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| Number | Title | Issue Date |
| 6733791 | Sublingual compositions comprising thymosin fraction 5 and methods for administration thereof Methods and compositions are described which allow for the sublingual absorption of peptides by oral administration. A liquid and a tablet format for the sublingual approach are demonstrated. The peptides are stable at room temperature and in the compositions herein... | 05/11/2004 |
| 5883227 | Multiple sclerosis associated polypeptide The present invention relates to the diagnosis of multiple sclerosis. More specifically, this invention relates to an assay for detecting antigen(s) associated with multiple sclerosis. The present invention also relates to the generation of hybridomas whi... | 03/16/1999 |
| 5863540 | Adhesion molecule The present invention relates, in general, to a method of treating inflammation or inhibiting cancer cell metastasis. In particular, the present invention relates to a method of suppressing T cell activation, inhibiting CD44-mediated cell adhesion and CD4... | 01/26/1999 |
| 5856448 | Antibodies specifically reactive with thrombin receptor and its components The DNA encoding the cell surface receptor for thrombin has been cloned and sequenced. The availability of this DNA permits the recombinant production of thrombin receptor which can be produced at cell surfaces and is useful in assay systems both for the ... | 01/05/1999 |
| 5714462 | Antiviral agent comprising CD4 and H2 histone The invention provides an agent against HIV and/or related viruses, comprising CD4 or a CD4-like substance and an H2 histone or an H2 histone-like protein. The content of the CD4 or CD4-like substance is preferably less than the antivirally effective dose... | 02/03/1998 |
| 5643550 | Method of treating colorectal carcinoma lesion and composition for use therein This invention provides a method of imaging a colorectal carcinoma lesion in a human patient which comprises administering to the patient a monoclonal antibody capable of binding to a cell surface antigen associated with the colorectal carcinoma lesion an... | 07/01/1997 |
| 5641860 | Cell surface protein JL-1 expressed on human cortical thymocyte and its use A novel isolated protein which is glycoprotein with 120,000 molecular weight and is expressed on T lymphoblastic lymphoma and leukemia cells, is useful in the diagnosis of T lymphoblastic lymphoma and leukemia.... | 06/24/1997 |
| 5518914 | Growth medium containing a complex of prealbumin, a retinoid and retinol-binding protein used to enhance B cell growth This invention provides a complex consisting essentially of prealbumin, retinol-binding protein, and a retinoid which binds to retinol-binding protein, wherein the concentration of retinoid in the complex is from about 2×10-5 M to about 10 | 05/21/1996 |
| 5476839 | Basophil granule proteins Several natural polypeptides (basophil granule proteins, "BGP") derived from the cytoplasmic granules of human basophils, and modified forms thereof, are described. These polypeptides, the DNA which encodes them and antibodies which recognize them, are us... | 12/19/1995 |
| 5354845 | FK-506 and rapamycin specific binding immunophilin A new homogeneous cytosolic binding protein (FKBP-14.6 immunophilin) having a molecular weight of about 14.6 kDa (calculated from its amino acid composition), reversibly binds the immunosuppressive drugs FK-506, rapamycin or chemically related compounds, ... | 10/11/1994 |
| 5304635 | Antigen specifically expressed on the surface of B cells and Hodgkin's cells The invention relates to a new antigen termed BLA-35 specifically expressed on the surface of Hodgkin's cells, Reed-Sternberg cells and B lymphocytes, and to a new monoclonal antibody (anti-BLA-36) specific thereto. The antigen is characterized by the fol... | 04/19/1994 |
| 5281700 | Method of recovering endothelial membrane from tissue and applications thereof A process is disclosed which makes possible the isolation of the luminal endothelial cell membrane from associated tissue. It is particularly applicable to vasculature, but broadly is applicable to all tissue cavities which are accessible from adjacent pe... | 01/25/1994 |
| 5132401 | MB-35 a peptide enhancing the production of growth hormone and prolactin from the anterior pituitary A peptide of the formula ##STR1## has been isolated from thymosin fraction 5 (TF-5) and synthetically produced. This peptide, which has 100% homology with a region of histone 2A is able to stimulate and enhance the production of growth hormone (GH) ... | 07/21/1992 |
