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| Number | Title | Issue Date |
| 7348400 | α-conotoxin peptides with analgesic properties This invention relates to novel α-conotoxin-like peptides comprising the following sequence of amino acids: Xaa1CCSXaa2Xaa3Xaa4CXaa5Xaa6Xaa7Xaa8Xaa9Xaa10Xa... | 03/25/2008 |
| 7264812 | vaccine The present invention relates to nucleic acid sequences encoding Ostertagia ostertagi proteins and to parts of such nucleic acid sequences that encode an immunogenic fragment of such proteins, and to DNA fragments, recombinant DNA molecules, live recombinant ... | 09/04/2007 |
| 7125556 | Nucleic acid molecule comprising a nucleic acid sequence coding for a haemocyanin A nucleic acid molecule or construct alone or with a promoter suitable for expression control is contemplated that codes for a haemocyanin, a haemocyanin domain or a fragment thereof with the immunological properties of at least one domain of haemocyanin, and compri... | 10/24/2006 |
| 7125557 | Nucleic acid molecule comprising a nucleic acid sequence which codes for a haemocyanin, and comprising at least one intron sequence A nucleic acid molecule or construct alone or with a promoter suitable for expression control is contemplated that codes for a haemocyanin, a haemocyanin domain or a fragment thereof with the immunological properties of at least one domain of haemocyanin, and compri... | 10/24/2006 |
| 6800733 | Modified green fluorescent proteins Modifications in the sequence of Aequorea wild-type GFP provide products having markedly different excitation and emission spectra from corresponding products from wild-type GFP. In one class of modifications, the product derived from the modified GFP exhibits an al... | 10/05/2004 |
| 6797808 | α-conotoxin peptides The invention relates to relatively short peptides (termed α-conotoxins herein), about 10-30 residues in length, which are naturally available in minute amounts in the venom of the cone snails or analogous to the naturally available peptides, and which preferably i... | 09/28/2004 |
| 6794360 | Treatment of allergic rhinitis The invention relates to the discovery that various proteins isolated from ticks are effective in the treatment and prevention of allergic rhinitis. These proteins may most suitably be applied to an effected area and are thus effective to treat this condition and to... | 09/21/2004 |
| 6764838 | Use of parasitic biological agents for prevention and control of autoimmune diseases The invention relates to a method of treating an excessive immune response including an aberrant/enhanced Th1 response by administering a helminthic parasite preparation in an amount sufficient to reduce the excessive immune response in an individual. This invention... | 07/20/2004 |
| 6737399 | Treatment of conjunctivitis The present invention relates to the discovery that various proteins isolated from ticks are effective in the treatment of conjunctivitis. These proteins may most suitably be applied topically to an affected area and are effective to ameliorate the symptoms of this ... | 05/18/2004 |
| 6719975 | Anti-hirudin polyclonal antibodies and their use for the identification, immunopurification and quantitative determination of hirudin A method of making antibodies to hirudin by immunizing with an immunogenic composition containing polymerized hirudin monomers in the absence of carrier protein is taught. ... | 04/13/2004 |
| 6566496 | Neurogenin The invention relates to novel neurogenin proteins, nucleic acids and antibodies.... | 05/20/2003 |
| 6413729 | Peptidoglycan recognition proteins and their production A gene coding for a peptidoglycan recognition peptide (PGRP) is cloned, a recombinant vector into which said gene is introduced is obtained, and a transformant transformed with said recombinant vector is cultivated, thereby producing the PGRP in large amo... | 07/02/2002 |
| 6274553 | Method for stabilizing peptides and freeze-dried medicinal compositions containing peptides obtained by using the method A method is provided for elevating the stability of peptides containing the sequence -Asp-Gly- or -Asn-Gly- by preventing these sequences from changing into succinimide compounds or ଲ-transition compounds. The method comprises adding an organic acid... | 08/14/2001 |
