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| Number | Title | Issue Date |
| 7198776 | Metal complex compounds The invention relates to metal complex compounds, contrast agents for MRI and in vivo NMR markers for NMR spectroscopy comprising said metal complex compounds and methods for in vivo determination of physiological parameters, e.g. enzyme activity or pH using said me... | 04/03/2007 |
| 7163935 | Scorpionate-like pendant macrocyclic ligands, complexes and compositions thereof, and methods of using same Substituted 1,4,7-triazacyclononane-N,N′,N″-triacetic acid compounds with a pendant donor amino group, metal complexes thereof, compositions thereof, and methods of use in diagnostic imaging and treatment of a cellular disorder. ... | 01/16/2007 |
| 7112671 | Non-symmetric tripyrranes in the synthesis of novel macrocycles The present invention provides certain non-symmetric tripyrranes; that is, tripyrranes that do not contain a mirror plane of symmetry perpendicular to the plane containing the tripyrrane. Further, the invention includes texaphyrin compounds and sapphyrin compounds, ... | 09/26/2006 |
| 7081452 | Scorpionate-like pendant macrocyclic ligands, complexes and compositions thereof, and methods of using same Substituted 1,4,7-triazacyclononane-N,N′,N″-triacetic acid compounds with a pendant donor amino group, metal complexes thereof, compositions thereof, and methods of use in diagnostic imaging and treatment of a cellular disorder. ... | 07/25/2006 |
| 6462192 | Processes for large scale production of tetrapyrroles Processes for the large scale production of tetrapyrrolic compounds useful as photosensitizers in photodynamic therapy, such as meso-formyl porphyrins, meso-acrylate porphyrins, purpurins and benzochlorins. In particular, tin ethyl etiopurpurin (SnET2) an... | 10/08/2002 |
| 6340560 | Aminopolycarboxylic acid chelating agent, heavy metal chelate compound thereof, photographic additive and processing method An aminopolycarboxylic acid compound represented by the following formula or analogous thereof: ##STR1## The aminopolycarboxylic acid compound of the present invention can be used as a chelating agent for various metals, which is excellent in the bio... | 01/22/2002 |
| 6207130 | Metal-exchanged carboxylato-alumoxanes and process of making metal-doped alumina A method has been developed for the solution-based metal exchange of carboxylato-alumoxanes [Al(O)x (OH)y (O2 CR)z ]n with a wide range of metal cations. Metal-exchanged carboxylato-alumoxanes are new... | 03/27/2001 |
| 6191262 | Contrast agent preparation In the metallation of complexing agents such as DTPA-BMA with a lanthanide using a lanthanide oxide such as the lanthanide source, oxalic acid is used as a reaction accelerator.... | 02/20/2001 |
| 6124491 | Polycondensates and polymerizates made from hydrolyzable and polymerizable silanes The invention includes hydrolyzable and polymerizable silanes, methods of making them and using them to obtain silicic acid(hetero)polycondensates and silicic acid(hetero)polymerizates. The hydrolyzable and polymerizable silanes have the formula I, #... | 09/26/2000 |
| 6075130 | Ion binding compounds, radionuclide complexes, methods of making radionuclide complexes, methods of extracting radionuclides, and methods of delivering radionuclides to target locations The invention pertains to compounds for binding lanthanide ions and actinide ions. The invention further pertains to compounds for binding radionuclides, and to methods of making radionuclide complexes. Also, the invention pertains to methods of extractin... | 06/13/2000 |
| 6072038 | Conjugates of texaphyrins The invention relates to the field of radiation sensitizers and the use of texaphyrins for radiation sensitization and other conditions for which X-ray radiation has proven to be therapeutic.... | 06/06/2000 |
| 6025351 | Method of treating blood which comprises use of diels alder adducts of vinyl porphyrins and metal complexes thereof Families of Diels Alder adducts and of metal complexes of Diels Alder adducts, which are useful as particularly active compounds for use in photodynamic therapy, are disclosed. The Diels Alder adducts and a preferred family of metal complexes have the str... | 02/15/2000 |
| 6022959 | Nucleic acids internally-derivatized with a texaphyrin metal complex and uses thereof Texaphyrin metal complex-oligonucleotide and -oligonucleotide analog conjugates are provided where the texaphyrin is bound to an internal linkage of the oligonucleotide or oligonucleotide analog, the conjugates having catalytic activity for the hydrolysis... | 02/08/2000 |
