resistant to aminoglycoside antibiotics, and a method of prepar... | 02/05/1980 |
| 4169941 | Derivatives of XK-88-5 and process for the production thereof A new compound which is useful as an antibacterial agent or a synthetic intermediate thereof and has the general formula: ##STR1## (wherein R is hydrogen, benzyloxycarbonyl or t-butyloxycarbonyl) is produced by reacting the compound XK-88-5 with an u... | 10/02/1979 |
| 4145530 | 2'-Deamino-3'-epiamino-3'-deoxy-XK-88-5 and process for the production thereof A new antibiotic, 2'-deamino-3'-epiamino-3'-deoxy-XK-88-5 represented by the formula: ##STR1## is produced by chemically modifying the antibiotic XK-88-5 represented by the formula: ##STR2##... | 03/20/1979 |
| 4132846 | 1-N-(-Hydroxy-ଲ-aminopropionyl) XK-62-2 and method of production thereof 1-N-(-Hydroxy-ଲ-aminopropionyl) XK-62-2 is produced by chemically modifying the antibiotic XK-62-2 to introduce an ଲ-hydroxy-ଲ-aminopropionyl group to the amino group bonded to the carbon atom at the 1-position. The derivative is ... | 01/02/1979 |
| 4109077 | Antibiotic derivatives of XK-62-2 compounds Derivatives of the antibiotic XK-62-2 are prepared by chemically modifying the antibiotic XK-62-2. An example of one such derivative is 1-N-[L-(-)--hydroxy-γ-aminobutyryl] XK-62-2.... | 08/22/1978 |
| 4097664 | Derivatives of an antibiotic XK-62-2 New 3"-N-demethyl- and 3"-N, 6'-N-didemethyl-1--hydroxy-ω-aminoacyl derivatives of the antibiotic XK-62-2, their pharmaceutically-acceptable acid addition salts, and a process for preparing the same are disclosed.... | 06/27/1978 |
| 4076931 | Derivatives of an antibiotic XK-62-2 and the process for the production thereof New derivatives of an antibiotic XK-62-2 are produced by chemically modifying the antibiotic XK-62-2. The new derivatives are 1-N-(-hydroxy-δ-aminovaleryl)XK-62-2 and 1-N-(-hydroxy-&3xb5;-aminocaproyl)XK-62-2 as well as acid addition s... | 02/28/1978 |
| 4055715 | Method of producing 1-N-[L-(-)--hydroxy-γ-aminobutyryl]XK-62-2 1-N-[L-(-)--hydroxy-γ-aminobutyryl]XK-62-2 is produced by chemically modifying the antibiotic XK-62-2.... | 10/25/1977 |
| 4053591 | 5-Deoxy-4,6-di-O-(aminoglycosyl)-1,3-diaminocyclitols, methods for their manufacture, method for their use as antibacterial agents and compositions useful therefor 5-Deoxy-4,6-di-O-(aminoglycosyl)-1,3-diaminocyclitols, useful antibacterial agents, are prepared by the reaction of the corresponding 5-O-thioformyl-4,6-di-O-(aminoglycosyl)-1,3-diaminocyclitol having all amino functions and all primary and secondary hydr... | 10/11/1977 |
| 4045298 | Antibiotic XK-62-2 and process for production thereof The antibiotic XK-62-2 is produced by fermentation of microorganisms belonging to the genus Micromonospora. The antibiotic is accumulated in the culture liquor and is isolated therefrom.... | 08/30/1977 |
| 4045610 | Antibiotics designated XK-88 series A novel series of antibiotics designated the XK-88 series are produced by culturing a microorganism belonging to the genus Streptomyces in a nutrient medium and thereafter recovering the antibiotics from the culture liquor.... | 08/30/1977 |
| 4002608 | 1-N-alkyl-aminoglycoside-XK-88 derivatives and methods for their manufacture 1-N-Alkyl-Aminoglycoside-XK-88 derivatives, valuable as antibacterial agents, are prepared by the reaction of an acid addition salt of the corresponding 1-N-unsubstituted-Aminoglycoside-XK-88 antibacterial derivative or of a 2"-N-alkanoyl-Aminoglycoside-X... | 01/11/1977 |
| 3939043 | Antibiotics designated XK-88 series and process for production thereof A novel series of antibiotics designated the XK-88 series are produced by culturing a microorganism belonging to the genus Streptomyces in a nutrient medium and thereafter recovering the antibiotics from the culture liquor. BACKGROUND OF THE INVENTION The... | 02/17/1976 |
