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| Number | Title | Issue Date |
| 7160676 | Method of determining sperm capacitation This invention describes unique patterns of distribution of ganglioside GM1 in non-capacitated sperm and demonstrates that the pattern of distribution of GM1 undergoes changes that can be correlated with the process of capacitation and/or with ... | 01/09/2007 |
| 6767711 | Treatment and diagnosis of prostate cancer The present invention is directed to the use of antibodies or binding portions thereof or probes which recognize an antigen of normal, benign, hyperplastic, and cancerous prostate epithelial cells or portions thereof. These antibodies or binding portions thereof or ... | 07/27/2004 |
| 6509316 | Pharmaceutical compositions, methods, and kits for treatment and diagnosis of lung cancer The present invention relates to pharmaceutical compositions, methods and kits that provide for the early diagnosis and treatment of lung cancer. More particularly, the present invention relates to pharmaceutical compositions containing uteroglobin for pr... | 01/21/2003 |
| 6469139 | Modified human chorionic gonadotropin (ଲ-hCG) proteins and their medical use The present invention relates to modified human chorionic gonadotropin (ଲ-hCG) proteins and their medical use as immunological contragestatives. The modification causes a reduction in the cross-reactivity of the modified ଲ-hCG protein with lut... | 10/22/2002 |
| 6369195 | Prostate-specific gene for diagnosis, prognosis and management of prostate cancer Disclosed are nucleic acid and amino acid sequences encoded by a novel, prostate specific gene (UC41) and diagnostic techniques for the detection of human prostate cancer utilizing such nucleic acid and amino acid sequences. Genetic probes and methods use... | 04/09/2002 |
| 6303123 | Methods for the treatment of hormone-dependent tumors with immunogens against gonadotropin releasing hormone Immunogenic compositions capable of generating an immune response in mammals against GnRH are disclosed. The immunogenic compositions are effective in methods of treating gonadotropin and gonadal steroid hormone dependent diseases and immunological contra... | 10/16/2001 |
| 6255281 | Use of recombinant human uteroglobin in treatment of inflammatory and fibrotic conditions Method for treatment of inflammatory and fibrotic conditions in vivo using pure rhUG is disclosed. Method for treating or preventing inflammatory or fibrotic conditions characterized by a deficiency of endogenous functional UG is also disclosed. Compositi... | 07/03/2001 |
| 6132720 | Immunogens against gonadotropin releasing hormone Immunogenic compositions capable of generating an immune response in mammals against GnRH are disclosed. The immunogenic compositions are effective in methods of treating gonadotropin and gonadal steroid hormone dependent diseases and immunological contra... | 10/17/2000 |
| 6103483 | Molecule involved in binding of sperm to egg surfaces and procedures for use of this molecule to enhance or decrease potential fertility A purified polypeptide which provides for initial binding of sperm to oocyte investments and has an active amino acid sequence of SEQ ID NO:12 (Cys-Gln-Ser-Leu-Gln-Glu-Tyr-Leu-Ala-Glu-Gln-Asn-Gln-Arg-Gln-Leu-Glu-Ser-A sn-Lys-Ile-Pro-Glu-Val-Asp-Leu-Ala-Arg... | 08/15/2000 |
| 6004586 | Molecule involved in binding of sperm to egg surfaces and procedures for use of this molecule to enhance or decrease potential fertility A purified polypeptide which provides for initial binding of sperm to oocyte investments and has an active amino acid sequence of SEQ ID NO:12 (Cys-Gln-Ser-Leu-Gln-Glu-Tyr-Leu-Ala-Glu-Gln-Asn-Gln-Arg-Gln-Leu-Glu-Ser-A sn-Lys-Ile-Pro-Glu-Val-Asp-Leu-Ala-Arg... | 12/21/1999 |
| 5972652 | Polynucleotides encoding secreted proteins Novel polynucleotides and the proteins encoded thereby are disclosed.... | 10/26/1999 |
| 5945302 | Polynucleotides encoding secreted proteins Novel polynucleotides and the proteins encoded thereby are disclosed.... | 08/31/1999 |
| 5932700 | Protein inhibiting the growth of human endometrial fibroblasts A novel cell growth-inhibiting protein is provided. The cell growth-inhibiting protein, obtainable from extract of human uterine endometrial carcinoma, has the amino acid sequence rich in hydrophobic residue at its N-terminal, has a molecular weight of ab... | 08/03/1999 |
