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| Number | Title | Issue Date |
| 6455678 | Human hematopoietic stem and progenitor cell antigen A hematopoietic progenitor cell antigen and reagents, notably antibodies, that specifically bind to the antigen are provided. Expression of the antigen is highly tissue specific. It is only detected on a subset of hematopoietic progenitor cells derived fr... | 09/24/2002 |
| 6020466 | Myeloid cell leukemia associated gene mcl-1 A gene, mcl-1, of the bcl-2 family is disclosed along with its nucleotide and amino acid sequence. Also disclosed are diagnostic and therapeutic methods of utilizing the mcl-1 nucleotide and polypeptide sequences.... | 02/01/2000 |
| 5883227 | Multiple sclerosis associated polypeptide The present invention relates to the diagnosis of multiple sclerosis. More specifically, this invention relates to an assay for detecting antigen(s) associated with multiple sclerosis. The present invention also relates to the generation of hybridomas whi... | 03/16/1999 |
| 5863540 | Adhesion molecule The present invention relates, in general, to a method of treating inflammation or inhibiting cancer cell metastasis. In particular, the present invention relates to a method of suppressing T cell activation, inhibiting CD44-mediated cell adhesion and CD4... | 01/26/1999 |
| 5714462 | Antiviral agent comprising CD4 and H2 histone The invention provides an agent against HIV and/or related viruses, comprising CD4 or a CD4-like substance and an H2 histone or an H2 histone-like protein. The content of the CD4 or CD4-like substance is preferably less than the antivirally effective dose... | 02/03/1998 |
| 5518914 | Growth medium containing a complex of prealbumin, a retinoid and retinol-binding protein used to enhance B cell growth This invention provides a complex consisting essentially of prealbumin, retinol-binding protein, and a retinoid which binds to retinol-binding protein, wherein the concentration of retinoid in the complex is from about 2×10-5 M to about 10 | 05/21/1996 |
| 5476839 | Basophil granule proteins Several natural polypeptides (basophil granule proteins, "BGP") derived from the cytoplasmic granules of human basophils, and modified forms thereof, are described. These polypeptides, the DNA which encodes them and antibodies which recognize them, are us... | 12/19/1995 |
| 5284656 | Pulmonary administration of granulocyte colony stimulating factor Granulocyte-colony stimulating factor (G-CSF) can be delivered systemically in therapeutically or prophylactically effective amounts by pulmonary administration using a variety of pulmonary delivery devices, including nebulizers, metered dose inhalers and... | 02/08/1994 |
| 5264418 | Hemolymphopoietic growth factors, process for purifying and producing hemolymphopoietic growth factors and pharmaceutical compositions made therefrom This invention relates to hemolymphopoeitic growth factors (HLGF-1) that synergize with CSF-1, IL3 and GM-CSF and have pre-B cell potentiating activity. The invention also relates to a process for purifying such HLGF-1's from murine marrow cells and for p... | 11/23/1993 |
| 5226914 | Method for treating connective tissue disorders The present invention is directed to various processes and devices for utilizing isolated and culturally expanded marrow-derived mesenchymal cells (i.e. mesenchymal stem cells) for treating skeletal and other connective tissue disorders.... | 07/13/1993 |
| 5197985 | Method for enhancing the implantation and differentiation of marrow-derived mesenchymal cells The present invention is directed to a method and device for enhancing the implantation and differentiation of marrow-derived mesenchymal cells (i.e. mesenchymal stem cells). The method and device of the invention are an effective means for treating skele... | 03/30/1993 |
| 5149544 | Method of inhibiting progenitor cell proliferation The invention comprises a factor having the following characteristics: a) It inhibits granulocyte-macrophage colony and cluster formation; b) It has a molecular weight of about 8 kDa as determined by SDS-PAGE; c) It has a weak anionic charge at pH 7.4 as shown by anion ... | 09/22/1992 |
| 5130297 | Conjugates useful in ameliorating autoimmunity MHC-II-peptide The invention is directed to methods and materials useful in treating autoimmune diseases. The therapeutic agents are of the formula X--MHC--peptide or MHC--peptide--X wherein X represents a functional moiety selected from a toxin and a labeling group; MH... | 07/14/1992 |
| 5026826 | Human neutrophilic granulocyte end-stage maturation factor and its preparation and use A purified inhibitor free human neutrophilic granulocyte end-stage maturation factor (GMF) inhibitor-free human neutrophilic granulocyte end-stage maturation factor is disclosed. The GMF is distinct from granulocyte colony stimulating factor (G-CSF) in bo... | 06/25/1991 |
| 4904259 | Compositions and methods for repair of cartilage and bone A defect is provided in cartilage or bone, or both, to excise damaged or pathological tissue, and it is filled with an implant having capability for complete regeneration of the skeletal tissue as a chondrogenic or osteogenic phenotype. The implant compri... | 02/27/1990 |
