Celebrity Inventors
Mark Twain (Samuel L. Clemens) received Patent No. 121,992 for "An Improvement in Adjustable and Detachable Straps for Garments." He later received two more patents: one for a self-pasting scrapbook and one for a game to help players remember important historical dates.
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| Number | Title | Issue Date |
| 7410771 | Reagent and method for detecting a sporozoite antigen A reagent and method for the specific and highly sensitive detection of C. parvum in which the reagent is an antibody for a soluble C. parvum sporozoite antigen and the method is an immunoassay in which the antibody is used to detect or quantify C. ... | 08/12/2008 |
| 7056509 | Antibody methods for selectively inhibiting VEGF Disclosed are antibodies that specifically inhibit VEGF binding to only one (VEGFR2) of the two VEGF receptors. The antibodies effectively inhibit angiogenesis and induce tumor regression, and yet have improved safety due to their specificity. The present invention ... | 06/06/2006 |
| 6531578 | Immunoassay method employing monoclonal antibody reactive to human iNOS A panel of monoclonal antibodies recognizing and binding to human inducible nitric oxide synthase (iNOS or type II iNOS) enzyme have been developed. The monoclonal antibodies may also be employed in an assay to detect the presence and/or quantitate the am... | 03/11/2003 |
| 6524583 | Antibody methods for selectively inhibiting VEGF Disclosed are antibodies that specifically inhibit VEGF binding to only one (VEGFR2) of the two VEGF receptors. The antibodies effectively inhibit angiogenesis and induce tumor regression, and yet have improved safety due to their specificity. The present... | 02/25/2003 |
| 6423546 | Monoclonal antibodies for assaying lipid transfer proteins The present invention relates to novel monoclonal antibodies reactive with lipid transfer proteins typically found in foaming beverages. More specifically, the present invention relates to novel monoclonal antibodies raised against the native and denature... | 07/23/2002 |
| 6372215 | Monoclonal antibodies to human CD6 The invention provides antibodies and other binding agents that bind specifically to SRCR domains of human CD6 (hCD6) and have advantageous properties, including the capacity to substantially inhibit binding of activated leukocyte adhesion molecule (ALCAM... | 04/16/2002 |
| 6342219 | Antibody compositions for selectively inhibiting VEGF Disclosed are antibodies that specifically inhibit VEGF binding to only one (VEGFR2) of the two VEGF receptors. The antibodies effectively inhibit angiogenesis and induce tumor regression, and yet have improved safety due to their specificity. The present... | 01/29/2002 |
| 6333397 | Monoclonal antibodies to troponin T and their production An immunoassay for the determination of myocardial necroses using antibodies to troponin T and a binding partner B for troponin T or for the an antibody, whereby either the antibody or the binding partner B is labelled with a determinable group. The immun... | 12/25/2001 |
| 6133428 | Gab1, a Grb2 binding protein, and compositions for making and methods of using the same A substantially pure protein, Gab1, that binds to Grb2 is disclosed. Isolated nucleic acid molecules that encode Gab1 is disclosed. Pharmaceutical compositions comprising a pharmaceutically acceptable carrier in combination with nucleic acid molecules are... | 10/17/2000 |
| 6124439 | OB polypeptide antibodies and method of making The present invention relates generally to the control of body weight of animals including mammals and humans, and more particularly to materials identified herein as modulators of body weight, and to diagnostic and therapeutic uses of such modulators. In... | 09/26/2000 |
| 5965378 | Antibody class-specific interference eliminating reagent The invention concerns a composition composed of several different antibodies or/and antibody fragments which is suitable as a reagent to reduce interferences in an immunological method for the class-specific detection of antibodies from one or several of... | 10/12/1999 |
| 5534255 | Monoclonal antibody specific to human 2 -plasmin inhibitor This invention provides a monoclonal antibody or its fragment specific to a human 댒 -plasmin inhibitor, said antibody having the function of specifically blocking that site of the human 댒 -plasmin inhibitor which inhibi... | 07/09/1996 |
| 5532137 | Anti-FR-900506 substance antibodies and highly-sensitive enzyme immunoassay method Monoclonal or polyclonal antibodies capable of recognizing at least one antigenic determinant located on the FR-900506 compound, are disclosed. FR-900506 is a compound having pharmacological activities such as immunosuppressive activity and antimicrobial ... | 07/02/1996 |