| 5969111 | Texaphyrins substituted with imidazole are provided Texaphyrins substituted with imidazda are provided.... | 10/19/1999 |
| 5808013 | Process for the preparation of N-alkyl substituted metal carbamate solutions and their use Process for the preparation of N-alkyl substituted metal carbamate solutions characterized in that a water solution of the salt of the metal of which the corresponding carbamate is to be obtained, is reacted with an organic solution, basically consisting ... | 09/15/1998 |
| 5801229 | Metal complexes of texaphyrins Texaphyrins are provided for use as radiation sensitizers. Advantageous properties of texaphyrins for use as a radiation sensitizer include: i) a low redox potential which allows radiation-induced hydrated electrons to flow to texaphyrin rather than neutr... | 09/01/1998 |
| 5789586 | Efficient functionalization of porphyrin derivatives possessing sulfonic acid groups A method for preparing functionalized derivatives of organic or inorganic compounds and tetrapyrrolic compounds in particular, all of which compounds have at least one sulfonic acid group, by first preparing a sulfonyl halide intermediate of the compound ... | 08/04/1998 |
| 5783171 | Radionuclide metal N2 S2 chelates substituted with glucose and biotin moieties Chelating compounds of specified structure are useful for radiolabeling targeting proteins such as antibodies as well as proteinaceous and non-proteinaceous ligands and anti-ligands. The radiolabeled antibodies, ligands or anti-ligands, or catabolites the... | 07/21/1998 |
| 5746995 | DTPA derivatives substituted in a novel way, their metal complexes, and their use in diagnosis and therapy The invention relates to new diethylenetriaminepentaacetic acid derivatives, their complexes and complex salts, that contain an element of atomic numbers 20-32, 39-51 or 57-83, pharmaceutical agents that contain these compounds and their use as contrast m... | 05/05/1998 |
| 5676923 | Substituted DTPA monoamides of the central carboxylic acid group and their metal complexes Diethylenetriaminepentaacetic acid monoamide derivatives, their complexes and complex salts, containing an element of atomic numbers 21-29, 31, 32, 39, 42-44, 49 or 57-83, pharmaceutical agents containing these compounds, their use as contrast media and p... | 10/14/1997 |
| 5633354 | Phosphoramidite derivatives of texaphyrins The invention is directed to a method of incorporating expanded porphyrins, and particularly of incorporating a sapphyrin or a texaphyrin, before, during, or after chemical synthesis of an oligomer to form an expanded porphyrin-oligonucleotide conjugate, ... | 05/27/1997 |
| 5587394 | Production and use of diels alder adducts of vinyl porphyrins, of metal complexes thereof, and of compositions containing such adducts and complexes Families of Diels Alder adducts and of metal complexes of Diels Alder adducts, which are useful as particularly active compounds for use in photodynamic therapy, are disclosed. The Diels Alder adducts and a preferred family of metal complexes have the str... | 12/24/1996 |
| 5587371 | Texaphyrin-oligonucleotide conjugates Texaphyrins are provided for use as radiation sensitizers. Advantageous properties of texaphyrins for use as a radiation sensitizer include: i) a low redox potential which allows radiation-induced hydrated electrons to flow to texaphyrin rather than neutr... | 12/24/1996 |
| 5580543 | Method of magnetic resonance image enhancement Texaphyrins are provided for use as radiation sensitizers. Advantageous properties of texaphyrins for use as a radiation sensitizer include: i) a low redox potential which allows radiation-induced hydrated electrons to flow to texaphyrin rather than neutr... | 12/03/1996 |
| 5565552 | Method of expanded porphyrin-oligonucleotide conjugate synthesis The invention is directed to a method of incorporating expanded porphyrins, and particularly of incorporating a sapphyrin or a texaphyrin, before, during, or after chemical synthesis of an oligomer to form an expanded porphyrin-oligonucleotide conjugate, ... | 10/15/1996 |
| 5563262 | Diels alder adducts of vinyl porphyrins Families of Diels Alder adducts and of metal complexes of Diels Alder adducts, which are useful as particularly active compounds for use in photodynamic therapy, are disclosed. The Diels Alder adducts and a preferred family of metal complexes have the str... | 10/08/1996 |
