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| Number | Title | Issue Date |
| 8106185 | Modified hydroxypolymer conjugates with killing effect on tumor cells The present invention is related to a modified hydroxypolymer conjugates preferably a guanidine-dextran conjugate having a tumor cell killing activity. The modified hydroxypolymer conjugate is used as medicine, particularly for manufacturing a medicine or tumor kill... | 01/31/2012 |
| 7364919 | Nanoparticles Materials and methods for studying and modulating the interaction of carbohydrate-containing moieties with other species are described, in particular, small particles, e.g. clusters of metal or semiconductor atoms, which can be employed as a substrate for immobilizi... | 04/29/2008 |
| 7345166 | Water soluble biodegradable polymeric photocatalysts Novel antenna polymers characterized by a polymeric background of a biodegradable water soluble polymer and chromophores chemically bonded to the polymeric background have been found to be useful as photocatalysts in aqueous media. On completion of the desired photo... | 03/18/2008 |
| 7294614 | Phosphoprotein affinity resins and methods for making and using the same Phosphorylated protein (i.e., phosphoprotein) affinity resins and methods for making and using the same are provided. The subject resins include a substrate bonded to aspartate-based tetradentate ligand/metal ion complexes, where the tetradentate ligand/metal ion co... | 11/13/2007 |
| 7288264 | Contact-killing antimicrobial devices Contact killing antimicrobial articles, devices and formulations are described which kill microorganisms on contact. The articles, devices or formulations contain a non-leaching antimicrobial material which is a unique combination of an organic matrix having biocida... | 10/30/2007 |
| 7265098 | Polyacid/polyalkylene oxide gels and methods for their delivery The present invention relates to improved methods for delivering bioadhesive, bioresorbable, anti-adhesion compositions. Antiadhesion compositions can be made of intermacromolecular complexes of carboxyl-containing polysaccharides, polyethers, polyacids, polyalkylen... | 09/04/2007 |
| 7256054 | Core-shell metal particles coated with dextran or aminodextran carrying SH groups, and use thereof Colloidal metal particles having a coating comprising non cross-linked, SH-activated dextran or aminodextran. Biomolecules may be linked directly or indirectly to the particles, which are useful as detection reagents in immunological assays. ... | 08/14/2007 |
| 7108971 | Reversible binding of molecules to metal substrates through affinity interactions This invention is related to methods for the immobilization of labeled ligands on solid surfaces using soft metal-soft base bonding. The ligand-binding solid surface comprises a soft metal solid support and a heterobifunctional spacer chemi- or physisorbed to said s... | 09/19/2006 |
| 7101862 | Hemostatic compositions and methods for controlling bleeding The invention provides hemostatic compositions useful to promote hemostasis at active bleeding wound sites. The hemostatic compositions typically include an article containing cellulose, e.g., cotton gauze, and a polysaccharide covalently linked to the cellulose, or... | 09/05/2006 |
| 7083812 | Chemical library preparation method from natural product The present invention relates to a preparation method of a general library and a focused library from crude extracts of natural products including herbal drugs, said libraries, and the method for developing new drugs such as an anticancer drug and new substances usi... | 08/01/2006 |
| 7060259 | Hydrolytically degradable carbamate derivatives of poly(ethylene glycol) Poly(ethylene glycol) carbamate derivatives useful as water-soluble prodrugs are disclosed. These degradable poly(ethylene glycol) carbamate derivatives also have potential applications in controlled hydrolytic degradation of hydro... | 06/13/2006 |
| 7052724 | Method of producing active dry yeast A novel technique is provided for drying a yeast for brewing and a method of producing alcoholic beverages by using the yeast. It is intended to provide a method of producing a dry yeast which has the optimum fermentability when directly used in fermentation and giv... | 05/30/2006 |
| 7053068 | Chitosan-thio-amidine conjugates and their cosmetic as well as pharmaceutic use By the reaction of chitosan with iminothiolactones such as 2-iminothiolane, thiol groups can be covalently immobilized on the polymer. The resulting chitosan derivatives exhibit thiol groups which are capable of forming inter- and intramolecular disulfide bonds. Bec... | 05/30/2006 |
