Did You Know...
...that one person who claimed to be the inventor of the television is Russian emigre Vladimir Zworykin? In 1929 David Sarnoff, founder of RCA, asked Zworykin what it would take to develop TV for commercial use. He said: a year and a half and $100,000. In reality, it took 20 years and $50 million! Before his death in 1982 at the age of 92, Zworykin said of his invention: "The technique is wonderful. It is beyond my expectations. But the programs! I would never let my children even come close to this thing."
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| Number | Title | Issue Date |
| 7847072 | Rapid isolation of osteoinductive protein mixtures from mammalian bone tissue A method for purifying bone-derived osteogenic proteins including a demineralization process, a protein extraction process, a high molecular weight ultrafiltration process, a low molecular weight ultrafiltration process, and a recovery process. The high and low ultr... | 12/07/2010 |
| 7622562 | Rapid isolation of osteoinductive protein mixtures from mammalian bone tissue A method for purifying bone-derived osteoinductive proteins including a demineralization process, a protein extraction process, a high molecular weight ultrafiltration process, a low molecular weight ultrafiltration process, and a recovery process. The high and low ... | 11/24/2009 |
| 7410770 | Method for monitoring collagen type II degradation in cartilage A method for improving the diagnostic assessment of cartilage degenerative processes, and to provide means of monitoring the effects of therapeutical measures taken towards arthritic diseases in most mammals utilizes an immunoassay to detect fragments of collagen ty... | 08/12/2008 |
| 7393649 | Detection of specific nitrated markers Methods are described for improving the diagnostic possibilities of diseases where oxidative NO-modifications occur, for example inflammatory conditions, cancer, Parkinson's or Alzheimer's disease, and to provide means of monitoring the effects of therapeutical meas... | 07/01/2008 |
| 7354723 | Assay of isomerised and/or optically inverted proteins and protein fragments Disclosed are compositions and methods for performing an immuno-assay that includes measuring the amount of an isomerised or optically inverted non-collagen protein derived from cartilage. ... | 04/08/2008 |
| 7258999 | PTH responsive gene This invention relates to a novel PTH gene. The invention further relates to methods of screening, diagnosis and development of therapies for bone related disorders. ... | 08/21/2007 |
| 7241874 | Rapid isolation of osteoinductive protein mixtures from mammalian bone tissue A method for purifying bone-derived osteogenic proteins including a demineralization process, a protein extraction process, a high molecular weight ultrafiltration process, a low molecular weight ultrafiltration process, and a recovery process. The high and low ultr... | 07/10/2007 |
| 7208469 | Therapeutic method We claim a method of treating a patient to stimulate chondrocyte proliferation comprising administering to said patient an adrenomedullin analog that is adrenomedullin-(27–52) wherein said patient is suffering from cartilage disorders, and a method of stimulating ... | 04/24/2007 |
| 7186811 | Osteogenic device and a method for preparing the device The present invention is related to an osteogenic device and its preparation. Said device comprises a bone morphogenetic protein (BMP), preferably a modified BMP complex obtainable by a modification of the conventional guanidum hydrochloride extraction method and co... | 03/06/2007 |
| 7081240 | Protein mixtures for wound healing A protein mixture that is useful in the treatment of wounds, where the mixture is isolated from bone or is produced from recombinant proteins and may include two or more of BMP-2, BMP-3, BMP-4, BMP-5, BMP-6, BMP-7, TGF-β1, TGF-β2, TGF-β3, and FGF-1. ... | 07/25/2006 |
| 6841644 | Biopolymers obtained by solid state irradiation in an unsaturated gaseous atmosphere Disclosed are modified naturally occurring biocompatible biopolymers of plant and animal origin made by subjecting same to ionizing radiation in the presence of a mediating gas, typically acetylene to enable one to selectively enhance and modify one or more of the p... | 01/11/2005 |
| 6746865 | Nucleic acids encoding for endostatin protein Nucleic acid sequences encoding for endostatin protein. Ribonucleic and deoxyribonucleic acid sequences that encode for endostatin protein are useful for gene therapy or recombinant expression for the treatment of angiogenesis-related diseases, specifically angiogen... | 06/08/2004 |
