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| Number | Title | Issue Date |
| 8158763 | Sugar chain asparagine derivatives, sugar chain asparagine, sugar chain and processes for producing these An asparagine-linked α2,3-oligosaccharide having undeca- to hepta-saccharides, an asparagine-linked α2,6-oligosaccharide having undeca- to hepta-saccharides and containing fluorine and an asparagine-linked oligosaccharide derivative containing at least one fucose ... | 04/17/2012 |
| 8058413 | Molecular transporters based on sugar and its analogues and processes for the preparation thereof The inventive molecular transporter compound shows significantly high permeability through a biological membrane such as a plasma membrane, nuclear membrane and blood-brain barrier, and accordingly, can be effectively used in delivering various biologically active m... | 11/15/2011 |
| 8048996 | Molecular transporters based on sugar and its analogues and processes for the preparation thereof The inventive molecular transporter compound shows significantly high permeability through a biological membrane such as a plasma membrane, nuclear membrane and blood-brain barrier, and accordingly, can be effectively used in delivering various biologically active m... | 11/01/2011 |
| 8017742 | Gene carrier Disclosed is a gene carrier composed of a hydrogen-bonding polymer having a polymer chain with hydrogen-bonding sites formed on the polymer chain, in which the polymer chain has a conformation similar to the conformation of a nucleic acid, and particularly, the poly... | 09/13/2011 |
| 7977466 | C-glycoside derivatives and salts thereof The present invention provides C-glycoside derivatives and salts thereof, wherein B ring is bonded to A ring via —X— and A ring is directly bonded to the glucose residue, and it is usable as a Na+-glucose cotransporter inhibitor, especially for a ther... | 07/12/2011 |
| 7943748 | Glucitol derivative, prodrug thereof and salt thereof, and therapeutic agent containing the same for diabetes The invention provides a glucitol derivative having the function of reducing a blood sugar level and having preferable properties required of medicines, such as long-lasting drug activity; and a medicinal composition for use in the prevention or treatment of disease... | 05/17/2011 |
| 7919598 | Crystal structures of SGLT2 inhibitors and processes for preparing same The present invention relates to physical crystal structures of a compound of the formula I: wherein R1, R2, R2a, R3 and R4 are as defined herein, especially | 04/05/2011 |
| 7875707 | Disaccharides for drug discovery Methods are described for the preparation of combinatorial libraries of potentially biologically active disaccharide compounds. These compounds are variously functionalized, with a view to varying lipid solubility size, function an other properties, with the particu... | 01/25/2011 |
| 7851602 | Glucopyranosyl-substituted ((hetero)cycloalkylethynyl-benzyl)-benzene derivatives, medicaments containing such compounds, their use and process for their manufacture Glucopyranosyl-substituted ((hetero)cycloalkylethynyl-benzyl)-benzene derivatives of the general formula I where the groups R1 to R6 as well as R7a, R7b, R7c are define... | 12/14/2010 |
| 7847074 | Processes for preparing of glucopyranosyl-substituted (ethynyl-benzyl)-benzene derivatives and intermediates thereof The present invention relates to processes for preparing the compounds of general formula I, wherein the groups R1, R2 and R3 are defined according to claim 1 and to intermediates of ... | 12/07/2010 |
| 7812142 | Pentose derivatives as anti-hyperglycemic drugs The present invention relates to pentose and pentose derivatives that are effective at increasing glucose transport in a non-insulin dependent manner, and to uses thereof for a) treating and/or preventing hyperglycemia; b) treating and/or preventing the complication... | 10/12/2010 |
| 7772378 | Glucopyranosyl-substituted ((hetero)arylethynyl-benzyl)-benzene derivatives, medicaments containing such compounds, their use and process for their manufacture Glucopyranosyl-substituted (hetero)arylethynyl-benzene derivatives of the general formula I where the groups R1 to R6 as well as R7a, R7b, R7c are defined according to ... | 08/10/2010 |
| 7700745 | Method for separating carbohydrate in glycoside-linkage-having compound, carbohydrate separating system, carbohydrate separating reagent kit, standard sample for carbohydrate separation, and evaluation system In an in-flow chemical reaction system (A) of the present invention, a sample solution (1) containing glycoprotein is injected into a reaction tube (7) in which an alkaline solution continuously flows. When a mixed solution of the sample solution and t... | 04/20/2010 |
