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| Number | Title | Issue Date |
| 7943749 | Antimicrobial 2-deoxystreptamine compounds The present invention is directed to analogs of paromomycin having a variety of chemical functional groups attached at the 2″-O-position as well as their preparation and use as prophylactic or therapeutics against microbial infection. ... | 05/17/2011 |
| 7244712 | Aminoglycoside antibiotics and methods of using same The present invention relates to aminoglycoside compounds having antibiotic activity. Moreover, the present invention relates to L-aminoglycoside compounds and diastereomers thereof which posses antibiotic activity and are not susceptible to development of resistant... | 07/17/2007 |
| 7160992 | Amino-modified polysaccharides and methods of generating and using same Novel amino-modified polysaccharides are provided. The amino-modified polysaccharides have one or more amino groups, each being linked to one or more arginine residues. ... | 01/09/2007 |
| 6967242 | Antimicrobial 2-deoxystreptamine compounds The present invention is directed to analogs of aminoglycoside compounds of the class having a glycosylated 2-deoxystreptamine (2-DOS) ring as well as their preparation and use as prophylactic or therapeutics against microbial infection. Compounds of the invention c... | 11/22/2005 |
| 6833445 | Guanidinylation, guanidinoglycosides, uses, and methods of assaying their activity Provided are reagents and methods useful for the synthesis of guanidinylated compounds. Also provided are methods for assaying molecules, including guanidinylated molecules that modulate viral infection and replication. ... | 12/21/2004 |
| 6759523 | Antimicrobial 2-deoxystreptamine compounds The present invention is directed to analogs of aminoglycoside compounds of the class having a glycosylated 2-deoxystreptamine (2-DOS) ring as well as their preparation and use as prophylactic or therapeutics against microbial infection. Compounds of the invention c... | 07/06/2004 |
| 6642365 | Anti-(retro)viral conjugates of saccharides and acetamidino or guanidino compounds Conjugates of a saccharide and an acetamidino- or guanidino-compound, of the formula: ##STR1## wherein A is CH3 or NH2 ; X is a linear or branched C1 -C8 alkyl chain optionally containing hydroxy, amino and/or o... | 11/04/2003 |
| 6573060 | Methods and compositions for targeting DNA metabolic processes using aminoglycoside derivatives Protein targets for disease intervention through inhibition of nucleic acid metabolism are disclosed. Novel polypeptides for one such target, DNA-dependent ATPase A, and novel polynucleotides encoding DNA-dependent ATPase A are disclosed. Phosphoaminoglyc... | 06/03/2003 |
| 6541456 | Antimicrobial 2-deoxystreptamine compounds The present invention is directed to analogs of aminoglycoside compounds of the class having a glycosylated 2-deoxystreptamine (2-DOS) ring as well as their preparation and use as prophylactic or therapeutics against microbial infection. Compounds of the ... | 04/01/2003 |
| 6525182 | Guanidinylation, guanidinoglycosides, uses, and methods of assaying their activity Provided are reagents and methods useful for the synthesis of guanidinylated compounds. Also provided are methods for assaying molecules, including guanidinylated molecules that modulate viral infection and replication.... | 02/25/2003 |
| 6482802 | Use of neomycin for treating angiogenesis-related diseases The present invention is directed to using neomycin or an analogue thereof as an therapeutic agent to treat angiogenesis-related diseases, which are characterized by excessive, undesired or inappropriate angiogenesis or proliferation of endothelial cells.... | 11/19/2002 |
| 6403777 | Metalloligands for cleaving nucleic acids Transition metal complexes, referred to hereinafter as "metalloligands", that catalyze the degradation of DNA and the cleavage of RNA at select sites are provided. In one embodiment, the metalloligand has the following structure: ##STR1## wherein R1 ... | 06/11/2002 |
| 5486471 | Tissue plasminogen activator analogs having modified growth factor domains Tissue plasminogen activator analogs containing the growth factor domain of native t-PA, the domain having at least one cysteine residue replaced with another amino acid. The t-PA analogs may further contain a variety of substitutions and/or modifications... | 01/23/1996 |
| 5324828 | 1-amino-1-deoxyoligosaccharides and derivatives thereof A derivatized 1-amino-1-deoxyoligosaccharide prepared by reacting, at a pH of at least 6.5, a glycopeptide or glycoprotein containing one or more Asn-linked oligosaccharides with a ଲ-aspartylglycosylamine amidohydrolase, and contacting the products ... | 06/28/1994 |
