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| Number | Title | Issue Date |
| 7411044 | Polymerized hemoglobin solutions having reduced amounts of tetramer and method for preparing A substantially tetramer free hemoglobin solution and a method for producing a substantially tetramer free hemoglobin solution. The method includes polymerizing a solution of hemoglobin, treating the polymerized hemoglobin solution to partially degrade the polymer t... | 08/12/2008 |
| 7291592 | Method for treating patients with massive blood loss Methods for treating a mammal suffering from massive blood loss comprising administering to the mammal a polymerized hemoglobin solution. ... | 11/06/2007 |
| 7247707 | Albumin-free factor VIII formulations A Factor VIII composition formulated without albumin, comprising the following formulation excipients in addition to Factor VIII: 4% to 10% of a bulking agent selected from the group consisting of mannitol, glycine and alanine; 1% to 4% of a stabilizing agent select... | 07/24/2007 |
| 7135553 | Polymerized hemoglobin solutions having reduced amounts of tetramer and method for preparing A substantially tetramer free hemoglobin solution and a method for producing a substantially tetramer free hemoglobin solution. The method includes polymerizing a solution of hemoglobin, treating the polymerized hemoglobin solution to partially degrade the polymer t... | 11/14/2006 |
| 7115710 | Diagnosis and treatment of PTP related disorders The present invention relates to PTP05 polypeptides and PTP10 polypeptides, nucleic acids encoding such polypeptides, cells, tissues and animals containing such nucleic acids, antibodies to such polypeptides, assays utilizing such polypeptides, and methods relating ... | 10/03/2006 |
| 7101846 | Methods and compositions for optimization of oxygen transport by cell-free systems Compositions, and methods of use thereof, for use as blood substitute products comprise aqueous mixtures of oxygen-carrying and non-oxygen carrying plasma expanders and methods for the use thereof. The oxygen-carrying component may consist of any hemoglobin-based ox... | 09/05/2006 |
| 7101557 | Combined tissue factor methods for coagulation and tumor treatment The invention embodies the surprising discovery that Tissue Factor (TF) compositions and variants thereof specifically localize to the blood vessels within a vascularized tumor following systemic administration. The invention therefore provides methods and compositi... | 09/05/2006 |
| 7087719 | Method for the crystallization of human serum albumin The present invention relates to the purification and production of human albumin from various sources through crystallization and repeated crystallization. Basic features of the invented process include providing specific reaction conditions and precipitating reage... | 08/08/2006 |
| 7087723 | Albumin-free factor VIII formulations A Factor VIII composition formulated without albumin, comprising the following formulation excipients in addition to Factor VIII: 4% to 10% of a bulking agent selected from the group consisting of mannitol, glycine and alanine; 1% to 4% of a stabilizing agent select... | 08/08/2006 |
| 6986984 | Use of defibrinated blood for manufacture of a hemoglobin-based oxygen carrier Red blood cells are purified by defibrinating whole blood and then filtering the defibrinated whole blood, whereby at least a portion of a plasma component is separated from the red blood cells to form a suspension of red blood cells, thereby purifying the red blood... | 01/17/2006 |
| 6936423 | Anti-LTNF for in vitro assay of biological toxins Lethal Toxin Neutralizing Factor has been isolated in purity from opossum serum by high pressure liquid chromatography (HPLC) fractionation. The amino acid sequence from the N-terminal for the first fifteen amino acids of LTNF-n is: Leu Lys Ala Met Asp Pro Thr Pro P... | 08/30/2005 |
| 6884773 | Modified hemoglobins, including nitrosylhemoglobins, and uses thereof Diseases which can be ameliorated by delivery of NO to tissues affected by the disease can be treated by administration of nitrosyl-heme-containing donors of NO, including nitrosylhemoglobin. Nitrosylhemoglobin can be made by the reaction of NO with hemoglobin under... | 04/26/2005 |
| 6872808 | Nematode-extracted serine protease inhibitors and anticoagulant proteins Proteins which have activity as anticoagulants and/or serine protease inhibitors and have at least one NAP domain and are described. Certain of these proteins have factor Xa inhibitory activity and others have activity as inhibitors of factor VIIa/TF. These proteins... | 03/29/2005 |