| 7683160 | Glucopyranosyl-substituted benzyl-benzene derivatives, medicaments containing such compounds, their use and process for their manufacture Glucopyranosyl-substituted benzyl-benzene derivatives of the general formula I where the groups R1 to R6 as well as R7a, R7b, R7c are defined according to claim 1 | 03/23/2010 |
| 7601820 | Preparation of alkyl-substituted 2-deoxy-2-fluoro-D-ribofuranosyl pyrimidines and purines and their derivatives The present invention provides (i) a process for preparing a 2-deoxy-2-fluoro-2-methyl-D-ribonolactone derivative, (ii) conversion of the lactone to nucleosides with potent anti-HCV activity, and their analogues, and (iii) a method to prepare the anti-HCV nucleoside... | 10/13/2009 |
| 7579449 | Glucopyranosyl-substituted phenyl derivatives, medicaments containing such compounds, their use and process for their manufacture Glucopyranosyl-substituted benzene derivatives of general formula I where the groups R1 to R6 as well as R7a, R7b, R7c are defined herein and the tautomers, the stereoi... | 08/25/2009 |
| 7456265 | Carboxylated polysaccharides and method of preparation and use Chemically modified dicarboxy polysaccharides are described. The modified polysaccharides are useful as a carrier for cosmetics, pharmaceuticals, veterinary products and the like. The modified polysaccharides can provide a timed release of active ingredients. ... | 11/25/2008 |
| 7435722 | Non-toxic crosslinking reagents to resist curve progression in scoliosis and increase disc permeability A method of improving the resistance of collagenous tissue to mechanical degradation in accordance with the present invention comprises the step of contacting at least a portion of a collagenous tissue with an effective amount of a crosslinking reagent. Methods and ... | 10/14/2008 |
| 7422748 | Vaccine composition of surfactants as adjuvant of immunity A composition comprising an aqueous solution comprising: (i) at least one antigen or at least one in vivo generator of a compound comprising an amino acid sequence, and (ii) as an adjuvant of immunity, a surfactant... | 09/09/2008 |
| 7423126 | Antibody that reacts with 6-sulfated sialyl Lewis X A polypeptide of N-acetylglucosamine-6-O-sulfotransferase and a DNA encoding the peptide are provided. The polypeptide is (a) or (b) below: (a) a polypeptide consisting of an amino acid sequence represented by SEQ ID NO: 2; or... | 09/09/2008 |
| 7419959 | D-pyranosyl-substituted phenyl derivatives, medicaments containing such compounds, their use and process for their manufacture D-pyranosyl-substituted phenyls of general formula I wherein the groups R1 to R5, X, Z and R7a, R7b, R7c are defined as in claim 1, have an inhibiting effect on ... | 09/02/2008 |
| 7420029 | Tissue-specific transporter inhibitor The present invention is to provide a tissue-specific transporter inhibitor which is not absorbed through the digestive tract and can prevent deterioration in the QOL of a patient caused by diet therapy, and a therapeutic drug for tissue dysfunction diseases and a t... | 09/02/2008 |
| 7417032 | D-xylopyranosyl-phenyl-substituted cycles, medicaments containing such compounds, their use and process for their manufacture D-Glucopyranosyl-phenyl-substituted cycles of general formula I wherein the groups R1 to R6, Z, Cy and R7a, R7b, R7c, R7d are defined as in claim 1, h... | 08/26/2008 |
| 7399604 | Methods and products related to evaluating the quality of a polysaccharide The invention relates to methods and products for characterizing and using polysaccharides. Low molecular weight heparin products and methods of use are described. Methods for characterizing purity and activity of polysaccharide preparations including glycosaminogly... | 07/15/2008 |
| 7393836 | D-xylopyranosyl-substituted phenyl derivatives, medicaments containing such compounds, their use and process for their manufacture A D-Xylopyranosyl-substituted phenyl compound of general formula I wherein the groups R1 to R5, X, Z and R7a, R7b, R7c are defined as in claim 1, have an inhibiting eff... | 07/01/2008 |
| 7375064 | Functionalized polymeric surfactants based upon alkyl polyglycosides The invention relates to a series of multifunctional polyglycosides derivatives that are made by the polymerized by the reaction of polyoxyalkylene containing crosslinking reagent and polyglycosides, together with a functionalizing agent that contains a sulfate, sul... | 05/20/2008 |
| 7375213 | Methods of producing C-aryl glucoside SGLT2 inhibitors Method for the production of C-aryl glucoside SGLT2 inhibitors useful for the treatment of diabetes and related diseases. and intermediates thereof. The C-aryl glucosides may be complexed with amino acid complex forming reagents. ... | 05/20/2008 |
