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| Number | Title | Issue Date |
| 7387997 | α-conotoxin MII analogues The invention relates to novel conopeptides and/or novel Luses of conopeptides. The conopeptides of the invention are analogs of α-Conotoxin MII that are selective for α6-containing nAChRs as described herein. ... | 06/17/2008 |
| 7381706 | Gonadotropin-releasing hormone, precursor peptides thereof and genes encoding the same A novel peptide found as gonadotropin-releasing hormone (GnRH) in octopuses, a member of mollusks. The structure and the activities of the peptide have been unraveled. The peptide finds use as a reagent used in the studies of correlations between the structure and t... | 06/03/2008 |
| 7368432 | Conotoxin peptides The invention relates to relatively short conotoxin peptides, about 10-20 residues in length as described herein, which are naturally available in minute amounts in the venom of the cone snails or analogous to the naturally available peptides, and which preferably i... | 05/06/2008 |
| 7358332 | Bioactive peptides, uses thereof and process for the production of same Novel bioactive peptide compositions and process for producing the same and the use of such compositions for enhancing the growth of warm blooded animals and fish is disclosed. ... | 04/15/2008 |
| 7351693 | Peptides and nucleic acids of the cathelicidin family, derived from fish, and uses thereof The invention relates to anti-microbial and immunostimulatory molecules of the cathelicidin family derived from fish. The invention provides a novel cathelicidin molecule, fragments, derivatives and uses thereof, and nucleic acids encoding the same. ... | 04/01/2008 |
| 7314915 | Fluorescent proteins The present invention relates to novel variants of the fluorescent protein GFP having improved fluorescence properties. ... | 01/01/2008 |
| 7279549 | Apha-conotoxin peptides The invention relates to relatively short peptides (termed α-conotoxins herein), about 10-30 residues in length, which are naturally available in minute amounts in the venom of the cone snails or analogous to the naturally available peptides, and which preferably i... | 10/09/2007 |
| 7271242 | Cytotoxic cyplasin of the sea hare, aplysia punctata, cdna cloning and expression of bioreactive recombinants Described is a nucleic acid coding for a protein called “cyplasin” that shows a preferential toxicity to autonomously growing mammalian cells. Cell death induced by this protein differs from both apoptosis and necrosis. An intracellular cell death which occurs w... | 09/18/2007 |
| 7179793 | Anti-hypertensive dietary supplement An anti-hypertensive fish protein hydrolysate is provided, wherein the fish is of the genus Salmo or Oncorhynchus, and wherein the fish protein hydrolysate comprises at least 1 peptide selected from the group consisting of: Leu-Ala-Phe, Leu-Thr-Phe, Il... | 02/20/2007 |
| 7138488 | Polypeptides having anti-HIV activity and compositions comprising same Polypeptides of A1-Arg-A2-Cys-Tyr-A3-A4-X-A5-A6-Cit Cys-A7 (I) or their salts (wherein A1 is hydrogen or a residue of arginine, lysine, ornithine, citrulline, alanine, or the like; A2 is an aromatic amino acid residue; A3, A4 and A6 are each a residue of arginine, l... | 11/21/2006 |
| 7128921 | Dermatophagoides proteins and fragments thereof The present invention relates to high molecular weight Dermatophagoides proteins, nucleic acid molecules encoding such proteins, and therapeutic and diagnostic reagents derived from such proteins. ... | 10/31/2006 |
| 6958385 | Bioactive peptides, uses thereof and process for the production of same Novel bioactive peptide compositions and process for producing the same and the use of such compositions for enhancing the growth of warm blooded animals and fish is disclosed. ... | 10/25/2005 |
| 6916908 | Product and composition containing a Concholepas concholepas hemocyanin (CCH) subunit, and a method of use thereof The use of CCH-A subunit isolated from hemocyanin of the marine gastropod Concholepas concholepas (CCH), or a combination thereof, as an immunostimulant agent in the innate or adaptive immune response of vertebrates or as an immunotherapeutic agent in cancer ... | 07/12/2005 |
| 6905704 | Peptide SY Peptide SY is produced by applying a mixture of peptides obtained by processing fish meat with a protease to a peptide-adsorbing resin (ODS resin or the like), eluting this with water, then with a 11 to 18% v/v ethanol aqueous solution and further with water, and co... | 06/14/2005 |