| 6077680 | ShK toxin compositions and methods of use Disclosed are methods and compositions comprising DNA segments, and proteins derived from sea anemone species. More particularly, it concerns the novel ShK toxin, ShK toxin analogs, chemically-modified toxin analogs, and nucleic acid segments encoding the... | 06/20/2000 |
| 6066476 | Modified green fluorescent proteins Modifications in the sequence of Aequorea wild-type GFP provide products having markedly different excitation and emission spectra from corresponding products from wild-type GFP. In one class of modifications, the product derived from the modified GFP exh... | 05/23/2000 |
| 6034217 | Peptidoglycan recognition proteins and their production A gene coding for a peptidoglysan recognition peptide (PGRP) is cloned, a recombinant vector into which said gene is introduced is obtained, and a transformant transformed with said recombinant vector is cultivated, thereby producing the PGRP in large amo... | 03/07/2000 |
| 5977056 | Treatment of thrombotic events A method for preventing the formation of platelet-rich clots or thrombus, and for deaggregating platelet-rich clots or thrombus, using hementin, a polypeptide derived from leech salivary glands. Hementin may be administered for this purpose in a pharmaceu... | 11/02/1999 |
| 5859197 | Neurogene Disclosed are DNA and amino acid sequences for a novel polypeptide termed Neuritin which is expressed primarily in selected regions of the brain.... | 01/12/1999 |
| 5777079 | Modified green fluorescent proteins Modifications in the sequence of Aequorea wild-type GFP provide products having markedly different excitation and emission spectra from corresponding products from wild-type GFP. In one class of modifications, the product derived from the modified GFP exh... | 07/07/1998 |
| 5776896 | Analgesic peptides from venom of grammostola spatulata and use thereof The present invention provides novel methods of treating pain comprising administering to a mammal in need of such treatment an effective analgesic amount of a peptide having the amino acid sequence of SEQ ID. NO.:1 or SEQ ID NO: 2. The invention further ... | 07/07/1998 |
| 5766941 | Recombinant DNA vectors capable of expressing apoaequorin A gene which codes for the protein apoaequorin is disclosed along with recombinant DNA vectors containing this gene. Homogeneous peptides having the bioluminescence properties of natural, mixed apoaeqorin are also disclosed.... | 06/16/1998 |
| 5710131 | Inhibitor of collagen-stimulated platelet aggregation A protein isolated from crude extracts of Hirudo medicinalis is disclosed, which strongly inhibits the binding to collagen of platelets and their subsequent activation, which leads to platelet aggregation and thrombus formation. Additionally the protein p... | 01/20/1998 |
| 5698104 | Purification process for hirudin using affinity chromatography Disclosed herein is a process for purifying hirudin from a solution containing hirudin and other substances, characterized in that the process comprises a step of subjecting the solution to a metal ion affinity chromatography wherein copper ion (Cu++... | 12/16/1997 |
| 5670622 | Conotoxin peptide PIIIA The invention is directed to a new μ-conotoxin named GIIIA. μ-Conotoxin PIIIA consists of 22 amino residues and is found in the Eastern Pacific fish-hunting species Conus purpurascens. This conotoxin is a new Na+ channel blocker and can be u... | 09/23/1997 |
| 5583111 | Thrombin inhibitors The invention relates to novel polypeptides with antithrombin activity obtainable from extracts of tissues or secretions of leeches of the order Rhynchobdellida, particularly of the species Theromyzon tessulatum. The polypetides have molecular weights of ... | 12/10/1996 |
| 5580856 | Formulation of a reconstituted protein, and method and kit for the production thereof Dried proteins are stabilized against loss of biological activity in formulations by adding an reconstitution stabilizer upon rehydration of the dried protein. A kit for producing and a formulation produced by dissolving the dried composition in a solvent... | 12/03/1996 |
| 5565198 | Zona pellucida as a growth stimulant Zona pellucida is useful for growth stimulation in animals and especially in female ruminants such as heifers. Immunization of heifers with Zona pellucida obtained from young pig ovaries leads to increased weight gains that are comparable to, or exceed th... | 10/15/1996 |