| 5876730 | Heparin-binding growth factor (HBGF) polypeptides Substantially pure heparin-binding growth factor polypeptides (HBGFs), nucleic acids encoding the HBGFs and antibodies which bind to the HBGFs of the invention are provided. The HBGF polypeptides are useful in methods for the induction of bone, cartilage ... | 03/02/1999 |
| 5864011 | Cancer related antigen A method of determining the prognosis of a solid tumor is provided, in which a sample from a patient bearing a tumor is assayed for the presence of a protein which is immunologically cross-reactive with the hpr gene product, but not with haptoglobin 1 or ... | 01/26/1999 |
| 5849713 | Chemotactic factors for human spermatozoa and their use in human assisted fertilization The invention relates to chemotactic factors for human spermatozoa that are purifiable from human follicular fluid. The factors are of peptidic and hydrophilic nature and have, one, a molecular size of about 13 kDa and, the other, an apparent molecular si... | 12/15/1998 |
| 5831035 | Antibody against human endometrial stromal cell glycoprotein An antibody to the purified and isolated glycoprotein and functional analogs thereof characterized by being progesterone induced and estradiol inhibited secretory glycoprotein specifically from stromal cells of endometrial origin. The protein has the mole... | 11/03/1998 |
| 5820863 | Methods of preparation and use for zona pellucida antigens and antibodies for sterilization and contraception The invention relates to antigenic preparations useful for inducing the production of antibodies in an individual which will bind to epitopes on zona pellucida. Also disclosed are immunogenic compositions and methods for immunizing an individual to enable... | 10/13/1998 |
| 5708157 | Secreted proteins and polynucleotides encoding them Novel polynucleotides and the proteins encoded thereby are disclosed.... | 01/13/1998 |
| 5691455 | Gonadotropins with non-native disulfide bridges The present invention relates to gonadotropins consisting of an and ଲ subunit, said gonadotropins comprising non-native disulfide bridges, preferably non-native intersubunit disulfide bridges. The gonadotropins according to the invention hav... | 11/25/1997 |
| 5688506 | Immunogens against gonadotropin releasing hormone Immunogenic compositions capable of generating an immune response in mammals against GnRH are disclosed. The immunogenic compositions are effective in methods of treating gonadotropin and gonadal steroid hormone dependent diseases and immunological contra... | 11/18/1997 |
| 5559097 | Use of a pregnancy specific protein as an immunosuppressive Methods and compositions are provided for maintaining pregnancy and preventing rejection of transplanted tissue. A polypeptide characterized as capable of isolation from conceptus tissue and capable of inhibiting mitogen induced lymphocyte blastogenesis i... | 09/24/1996 |
| 5554595 | Selective regulation of B lymphocyte precursors by hormones Based on the discovery that normal pregnant mice have a striking reduction in committed precursors of B lymphocytes, which could be documented in mice as early as day 6 of gestation, when IL-7 responding colony forming cells were reduced as much as two-th... | 09/10/1996 |
| 5549904 | Biological adhesive composition and method of promoting adhesion between tissue surfaces A formulated biological adhesive composition utilizes tissue transglutaminase in a pharmaceutically acceptable aqueous carrier. The tissue transglutaminase is used in an effective catalytic amount to promote adhesion between tissue surfaces upon treatment... | 08/27/1996 |
| 5516754 | Method for the selective dissolution of cancer cells using a composition derived from the photosynthetic system of plants and mammalian embryonic tissue By the combined use of an agent which selectively dissolves tumor cells and which contains a protein fraction which has oxygen-liberating action and which is derived from the photosynthetic system of plants, together with a further agent which inhibits th... | 05/14/1996 |
| 5494899 | Selective regulation of B lymphocyte precursors by hormones It has been determined that estrogen and other hormones elevated in pregnancy induce a specific modulation of lymphocyte precursor cell production. The immune system of an animal or bone marrow cells in culture can therefore be modulated in a specific man... | 02/27/1996 |
| 5470826 | Single chain proteins with FHS suppressing activity isolated from follicular fluid and uses thereof Polypeptides exhibiting an inhibitory action over follitropin are disclosed. These polypeptides are designated follitropin suppressing proteins, or "FSP's," and range in size from 30 to 60 kD as determined by SDS-PAGE. Uses for FSP's, including regulation... | 11/28/1995 |