| 5496802 | Control of milk secretion A protein which inhibits milk secretion by lactating cows and which is present in the eighth (6B, Figure) significant peak when a nominally 10-30 KDa fraction of the whey proteins of the milk is resolved on a "Mono Q" anion exchange column using 10 mM imi... | 03/05/1996 |
| 5194592 | Monoclonal antibodies to novel polypeptide derivatives of human granulocyte colony stimulating factor Novel hG-CSF polypeptide derivatives having an amino acid sequence derived from the amino acid sequence of the human granulocyte colony stimulating factor polypeptide by substitution of at least one amino acid by a different aminoacid and/or deletion of a... | 03/16/1993 |
| 5171667 | Hybridomas producing monoclonal antibodies to mono-, di- and trifucosylated type 2 chain Hybridoma cell lines that produce monoclonal antibodies that differentially recognize glycolipids with mono-, di-, and trifucosylated type 2 chain structures are disclosed. The monoclonal antibodies can be used to detect specific types of tumor cells that... | 12/15/1992 |
| 5171666 | Monoclonal antibodies reactive with a cell-surface gylcoprotein expressed on human carcinomas The present invention relates to a novel tumor-associated antigen that is a cell-surface glycoprotein having a molecular weight in the range of 110,000-140,000 daltons that is present in a variety of carcinomas, including squamous cell carcinomas and aden... | 12/15/1992 |
| 5169774 | Monoclonal anti-human breast cancer antibodies Murine monoclonal antibodies, or fragments thereof, that bind selectively to human breast cancer cells, are IgGs or IgMs, and when conjugated to ricin A chain, exhibit a TCID 50% against at least one of MCF-7, CAMA-1, SKBR-3, or BT-20 cells of less than a... | 12/08/1992 |
| 5166050 | Monoclonal antibodies and peptides useful in treating and diagnosing HIV infections Methods and composition for HIV diagnosis and treatment using monoclonal antibodies reactive with one or more neutralizing regions of HIV proteins, using the peptides or homologs thereof from that region, and using related nucleic acid segments. Exemplary... | 11/24/1992 |
| 5157113 | Removal of nucleic acids from monoclonal antibody preparations An essentially pure and stablized antibody preparation comprising IgM antibodies having a purity greater than about 98% by weight and a nucleic acid content of less than about 200 pg per mg IgM. In one embodiment IgM antibodies from a monoclonal source ar... | 10/20/1992 |
| 5141864 | Monoclonal antibody recognizing alpha 2.fwdarw.3 bonds A hybridoma capable of producing a monoclonal antibody specific to a sialic acid containing glycolipid carrying N-acetylneuraminic acid residue having alpha 2.fwdarw.3 linkage is herein disclosed. The hybridoma can be generated by fusing (i) B cells or ly... | 08/25/1992 |
| 5118796 | Efficient large-scale purification of immunoglobulins and derivatives Improved methods for direct purification of product immunoglobulins or their derivatives from large volumes of mammalian cell culture medium include directly subjecting the cell culture medium to cation exchange treatment, so as to adsorb the product but ... | 06/02/1992 |
| 5112952 | Composition and method for isolation and purification of Immunoglobulin M Preparation of a composite of mannan binding protein attached to an insoluble, support matrix is accomplished by reacting cyanogen bromide activated beaded agarose with a buffered solution of mannan binding protein isolated from rabbit serum. The composit... | 05/12/1992 |
| 5104652 | Compositions and method for treatment of cancer using monoclonal antibody against GD3 ganglioside together with IL-2 Cell surface gangliosides are presumed to play a role in cell growth and differentiation. Using monoclonal antibodies directed against GD3, a disialoganglioside expressed predominantly by cells of neuroectodermal origin, we have found that G | 04/14/1992 |
| 5087560 | Monoclonal antibody for use in drug resistant cancers and production thereof Monoclonal antibodies are disclosed that may be produced by hybridomas obtained by fusing a mouse spleen cell immunized with an ADRIAMYCIN.RTM.-resistant human tumor cell and a mouse myeloma cell and which inhibit selectively the growth of cancer cells po... | 02/11/1992 |
| 5084396 | Enhanced production of antibodies utilizing insolubilized immune complexes A method for enhancing production of antibodies through immunization with insolubilized immune complexes is disclosed. Purified antigen or heterogeneous antigen mixtures may be combined with polyclonal or monoclonal antibody and the resultant complex boun... | 01/28/1992 |
