Class 536/13.3 - Paromomycin or derivative (e.g., neomycin E, etc.)

Subclass of Class 536 - Organic compounds -- part of the class 532-570 series
Definition: Compounds which have the following structural formula (below)
No. of patents: 29
Last issue date: 12/04/2007

Number	Title	Issue Date
7303768	Preparation of aqueous clear solution dosage forms with bile acids Compositions for pharmaceutical and other uses comprising clear aqueous solutions of bile acids which do not form any detectable precipitates over selected ranges of pH values of the aqueous solution and methods of making such solutions. The compositions of the inve...	12/04/2007
7160992	Amino-modified polysaccharides and methods of generating and using same Novel amino-modified polysaccharides are provided. The amino-modified polysaccharides have one or more amino groups, each being linked to one or more arginine residues. ...	01/09/2007
6967242	Antimicrobial 2-deoxystreptamine compounds The present invention is directed to analogs of aminoglycoside compounds of the class having a glycosylated 2-deoxystreptamine (2-DOS) ring as well as their preparation and use as prophylactic or therapeutics against microbial infection. Compounds of the invention c...	11/22/2005
6833445	Guanidinylation, guanidinoglycosides, uses, and methods of assaying their activity Provided are reagents and methods useful for the synthesis of guanidinylated compounds. Also provided are methods for assaying molecules, including guanidinylated molecules that modulate viral infection and replication. ...	12/21/2004
6759523	Antimicrobial 2-deoxystreptamine compounds The present invention is directed to analogs of aminoglycoside compounds of the class having a glycosylated 2-deoxystreptamine (2-DOS) ring as well as their preparation and use as prophylactic or therapeutics against microbial infection. Compounds of the invention c...	07/06/2004
6573060	Methods and compositions for targeting DNA metabolic processes using aminoglycoside derivatives Protein targets for disease intervention through inhibition of nucleic acid metabolism are disclosed. Novel polypeptides for one such target, DNA-dependent ATPase A, and novel polynucleotides encoding DNA-dependent ATPase A are disclosed. Phosphoaminoglyc...	06/03/2003
6541456	Antimicrobial 2-deoxystreptamine compounds The present invention is directed to analogs of aminoglycoside compounds of the class having a glycosylated 2-deoxystreptamine (2-DOS) ring as well as their preparation and use as prophylactic or therapeutics against microbial infection. Compounds of the ...	04/01/2003
6525182	Guanidinylation, guanidinoglycosides, uses, and methods of assaying their activity Provided are reagents and methods useful for the synthesis of guanidinylated compounds. Also provided are methods for assaying molecules, including guanidinylated molecules that modulate viral infection and replication....	02/25/2003
5686588	Amine acid salt compounds and process for the production thereof A stoichiometric acid moiety transfer reaction for the preparation of an acid salt of an amine compound is disclosed. The acid moiety transfer reaction provides amine acid salts of high purity and having crystalline structure of uniform size and shape....	11/11/1997
5470836	Paromomycin or its derivatives or salts thereof in combination with sodium stirogluconate for parenteral treatment of human parasitic diseases A compound of formula (I): ##STR1## wherein: R1 is a hydroxy group or an amino group optionally substituted with a C1 -C4 alkyl or phenyl-(C1 -C4) alkyl group, R2 is hydrogen or a hydr...	11/28/1995
4937257	Flavanone derivatives New flavanone derivatives of the formula I ##STR1## wherein Ar1 and Ar2 are each phenyl which is unsubstituted or monosubstituted to trisubstituted by OH, alkyl, alkoxy, acylamino, halogen, COOalkyl and/or NO2 and/or ...	06/26/1990
4877775	Polymeric aminosaccharides as antihypercholesterolemic agents Crosslinked copolymers of monomeric aminosaccharides such as aminoglycosidic antibiotics, e.g. neomycin, or of polymeric aminosaccharides, e.g., chitosan, with dialdehydes are useful antihypercholesterolemic agents due to their ability to bind with bile ...	10/31/1989
4645760	Activated aminoglycosides and aminoglycoside-aminocyclitols pharmaceutical compositions and method of use Aminoglycosides and aminoglycoside-aminocyclitols which have been oxygen-radical activated show a broad spectrum of antibacterial activity. The activated compounds are able to penetrate the cell membranes of bacteria and show substantially enhanced activi...	02/24/1987
4617293	Flavonoid phosphate salts of aminoglycoside antibiotics Flavonoid phosphates of aminoglycoside antibiotics are useful sparingly soluble salts, e.g., for achieving a depot effect....	10/14/1986