| 5449757 | Mammalian adipogenic factors Mammalian adipogenic factors, including purified proteins or glycoproteins, capable of inducing the adipose differentiation of adipogenic cells are disclosed, as are antibodies to such proteins, DNA encoding the proteins and host cells expressing the prot... | 09/12/1995 |
| 5384132 | Stabilized gonadotropin containing preparations Disclosed are lyophilized gonadotropin containing preparations containing a dicarboxylic acid salt stabilizer. The particular proteins (e.g. LH, TSH, FSH, or HCG) are in admixture with, and at least partially capable of stabilization by, the particular st... | 01/24/1995 |
| 5270057 | Stabilized gonadotropin containing preparations Disclosed are lyophilized gonadotropin containing preparations containing a dicarboxylic acid salt stabilizer. The particular proteins (e.g. LH, TSH, FSH, or HCG) are in admixture with, and at least partially capable of stabilization by, the particular st... | 12/14/1993 |
| 5211952 | Contraceptive methods and formulations for use therein Contraceptive devices which are effective for extended periods of time are described, in the form of means for releasing an effective amount of a gonadotropin hormone releasing hormone composition and means for releasing an effective amount of an estrogen... | 05/18/1993 |
| 5140100 | Protein that inhibits production of human choriogonadotropin A substance having an inhibitory effect on the production of human choriogonadotropin (hCG) is described, which comprises a protein isolated from human decidual cells with a molecular weight of about 7,000 to about 10,000 daltons, and useful for use in in... | 08/18/1992 |
| 5102807 | Inhibin isolated from ovarian follicular fluid A protein which satisfies all the biological criteria which are characteristic of inhibin has been isolated from a gonadal source. The purification and characterization of inhibin and the use of the purified material to raise antibodies, the use of inhibi... | 04/07/1992 |
| 4996297 | Recombinantly expressed rabbit zona pellucida polypeptides The invention relates to antigenic preparations useful for inducing the production of antibodies in an individual which will bind to epitopes on zona pellucida. Also disclosed are immunogenic compositions and methods for immunizing an individual to enable... | 02/26/1991 |
| 4973578 | Synthetic peptides derived from the alpha-subunit of human lycoprotein hormones Synthetic peptides corresponding to -subunit of human glycoprotein hormone amino acid regions -45, -35, -46 and -92; were found to inhibit binding of 125I-bTSH to human thyroid. Peptides corresponding ... | 11/27/1990 |
| 4919889 | Sample collection and transport fluid composition Sensitive proteins in human biological secretion samples are preserved by dispersing them in an aqueous solution containing from 0.05 to 0.5M of a buffer which is effective to maintain the solution pH within the range of from 6.5 to 8.0; from 0.1 to 10 wt... | 04/24/1990 |
| 4882270 | Monoclonal antibodies to placental isoferritin for use in detecting oncofetal ferritin associated with breast cancer and Hodgkins disease There are provided monoclonal antibodies which react with human oncofetal ferritin and which do not react with human spleen ferritin or with liver ferritin; there are also provided monoclonal antibodies which react both with human placenta oncofetal ferri... | 11/21/1989 |
| 4882421 | Pharmaceutical for treating tumors and method for making it Rana pipiens eggs are subjected to fertilization and the embryos are grown to a predetermined stage of development. The embryos and unfertilized eggs are then subjected to mechanical processing in the presence of a weakly acidic buffer to produce an extra... | 11/21/1989 |
| 4755460 | Bovine antigen glycoprotein, related antibody, and use in detection of pregnancy in cattle A bovine pregnancy antigen, determined to be a glycoprotein, has been isolated and purified. If is diagnostic for the presence of pregnancy in cattle when detected by the use of antibodies to the antigen.... | 07/05/1988 |
| 4510131 | Purified Mullerian Inhibiting Substance and method of use A process for purifying Mullerian Inhibiting Substance (MIS) from testicular tissue which comprises incubating testicular tissue in a culture media in the presence of a protease inhibitor in order to extract MIS from the tissue, chromatographing the extra... | 04/09/1985 |