| 7041818 | DDS compound and method for measurement thereof A DDS compound comprising a carboxy(C1-4)alkyldextran polyalcohol modified with a saccharide compound and a residue of drug compound bound to the carboxy(C1-4)alkyldextran polyalcohol, and a method for measuring a DDS compound in which a polyme... | 05/09/2006 |
| 6987182 | Process for producing cold-gelling hydrocolloids A dry hydrocolloid powder with cold-gel capabilities is produced by: dissolving a hydrocolloid comprising polysaccharide chains in an aqueous solution; heating the dissolved hydrocolloid solution to a temperature and for a time sufficient to induce a substantial alt... | 01/17/2006 |
| 6953784 | Cross-linked polysaccharide drug carrier A carrier and a method for preparing it are provided for use in the delivery of therapeutic agents. A polysaccharide is reacted with an oxidizing agent to open sugar rings on the polysaccharide to form aldehyde groups. The aldehyde groups are reacted to form covalen... | 10/11/2005 |
| 6899867 | Hydrolytically degradable carbamate derivatives of poly(ethylene glycol) Poly(ethylene glycol) carbamate derivatives useful as water-soluble prodrugs are disclosed. These degradable poly(ethylene glycol) carbamate derivatives also have potential applications in controlled hydrolytic degradation of hydrogels. In such degradable hydrogels,... | 05/31/2005 |
| 6884885 | Production of cyclodextrin complexes The process entails increasing the concentration of cyclodextrin to 15% (w/w) and above to form complexes through a precipitation process in order to increase the yield of complexes, increase the amount of guest complexed, and decrease the particle size of the compl... | 04/26/2005 |
| 6872820 | Finely divided polysaccharide derivatives Finely divided polysacharide derivatives are described. The finely divided polysacharide derivatives are prepared by a process comprising: a) forming an aqueous composition comprising a polysaccharide derivative and water, in which the polysaccharide derivative is s... | 03/29/2005 |
| 6869938 | Compositions of polyacids and polyethers and methods for their use in reducing adhesions The present invention relates to improved methods for making and using bioadhesive, bioresorbable, anti-adhesion compositions made of intermacromolecular complexes of carboxyl-containing polysaccharides, polyethers, polyacids, polyalkylene oxides, multivalent cation... | 03/22/2005 |
| 6838450 | Drug complex A drug complex characterized in that a residue of a drug compound such as antineoplastic agents and a carboxy(C1-4)alkyldextran polyalcohol obtained by treating a dextran under conditions that enable substantially complete polyalcoholization are bound to ... | 01/04/2005 |
| 6835807 | Drug complex and drug delivery system A drug complex useful as a DDS compound, which is represented by the following formula: A-R—NH—Y—CH2—O—CO-Q, wherein A is a polymer as a drug carrier; R is a spacer, wherein the spacer is an amino acid or an oligopeptide comprising 2 to 8 amino ... | 12/28/2004 |
| 6828310 | Compositions including reduced malto-oligosaccharide preserving agents, and methods for preserving a material Disclosed is a composition that includes a material that is susceptible to degradation and a preserving agent in an amount effective to preserve the material comprising one or more reduced malto-oligosaccharide species. The preserving agent can include a single redu... | 12/07/2004 |
| 6815435 | Pharmaceutical compositions containing DDS compounds A pharmaceutical composition having an ensured preservation stability, which contains a compound, wherein a polysaccharide derivative having a carboxyl group is bonded to a camptothecin derivative via a spacer or without mediated by any spacer, and a sugar or a suga... | 11/09/2004 |
| 6811996 | DDS compounds and method for assaying the same A drug delivery system compound comprising a carboxy(C1-4)alkyldextran polyalcohol modified with a saccharide compound and a residue of drug compound bound to the carboxy(C1-4)alkyldextran polyalcohol, and a method for measuring a drug delivery... | 11/02/2004 |
| 6800298 | Biological lubricant composition and method of applying lubricant composition Fluid compositions and methods for lubrication of mammalian joints are disclosed, including both natural and artificial fluids. Synovial fluid acts to lubricate the bearing surfaces of bones and bone-like structures which are held in frictional contact within biolog... | 10/05/2004 |
| 6790840 | Reversibly cross-linked hydrogels A hydrogel composition and methods of preparing and using the same are disclosed. The hydrogel composition comprises an oxidized polysaccharide, and a cross-linker having at least two functional cross-linking groups. The cross-linker reversibly cross-links the polys... | 09/14/2004 |