| 5531978 | Aminopolycarboxylic acids and derivatives thereof There are provided chelating agents particularly useful for the preparation of diagnostic and therapeutic agents for magnetic resonance imaging, scintigraphy, ultrasound imaging, radiotherapy and heavy metal detoxification, said agents being compounds of ... | 07/02/1996 |
| 5457183 | Hydroxylated texaphyrins A method of using texaphyrins as radiosensitizers. Advantageous properties of texaphyrins for use as a radiosensitizer include i) a low redox potential which allows radiation induced solvated electrons to flow to texaphyrin rather than neutralizing hydrox... | 10/10/1995 |
| 5419894 | Complexing agents, complexes and complex salts Compounds of the general formula I: ##STR1## wherein R1 signifies a COOX group or the group ##STR2## R2 and R3 are the same or different and signify a hydrogen atom, a lower straight- or branched-chain, hydrocarb... | 05/30/1995 |
| 5374416 | Nitrogenous macrocyclic ligands, polymetallic complexes and diagnostic and therapeutic composition The invention relates to ligands of formula ##STR1## in which B represents an ##STR2## W representing the ##STR3## group, in which groups X and Z represent a heterocycle. The invention also relates to the monometallic or polymetallic c... | 12/20/1994 |
| 5371234 | Ion specific chelating agents derived from ଲ-hydroxyhistidine, 4-(1-hydroxy-1-alkyl)imidazole and derivatives thereof ଲ-hydroxyhistidine, 4-(1-hydroxy-1-alkyl)imidazole or derivatives thereof can be used as a bidentate ligand in the chelation of iron(III), Al(III), Cr(III), Ga(III) and the actinides(IV), such as plutonium 238. ଲ-hydroxyhistidine is found in a... | 12/06/1994 |
| 5369101 | Expanded porphyrins: large porphyrin-like tripyrroledimethine-derived macrocycles The present invention involves a novel tripyrrole dimethine-derived "expanded porphyrin" (texaphyrin), the synthesis of such compounds, their analogs or derivatives and their uses. These expanded porphyrin-like macrocycles are efficient chelators of dival... | 11/29/1994 |
| 5364613 | Polychelants containing macrocyclic chelant moieties There are provided polychelants and their metal chelates which are useful in diagnostic imaging and in radiotherapy and which comprise a plurality of macrocyclic chelant moieties, e.g, DOTA residues, conjugated to a polyamine backbone molecule, e.g, polyl... | 11/15/1994 |
| 5328992 | Metal complexes of polyethylene glycol carbamate derivatives of desferrioxamine B Compounds of the formula ##STR1## in which R is alkyl having up to 4 carbon atoms, n has an average value of at least 9, X is a radical of the formula --C(.dbd.O)--(NH--SO2)m -- in which m is 0 or 1 and, if m is 1, the carh... | 07/12/1994 |
| 5250668 | Production and use of porphyrin derivatives and of compositions containing such derivatives A family of benzochlorins, a family of verdins, a family of porphyrin derivatives and metal complexes thereof are disclosed. The benzochlorins have the formula of FIG. 3 of the attached drawings; their metal complexes have the formula of FIG. 1 . The verd... | 10/05/1993 |
| 5217706 | Complexes and compositions for magnetic resonance imaging Novel magnetic resonance imaging agents comprise complexes of paramagnetic ions with hydrazide derivatives of polyaminocarboxylic acid chelating agents. These novel imaging agents are characterized by excellent NMR image-contrasting properties and by high... | 06/08/1993 |
| 5198208 | Aminopolycarboxylic acids and derivatives thereof There are provided chelating agents particularly useful for the preparations of diagnostic and therapeutic agents for magnetic resonance imaging, scintigraphy, ultrasound imaging, radiotherapy and heavy metal detoxification, said agents being compounds of... | 03/30/1993 |
| 5141740 | Complexes and compositions for magnetic resonance imaging and usage methods Novel magnetic resonance imaging agents comprise complexes of paramagnetic ions with hydrazide derivatives of polyaminocarboxylic acid chelating agents. These novel imaging agents are characterized by excellent NMR image-contrasting properties and by high... | 08/25/1992 |
| 5124471 | Bifunctional DTPA-type ligand The subject matter of the present invention relates to bifunctional cyclohexyl DPTA ligands and methods for utilizing these compounds.... | 06/23/1992 |
| 5109129 | Porphyrin derivatives A family of benzochlorins, a family of verdins, a family of porphyrin derivatives and metal complexes thereof are disclosed. the benzochlorins have the formula of FIG. 3 of the attached drawings; their metal complexes have the formula of FIG. 1. The verdi... | 04/28/1992 |