| 6645485 | Method of treating inflammation in the joints of a body A process for treating inflammation in a joint whether heat, redness, pain, swelling and/or stiffness, and for increasing motion and increasing joint space and correcting malalignment, comprising the steps of dissolving a quantity of growth hormone (somat... | 11/11/2003 |
| 6589590 | Composite material and methods of making the same A method of making artificial bone comprises providing a membrane of collagen with solutions of calcium ions and of phosphate ions on opposite sides of the membrane. The calcium ions and phosphate ions diffuse through the membrane and precipitate as a hyd... | 07/08/2003 |
| 6511958 | Compositions for regeneration and repair of cartilage lesions Disclosed is a cartilage repair product that induces both cell ingrowth into a bioresorbable material and cell differentiation into cartilage tissue. Such a product is useful for regenerating and/or repairing both vascular and avascular cartilage lesions,... | 01/28/2003 |
| 6461630 | Terminally sterilized osteogenic devices and preparation thereof Disclosed are terminally sterilized osteogenic devices for implantation into a mammal. The devices contain a combination of a biologically active osteogenic protein and an insoluble carrier which after being combined are sterilized by exposure to ionizing... | 10/08/2002 |
| 6368787 | Methods and compositions for identifying morphogenic protein analogs using morphogenic protein responsive inhibitory elements The present invention relates generally to methods and compositions for identifying morphogenic protein analogs. In one embodiment, this invention relates to an osteogenic protein reponsive transcription inhibitory element. This invention also relates to ... | 04/09/2002 |
| 6287816 | BMP-9 compositions Purified bone morphogenetic protein-9 (BMP-9) proteins and processes for producing them are disclosed. The proteins may be used in the treatment of bone and cartilage defects and in wound healing and related tissue repair.... | 09/11/2001 |
| 6261586 | Bone graft composites and spacers A bone graft substitute including a composition of natural selectively deactivated bone material which has been processed to remove associated non-collagenous bone proteins, said bone material containing native collagen materials and naturally associated ... | 07/17/2001 |
| 6180606 | Compositions with enhanced osteogenic potential, methods for making the same and uses thereof Osteogenic compositions, and methods for preparing same, which compositions comprise a porous or semi-porous matrix, an osteogenic factor and an agent such as growth factors, nutrient factors, drugs, calcium-containing compounds, blood products, large mol... | 01/30/2001 |
| 6180605 | Composition with enhanced osteogenic potential, method for making the same and therapeutic uses thereof The present invention provides improved osteogenic compositions having enhanced by the sorption of growth factors, of nutrient factors, or drugs onto or into the compositions. Compositions may consist of collagen and demineralized bone materials onto and ... | 01/30/2001 |
| 6117979 | Process for making a bioprosthetic device and implants produced therefrom Bioprosthetic devices made of collagen-based material having collagen amine groups and collagen carboxyl groups are provided as well as methods for their formation. The methods comprise combining an epoxy functionalized crosslinking agent with the collage... | 09/12/2000 |
| 6034061 | BMP-9 compositions Purified Bone Morphogenetic Protein (BMP)-9 proteins and processes for producing them are disclosed. The proteins may be used in the treatment of bone and cartilage defects and in wound healing and related tissue repair, and in hepatic growth and function... | 03/07/2000 |
| 5972368 | Bone graft composites and spacers A bone graft substitute including a composition of natural selectively deactivated bone material which has been processed to remove associated non-collagenous bone proteins, said bone material containing native collagen materials and naturally associated ... | 10/26/1999 |
| 5948766 | Use of tasteless, hydrolyzed collagen and agent containing the same Tasteless, hydrolyzed collagen from gelatin, gelatin or animal collagenic connective tissue having an average molecular weight of from 1 to 40 kD for the preparation of agents for the treatment of osteoporosis. It may be combined with conventional agents ... | 09/07/1999 |
| 5936035 | Biocompatible adhesive compositions Collagen-based compositions useful in the attachment of tissues, or the attachment of tissues to synthetic implant materials, are disclosed. The compositions comprise collagen crosslinked using a multifunctionally activated synthetic hydrophilic polymer. ... | 08/10/1999 |