| 6747001 | Bioactive peptides, uses thereof and process for the production of same Novel bioactive peptide compositions and process for producing the same and the use of such compositions for enhancing the growth of warm blooded animals and fish is disclosed. ... | 06/08/2004 |
| 6683161 | Human ependymin The present invention relates to a novel human Ependymin protein which is a member of the ependymin family. In particular, isolated nucleic acid molecules are provided encoding the human Ependymin protein. Ependymin polypeptides are also provided as are v... | 01/27/2004 |
| 6635285 | Shark cartilage extract: process of making, methods of using, and compositions thereof The present invention relates to cartilage extracts and to a method of producing the same. Shark cartilage extracts having anti-angiogenic, anti-tumor, anti-inflammatory and anti-collagenolytic activities have been obtained by an improved process. The pro... | 10/21/2003 |
| 6475792 | Methods for raising pre-adult anadromous fish The invention relates to methods, compositions and kits for improving the raising of pre-adult anadromous fish, or preparing pre-adult anadromous fish for transfer to seawater. The methods involve adding PVCR modulators (e.g., calcium and/or magnesium) to... | 11/05/2002 |
| 6417173 | Methods and compositions based on inhibition of cell invasion and fibrosis by anionic polymers The present invention relates to the discovery that biocompatible anionic polymers can effectively inhibit fibrosis, scar formation, and surgical adhesions. The invention is predicated on the discovery that anionic polymers effectively inhibit invasion of... | 07/09/2002 |
| 6391861 | Method for the prevention of tissue elastic fiber injury The subject invention is directed to the prevention of elastic fiber injury by administering HA or any other polysaccharide or carbohydrate moiety that binds to and coats elastic fibers, thereby preventing enzymes, oxidants, or other injurious agents from... | 05/21/2002 |
| 6384200 | Endotoxin binding and neutralizing protein and uses thereof Endotoxin binding/neutralizing proteins capable of binding endotoxin in vivo, thereby neutralizing the toxic effect or bioactivity of endotoxin which are isolated from a horseshoe crab such as Limulus polyphemus, pharmaceutical compositions and pharmaceut... | 05/07/2002 |
| 6376650 | Bioactive peptides, uses thereof and process for the production of same Novel bioactive peptide compositions and process for producing the same and the use of such compositions for enhancing the growth of warm blooded animals and fish is disclosed.... | 04/23/2002 |
| 6335430 | Process of producing polyphenolic adhesive proteins and proteins produced in accordance with the process The invention relates to a process of producing MAP-products from mussel feet. The process is characterised by extracting the mussel feet in a weakly acid aqueous solution containing, for instance, 1-10 percent by weight of a weak acid and 0.5-3 percent b... | 01/01/2002 |
| 6156519 | (.fwdarw.)-ଲ- d-glucan binding protein, an antibody recognizing the protein and use thereof A (1.fwdarw.3)-ଲ-D-glucan binding protein obtainable by affinity chromatography or gel filtration of an extract of horseshoe crab amoebocytes and having a molecular weight of about 580 kDa, as determined by gel filtration under non-reducing conditio... | 12/05/2000 |
| 6153738 | Contryphan peptides The present invention is directed to contryphan peptides having 6-12 amino acids, preferably including one or more D-tryptophan or D-leucine residues. The peptides of the present invention are generically termed "contryphans," although the D-leucine conta... | 11/28/2000 |
| 6153731 | Dehydrodidemnin B Dehydrodidemnin B with useful biological activity has formula (1). It can be isolated from natural sources or synthesized, and it forms active derivatives. ##STR1##... | 11/28/2000 |
| 6127348 | Methods and compositions based on inhibition of cell invasion and fibrosis by anionic polymers The present invention relates to the discovery that biocompatible anionic polymers can effectively inhibit fibrosis, scar formation, and surgical adhesions. The invention is predicated on the discovery that anionic polymers effectively inhibit invasion of... | 10/03/2000 |