4505901	Compositions and methods for topical treatment of cutaneous leishmaniasis with paromomycin The compositions contain a mixture of paromomycin or a non-toxic acid addition salt thereof and dimethylsulfoxide or a quaternary ammonium salt having topical anti-infective activity, together with an inert carrier. There is also provided a method for the...	03/19/1985
4468386	1-Deamino-1-hydroxy-aminoglycoside compounds, antibacterial compositions and method of use Antibiotic Bu-2659 complex, containing components A, B, C, D and E, is produced by cultivation of Streptomyces hygroscopicus Strain No. J296-21, ATCC No. 39150....	08/28/1984
4468512	1-N-Acylated and 1-N-alkylated derivatives of 4-O-substituted-2-deoxystreptamine aminoglycosides Zinc salts are used to effect the regio-selective acylation and alkylation of the 1-amino group of 4-O-substituted-2-deoxystreptamine-containing aminoglycosides. The 1-N-substituted derivatives of apramycin, 3'-hydroxyapramycin, certain ଱ or ଲ...	08/28/1984
4337248	Paromomycin containing compounds and method of use Compounds are disclosed of the formula ##STR1## wherein R1 represents a hydrogen or chlorine atom, as well as intermediates. These include 4'-deoxy-paromomycin; 4'-deoxy-4'-epi-chloro-paromomycin; 4'-deoxy-4'-epi-chloro-penta-N-benzyl...	06/29/1982
4247687	Aminoglycoside antibiotic derivatives and process for their preparation A process is disclosed for preparing 4'-deoxy-neomycin B, having the formula: ##STR1## Chlorination with sulphuryl chloride in pyridine gives the corresponding 4'-6'-dichloro analog which is selectively dechlorinated at position 4' with tributyl...	01/27/1981
4170643	Aminoglycoside-aminocyclitol derivatives and method of use Novel aminoglycoside-aminocyclitol derivatives corresponding to the general formula: ##STR1## wherein R1 and R2, which are different, represent hydrogen or CH2 NH2 and R is selected from the group consistin...	10/09/1979
4169197	6-Deoxyneamines aminoglycoside compounds 6-Deoxyneamine, 6-deoxy-5-epineamine, their 5-O-glycosyl derivatives, 6-deoxy-5-oxoneamine and the derivatives therefrom are useful as antibacterial agents and/or as intermediates in the synthesis of antibacterially active 6-deoxyneamines....	09/25/1979
4125707	Protected pseudotrisaccharide intermediate for paromomycin and neomycin derivatives Amino- and oxygen-protected pseudotrisaccharide is disclosed, which has been proved to be a useful intermediate for preparing aminoglycoside antibacterial antibiotics related to paromomycin and neomycin. Process for its preparation is also disclosed....	11/14/1978
4066753	Neomycin and paromomycin derivatives The invention relates to novel neomycin and paromomycin derivatives having antibiotic activity. The derivatives have the formula: ##STR1## wherein R' is --NH2 or --OH, either R2 or R3 is --CH2 NH2	01/03/1978
4065615	Deoxyaminoglycoside antibiotic derivatives A new deoxystreptamine-containing aminoglycoside antibiotic derivative in which all the amino groups other than the amino group at the 1-position of the deoxystreptamine moiety are formylated is obtained in a high yield by treating a deoxystreptamine-cont...	12/27/1977
4029883	Dehydroxylation of aminosugars Dehydroxylation of aminoglycoside antibiotics is carried out by halogenation of phosphorylated aminoglycoside antibiotics followed by reduction of thus halogenated antibiotics. The dehydroxylation process is entirely new and gives the final product in a h...	06/14/1977
4021601	Paromomycin derivatives and process for the preparation thereof A process is disclosed for preparing paromomycin derivatives N-substituted in the 2'-position and having the general formula: ##STR1## wherein R2 is an alkyl radical having from 1 to 10 carbon atoms or an arylalkyl radical having not more ...	05/03/1977
3984393	Aminoglycoside antibiotics 6-0- AND 3'-0-D-glycosyl analogs of 4-0-(଱-D-glycosyl)-2-deoxystreptamine, 6-0- and 3'-0-D-glycosyl ortho esters of 4-0-(଱-D-glycosyl)-2-deoxystreptamine, novel aminoglycoside antibiotics, and novel intermediates are prepared by a new che...	10/05/1976
3965089	Process for the production of a cyclic ureido-derivative of a deoxystreptamine-containing antibiotic and products thereof A new cyclic ureido-derivative of a deoxystreptamine-containing antibiotic represented by the general formula: ##SPC1## Wherein Ra, Rb and Rc stand for the residues present in the molecule of said antibiotic other than the...	06/22/1976
3956274	New compound 6'-deoxy-'-substituted or unsubstituted amino-lividomycins and the production thereof Lividomycin B derivatives having enhanced antibacterial activity are provided; the 6'-deoxy-6' substituted or unsubstituted amino lividomycins are prepared by masking the functional groups other than the 4' - and 6' -hydroxyl groups, converting the 6' hyd...	05/11/1976

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Class 536/13.3 - Paromomycin or derivative (e.g., neomycin E, etc.)