| 5070076 | Thymus-gland preparation and method for producing same A thymus-gland preparation is provided which contains polypeptides with a molecular weight of 600-6,000 Dalton and has the following composition, in percent by weight: ______________________________________ polypeptides with an isoelectric point ... | 12/03/1991 |
| 5034513 | Avian interleukin-2 A substantially pure species of avian Interleukin-2 has a molecular weight of about 30 kda. as determined by SDS-polyacrylamide gel electrophoresis. The compound is obtained from avian lymphocytes. It is produced by collecting lymphocytes from an avian do... | 07/23/1991 |
| 4994556 | Novel lymphokine and its production and uses A novel lymphokine and its production and uses are disclosed. The lymphokine is a glycoprotein with a molecular weight of 15,000&#b1;2,000 daltons; isoelectric point pI, 4.5&#b1;0.5; electrophoretic mobility Rf, 0.73&#b1;0.05; cytotoxic on L 929 cell; and... | 02/19/1991 |
| 4988676 | Cellular proliferation T cell suppressor factor New human T cell suppressor factors have been identified which suppress mitogen, antigen or alloantigen driven cellular proliferation of human peripheral blood leukocytes, as well as antibody synthesis and secretion and growth of human tumor cell lines. S... | 01/29/1991 |
| 4904643 | Thymus derivative active after oral administration, methods of preparation and pharmaceutical compositions Thymolymphotropin, a thymus derivative able to stimulate the differentiation and the function of T-lymphycytes, is active after oral administration and can be prepared through a process of partial acid lysis of mammal thymuses. Pharmaceutical compositions... | 02/27/1990 |
| 4902782 | Isolation of fibroblast growth factor Basic Fibroblast Growth Factor (FGF) is substantially purified by the employment of affinity chromatography using heparin-linked support material. Described is a simplified three step procedure for extracting basic FGF from either mammalian brain or mamma... | 02/20/1990 |
| 4843004 | Method for the production of human T-T cell hybrids and production suppressor factor by human T-T cell hybrids A new method is described for fusing and selecting human-human hybrid cells. The selection process begins after longer incubation times in culture medium and involves selection without using HAT or any other drug regimen. Certain T-T cell hybrids produced... | 06/27/1989 |
| 4814434 | Inducer of T-suppressor cells A biologically active composition extracted from thymus tissue, capable of inducing immature bone marrow cells to differentiate into competent suppressor T-cells.... | 03/21/1989 |
| 4701442 | Treatment of symptoms of neoplastic diseases with nucleoproteins A process for preparing nucleoproteic material which comprises immersing organic material into a suitable solvent for a sufficient time to extract nucleoproteins from said material, adding a sufficient amount of an acid to form a precipitate of nucleoprot... | 10/20/1987 |
| 4619895 | Lipoprotein marker for hypertriglyceridemia Methods and compositions are provided for the detection of a particular low density lipoprotein which has been found to be a marker for patients suffering from type IV hypertriglyceridemia. A monoclonal antibody capable of specifically binding to a charac... | 10/28/1986 |
| 4614731 | Peptide having immunopotentiating activity similar to thymosin alpha1 A new biologically active polypeptide hormone has been isolated from calf thymosin fraction 5 and has been given the designation thymosin alpha11. The peptide contains seven additional amino acid residues at the carboxy terminus when compared t... | 09/30/1986 |
| 4571336 | Immune stimulation Immunostimulatory peptide is isolated from bovine thymus tissue and is useful to treat mammals and birds at risk from viral or fungal infections or other trauma.... | 02/18/1986 |
| 4500450 | Polypeptide having an action on the immunological system, process for its isolation and purification, its use, agents containing this compound, and its cleavage products, their use and agents containing these products The invention relates to a polypeptide which can be isolated from thymus glands and has an action on the immunological system, and which has a molecular weight of 3,480, a UV absorption with a maximum at 205 to 210 nm and an isoelectric point of 3.95+0.15... | 02/19/1985 |