| 7371731 | Methods for using glucose pentasulfate for treating amyloid associated with type II diabetes A pharmaceutical agent for treating an amyloid disease in a patient, wherein the pharmaceutical agent comprises glucose pentasulfate or a pharmaceutically acceptable salt thereof. The agent is directed to amyloid diseases in general and to type II diabetes in partic... | 05/13/2008 |
| 7338932 | Methods of modulating functions of polypeptide GalNAc-transferases and of screening test substances to find agents herefor, pharmaceutical compositions comprising such agents and the use of such agents for preparing medicaments Attachment of O-glycans to proteins is controlled by a large family of homologous polypeptide GalNAc-transferases. Polypeptide GalNAc-transferases contain a C-terminal sequence with similarity to lectins. This invention discloses that the putative lectin domains of ... | 03/04/2008 |
| 7335627 | Polymeric alkylpolyglycoside carboxylates The products of the invention are polymers of carboxylated alkylpolyglycosides. The products are very mild surfactants that are useful in personal care applications. ... | 02/26/2008 |
| 7332600 | Process for the preparation of crystalline imipenem The present invention relates to a cost effective and industrially advantageous process for the preparation of imipenem of high purity, which comprises dissolving crude imipenerm in warm water to which some base has been added to obtain a solution, subjecting the re... | 02/19/2008 |
| 7312194 | Delivery systems The invention relates to compounds which are useful in the delivery of a wide variety of therapeutically useful molecules. In particular, the invention relates to compounds which are able to act as carriers for therapeutically useful molecules, and to pharmaceutical... | 12/25/2007 |
| 7307065 | 2′-Fluoronucleosides A class of 2′-fluoro-nucleoside compounds are disclosed which are useful in the treatment of hepatitis B infection, hepatitis C infection, HIV and abnormal cellular proliferation, including tumors and cancer. The compounds have the general formulae: | 12/11/2007 |
| 7306910 | Breast cancer prognostics A method of providing a prognosis of breast cancer is conducted by analyzing the expression of a group of genes. Gene expresson profiles in a variety of medium such as microarrays are included as are kits that contain them. ... | 12/11/2007 |
| 7304039 | Glucose-based compounds with affinity to P-selectin The present invention relates to certain glucose-based compounds that have an affinity to P-selectin. Further, the invention relates to the use of these glucose-based compounds for the preparation of pharmaceutical compositions for the treatment of disorders associa... | 12/04/2007 |
| 7304148 | Sugar chain asparagine derivatives, sugar chain asparagine, sugar chain, and processes for producing these An asparagine-linked α2,3-oligosaccharide having undeca- to hepta-saccharides, an asparagine-linked α2,6-oligosaccharide having undeca- to hepta-saccharides and containing fluorine and an asparagine-linked oligosaccharide derivative containing at least one fucose ... | 12/04/2007 |
| 7301016 | Human transferase family members and uses thereof The invention provides isolated nucleic acids molecules, designated 33877, 47179, 26886, 25552, 32132, 32244, 23680, 32624, 47174, 60491, 46743, 27417, 27960, 32252, and 53320 nucleic acid molecules, which encode novel human transferase family members. The invention... | 11/27/2007 |
| 7288640 | Processes for the production of aminoalkyl glucosaminide phosphate and disaccharide immunoeffectors, and intermediates therefor This invention relates to processes for production of alkylamino glucosaminide phosphate compounds, and of disaccharide compounds, including various novel intermediates and intermediate processes. In one aspect, glycosyl halides are produced by reaction of an O-sily... | 10/30/2007 |
| 7276251 | Sustained-release composition of drugs encapsulated in microparticles of hyaluronic acid A sustained-release drug composition consisting essentially of microparticles of hyaluronic acid having a high molecular weight or an inorganic salt thereof and a protein or peptide drug encased in said microparticles, wherein the average size of said microparticles... | 10/02/2007 |
| 7270980 | Compounds for immunodiagnosis of prostate cancer and methods for their use Compounds and methods for diagnosing prostate cancer are provided. The inventive compounds include polypeptides containing at least a portion of a prostate tumor protein. The inventive polypeptides may be used to generate antibodies useful for the diagnosis and moni... | 09/18/2007 |