| 5077391 | Purification of immunoglobulin M Immunoglobulin M is purified by absorption upon an insoluble matrix material having chemically bound thereon the protein C1q. The matrix is washed and purified immunoglobulin M is then released from the matrix.... | 12/31/1991 |
| 5071759 | Hybridoma cell lines and monoclonal antibodies to clostridum difficile toxins A and B Monoclonal antibodies produced by a family of murine hybrid cell lines are cross-reactive with both toxin A and toxin B of Clostridium difficile. The monoclonal antibodies are useful in an immunoassay for toxin A and toxin B of C. difficile, a casual agen... | 12/10/1991 |
| 5069896 | Malodor inhibiting skin deodorant composition comprising a monoclonal antibody and method of deodorizing The present invention is concerned with a monoclonal antibody or antigen-binding fragment of a monoclonal antibody produced by a hybridoma formed by fusion of cells from mouse myeloma cells and spleen cells wherein said monoclonal antibody or fragment the... | 12/03/1991 |
| 5053491 | Monoclonal antibodies and cell lines for parathyroid tissue-specific antigen Monoclonal antibodies specific for an antigen present on the surface of parathyroid tissue are useful in imaging such tissue when conjugated to suitable label. The antibodies of the invention bind exclusively to parathyroid surfaces and do not bind to oth... | 10/01/1991 |
| 5051371 | Modified ଲ2 -microglobulin Substantially pure modified 댢 -microglobulin (m댢 m) of the formula I ##STR1## wherein R1 is 24-amino acid residue, with the sequence Ile-Gln-Arg-Thr-Pro-Lys-Ile-Gln-Val-Tyr-Ser-Arg-His-Pro-Ala-Glu-Asn-Gl... | 09/24/1991 |
| 5049502 | Chicken-derived immunoglobulin-producing cell lines The present invention involves a method for preparing antibody-producing chicken cell clones. This method comprises a series of steps including initially immunizing a first chicken with a desired antigen. A population of antibody-producing lymphocytes fro... | 09/17/1991 |
| 5045466 | Purified mammalian cell binding receptor for bacterial lipopolysaccharide endotoxin and monoclonal antibody The invention is directed to hydridoma cell lines and the monoclonal antibodies produced by the cell lines, where the monoclonal antibodies specifically bind to the lipopolysaccharide endotoxin binding receptor of mammalian cells. Specifically, the monocl... | 09/03/1991 |
| 5028540 | Avian immunoglobulin-producing cell lines The present invention involves a method for preparing antibody-producing chicken cell clones. This method comprises a series of steps including initially immunizing a first chicken with a desired antigen. A population of antibody-producing lymphocytes fro... | 07/02/1991 |
| 5028424 | Antibodies to receptor and antigen for natural killer and non-specific cytotoxic cells The present invention encompasses a receptor molecule present on the surface of natural killer cells (NK cells) and non-specific cytotoxic cells (NCC) which is involved in non-specific lysis of target cells bearing an antigen recognized by the receptor mo... | 07/02/1991 |
| 5021553 | Anti-human adenocarcinoma antigen specific monoclonal antibody A monoclonal antibody against human cancer, characterized in that the monoclonal antibody is produced by a hybridoma cell line obtained from the fusion of B-lymphocyte immunized with cells of human cancer origin and tumor cells, and reactive with cancer c... | 06/04/1991 |
| 5019497 | Human squamous lung carcinoma cell specific antigens and antibodies Methods and compositions are provided for detecting antigens having a specific epitope associated with squamous lung carcinoma. The antigen may be found at lesion sites or in the blood as indicative of the squamous lung carcinoma. Specific antibodies may ... | 05/28/1991 |
| 5011676 | Method to directly radiolabel antibodies for diagnostic imaging and therapy The invention is a novel method and kit for directly radiolabeling proteins such as antibodies or antibody fragments for diagnostic and therapeutic purposes. The method comprises incubating a protein-containing solution with a solution of sodium ascorbate... | 04/30/1991 |
| 5001225 | Monoclonal antibodies to a pan-malarial antigen A continuous hybridoma cell line, designated 7H8, which secretes a monoclonal antibody (MAb 7H8) of the IgM class and which binds to a protein present in species of the genus Plasmodium. MAb 7H8 also recognizes an antigen (antigen Pf93) unique to P. falci... | 03/19/1991 |
| 4990454 | YH206 cell line and monoclonal antibody produced by it A monoclonal antibody specifically reactive to a human adenocarcinoma cell, which is obtainable by cultivating a fused cell obtained by fusing a mammalian animal cell, immunized with a human adenocarcinoma cell, with a myeloma cell.... | 02/05/1991 |