| 4485038 | Method for the production and purification of human leukocyte interferon A process for the production and purification of human interferon derived from leukocyte of lymphoblastoid cell origin characterized by a sequence of steps involving chromatography of a solution of crude interferon on porous glass, utilizing three new cla... | 11/27/1984 |
| 4438032 | Unique T-lymphocyte line and products derived therefrom Human T-lymphoblast cell line, Proteinaceous products produced therefrom, messenger RNA and DNA expressing the proteinaceous products. A human T-lymphoblast cell line (Mo) maintained as a continuous culture constitutively produces proteins, including immu... | 03/20/1984 |
| 4396605 | Bis-thymosine -1 compounds Bis-thymosine -1 consisting of two desacetylthymosine -1 un N-terminally linked by a bridge bond of 1 to 10 carbon atoms, especially an ,ω-diacyl residue with 2 to 10 carbon atoms. This new compound is made by converting a synthetic... | 08/02/1983 |
| 4395404 | Synthetic thymosin ଲ3 and ଲ4 analogues Novel peptides representing fragments of thymosin 댣 and 댤 have been synthesized and are active agents affecting regulation, differentiation and function of thymus dependent lymphocytes and macrophages.... | 07/26/1983 |
| 4389343 | Immunopotentiating peptides from thymus Novel polypeptides, designated thymosin 댨 and thymosin 댩, have been isolated from calf thymus and their amino acid sequences established. These peptides are active agents for restoring or stimulating immune function, es... | 06/21/1983 |
| 4377514 | Method for producing factor for the stimulation of the liver cell proliferation rate A process for making factor for stimulating the rate of proliferation of liver cells comprising homogenizing animal Peyer's glands, adjusting pH to about 5.5, thermally denaturing the product and recovering the desired factor in the supernatant by centrif... | 03/22/1983 |
| 4377513 | Process for the production of human erythropoietin The present invention relates to a process for the production of human erythropoietin. More precisely, the invention relates to a process for the mass production of human erythropoietin, comprising in vivo multiplication of human lymphoblastoid cells capa... | 03/22/1983 |
| 4377511 | Preparation for control of T-system of immunity and method for producing same The present invention relates to immunopharmacology and, more specifically, to a preparation controlling the T-system of immunity and to a method for producing the same. The preparation controlling the T-system of immunity is characterized by its content ... | 03/22/1983 |
| 4374828 | Biologically active thymones from the thymus A class of three substances has been isolated in highly purified form and in substantially pure form by utilizing thymus tissue as a source material. These three substances are designated thymone A, thymone B and thymone C. Thymones A and B are new peptid... | 02/22/1983 |
| 4343736 | Process for recovering interferon A process for recovering interferon which comprises contacting a solution containing an interferon produced by the induced cells of human origin with a water-insolubilized sulfated polysaccharide to allow the interferon to be adsorbed on the water-insolub... | 08/10/1982 |
| 4339427 | Radioimmunoassay of thymosin An improved radioimmunoassay for the polypeptidic thymic hormone thymosin댑 is described. The assay employs a radiolabelled [Tyr1 ]-thymosin댑 or [Tyr1 ]-desacetylthymosin댑 as probe... | 07/13/1982 |
| 4335040 | Therapeutic product and method Described herein are compositions obtained in accordance with the procedure which comprises placing in a pressure vessel a quantity of material comprising animal tissue selected from the group consisting of fresh human placenta or other animal tissues, en... | 06/15/1982 |
| 4314935 | Process for recovering interferon A process for recovering interferon which comprises contacting a solution containing an interferon produced by the induced cells of human origin with a water-insolubilized sulfated polysaccharide to allow the interferon to be adsorbed on the water-insolub... | 02/09/1982 |
| 4250084 | Purified thymic hormone (THF), its preparation and pharmaceutical compositions containing it Chemically substantially pure and uniform THF (thymic hormone), substantially devoid of endotoxins, having a molecular weight of 3323&#b1; 220, an isoelectric point of from 5.7 to 5.9; an amino acid composition of approximately: aspartic acid--... | 02/10/1981 |