| 6855691 | Methods for producing and using S-nitrosohemoglobins Nitric oxide (NO) interacts with hemoglobin (Hb) at its metal centers, whereas S-nitrosothiols (RSNOs) can donate the NO group to β93 cysteine residues, thereby shielding the NO functionality from heme inactivation. S-nitrosylation of Hb is under the allosteric con... | 02/15/2005 |
| 6770278 | Methods of making and using immunoglobulin (Ig) compositions The invention is directed to methods of using Ig compositions to prevent and/or treat humans, livestock and/or domesticated animals suffering from stress induced respiratory disorders. The Ig composition comprises a concentrated amount of one or more immunoglobulins... | 08/03/2004 |
| 6686332 | Method of treating depressed reticuloendothelial system function The present invention provides methods of treating adverse physiological effects associated with depressed reticuloendothelial system function comprising administering to a subject suffering from depressed reticuloendothelial system function an effective ... | 02/03/2004 |
| 6627193 | Methods and compositions for control of blood coagulation Methods for controlling blood coagulation, and suitable pharmaceutical compositions that include a polypeptide that enhances the anticoagulation process (or inhibitors thereof for reversing the anticoagulation process) are provided.... | 09/30/2003 |
| 6627404 | Methods for improving the recovery of troponin I and T in membranes, filters and vessels A method to facilitate recovery troponin I and/or troponin T from a sample comprising addition of troponin C to the sample or to a surface from which the troponin I and/or troponin T are recovered.... | 09/30/2003 |
| 6599881 | Antithrombotic materials and methods Antithrombotic materials and methods are provided for the treatment of thrombotic disorders, in which therapeutically effective amounts of BPI protein products are administered.... | 07/29/2003 |
| 6596691 | Therapeutic uses of BPI protein products for human meningococcemia Methods and materials for the treatment of human meningococcemia are provided in which therapeutically effective amounts of BPI protein products are administered.... | 07/22/2003 |
| 6586573 | Albumin-free Factor VIII formulations A Factor VIII composition formulated without albumin, comprising the following formulation excipients in addition to Factor VIII: 4% to 10% of a bulking agent selected from the group consisting of mannitol, glycine and alanine; 1% to 4% of a stabilizing a... | 07/01/2003 |
| 6583113 | Nitrosated and nitrosylated heme proteins Nitrosylation of proteins and amino acid groups enables selective regulation of protein function, and also endows the proteins and amino acids with additional smooth muscle relaxant and platelet inhibitory capabilities. Thus, the invention relates to nove... | 06/24/2003 |
| 6521591 | Pharmaceutical composition for muscular anabolism A pharmaceutical composition suitable for enhancing muscular anabolism contains, per daily dose, at least 5 mg of anabolic initiators comprising anabolic growth factors, at least 0.12 g of protein equivalents of anabolic substrates and at least 3 g of ana... | 02/18/2003 |
| 6514701 | Antimicrobial peptides and methods of use thereof Novel peptide analogs derived from the native sequences of CAP37 peptides 20-44 and 23-42, and their use as therapeutics against bacterial infections and diseases caused by bacterial infection. The peptide analog includes a serine or threonine substitutio... | 02/04/2003 |
| 6498141 | Method and apparatus for preparing an acellular red blood cell substitute A process is disclosed for the preparation of an essentially tetramer-free, substantially stroma-free, polymerized, pyridoxylated hemoglobin. Also disclosed is an essentially tetramer-free, substantially stroma-free, polymerized, pyridoxylated hemoglobin ... | 12/24/2002 |
| 6432918 | Methods and compositions for optimization of oxygen transport by cell-free systems Compositions, and methods of use thereof, for use as blood substitute products comprise aqueous mixtures of oxygen-carrying and non-oxygen carrying plasma expanders and methods for the use thereof. The oxygen-carrying component may consist of any hemoglob... | 08/13/2002 |