| 5849880 | Bone morphogenetic protein (BMP)--6 Purified bone morphogenetic protein (BMP)-6 proteins and processes for producing them are disclosed. The proteins may be used in the treatment of bone and/or cartilage defects and in wound healing and related tissue repair.... | 12/15/1998 |
| 5741895 | Identification of cell density signal molecule Disclosed herein is a novel proteinaceous cell density signal molecule (CDS) between 25 and 35 kD, which is secreted by fibroblastic primary avian tendon cells in culture, and causes the cells to self-regulate their proliferation and the expression of dif... | 04/21/1998 |
| 5714589 | Method of selectively extracting osteogenic protein Disclosed are (1) osteogenic devices comprising a matrix containing substantially pure natural-sourced mammalian osteogenic protein; (2) DNA and amino acid sequences for novel polypeptide chains useful as subunits of dimeric osteogenic proteins; (3) vecto... | 02/03/1998 |
| 5707962 | Compositions with enhanced osteogenic potential, method for making the same and therapeutic uses thereof The present invention provides improved osteogenic compositions having enhanced by the sorption of growth factors, of nutrient factors, or drugs onto or into the compositions. Compositions may consist of collagen and demineralized bone materials onto and ... | 01/13/1998 |
| 5693615 | Therapeutic compositions for osteoinduction A method for generating new bone growth in a mammal comprising administrating to the mammal a safe and effective amount of a Vitamin D compound in combination with a safe and effective amount of osteoinductive extract or at least one BMP.... | 12/02/1997 |
| 5656598 | Use of fibroblast growth factors to stimulate bone growth The present invention provides therapeutic compositions for the prevention and treatment of pathological conditions involving bone and dental tissue. The present invention also provides a method to promote bone repair and/or growth for the treatment of pa... | 08/12/1997 |
| 5637466 | Method of detecting bone acidic glycoprotein-75 and its 50,000 MW fragment and antibodies therefor A method of detecting bone acidic glycoprotein-75 (BAG-75) antigen includes the steps incubating a serum or synovial fluid sample with anti-BAG antibody, reacting the incubated sample with a signal generating antibody to the anti-BAG-75 antibody, and dete... | 06/10/1997 |
| 5629009 | Delivery system for controlled release of bioactive factors A composition and method for controlled release of water-soluble proteins comprising a surface-eroding polymer matrix and water-soluble bioactive factors is described. The composition bioerodes in the biological environment of the subject at a controlled ... | 05/13/1997 |
| 5614496 | Use of fibroblast growth factors to stimulate bone growth The present invention provides therapeutic compositions for the prevention and treatment of pathological conditions involving bone and dental tissue. The present invention also provides a method to promote bone repair and/or growth for the treatment of pa... | 03/25/1997 |
| 5607920 | Concanavalin a binding proteins and a 76kD chondrocyte membrane protein (CMP) from chondrocytes and methods for obtaining same The invention is directed to purified and isolated concanavalin A-binding proteins from chondrocytes that are not present in dedifferentiated cells from chondrocytes. The invention is also directed to a purified and isolated chondrocyte membrane protein, ... | 03/04/1997 |
| 5567806 | Collagen crosslinked with a crosslinking agent for the manufacture of a suturable, biocompatible slowresorbing membrane, and such a membrane Suturable, biocompatible, control-resorbing membranes are disclosed for use in guided tissue regeneration, comprising a cross-linked collagen material either obtained by crosslinking a starting collagen material in the coagulated state produced by coagula... | 10/22/1996 |
| 5549904 | Biological adhesive composition and method of promoting adhesion between tissue surfaces A formulated biological adhesive composition utilizes tissue transglutaminase in a pharmaceutically acceptable aqueous carrier. The tissue transglutaminase is used in an effective catalytic amount to promote adhesion between tissue surfaces upon treatment... | 08/27/1996 |
| 5545409 | Delivery system for controlled release of bioactive factors A composition and method for controlled release of water-soluble proteins comprising a surface-eroding polymer matrix and water-soluble bioactive factors is described. The composition bioerodes in the biological environment of the subject at a controlled ... | 08/13/1996 |
| 5508267 | Bioactive material A self-supporting composite bioactive material and method of making it, which comprises immersing a body of collagen in a solution comprising a calcium phosphate and a phosphoprotein (preferably containing o-phosphoserine residues) to deposit on the colla... | 04/16/1996 |