| 6083930 | Methods and compositions based on inhibition of cell invasion and fibrosis by anionic polymers The present invention relates to the discovery that biocompatible anionic polymers can effectively inhibit fibrosis, scar formation, and surgical adhesions. The invention is predicated on the discovery that anionic polymers effectively inhibit invasion of... | 07/04/2000 |
| 6020326 | Method for inhibition of bone growth by anionic polymers The present invention relates to the discovery that biocompatible anionic polymers can effectively inhibit fibrosis, scar formation, and surgical adhesions. The invention is predicated on the discovery that anionic polymers effectively inhibit invasion of... | 02/01/2000 |
| 6007811 | Method of producing fibrin sealant from clotting factors in fish blood The present invention is a fibrin sealant and a method for producing a fibrin sealant from fish blood. Whole blood is drawn from the donor fish and centifuged to separate blood cells from plasma. Prothrombin and fibrinogen are extracted from this plasma, ... | 12/28/1999 |
| 5994325 | Methods and compositions based on inhibition of cell invasion and fibrosis by anionic polymers The present invention relates to the discovery that biocompatible anionic polymers can effectively inhibit fibrosis, scar formation, and surgical adhesions. The invention is predicated on the discovery that anionic polymers effectively inhibit invasion of... | 11/30/1999 |
| 5965534 | Use of ω-conotoxin analogs for treating retinal and optic nerve head damage The invention is directed to the use of ω-conotoxins for the prevention and treatment of retinal or optic nerve head damage in humans. Compositions and methods are disclosed.... | 10/12/1999 |
| 5958248 | Method of precipitating protein at the time of removal of heavy metals A method and a system which enable simple and inexpensive removal of heavy metals from a heavy-metal-containing substance. In this method, a substance containing heavy metals and water are introduced into a mixing bath in proportions by weight of 1:3 to 1... | 09/28/1999 |
| 5932697 | Synthetic antifreeze peptide A synthetic antifreeze peptide and a synthetic gene coding for the antifreeze peptide have been produced. The antifreeze peptide has a greater number of repeating amino acid sequences than is present in the native antifreeze peptides from winter flounder ... | 08/03/1999 |
| 5866682 | Conopeptides AuIA, AuIB and AuIC This invention relates to relatively short peptides about 14-17 residues in length, which are naturally available in minute amounts in the venom of the cone snails or analogs to the naturally available peptides, and which include two cyclizing disulfide l... | 02/02/1999 |
| 5861378 | Horseshoe crab hemocyte polypeptides, and preparation and DNA encoding thereof The present invention relates to polypeptide having a primary structure of amino acid sequence shown by Sequence List Sequence No. 1 and DNA encoding for the polypeptide. The polypeptide is obtainable by following steps (1)-(3): Step (1): extracting small... | 01/19/1999 |
| 5780429 | Anti-LPS factor from horseshoe crabs and methods of use This invention is directed to pharmaceutical and cosmetic compositions comprising anti-lipopolysaccharide (anti-LPS) factor proteins derived from horseshoe crabs, either in the native form or produced by recombinant means. The pharmaceutical formulations,... | 07/14/1998 |
| 5770560 | Method for increasing tissue oxygenation using fish hemoglobin exhibiting a root effect The invention relates to the use of fish hemoglobins that exhibit a Root effect to increase tissue oxygenation in patients suffering from disease states associated with compromised oxygen delivery to tissues.... | 06/23/1998 |
| 5747322 | Recombinant crab collagenase An isolated sequence is provided that encodes crab procollagenase (Seq ID NO 5) that upon cleaving off the 29 amino acid propeptide (Seq ID NO 6) transforms into an active collagenase (Seq ID NO 4). The procollagenase has the MW of about 26.6 kD and the m... | 05/05/1998 |
| 5747455 | Endotoxin binding and neutralizing protein and uses thereof Endotoxin binding/neutralizing proteins capable of binding endotoxin in vivo, thereby neutralizing the toxic effect or bioactivity of endotoxin which are isolated from a horseshoe crab such as Limulus polyphemus, pharmaceutical compositions and pharmaceut... | 05/05/1998 |