| 6387877 | Purification method The invention relates to a method of removing endotoxin from preparations of alpha-1-acid glycoprotein (orosomucoid) by contact with a finely divided non-toxic resin such as fumed silica. The invention also relates to a purification process for alpha-1-ac... | 05/14/2002 |
| 6340667 | Reptilian-derived peptides for the treatment of microbial infections The present invention provides compositions useful as antimicrobial agents which include reptilian hemoglobin, the and ଲ chains of hemoglobin free of heme, fragments of said proteins or polypeptide fragments thereof and combinations thereof.... | 01/22/2002 |
| 6337314 | Mammalian-derived peptides for the treatment of microbial infections The present invention provides compositions useful as antimicrobial agents which include mammalian hemoglobin, the and ଲ chains of hemoglobin free of heme, fragments of the and ଲ chains that result from cyanogen bromide cleavag... | 01/08/2002 |
| 6329500 | Transforming growth factor-ଲ binding site The present invention relates to a composition and method for inhibiting TGF-ଲ activity. The composition comprises a TGF-ଲ neutralizing peptide derived from 댒 -macroglobulin that binds to TGF-ଲ and inhibits TGF-ଲ ... | 12/11/2001 |
| 6320029 | Methods of production and use of liquid formulations of plasma proteins The present invention relates to the preparation and use of liquid formulations of plasma proteins, particularly blood coagulation factors. More specifically, the present invention relates to stable liquid formulations of Factor VIII and Factor IX that ca... | 11/20/2001 |
| 6291424 | Nitrosated and nitrosylated heme proteins Nitrosylation of proteins and amino acid groups enables selective regulation of protein function, and also endows the proteins and amino acids with additional smooth muscle relaxant and platelet inhibitory capabilities. Thus, the invention relates to nove... | 09/18/2001 |
| 6284871 | Factor IX binding peptides, derived from factor VIII and their use as inhibitors of blood coagulation The present invention relates to biologically active peptides which specifically inhibit the Factor IX-dependent pathway of blood coagulation. These peptides are based on a specific motif which represents a sequence of Factor VIII (amino acid 1811-1818) i... | 09/04/2001 |
| 6242418 | Therapeutic uses of BPI protein products for human meningococcemia Methods and materials for the treatment of human meningococcemia are provided in which therapeutically effective amounts of BPI protein products are administered.... | 06/05/2001 |
| 6197745 | Methods for producing nitrosated hemoglobins and therapeutic uses therefor S-nitrosothiols (RSNOs) can donate the NO group to the cysteine residues of hemoglobin (Hb) without inactivating the heme. S-nitrosylation of Hb is under the allosteric control of oxygen and the oxidation state of heme. NO group release from S-n... | 03/06/2001 |
| 6150331 | Human growth hormone-containing aqueous pharmaceutical composition Provided is an aqueous pharmaceutical composition comprising human growth hormone wherein said human growth hormone is dissolved in a benzalkonium chloride-containing, slightly to weakly acidic solution buffered, most preferably, with maleate. The composi... | 11/21/2000 |
| 6143867 | Human eosinophil-derived basic protein The present invention provides a human eosinophil-derived basic protein (EBPH) and polynucleotides which identify and encode EBPH. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences e... | 11/07/2000 |
| 6132729 | Combined tissue factor and chemotherapeutic methods and compositions for coagulation and tumor treatment The invention embodies the surprising discovery that Tissue Factor (TF) compositions and variants thereof specifically localize to the blood vessels within a vascularized tumor following systemic administration. The invention therefore provides methods an... | 10/17/2000 |
| 6132730 | Combined tissue factor and factor VIIa methods and compositions for coagulation and tumor treatment The invention embodies the surprising discovery that Tissue Factor (TF) compositions and variants thereof specifically localize to the blood vessels within a vascularized tumor following systemic administration. The invention therefore provides methods an... | 10/17/2000 |
| 6117838 | Use of hemoglobin in the treatment of hypotension A method of treating a mammal suffering from hypotension by administering intermolecularly- or intramolecularly-crosslinked stroma-free hemoglobin to the mammal.... | 09/12/2000 |