| 6762282 | High yield S-nitrosylation process A method for producing a S-nitrosylated species is provided. The method comprises: (a) providing a deoxygenated, alkaline aqueous solution comprising a thiol and a nitrite-bearing species; (b) acidifying the solution by adding acid to the solution while concurrently... | 07/13/2004 |
| 6703499 | Process of making carboxylated dextran The present invention provides a process of preparing a novel carboxylic acid derivative of dextran. In particular, in the present invention, carboxylated dextran containing at least one carboxylic acid is reduced to remove all or substantially all reduci... | 03/09/2004 |
| 6703498 | Water-soluble polymeric metal ion affinity compositions and methods for using the same Water-soluble metal ion affinity compounds and methods for using the same are provided. The subject compounds include an aspartate based metal chelating ligand bonded to a water-soluble polymeric substrate, where the ligand is complexed with a metal ion. ... | 03/09/2004 |
| 6686341 | Nutritional compositions which contain slightly negatively charged, non-digestible polysaccharides and use thereof for reducing transport through tight junctions A nutritional composition which contains slightly negatively charged non-digestible polysaccharides having a molecular weight of 8 kD to 40,000 kD, characterized in that the rise in the viscosity of the composition caused by the polysaccharides is less th... | 02/03/2004 |
| 6683064 | Cross-linked polysaccharide drug carrier A carrier and a method for preparing it are provided for use in the delivery of therapeutic agents. A polysaccharide is reacted with an oxidizing agent to open sugar rings on the polysaccharide to form aldehyde groups. The aldehyde groups are reacted to f... | 01/27/2004 |
| 6632801 | Method and composition for inhibiting human cholesterol esterase A method and composition for inhibiting human cholesterol absorption comprising ingesting a therapeutic amount of an inhibitor of human cholesterol esterase comprising very high molecular weight sulfated polysaccharide having a sulfate to monomer ratio of... | 10/14/2003 |
| 6632939 | Process for producing dextran reduced in boron content The present invention relates to dextran whose boron content is reduced to a value less than 0.30 μg/g (dry basis) calculated on the basis of boron atom, a process for producing the same, and dextran with which a container is filled in a solution state. ... | 10/14/2003 |
| 6596699 | Nucleic acid coating compositions and methods A nucleic acid coating composition including a polyanion bound, directly or through one or more intermediates, to a medical device surface, with a condensate comprising a polycation and nucleic acid bound to the polyanion, devices incorporating such coati... | 07/22/2003 |
| 6593469 | Compositions including reduced malto-oligosaccharide preserving agents Disclosed is a composition that includes a material that is susceptible to degradation and a preserving agent in an amount effective to preserve the material comprising one or more reduced malto-oligosaccharide species. The preserving agent can include a ... | 07/15/2003 |
| 6590096 | Process for the production of polysaccharide beads The present invention relates to a method for producing porous polysaccharide beads, comprising: (a) mixing a water-based solution of a polysaccharide under stirring with an essentially water-immiscible first organic phase to form an emulsion which separa... | 07/08/2003 |
| 6562459 | Method for the production of spherical microparticles consisting totally or partly of at least one water insoluble polyglucan containing branches and microparticles produced according to said method The invention relates to a method for the production of spherical microparticles consisting totally or partly of at least one water-insoluble polysaccharide, wherein the at least one water-insoluble polysaccharide is dissolved in a solvent or solvent mixt... | 05/13/2003 |
| 6541015 | Hydrolytically degradable carbamate derivatives of poly(ethylene glycol) Poly(ethylene glycol) carbamate derivatives useful as water-soluble pro-drugs are disclosed. These degradable poly(ethylene glycol) carbamate derivatives also have potential applications in controlled hydrolytic degradation of hydrogels. In such degradabl... | 04/01/2003 |
| 6534294 | Production of chitosan-and chitin-like exopolymers A method of producing biosynthetic copolymers comprising glucose and glucose analogs is provided. Glucose:glucose analog copolymers such as glucose:glucosamine, glucose:N-acetylglucosamine and glucose:glucosamine:N-acetylglucosamine are also provided.... | 03/18/2003 |