| 4937257 | Flavanone derivatives New flavanone derivatives of the formula I ##STR1## wherein Ar1 and Ar2 are each phenyl which is unsubstituted or monosubstituted to trisubstituted by OH, alkyl, alkoxy, acylamino, halogen, COOalkyl and/or NO2 and/or ... | 06/26/1990 |
| 4877775 | Polymeric aminosaccharides as antihypercholesterolemic agents Crosslinked copolymers of monomeric aminosaccharides such as aminoglycosidic antibiotics, e.g. neomycin, or of polymeric aminosaccharides, e.g., chitosan, with dialdehydes are useful antihypercholesterolemic agents due to their ability to bind with bile ... | 10/31/1989 |
| 4645760 | Activated aminoglycosides and aminoglycoside-aminocyclitols pharmaceutical compositions and method of use Aminoglycosides and aminoglycoside-aminocyclitols which have been oxygen-radical activated show a broad spectrum of antibacterial activity. The activated compounds are able to penetrate the cell membranes of bacteria and show substantially enhanced activi... | 02/24/1987 |
| 4617293 | Flavonoid phosphate salts of aminoglycoside antibiotics Flavonoid phosphates of aminoglycoside antibiotics are useful sparingly soluble salts, e.g., for achieving a depot effect.... | 10/14/1986 |
| 4567163 | Salicyclic acid derivatives of N-acetylcysteine and pharmacological use thereof The thioester of N-acetylcysteine with salicylic acid and the pharmacologically acceptable and non-toxic organic and inorganic salts thereof, exhibit anti-pyretic, anti-inflammatory and analgesic activity as well as mucolytic activity. The compounds are p... | 01/28/1986 |
| 4468386 | 1-Deamino-1-hydroxy-aminoglycoside compounds, antibacterial compositions and method of use Antibiotic Bu-2659 complex, containing components A, B, C, D and E, is produced by cultivation of Streptomyces hygroscopicus Strain No. J296-21, ATCC No. 39150.... | 08/28/1984 |
| 4256876 | Process for precipitating aminoglycosides A highly efficient process for the precipitation of an amorphous (non-crystalline) aminoglycoside antibiotic salt during the purification process. Illustratively, there are disclosed processes for precipitating gentamicin, neomycin, and sisomicin salts.... | 03/17/1981 |
| 4247687 | Aminoglycoside antibiotic derivatives and process for their preparation A process is disclosed for preparing 4'-deoxy-neomycin B, having the formula: ##STR1## Chlorination with sulphuryl chloride in pyridine gives the corresponding 4'-6'-dichloro analog which is selectively dechlorinated at position 4' with tributyl... | 01/27/1981 |
| 4170643 | Aminoglycoside-aminocyclitol derivatives and method of use Novel aminoglycoside-aminocyclitol derivatives corresponding to the general formula: ##STR1## wherein R1 and R2, which are different, represent hydrogen or CH2 NH2 and R is selected from the group consistin... | 10/09/1979 |
| 4107435 | Process for ω-amino-2-hydroxyalkyl derivatives of aminoglycoside antibiotics 1-N-(ω-Amino-2-hydroxyalkyl) derivatives of aminoglycoside antibiotics are prepared by reductive alkylation of the parent antibiotic, or a partially protected derivative thereof, with a 6-dihydroxymethyltetrahydro-1, 3-oxazin-2-one or 5-dihydroxymet... | 08/15/1978 |
| 4066753 | Neomycin and paromomycin derivatives The invention relates to novel neomycin and paromomycin derivatives having antibiotic activity. The derivatives have the formula: ##STR1## wherein R' is --NH2 or --OH, either R2 or R3 is --CH2 NH2 | 01/03/1978 |
| 4065615 | Deoxyaminoglycoside antibiotic derivatives A new deoxystreptamine-containing aminoglycoside antibiotic derivative in which all the amino groups other than the amino group at the 1-position of the deoxystreptamine moiety are formylated is obtained in a high yield by treating a deoxystreptamine-cont... | 12/27/1977 |
| 4029883 | Dehydroxylation of aminosugars Dehydroxylation of aminoglycoside antibiotics is carried out by halogenation of phosphorylated aminoglycoside antibiotics followed by reduction of thus halogenated antibiotics. The dehydroxylation process is entirely new and gives the final product in a h... | 06/14/1977 |
| 3996205 | Aminoglycoside antibiotics and intermediates 6-0- AND 3'-0-D-glycosyl analogs of neamine, 6-0- and 3'-0-D-glycosyl ortho esters of neamine, novel aminoglycoside antibiotics, and novel intermediates are prepared by a new chemical process. The compounds have utility as antibacterial agents or as inter... | 12/07/1976 |
| 3965089 | Process for the production of a cyclic ureido-derivative of a deoxystreptamine-containing antibiotic and products thereof A new cyclic ureido-derivative of a deoxystreptamine-containing antibiotic represented by the general formula: ##SPC1## Wherein Ra, Rb and Rc stand for the residues present in the molecule of said antibiotic other than the... | 06/22/1976 |