| 5523292 | Method of preventing restenosis following coronary angioplasty The present invention comprises a method of alleviating restenosis, post-PTCA or other coronary arterial intervention, and more particularly, to the use of ancrod to prevent restenosis in the coronary arteries.... | 06/04/1996 |
| 5482925 | Complexes of nitric oxide with cardiovascular amines as dual acting cardiovascular agents Novel complexes of nitric oxide (NO) and amines are described where the amine is a known cardiovascular agent having at least one or more primary or secondary amino groups and whereby the resulting complex is capable under physiological conditions of rele... | 01/09/1996 |
| 5403596 | Factor Xa inhibitor and pharmaceutical compositions containing same A novel anticoagulant/modulator factor isolated from the saliva of the meinal leech Hirudo medicinalis, specifically inhibiting bovine Xa factor but not inhibiting bovine thrombin.... | 04/04/1995 |
| 5393523 | Plasmodium falciparum vaccine comprising a recombinant histidine-rich protein-HRP-II Recombinant histidine-rich protein of Plasmodium falciparum, its preparation and use. It was possible, by screening two different Plasmodium falciparum cDNA gene banks with an antiserum against a 41 kD protein and by cross-hybridization with the insert DN... | 02/28/1995 |
| 5366728 | Stable forms of antigenic Taenia ovis polypeptides Stable forms of Taenia ovis peptide antigens, such as portions of a T. ovis oncosphere antigen which runs as a 47-52 kDa doublet, are suitable for use in vaccines to protect ruminants against infection by cestode parasites. The antigens are preferably obt... | 11/22/1994 |
| 5360728 | Modified apoaequorin having increased bioluminescent activity The present invention encompasses modified apoaequorin nucleotide and amino acid sequences capable of emitting light in the presence of luciferin and a light-triggering cation such as Ca2+, which possess bioluminescent activity greater than unm... | 11/01/1994 |
| 5324715 | Protein for inhibiting collagen-stimulated platelet aggregation A protein isolated from crude Haementeria officinalis extract which blocks stimulation of platelet aggregation by collagen. The protein has a molecular weight of approximately 16,000. A method of isolating the protein and using the protein to prevent or d... | 06/28/1994 |
| 5304310 | Method for concentrating and purifying hirudin from leeches A method for the concentration and purification of biomolecules is described and comprises introducing the biomolecule into an aqueous/organic solvent system and bringing about a phase separation by addition of salts, where the pH at which the concentrati... | 04/19/1994 |
| 5281693 | Isolation of spider toxins Methods and compositions for blocking Ca2+ channels within an organism are provided. For example, a toxin was isolated from the Agelenopsis aperta spider. The toxin comprised a 48 amino acid toxin having a molecular weight of approximately 5,27... | 01/25/1994 |
| 5246715 | Platelet-aggregating inhibitory agents from leech saliva and pharmaceutical preparations containing the same A composition of matter useful as an inhibitor of blood platelet aggregation, for the treatment of various clinical disorders such as thrombotic, inflammatory and immunological disorders. This composition of matter is derived from the saliva of leeches of... | 09/21/1993 |
| 5196316 | Enzyme and DNA coding therefor The invention concerns a peptidylhydroxyglycine N-C lyase (PHL) catalyzing the reaction R-GlyOH.fwdarw.R-NH2 wherein R represents a peptide residue, and GlyOH represents an -hydroxyglycine residue linked to the C-terminus of said peptide R ... | 03/23/1993 |
| 5194589 | Leech protein having anticoagulant and antimetastatic properties The present invention comprises a biochemically pure protein, termed antistasin, which exhibits both antimetastatic and anticoagulant properties. Methods of producing the protein and methods of using the protein to inhibit or reduce metastasis and/or coag... | 03/16/1993 |
| 5189019 | Antistasin derived anticoagulant protein A protein having a molecular weight of about 6,000 daltons which is biologically active in the inhibition of Factor Xa during the blood coagulation cascade, a method for producing the protein, methods for inhibiting blood coagulation using the protein, an... | 02/23/1993 |