| 4882270 | Monoclonal antibodies to placental isoferritin for use in detecting oncofetal ferritin associated with breast cancer and Hodgkins disease There are provided monoclonal antibodies which react with human oncofetal ferritin and which do not react with human spleen ferritin or with liver ferritin; there are also provided monoclonal antibodies which react both with human placenta oncofetal ferri... | 11/21/1989 |
| 4822776 | Lipoprotein lipase suppression by endotoxin-induced mediator (shock assay) A mediator substance exhibiting inhibitory effect upon anabolic enzyme activity in mammals, is prepared by a method comprising gathering a sample of macrophage cells from a mammal, incubating a portion of the macrophage cells with a stimulating mate This ... | 04/18/1989 |
| 4701442 | Treatment of symptoms of neoplastic diseases with nucleoproteins A process for preparing nucleoproteic material which comprises immersing organic material into a suitable solvent for a sufficient time to extract nucleoproteins from said material, adding a sufficient amount of an acid to form a precipitate of nucleoprot... | 10/20/1987 |
| 4545986 | Timothy grass antigen specific anti-idiotypic antibodies This invention provides a number of immunological reagents useful for the suppression of allergic reactions induced by Timothy-grass pollen allergen (or cross-reacting allergens thereof) and for methods of obtaining said reagents. The reagents include: (1... | 10/08/1985 |
| 4507229 | Tissue protein PP4, a process for isolating it and its use The protein PP4 which has (a) an electrophoretic mobility in the range between that of 댑 and 댒 globulins; (b) an isoelectric point of 4.85&#b1;0.15; (c) a sedimentation coefficient s20,w0 of 3.3&#... | 03/26/1985 |
| 4500450 | Polypeptide having an action on the immunological system, process for its isolation and purification, its use, agents containing this compound, and its cleavage products, their use and agents containing these products The invention relates to a polypeptide which can be isolated from thymus glands and has an action on the immunological system, and which has a molecular weight of 3,480, a UV absorption with a maximum at 205 to 210 nm and an isoelectric point of 3.95+0.15... | 02/19/1985 |
| 4478823 | Immunological preparations containing purified MHC antigens bonded to other antigens An immunologically active preparation for human or veterinary use comprises an antigenic material in combination with an MHC antigen.... | 10/23/1984 |
| 4438032 | Unique T-lymphocyte line and products derived therefrom Human T-lymphoblast cell line, Proteinaceous products produced therefrom, messenger RNA and DNA expressing the proteinaceous products. A human T-lymphoblast cell line (Mo) maintained as a continuous culture constitutively produces proteins, including immu... | 03/20/1984 |
| 4402872 | Protein and process for isolating it What are disclosed are an isolated tissue protein, denominated PP16, which can be used to prepare anti-sera useful as diagnostic agents, said protein being found in extracts of some human organs such as the placenta, spleen, stomach, and lung and being ca... | 09/06/1983 |
| 4384991 | Process for the preparation of a biologically active substance for selective inhibition of the proliferation of leukemic and normal myeloid cells The invention relates to a process for the preparation of a biologically active substance, which can be isolated from normal white blood cells and is capable of inhibiting the proliferation of normal and leukemic myeloid cells selectively. The substance o... | 05/24/1983 |
| 4382887 | Novel glycopeptide and methods of isolating and using the same A novel glycopeptide is disclosed, which consists of a sugar moiety having a structural formula ##STR1## and a peptide moiety linking to the sugar moiety through N-glycoside bond. The glycopeptide is isolated from organs of normal animals, especially... | 05/10/1983 |
| 4343736 | Process for recovering interferon A process for recovering interferon which comprises contacting a solution containing an interferon produced by the induced cells of human origin with a water-insolubilized sulfated polysaccharide to allow the interferon to be adsorbed on the water-insolub... | 08/10/1982 |
| 4314935 | Process for recovering interferon A process for recovering interferon which comprises contacting a solution containing an interferon produced by the induced cells of human origin with a water-insolubilized sulfated polysaccharide to allow the interferon to be adsorbed on the water-insolub... | 02/09/1982 |
| 4301064 | Ubiquitary tissue protein PP8 A new soluble tissue protein (PP8) and a process for isolating it from human organs is described. The protein has antigenic properties. In the case of diseases which involve tissue disintegration its presence in the blood in increased concentra... | 11/17/1981 |
| 4195017 | Malignin, derived from brain tumor cells, complexes and polypeptides thereof A product, Malignin, derived from brain tumor cells, which cells may be cultured in a suitable nutrient medium for many generations, and the method of preparing same. Malignin may be complexed with an inert carrier, such as bromoacetylcellulose, and emplo... | 03/25/1980 |
